Kutsanya
Back Clinic Fasting Functional Medicine Team. Kutsanya ndiko kurega kana kuderedzwa kubva kune zvimwe kana zvese zvekudya, zvinwiwa, kana zvese zviri zviviri kwenguva yakati.
Kunyatsokurumidza kana kukurumidza kukurumidza kunotsanangurwa sekuzvidzora kubva kune zvokudya zvose uye mvura kune imwe nguva yakatarwa.
Tea uye kofi yakasviba inogona kudyiwa.
Nguva yekudya inogona kunge iri pakati kana kuti inogona kudzivirira zvishoma, inogadzirisa zvinhu kana zvimwe zvokudya.
Muchirevo chechimiro chemuviri, inogona kureva chimiro chemunhu asina kudya kana chimiro cheMetabolic.
Kuchinja kwemagetsi kunowanika panguva yekutsanya.
Ex: munhu anotenda kuti ari kutsanya mushure memaawa 8-12 apera kubva pakudya kwavo kwokupedzisira.
Kuchinja kwemetabolic kubva kumamiriro ekukurumidza kunotanga mushure mekudya kwekudya, kazhinji maawa 3-5 mushure mekudya.
Health Benefits:
Inokurudzira Ropa Kurapa
Kurwisana Kurwisana
Kunowedzera Moyo Health
Triglycerides
Cholesterol Levels
Zvinodzivirira Neurodegenerative Matambudziko
Inowedzera Growth Hormone Secretion
Metabolism
Kuonda
Muscle Strength
Mitambo Yekudya:
Kukurumidza kuongororwa kunoreva kubva kumaawa 8-72 (zvichienderana nezera) rinoitwa pasi pekucherechedza kuti rifambise kuongororwa kwehutano hwehutano, hwakadai se hypoglycemia.
Mhando dzakawanda dzekutsanya dzinoitwa kwemaawa makumi maviri nemana kusvika makumi manomwe nemaviri
Utano hunobatsira hunowedzera kuora muviri
Unhu hwakanaka hunoshanda.
Vanhu vanogonawo kutsanya sechikamu chekurapa kana kuedza, zvakadai sekolonoscopy kana kushanda.
Pakupedzisira, inogona kuva chikamu chetsika.
Kuongororwa kwekuongorora kunowanikwa kuti uone kushanya kwenguva.
by Dr Alex Jimenez Kutsanya , Functional Medicine , Gastro Intestinal Health , Gut uye Utachiona Utano , utano , Natural Health , udyo , Wellness
Hutano hwedu hwekugaya hunobva mukuumbwa kwehutano hwedu hutumbu microbiome kana mabhakitiriya ari mudumbu medu (GI) turakiti. Iyi probiotic chimiro inoita basa rakakosha muma immune system edu uye izvi zvinogona pakupedzisira kukanganisa mhinduro yedu yekuzvimba. Zvakare, izvo zvikafu zvatinodya, mahormone, maurotransmitter, uye kunyangwe yedu adrenal uye mitochondrial chinzvimbo chinogona kukanganisa hutano hwedu hwekugaya. Asina kujairika kana akawandisa mabhakitiriya anogona kukonzera akawanda ekugaya ehutano nyaya. Vatsvagiri uye vezvehutano vakaona kuti "kutsanya" kunogona kubatsira kusimudzira hutano gut microbiome uye kutsigira hutano hwese hwekugaya.
Ongororo dzinoverengeka dzakaratidza kuti kudya zvakakwana fiber uye chikafu chinowedzera huwandu hwehutachiona mudumbu (GI) turakiti inosanganisirwa nekuvandudzwa kwe insulin senzwi pamwe nekuderedza immune immune uye kuzvimba, pakati pezvimwe zvakawanda zvehutano zvinobatsira. Izvi zvidzidzo zvakaratidzawo kuti kutsanya kunogona kuve neaya mabhenefiti ehutano. Mhando dzakasiyana dzekutsanya dzinogona kushandiswa senzira yekurapa yezvakasiyana zvehutano hwekudya. Sezvineiwo, zvimwe zvidzidzo zvakaratidza kuti kutsanya kunogona kubatsira kugadzirisa nyaya dzehutano hwekugaya senge SIBO, IBS, uye leaky gut.
Muedzo wekutsanya uye Hutano hwehutano
Mike Hoaglin, aimbova director director wekiriniki yaDz Oz uye azvino kiriniki inotungamira yeBiome, kambani yebiotechnology inobatsira vashandi vezvehutano nevarwere kuti vanzwisise kuti gut microbiome inokanganisa sei hutano hwakakwana uye hutano, yakaratidza kukosha kwebhakitiriya mune yedu dumbu (GI ) turakiti nekugovana zvabuda zviyero zvekuyedza kwaakazviedza pachezvake. Makambani eBiotechnology akaita seBiome anokwanisa kuona chimiro cheprobiotic yemurwere, kusanganisira "hutano" uye hutachiona hutachiona hunogona kunge huchienderana nenyaya dzehutano hwekugaya seCrohn's disease uye ulcerative colitis.
Mushure mekudzidza kuti kutsanya kunogona kubatsira sei kugadzirisa immune system, kumutsa maseru emukati, uye kudzikisa njodzi yako yekukudziridza mhando zhinji dzekenza, Mike akakurudzirwa kuita yake yemazuva mashanu mvura nekukurumidza kuti aone kuti nzira yekudyira iyi ingakanganisa sei ura hwake microbiome. Akafemerwa zvakare kuti azive kuti kutsanya kunogona kukanganisa sei simba rake pamwe nekugona kwepfungwa uye hutsi hwehuropi. Nekutumira stool sampuro, akasarudza iwo huwandu hwebhakitiriya mune yake dumbu (GI) turakiti asati atanga nzira yekutsanya. Mike Hoaglin aive pasi pekutarisirwa kweanoshanda mushandi wezvekurapa.
Kunzwisisa zvakakonzeresa Kutsanya
Zvinoenderana neBiome probiotic profile miedzo yake, Mike aive nedysbiosis, kusaenzana mukuumbwa kwegumbu rake microbiome inoenderana nekudzikira kwezvinhu zvipenyu zvemabhakitiriya "ane hutano" uye akawedzera "anokuvadza" mabhakitiriya anozivikanwa nekukonzera kuzvimba. Mike Hoaglin akaronga mazuva mashanu muhurongwa hwake kuti atange kuita kwekutsanya mushure mekunge ataura nemurapi wake anoshanda. Sekutsanangurwa kwevanhu vazhinji mumazuva ekutanga ekutsanya, Mike akave nenguva yakaoma yekuenda asina kudya chero chikafu. Akatsanangura kunzwa kunhuwa uye nzara, zvisinei, aive achiri kugona kurara.
Nzara yaMike yakanga yaderera nekutenda nezuva rechitatu rekutsanya uye, kunyangwe aive achine mazuva akati wandei ekurapwa, akanzwisisa kuti kusara kwekutsanya kwacho kwaisazove kwakaoma sezvazvaive zvekutanga mazuva maviri, kunyangwe ropa rake glucose, kana shuga, iri shoma. Mike Hoaglin akanzwa kuwedzera kwesimba rake nezuva nezuva rechina rekutsanya. Akanzwa kujekeserwa kwepfungwa sezvo dumbu rake rekugaya rakatanga kushandisa mafuta sesimba pane kushandisa shuga, kana glucose. Akabva aziva kuti masero ake emashanga aive amiswa mukati mezuva rechina rekutsanya.
Mike akapedza kutsanya pazuva reshanu na5: 00 masikati nekudya mukombe webhuti muto. Bone muto ndeimwe yemhando yakakurudzirwa yezvikafu kubatsira vanhu kuchinja kubva mukutsanya nekuti ine maamino acids akakosha, senge glutamine uye glycine, ayo anopa zvinovaka muviri kumaturakiti emimba (GI) achangotanga kugaya chikafu zvakare. Zvakare, kuwedzera imwe yeHimalaya munyu kune rako pfupa muto kunogona zvakare kupa ako maseru aine akawedzera maminera. Mike akaenderera mberi nekuchinja kubva mukutsanya nekudya zvekudya zvine fiber-zvine mafuta, mafuta ane hutano, uye zvishoma zvidiki zveprotein, mukusiyana kuri nyore kugaya.
Mike Hoaglin akaedza gut rake microbiome zvichitevera kuita kwake kwekutsanya uye akashamisika nematanho ezviyero zveprobiotic yake. Sekuyedza kweBiome bvunzo, kutsanya kwaive "kwakamisikidza" hutumbu hwaMike, kana utachiona huri mudumbu (GI) turakiti. Mhedzisiro yacho yakaratidza kuumbwa kwakaringana kwetumbo microbiome uye anga awedzera kusiyanisa kwemabhakitiriya "ane hutano" uye akaderedza mabhakitiriya "anokuvadza". Mushure mekupedza kuyedza kwake, Mike Hoaglin akazoziva zvakanyanya kuti mhando yezvikafu zvatinodya zvinogona kukanganisa sei hutano hwekugaya.
Kutsanya inzira inozivikanwa, yakasarudzika yekudya inogona kuva nehutano hwakasiyana hwekudya hwakawanda kuvanhu vazhinji. Vanhu vazhinji vanogona kubatsirwa zvikuru nekutsanya. Kutsanya kunogona kuita kuti autophagy, kana yakasarudzika cellular detoxization maitiro, kubatsira kutsvaira mabhakitiriya akawandisa uye undigested chikafu chakabviswa kuti ubvise svina, zvakare kumisa anti-kuzvidzora maitiro kuderedza kuzvimba uye oxidative kusagadzikana. Munguva yekuyedza, kutsanya kwakaratidzwa kuve nekubatsira kukuru pahutano hwese hwekugaya. Nekudaro, zvakakosha kuti uzive kuti kutsanya kunogona kunge kusiri kwemunhu wese. Ita shuwa yekutaura nachiremba anokwanisa uye ane ruzivo usati waedza chero nzira yekutsanya inosvika. - Dr. Alex Jimenez DC, CCST Insight
Neurotransmitter Yekuongorora Fomu
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Iyi inotevera Neurotransmitter Yekuongorora Fomu inogona kuzadzwa uye kuendeswa kuna Dr. Alex Jimenez. Zviratidzo zvinotevera zvakanyorwa pane izvi fomu hazvina kuitirwa kuti zvishandiswe sekuongororwa kwechero rudzi rwechirwere, mamiriro, kana chero imwe mhando yehutano nyaya.
Hutano hwedu hwekugaya hunobva mukuumbwa kwehutano hwedu hutumbu microbiome kana mabhakitiriya ari mudumbu medu (GI) turakiti. Iyi probiotic chimiro inoita basa rakakosha muma immune system edu uye izvi zvinogona pakupedzisira kukanganisa mhinduro yedu yekuzvimba. Zvakare, izvo zvikafu zvatinodya, mahormone, maurotransmitter, uye kunyangwe yedu adrenal uye mitochondrial chinzvimbo chinogona kukanganisa hutano hwedu hwekugaya. Asina kujairika kana akawandisa mabhakitiriya anogona kukonzera akawanda ekugaya ehutano nyaya. Vatsvagiri uye vezvehutano vakaona kuti "kutsanya" kunogona kubatsira kusimudzira hutano gut microbiome uye kutsigira hutano hwese hwekugaya. Studies Ongororo dzinoverengeka dzakaratidza kuti kudya zvakakwana fiber uye zvekudya zvinowedzera huwandu hwehutachiona mudumbu (GI) turakiti inosanganisirwa nekuvandudzwa kwe insulin senzwi pamwe nekuderedza immune immune uye kuzvimba, pakati pezvimwe zvakawanda zvehutano zvinobatsira. Izvi zvidzidzo zvakaratidzawo kuti kutsanya kunogona kuve neaya mabhenefiti ehutano. Mhando dzakasiyana dzekutsanya dzinogona kushandiswa senzira yekurapa yezvakasiyana zvehutano hwekudya. Sezvineiwo, zvimwe zvidzidzo zvakaratidza kuti kutsanya kunogona kubatsira kugadzirisa nyaya dzehutano hwekugaya senge SIBO, IBS, uye leaky gut.
Chiyero cheruzivo rwedu chinogumira kune chiropractic, musculoskeletal, uye hutano hwehutano hwehutano kana zvinyorwa zvemushonga zvinoshanda, misoro uye hurukuro. Isu tinoshandisa zvinoshanda hutano protocol kuti tibate kukuvara kana kusagadzikana kwemasculoskeletal system. Hofisi yedu yakaedza zvine musoro kuti ipe rubatsiro rwekutsigira uye yakaratidza kufanira kutsvaga kana zvidzidzo zvinotsigira zvatatumira. Isu tinoita zvakare makopi ekutsvagisa zvidzidzo zvekutsvagisa kuwanikwa kubhodhi uye kana kuruzhinji kana uchinge wakumbira. Kuti uenderere mberi nekukurukura nyaya yenyaya pamusoro, ndapota inzwa wakasununguka kubvunza Dr. Alex Jimenez kana kuti utibata 915-850-0900
Yakapetwa naDr.Alex Jimenez
References:
Mhedzisiro yekutsanya pane yako Microbiome Naome Whittel , 12 Kurume 2019, www.naomiwhittel.com/the-impact-of-fasting-on-your-microbiome/.
Yekuwedzera Musoro Wehurukuro: Kurwadziwa Kusingaperi
Kungoerekana kurwadziwa kuri kwekupindura kwehurongwa hwemitsipa hunobatsira kuratidza kukuvara kunogona kuitika. Nenzira, semarwadzo anofamba kubva munzvimbo yakakuvara kuburikidza nemitsipa uye musana wechipfuva kuenda kuuropi. Marwadzo kazhinji haanyanyo kuomarara sekukuvara kunorapa, zvisinei, kurwadziwa kusingaperi kwakasiyana nemhando yepakati yekurwadziwa. Nokurwadziwa kusingaperi, muviri wemunhu unozoramba uchitumira zviratidzo zvekurwadziwa kuuropi, zvisinei kana kukuvara kwapora. Kurwadziwa kusingaperi kunogona kugara kwemavhiki akati wandei kunyange makore akati wandei. Kurwadziwa kusingaperi kunogona kukanganisa zvakanyanya kufamba kwemurwere uye kunogona kudzikisira kuchinjika, simba, uye kutsungirira.
VIDEO
Neural Zoomer Plus yeNeologicalological chirwere
Dr. Alex Jimenez anoshandisa zvakatevedzana bvunzo kuti ubatsire kuongorora chirwere chemitsipa. The Neural ZoomerTM Uyezve irongero yemaitiro emitsipa autoantibodies iyo inopa chaiyo antibody-kune-antigen kuzivikanwa. Iyo Vibrant Neural ZoomerTM Kunyanya yakagadzirirwa kuitisa reactivity yemunhu kune makumi mana nemasere maantigen ane mahukama nekubatana kune dzakasiyana siyana dzehutano hwehukama. Iyo Vibrant Neural ZoomerTM Zvakare zvine chinangwa chekudzora mamiriro etsinga nekupa simba kuvarapi uye navanachiremba nechisimba chakakosha chekutanga kuona njodzi uye kutariswa kwakanangana nekuzvidzivirira kwekutanga.
Chikafu Kunzwisisa kweIgG & IgA Immune Response
Dr. Alex Jimenez anoshandisa dzakatevedzana bvunzo kubatsira kubatsira kuongorora hutano nyaya dzakanangana nekunzwa kwechikafu. Iyo Chikafu Sensitivity ZoomerTM rondedzero zana nemakumi masere anowanzo kudyiwa maantigen ezvokudya ayo anopa chaiyo yakatarwa yekurwisa-ku-antigen. Ipaneru iyi inoyera munhu Igg uye IgA kunzwisisika kune zvekudya maantigen. Kugona kuyedza IgA antibodies inopa rumwe ruzivo kune zvekudya izvo zvinogona kunge zvichikonzera mucosal kukuvara. Pamusoro pezvo, bvunzo iyi yakanaka kune varwere vanogona kunge vachirwadziwa nekunonoka kugadzirisa kune zvimwe zvekudya. Kushandisa anti-based based food sensitivity test kunogona kubatsira kuisa pamberi pekudya kwakakodzera kubvisa uye kugadzira chirongwa chakarongeka chekudya chakakomberedza zvinodiwa nemurwere.
Gut Zoomer Yezvishoma Intestinal Bacterial Overgrowth (SIBO)
Dr. Alex Jimenez anoshandisa zvakatevedzana bvunzo kuti ubatsire kuyedza hutano hwechibereki hwakabatana neechidumbu remukati mehutachiona hwehutachiona (SIBO). Iyo Vibrant Gut ZoomerTM inopa mushumo unosanganisira zvinokurudzirwa nezvekudya uye zvimwe zvekuwedzera kwepanyama senge prebiotic, probiotic, uye polyphenols. Iyo gut microbiome inonyanya kuwanikwa mumatumbu makuru uye ine anopfuura 1000 marudzi ebhakitiriya anoita basa rakakosha mumuviri wemunhu, kubva pakuumba immune system uye kukanganisa metabolism yezvinhu zvinovaka muviri kusimbisa matumbo mucosal barrier (gut-barrier ). Izvo zvakakosha kuti unzwisise kuti huwandu hwebhakitiriya hunofananidzwa hunogara mudumbu remunhu (GI) turakiti hunokanganisa hutano hwematumbo nekuti kusaenzana mumatumbu microbiome kunogona kupedzisira kwaendesa kumatumbu (GI) maturakiti zviratidzo, mamiriro eganda, autoimmune kusagadzikana, kusagadzikana kwe immune system , uye dzakawanda kusagadzikana kusagadzikana.
Zvinyorwa zveMethylation Support
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Ndapota svitsai hofisi yedu kuitira kuti isu tipe chiremba kubvunzurudza kuti tive nekuwana nyore.
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by Dr Alex Jimenez Kutsanya , Functional Medicine , Gastro Intestinal Health , Gut uye Utachiona Utano , utano , Natural Health , udyo , Wellness
Masayendisiti nevanoona nezveutano vari kutanga kupenyesa mwenje pamusoro pekukosha kwekuumbwa kweyetu gut microbiome, kana huwandu hwe "hutano" hutachiona mune yedu gastrointestinal (GI) nzira. Maererano nezvidzidzo zvekutsvagisa, hutachiona kana huwandu hwakawandisa hwehutachiona hwematumbu hunogona kuve humwe hwezvakakonzera zvikonzero zvakasiyana siyana zvehutano hwekudya, kusanganisira SIBO uye IBS. Madzitateguru edu akabatanidza chikafu chakaviriswa senge yogati, kimchi, uye sauerkraut sechimwe chakakosha chechikafu chavo chechinyakare kurongedza nekutonga kuumbwa kwebhakitiriya “rine hutano”: nehunza hutachiona .
Kutsvaga nzira dzekuvandudza hunhu hwedu hwekugaya nekuchengetedza "hutano" chimiro cheprobiotic chave chiri chinyorwa chakakurumbira kumarudzi mazhinji. Nekuda kweizvozvo, kudya chikafu chakaviriswa senge zvakambonyorwa pamusoro, kusanganisira mamwe mapoka ezvikafu aine mamwe maprobiotic, uye kutora maprobiotic ekuwedzera kwakakura zvakanyanya mukuzivikanwa mumakore apfuura. Imwe nzira yekuzvigadzirisa inowedzeredza kugaya kwehutano iyo ichangobva kuve yakakurumbira kutsanya, kurongedza kuzvidzora kana kudzikiswa kubva kune akati wandei kana zvese zvekudya kwenguva yakati yenguva. Kutsanya kunogona pakupedzisira kubatsira kunatsiridza hutano hwese hwekugaya.
Kutsanya kunogona kubatsira kutsigira kuumbwa kwakanaka kweedu dumbu microbiome uye inogona kushandiswa senzira yekurapa kune akasiyana mamiriro ezvinhu nezvirwere, senge kutemwa nemusoro, migraines, eczema, metabolic syndrome, uye kufutisa. Masayendisiti uye vezvehutano vakatsunga kuti kutsanya kunogona kusimbisa muviri wemunhu nenzira inobatsira. Kushushikana uku kunobatsira mabhakitiriya ane hutano mudumbu (GI) turakiti nekuti inobatsira kumisikidza autophagy kana iyo chaiyo maseru maseru detoxification maitiro. Munyaya inotevera, isu tichakurukura kuti kutsanya uye kuzvitakura kunogona kusimudzira hutano hwekugaya.
Kutsanya uye Autophagy Kuongorora
Yedu gastrointestinal (GI) turakiti inogona kazhinji kuve nebasa rakaoma kuyedza kugadzirisa maseru edu tichitsvaira undigested marara kure kubvisa marara nekuti vanhu vazhinji vari kugara vachidya mukati mezuva rese. Vanhu vazhinji vanopesana zvachose nepfungwa yekutsanya, kana kuda kurega kudya kamwe chete kana maviri pazuva, kunyangwe paine mabhenefiti kune hutano hwedu hwekudya. Nekuti kune nzira dzakasiyana siyana uye nzira dzekutsanya, vanhu vazhinji vanogona kutevedzera nzira iyi yekudyira uye vachiri kutora mukana kune ese ayo ekugaya hutano mabhenefiti. Kutsanya, zvisinei, zvingangopedzisira kusiri kwemunhu wese.
Nhoroondo, mazhinji echitendero uye emweya maitiro aishandisa kutsanya sechinhu chakakosha mutsika yavo kusimudzira hutano hwese hwekugaya. Parizvino pane nzira dzakasiyana siyana dzekutsanya uye matekinoroji anoshandiswa kutsigira kugara zvakanaka. Zvakare, mabhenefiti ekurapa ekutsanya ave kuzivikanwa zviri nyore muzvidzidzo zvakawanda zvekutsvaga Mhando dzakasiyana dzekutsanya dzinogona kupatsanuka kubva pakudya zvishoma kana kusaita chinhu chakati kuti chenguva yekunwa chete mvura kwenguva yakati, dzimwe nguva kwemazuva mashanu, senzira yekuzvigadzirisa hutano hwekugaya.
Kutsanya kuri pakati nepakati, nzira ine hungwaru yekudya iyo inoteedzana nekuchinja pakati pekudya kusingabvumirwe uye kudya kune imwe nguva yenguva, ndiyo imwe yenzira dzinozivikanwa nekutsanya kwevanhu vese. Masayendisiti anoona kutsanya kwepakati nepakati kuve kwakachengeteka uye kunoshanda nekuti unongoenda usina kudya chero chikafu kwenguva pfupi. Ongororo dzekutsvagisa dzakaratidza kuti kushandisa kutsanya kwekumira kwemaawa gumi nematanhatu zuva rega rega kwakaringana kugadzira macaloric anodziviswa anodiwa kuti uwane mabhenefiti ekutsanya pamwe nekumisikidza autophagy kubatsira kudzoreredza hutano hwekugaya.
Chikafu che5: 2 ndiyo nzira yekudyira apo munhu anodya chikafu chepakati kwemazuva mashanu uye zvobva zvaderedza zvakanyanya kudyiwa kwavo kwechikamu chimwe chete muzvina chekudya kwavo kwemazuva ese evhiki. Nzira dzese dzekutsanya dzakasiyana asi chinangwa chekurega kana kudzikiswa kubva kuzvikafu kupa gut yedu microbiome zororo kubva kugaya kuti vakwanise kutarisa kugadzirisa maseru edu vachitsvaira marara asina kunyudzwa uye mabhakitiriya akawandisa kuti vabvise marara. Zvidzidzo zvekutsvaga zvinoratidza kuti iyo 16: 8 chikafu chingave iri nyore nzira yekutsanya kana hunyanzvi hwekuti vanhu vatevere.
Sei Kutsanya uye Autophagy Tsigira Digestive Hutano
Yedu pancreas inowanzo kukonzera kusunungurwa kweglucagon kana tiine low glucose yeropa apo kuburitswa kwe insulin kuchikonzerwa kubatsira kudzikisa huwandu hweropa glucose. Insulin inoderera uye glucagon inowedzera panguva yekutsanya iyo yakaratidzirwa kubatsira kusimudzira kunatsiridza metabolism pamwe nekupa simba, shanduko yemamiriro, uye kuonda. Kutsanya zvakare kunobatsira kusimudzira "hutano" kuumbika kwedu mudumbu microbiome kana huwandu hwevanhu "vane hutano" mabhakitiriya mune yedu dumbu (GI) turakiti. Masayendisiti akabatanidza kutsanya pamwe nekumisikidzwa kwegene inotsigira hutano hwese hwekugaya.
Hutano hwakakwana hwekugaya uye "hutano" hwemukati mabhakitiriya akakosha kubatsira kutidzivirira kubva kune asina kujairika kana akawandisa mabhakitiriya, chepfu, uye mamwe macomputer anogona kukonzera immune system. Chekupedzisira, kutsanya kunogona kubatsira kudzosera kuvimbika kwemukati matumbo nekugadzirisa kuzvimba uko kunogona pakupedzisira kubatsira kudzivirira muviri wemunhu kubva pamamiriro akasiyana siyana nezvirwere zvine chekuita nekuzvimba. Kubatsira kukuru kwekutsanya ndechekuti kunogona kuwedzera kuzvitora kana iyo chaiyo maseru maseru detoxification maitiro. Nekutsanya, ura hwako hutano hunovandudzika uye iwe unoderedza njodzi yako kune dzakasiyana siyana dzekugaya hutano nyaya.
Kutsanya inzira inozivikanwa, yakasarudzika yekudya inogona kuva nehutano hwakasiyana hwekudya hwakawanda kuvanhu vazhinji. Vanhu vazhinji vanogona kubatsirwa zvikuru nekutsanya. Kutsanya kunogona kuita kuti autophagy, kana yakasarudzika cellular detoxization maitiro, kubatsira kutsvaira mabhakitiriya akawandisa uye undigested chikafu chakabviswa kuti ubvise svina, zvakare kumisa anti-kuzvidzora maitiro kuderedza kuzvimba uye oxidative kusagadzikana. Nekudaro, zvakakosha kuti uzive kuti kutsanya kunogona kunge kusiri kwemunhu wese. Ita shuwa yekutaura nachiremba anokwanisa uye ane ruzivo usati waedza chero nzira yekutsanya inosvika. - Dr. Alex Jimenez DC, CCST Insight
Neurotransmitter Yekuongorora Fomu
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Iyi inotevera Neurotransmitter Yekuongorora Fomu inogona kuzadzwa uye kuendeswa kuna Dr. Alex Jimenez. Zviratidzo zvinotevera zvakanyorwa pane izvi fomu hazvina kuitirwa kuti zvishandiswe sekuongororwa kwechero rudzi rwechirwere, mamiriro, kana chero imwe mhando yehutano nyaya.
Chiyero cheruzivo rwedu chinogumira kune chiropractic, musculoskeletal, uye hutano hwehutano hwehutano kana zvinyorwa zvemushonga zvinoshanda, misoro uye hurukuro. Isu tinoshandisa zvinoshanda hutano protocol kuti tibate kukuvara kana kusagadzikana kwemasculoskeletal system. Hofisi yedu yakaedza zvine musoro kuti ipe rubatsiro rwekutsigira uye yakaratidza kufanira kutsvaga kana zvidzidzo zvinotsigira zvatatumira. Isu tinoita zvakare makopi ekutsvagisa zvidzidzo zvekutsvagisa kuwanikwa kubhodhi uye kana kuruzhinji kana uchinge wakumbira. Kuti uenderere mberi nekukurukura nyaya yenyaya pamusoro, ndapota inzwa wakasununguka kubvunza Dr. Alex Jimenez kana kuti utibata 915-850-0900
Yakapetwa naDr.Alex Jimenez
References:
Mhedzisiro yekutsanya pane yako Microbiome Naome Whittel , 12 Kurume 2019, www.naomiwhittel.com/the-impact-of-fasting-on-your-microbiome/.
Yekuwedzera Musoro Wehurukuro: Kurwadziwa Kusingaperi
Kungoerekana kurwadziwa kuri kwekupindura kwehurongwa hwemitsipa hunobatsira kuratidza kukuvara kunogona kuitika. Nenzira, semarwadzo anofamba kubva munzvimbo yakakuvara kuburikidza nemitsipa uye musana wechipfuva kuenda kuuropi. Marwadzo kazhinji haanyanyo kuomarara sekukuvara kunorapa, zvisinei, kurwadziwa kusingaperi kwakasiyana nemhando yepakati yekurwadziwa. Nokurwadziwa kusingaperi, muviri wemunhu unozoramba uchitumira zviratidzo zvekurwadziwa kuuropi, zvisinei kana kukuvara kwapora. Kurwadziwa kusingaperi kunogona kugara kwemavhiki akati wandei kunyange makore akati wandei. Kurwadziwa kusingaperi kunogona kukanganisa zvakanyanya kufamba kwemurwere uye kunogona kudzikisira kuchinjika, simba, uye kutsungirira.
VIDEO
Neural Zoomer Plus yeNeologicalological chirwere
Dr. Alex Jimenez anoshandisa zvakatevedzana bvunzo kuti ubatsire kuongorora chirwere chemitsipa. The Neural ZoomerTM Uyezve irongero yemaitiro emitsipa autoantibodies iyo inopa chaiyo antibody-kune-antigen kuzivikanwa. Iyo Vibrant Neural ZoomerTM Kunyanya yakagadzirirwa kuitisa reactivity yemunhu kune makumi mana nemasere maantigen ane mahukama nekubatana kune dzakasiyana siyana dzehutano hwehukama. Iyo Vibrant Neural ZoomerTM Zvakare zvine chinangwa chekudzora mamiriro etsinga nekupa simba kuvarapi uye navanachiremba nechisimba chakakosha chekutanga kuona njodzi uye kutariswa kwakanangana nekuzvidzivirira kwekutanga.
Chikafu Kunzwisisa kweIgG & IgA Immune Response
Dr. Alex Jimenez anoshandisa dzakatevedzana bvunzo kubatsira kubatsira kuongorora hutano nyaya dzakanangana nekunzwa kwechikafu. Iyo Chikafu Sensitivity ZoomerTM rondedzero zana nemakumi masere anowanzo kudyiwa maantigen ezvokudya ayo anopa chaiyo yakatarwa yekurwisa-ku-antigen. Ipaneru iyi inoyera munhu Igg uye IgA kunzwisisika kune zvekudya maantigen. Kugona kuyedza IgA antibodies inopa rumwe ruzivo kune zvekudya izvo zvinogona kunge zvichikonzera mucosal kukuvara. Pamusoro pezvo, bvunzo iyi yakanaka kune varwere vanogona kunge vachirwadziwa nekunonoka kugadzirisa kune zvimwe zvekudya. Kushandisa anti-based based food sensitivity test kunogona kubatsira kuisa pamberi pekudya kwakakodzera kubvisa uye kugadzira chirongwa chakarongeka chekudya chakakomberedza zvinodiwa nemurwere.
Gut Zoomer Yezvishoma Intestinal Bacterial Overgrowth (SIBO)
Dr. Alex Jimenez anoshandisa zvakatevedzana bvunzo kuti ubatsire kuyedza hutano hwechibereki hwakabatana neechidumbu remukati mehutachiona hwehutachiona (SIBO). Iyo Vibrant Gut ZoomerTM inopa mushumo unosanganisira zvinokurudzirwa nezvekudya uye zvimwe zvekuwedzera kwepanyama senge prebiotic, probiotic, uye polyphenols. Iyo gut microbiome inonyanya kuwanikwa mumatumbu makuru uye ine anopfuura 1000 marudzi ebhakitiriya anoita basa rakakosha mumuviri wemunhu, kubva pakuumba immune system uye kukanganisa metabolism yezvinhu zvinovaka muviri kusimbisa matumbo mucosal barrier (gut-barrier ). Izvo zvakakosha kuti unzwisise kuti huwandu hwebhakitiriya hunofananidzwa hunogara mudumbu remunhu (GI) turakiti hunokanganisa hutano hwematumbo nekuti kusaenzana mumatumbu microbiome kunogona kupedzisira kwaendesa kumatumbu (GI) maturakiti zviratidzo, mamiriro eganda, autoimmune kusagadzikana, kusagadzikana kwe immune system , uye dzakawanda kusagadzikana kusagadzikana.
Zvinyorwa zveMethylation Support
XYMOGEN s Exclusive Professional Formulas inowanika kuburikidza nekusarudza vadzidzisi vehutano hwehutano. Inotengesa kutengesa uye kugoverwa kwemafomu eXYMOGEN zvakarambidzwa zvachose.
Kuzvikudza, Dr. Alexander Jimenez inogadzira XYMOGEN mafomu anowanikwa chete kune varwere pasi pedu.
Ndapota svitsai hofisi yedu kuitira kuti isu tipe chiremba kubvunzurudza kuti tive nekuwana nyore.
Kana uri murwere we Kukuvadza Medical & Chiropractic Clinic , unogona kubvunza nezve XYMOGEN nekushevedzera 915-850-0900 .
Nekuda kwako nekudzokorora kwe XYMOGEN zvigadzirwa ndapota ongorora chinotevera chinongedzo. *XYMOGEN-Catalog- Download
* Zvose zviri pamusoro apa XYMOGEN mitemo inoramba ichishanda.
by Dr Alex Jimenez Kutsanya , Functional Medicine , Gastro Intestinal Health , Gut uye Utachiona Utano , utano , Natural Health , udyo , Wellness
Kune vanhu vazhinji, kutsanya, kana pfungwa yekuzvidira kurega kudya kwenguva yakati, inogona kunge isingaratike senzira inokwezva yekusimudzira hutano hwekugaya. Nekuti vanhu vazhinji vanodyawo kanenge katatu kudya pazuva, kusvetuka kamwe chete kana kaviri pazuva kunogona kupedzisira kwaita kuti vanzwe kushushikana, kuneta uye kuneta. Nekudaro, kune vanhu vane hutano hwekuzeya, senge SIBO, IBS, kana kuvuza gut, vanogona kunge vatove kunzwa izvi zviratidzo, kunyangwe mushure mekudya kwavo katatu pazuva. Muchikamu chino, tichakurukura kuti kutsanya kunogona kubatsira sei vamwe varwere uye kuti kunogona kubatsira sei kugadzirisa hutano hwavo hwekudya.
Kunzwisisa iyo Digestive System
Iyo yekugaya sisitimu inotanga maitiro ekuputsa chikafu kubva panguva yatinodya kuti titore zvinovaka muviri, senge mavitamini uye zvicherwa. Iyo yekugaya sisitimu inoshandisa angangoita makumi maviri neshanu muzana emakoriori atinoshandisa kutotanga maitiro ekugaya. Kugaya chikafu kunoda simba rakakura kubva mumuviri wemunhu nekuti zvinoshandura mazhinji emabasa ayo makuru uye kudhonza zviwanikwa zvakawanda kubva kune zvimwe zvivakwa kuti zviite chete. Ma immune immune anoitawo nguva dzese dzatinodya chikafu kuitira kudzivirira dumbu, kana GI, turakiti kubva kune chero chinhu uye zvese zvinopfuura.
Kana uchitsanya, zvakadaro, iyo yekugaya system inogona kutanga kupora uye kudzorera muviri wemunhu. Munguva yekutsanya, muviri wemunhu unoshandisa mafuta panzvimbo yeshuga sosi huru yemafuta emafuta. Munhu wepakati anongova ne2,500 Kcal yeglycogen yekushandisa seglucose yesimba nepo munhu wepakati aine anenge 100,000 Kcal emafuta esimba. Zvakare, zvinogona kutora nguva kuti muviri wemunhu uchinjike kushandisa mafuta panzvimbo yeshuga sosi sosi yemafuta emagetsi, ndosaka vanhu vazhinji vangasanzwa mushe kusvika mazuva akati wandei vatanga kutsanya. Kutsanya kunogona zvakare kuve kune zvimwe zvakanaka.
Kupisa
Kuzvimba ndechimwe chezvikonzero zvikuru zvekusiyana kwemamiriro ezvinhu nezvirwere, kusanganisira nyaya dzehutano hwekudya. Sekureva kwevaongorori uye vezvehutano, kuzvimba ndicho chikonzero chinowanzoitika cheSIBO, mudumbu wemukaka kubhakitiriya kuwanda, IBS, kuzvimba ura chirwere, uye kuvuza gut. Zvinhu zvakatipoteredza, zvakadai sehupfu, chikafu chakagadziriswa, zvinodhaka uye / kana mishonga, doro, uye kunzwisiswa kwezvokudya kana kusagadzikana zvinogona kukonzera kuzvimba. Uyezve, kushushikana kunogona kukonzera kuzvimba uye kunogona kukanganisa zvakanyanya kugaya uye hutano hwese hwekugaya.
Hapana chikafu chinozopfuura nemudumbu, kana GI, turakiti panguva yekutsanya. Kunze kwemvura, kutsanya kunodzora kudyiwa kwemakemikari ekuzvimba, zvichiwedzera kudzikisa kuzvimba mumuviri wemunhu. Anti-inflammatory cytokines inogadziriswa nepo pro-inflammatory cytokines isinganyanyi kushanda kana uchitsanya. Iyo yekugaya sisitimu inoziva patinenge tisiri kudya uye pakupedzisira inozokonzeresa ino mamiriro uye anoshanda shanduko. Kuzvimba kwakabatanawo zvakanyanya nekushushikana nekushushikana Kushushikana nekushushikana uye kuzvimba kunogona kukanganisa hutano hwedu hwekugaya.
Kunyanya Kushungurudzika
Kutsanya kunogona kubatsira kuderedza kuzvimba uye kushungurudzika oxidative kuburikidza nemitezo yedu. Kushungurudzika kweOxidative kunoreva kukuvara kunoitika kumasero uye zvinyama zvemuviri wemunhu kana zvichinge zvaratidzwa zvakasiyana siyana zvemamiriro ekunze, akadai sehupfu. Mapuroteni, lipids, uye kunyange iyo DNA yemasero edu inogona kukanganiswa nekuzvimba uye oxidative kusagadzikana, kushandura chimiro uye kushanda kwemasero. Kudya antioxidants kunogona kubatsira kuderedza kuzvimba uye oxidative kusagadzikana. Izvo zvakakosha iwe unoita shuwa kuti iwe unoshandisa yakakwana maoxoxidants kana usiri kutsanya kuitira kuti udzivise kukuvara kwemasero kubva mukuputika uye oxidative kusagadzikana.
Kutsanya uye iyo MMC yeDhivhairo Hutano
Vatsvagiri uye nyanzvi dzezvehutano vakurudzira kuti kuvandudzwa kwehutano hwakawanda hwekugaya, kusanganisira SIBO, IBS, uye leaky gut, inosanganisirwa nematanho akawedzera emakemikari ane oxidative pamwe nekuderera kwehuwandu hwemakemikari eantioxidant. Nekudaro, iyo sosi huru yezvinhu zvehutano hwekugaya inozopedzisira yabatanidza dumbu microbiome kana bhakitiriya riri mudumbu. Kuderera kwemukati mebhakitiriya kuwanda, kana SIBO, inyaya yekugaya inokonzereswa nekukura kwakanyanya kwebhakitiriya mumudumbu mudiki, zvichizopedzisira zvaunza kunodonha ura kana kukwana kwemukati, pakati pemamwe matambudziko.
Zvinoenderana nezvidzidzo zvekutsvaga uye kuyedza kwekiriniki, kutsanya kunogona kubatsira kushandura huwandu hwegumbo microbiome, kukurudzira kugadziriswa kwe "hutano" hutachiona. Iyi nzira yekugaya yekudya inozopedzisira yadzorwa neinotama mota yakaoma kana iyo MMC. Iyo MMC inzira yekuzeya iyo inogadzirisa uye inochengetedza mudumbu, kana GI, matinji ematanho mukati menguva yakati yenguva. Iyo inofamba mota yakaoma inobatsira kutsvaira mabhakitiriya uye undigested marara kunze kwekubviswa semarara. Neurohormonal sign, senge somatostatin, serotonin, motilin, uye ghrelin, inodzora iyo MMC kana uchidya nekutsanya.
MMC chiitiko chinokonzeresa patiri kutsanya kana pakati pekudya. Kana tangodya chikafu, zvakadaro, zvinovaka muviri zvakaita semavhitamini uye zvicherwa zvinogona kukanganisa kumisikidza mota inofamba, pakupedzisira ichidzikira kana zviitiko zveMMC zvichikonzera, uye zvichitangisa nzira yekugaya zvekare. Kana isu tikatendera iyo MMC kupedzisa basa rayo panguva yekutsanya, inogona kuve yakanyanya kuomera chikafu, marara asina kugayiwa, uye mabhakitiriya akawandisa kuti agare mudumbu, kana GI, turakiti. Ichi ndicho chikonzero kutsanya kwakakurudzirwa sekurapa kweSIBO. Zvisinei, kutsanya kunogona kusakwanira munhu wese. Kunyangwe kutsanya kuchigona kuve nemhando dzakasiyana dzekugaya hutano mabhenefiti, ita shuwa yekubata chiremba usati watanga chero chirongwa chekutsanya chirongwa kana chirongwa.
Kutsanya inzira inozivikanwa, yakasarudzika yekudya inogona kuva nehutano hwakasiyana hwekudya hwakawanda kuvanhu vazhinji. Nyaya dzinoverengeka dzehutano hwekudya, dzakadai SIBO, IBS, uye leaky gut, inogona kubatsirwa zvikuru nekutsanya. Bhakitiriya dumbu rakanyanya kukura, kana SIBO, inyaya yehutano hwakakomba inoita kuti mabhakitiriya akakura akure mudumbu diki. Kutsanya kunogona kusimudzira mota inofamba, kana iyo MMC, kuti ishandise, kutsvaira mabhakitiriya akawandisa uye isina kuchenesa marara kuitira kubvisa svina, zvakare kuchikonzera kurwisa-kurwisa maitiro ekudzikisa kuzvimba uye oxidative kusagadzikana. Nekudaro, kutsanya kunogona kunge kusiri kwemunhu wese. Ita shuwa yekutaura kune anokwanisa uye ane ruzivo nezvehutano hutano usati wadya. - Dr. Alex Jimenez DC, CCST Insight
Neurotransmitter Yekuongorora Fomu
Iyi inotevera Neurotransmitter Yekuongorora Fomu inogona kuzadzwa uye kuendeswa kuna Dr. Alex Jimenez. Zviratidzo zvinotevera zvakanyorwa pane izvi fomu hazvina kuitirwa kuti zvishandiswe sekuongororwa kwechero rudzi rwechirwere, mamiriro, kana chero imwe mhando yehutano nyaya.
Kune vanhu vazhinji, kutsanya, kana pfungwa yekuzvidira kurega kudya kwenguva yakati, inogona kunge isingaratike senzira inokwezva yekusimudzira hutano hwekugaya. Nekuti vanhu vazhinji vanodyawo kanenge katatu kudya pazuva, kusvetuka kamwe chete kana kaviri pazuva kunogona kupedzisira kwaita kuti vanzwe kushushikana, kuneta uye kuneta. Nekudaro, kune vanhu vane hutano hwekuzeya, senge SIBO, IBS, kana kuvuza gut, vanogona kunge vatove kunzwa izvi zviratidzo, kunyangwe mushure mekudya kwavo katatu pazuva. Muchikamu chino, takurukura kuti kutsanya kunogona kubatsira sei vamwe varwere uye kuti kunogona kubatsira sei kugadzirisa hutano hwavo hwekudya.
Chiyero cheruzivo rwedu chinogumira kune chiropractic, musculoskeletal, uye hutano hwehutano hwehutano kana zvinyorwa zvemushonga zvinoshanda, misoro uye hurukuro. Isu tinoshandisa zvinoshanda hutano protocol kuti tibate kukuvara kana kusagadzikana kwemasculoskeletal system. Hofisi yedu yakaedza zvine musoro kuti ipe rubatsiro rwekutsigira uye yakaratidza kufanira kutsvaga kana zvidzidzo zvinotsigira zvatatumira. Isu tinoita zvakare makopi ekutsvagisa zvidzidzo zvekutsvagisa kuwanikwa kubhodhi uye kana kuruzhinji kana uchinge wakumbira. Kuti uenderere mberi nekukurukura nyaya yenyaya pamusoro, ndapota inzwa wakasununguka kubvunza Dr. Alex Jimenez kana kuti utibata 915-850-0900
Yakapetwa naDr.Alex Jimenez
References:
Rory. Maitiro Ekurapa Gut Yako Nekutsanya. Chewsomegood , MSc Yakasarudzika Nutrition, 9 Aug. 2018, www.chewsomegood.com/fasting-ibs/.
Yekuwedzera Musoro Wehurukuro: Kurwadziwa Kusingaperi
Kungoerekana kurwadziwa kuri kwekupindura kwehurongwa hwemitsipa hunobatsira kuratidza kukuvara kunogona kuitika. Nenzira, semarwadzo anofamba kubva munzvimbo yakakuvara kuburikidza nemitsipa uye musana wechipfuva kuenda kuuropi. Marwadzo kazhinji haanyanyo kuomarara sekukuvara kunorapa, zvisinei, kurwadziwa kusingaperi kwakasiyana nemhando yepakati yekurwadziwa. Nokurwadziwa kusingaperi, muviri wemunhu unozoramba uchitumira zviratidzo zvekurwadziwa kuuropi, zvisinei kana kukuvara kwapora. Kurwadziwa kusingaperi kunogona kugara kwemavhiki akati wandei kunyange makore akati wandei. Kurwadziwa kusingaperi kunogona kukanganisa zvakanyanya kufamba kwemurwere uye kunogona kudzikisira kuchinjika, simba, uye kutsungirira.
VIDEO
Neural Zoomer Plus yeNeologicalological chirwere
Dr. Alex Jimenez anoshandisa zvakatevedzana bvunzo kuti ubatsire kuongorora chirwere chemitsipa. The Neural ZoomerTM Uyezve irongero yemaitiro emitsipa autoantibodies iyo inopa chaiyo antibody-kune-antigen kuzivikanwa. Iyo Vibrant Neural ZoomerTM Kunyanya yakagadzirirwa kuitisa reactivity yemunhu kune makumi mana nemasere maantigen ane mahukama nekubatana kune dzakasiyana siyana dzehutano hwehukama. Iyo Vibrant Neural ZoomerTM Zvakare zvine chinangwa chekudzora mamiriro etsinga nekupa simba kuvarapi uye navanachiremba nechisimba chakakosha chekutanga kuona njodzi uye kutariswa kwakanangana nekuzvidzivirira kwekutanga.
Chikafu Kunzwisisa kweIgG & IgA Immune Response
Dr. Alex Jimenez anoshandisa dzakatevedzana bvunzo kubatsira kubatsira kuongorora hutano nyaya dzakanangana nekunzwa kwechikafu. Iyo Chikafu Sensitivity ZoomerTM rondedzero zana nemakumi masere anowanzo kudyiwa maantigen ezvokudya ayo anopa chaiyo yakatarwa yekurwisa-ku-antigen. Ipaneru iyi inoyera munhu Igg uye IgA kunzwisisika kune zvekudya maantigen. Kugona kuyedza IgA antibodies inopa rumwe ruzivo kune zvekudya izvo zvinogona kunge zvichikonzera mucosal kukuvara. Pamusoro pezvo, bvunzo iyi yakanaka kune varwere vanogona kunge vachirwadziwa nekunonoka kugadzirisa kune zvimwe zvekudya. Kushandisa anti-based based food sensitivity test kunogona kubatsira kuisa pamberi pekudya kwakakodzera kubvisa uye kugadzira chirongwa chakarongeka chekudya chakakomberedza zvinodiwa nemurwere.
Gut Zoomer Yezvishoma Intestinal Bacterial Overgrowth (SIBO)
Dr. Alex Jimenez anoshandisa zvakatevedzana bvunzo kuti ubatsire kuyedza hutano hwechibereki hwakabatana neechidumbu remukati mehutachiona hwehutachiona (SIBO). Iyo Vibrant Gut ZoomerTM inopa mushumo unosanganisira zvinokurudzirwa nezvekudya uye zvimwe zvekuwedzera kwepanyama senge prebiotic, probiotic, uye polyphenols. Iyo gut microbiome inonyanya kuwanikwa mumatumbu makuru uye ine anopfuura 1000 marudzi ebhakitiriya anoita basa rakakosha mumuviri wemunhu, kubva pakuumba immune system uye kukanganisa metabolism yezvinhu zvinovaka muviri kusimbisa matumbo mucosal barrier (gut-barrier ). Izvo zvakakosha kuti unzwisise kuti huwandu hwebhakitiriya hunofananidzwa hunogara mudumbu remunhu (GI) turakiti hunokanganisa hutano hwematumbo nekuti kusaenzana mumatumbu microbiome kunogona kupedzisira kwaendesa kumatumbu (GI) maturakiti zviratidzo, mamiriro eganda, autoimmune kusagadzikana, kusagadzikana kwe immune system , uye dzakawanda kusagadzikana kusagadzikana.
Zvinyorwa zveMethylation Support
XYMOGEN s Exclusive Professional Formulas inowanika kuburikidza nekusarudza vadzidzisi vehutano hwehutano. Inotengesa kutengesa uye kugoverwa kwemafomu eXYMOGEN zvakarambidzwa zvachose.
Kuzvikudza, Dr. Alexander Jimenez inogadzira XYMOGEN mafomu anowanikwa chete kune varwere pasi pedu.
Ndapota svitsai hofisi yedu kuitira kuti isu tipe chiremba kubvunzurudza kuti tive nekuwana nyore.
Kana uri murwere we Kukuvadza Medical & Chiropractic Clinic , unogona kubvunza nezve XYMOGEN nekushevedzera 915-850-0900 .
Nekuda kwako nekudzokorora kwe XYMOGEN zvigadzirwa ndapota ongorora chinotevera chinongedzo. *XYMOGEN-Catalog- Download
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by Dr Alex Jimenez Kutsanya , Functional Medicine , utano , Kuonda , Wellness
Unonzwa here:
Nzara muawa kana maviri mushure mekudya? Kuwedzera uremu kuwana? Hormonal kusaenzana? Pfungwa yakazara yekubhururuka? Pfungwa yekuzara panguva yekudya nekudya?
Kana uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uine mamiriro ezvinhu aya, saka edza kufunga nezvekutsanya kwenguva pfupi.
Kubva zvave kukurumbira mumakore achangopfuura, kutsanya kwenguva pfupi inzira yekudya iyo vanhu vazhinji vanga vachishandisa mararamiro avo ane hutano. Munguva yenguva yevavhimi-vanounganidza vanhu, vanhu vakashandisa nzira iyi kwemazana emakore senzira yekupona. Zvidzidzo zvakaratidzirwa kuti vanhu vaishandisa izvo zvekurapa nekuda kwenhoroondo yese semushonga wekurapa. Vekare veRoma, vaGreek neChinese budiriro vaishandisa kutsanya muzvishoma muhupenyu hwavo hwezuva nezuva. Kutsanya kwakatoshandisirwa zvikonzero zvemweya mune zvimwe zvitendero, sechiBuddhism, chiIslam, uye chiKristu sevanhu vanozvishandisa senzira yekuzviratidza ivo pachavo uye kuva pedyo nevamwari vavo.
Kutsanya chii?
Kutsanya ndipo panotadza kudya munhu kana zvinwiwa kwemaawa gumi nemaviri masikati. Kana munhu atanga kutsanya, vanoona kuti metabolism yavo nemahormone avo achachinja mumiviri yavo. Pane kutsvagurudza kuri kuuya kutsanya kwepakati kunogona kusimudzira hutano hunoshamisa kumuviri. Izvo zvinobatsira zvehutano zvinowanikwa pakati nepakati kutsanya zvinopa kudzikisira huremu, zvinodzivirira zvinopinda muuropi, kuderera kuzvimba nekuvandudza ropa glucose uye huwandu hwe insulin mumuviri.
Nzira Dzakasiyana
Pane dzimwe nzira dzekutsanya izvo zvinosanganisira kutsanya kubva kuchikafu kwemazuva akati wandei kana mavhiki. Nedzimwe nzira dzakasiyana, dzinosanganisira nguva ipfupi iri pakati pe16 kusvika maawa 24. Mhando dzinoverengeka dzekutsanya dzinopindirana nepakati dzinoonekwa neyekudya hwindo rekureba (nguva yekudya chikafu) uye hwindo rekutsanya (nguva yekudzivirira chikafu). Hedzino dzimwe dzedzimwe nzira dzekutsanya, dzinosanganisira:
Nguva-inorambidzwa kudyisa (TRF): Iyi mhando yekutsanya ine nguva yekudyisa windows kubva pa4 kusvika kumaawa 12. Kwezosara kwezuva, mvura ndiyo chete chinhu chinotenderwa kunwiwa. Kusiyana kwakawanda kwekudya iyi mhando yekutsanya ndeye 16 / 8. Izvi zvinoreva kuti munhu anofanirwa kutsanya zvachose maawa e16 mazuva ese.Nguva yekutanga-inodzora kudya (eTRF): Iyi ndiyo mhando dzakasiyana dzekutsanya-kudzora nguva kubva ku8 am kusvika 2 pm Mushure maawa e6 apera, kuzorora kwezuva kunogadzirwa nenguva ino yekutsanya.Rimwe zuva kutsanya (ADF): Uku kutsanya kunosanganisira munhu kudya rimwe zuva uye zuva rinotevera ivo vanokurumidza kutsanya. Ivo vanochinjanisa pakati pekudya nekutsanya zuva rega rega kuti vawane izvo zvakanaka.Kutsanya kwechinguvana (cycling kufunga): Iyi mhando yekutsanya inosanganisira kutsanya kana kuti mazuva maviri kutsanya pavhiki uye kweyechishanu kana echitanhatu mazuva ekudya zvakanyanya sekuda kunoita munhu. Iyo akasiyana-siyana yenguva yekutsanya anogona kuva 5: 2 kana 6: 1.Kutsanya kwakagadziridzwa: Iyi mhando yekutsanya ine dzimwe nzira dzekupanana kutsanya dzakafanana nekumwe kutsanya-zuva kutsanya, asi kutsanya uku kunogona kushandurwa kune chero munhu. Munhu anogona kudya zvakanyanya-low-calorie zvinhu panguva yekutsanya yewindo.
Chinoshanda sei?
Kutsanya kwepakati ndiko kukonzeresa kwekuchinja kwemuviri sezvo maitiro emahormone uye metabolism yesimba iri kukanganiswa. Kana munhu achinge apedza kudya chikafu, zvirimo zviri kuputswa uye kushandurwa kuita michero, saka chinogona kubikwa muchikamu chekugaya. Izvo zvinoitika ndezvekuti macarbohydrate akaputswa uye anoshandurwa kuita glucose uye anopinda mukati meropa, achizvigovera mukati medumbu romuviri seyakakosha sosi yesimba. Iyo insulin mahormone inobatsira kudzora huwandu hweshuga yeropa nekusaina maseru kutora shuga kubva muropa nekushanduka kuita mafuta kuti muviri uite basa nemazvo.
Nekutsanya kwepakati, munhu anoitwa neupfu uye huwandu hweshuga hwawo hunopera kubva mumuviri. Kuti simba riite nezvinodiwa zvaro muviri unofanirwa kuputsa iyo glycogen inowanikwa muchiropa uye yemabhonzo emabhonzo ichikonzera gluconeogeneis. Gluconeogeneis ndipo apo chiropa ichigadzira shuga yeglu kubva kune isiri-carbohydrate zvinyorwa mumuviri. Zvino kana imwe insulin mazinga yakadzikira mushure meawa 18 yekutsanya, maitiro anonzi lipolysis anotanga. Zvinoitwa lipolysis ndezvekuti muviri unotanga kuputsa zvikamu zvemafuta mune emahara mafuta asidhi. Kana paine huwandu hwakaderera hweglucose kuti muviri utore simba, muviri pachawo nekutanga kushandisa mafuta acids uye ketones simba. Ketosis ndizvo mamiriro metabolic uko masero echiropa anotanga kubatsira mafuta kuputsa kupwanya uye kushandura iwo kuva ketone acetoacetate uye beta-hydro butyrate.
Maseru maseru uye masero euron anoshandisa ma ketones aya kugadzira ATP (adenosine triphosphate) inova ndiyo hombe yekutakura simba. Tsvagurudzo yakataura kuti kushandiswa uye kuwanikwa kwemafuta acids akasanganiswa nema ketones sekutsiurwa kwesimba kweglucose kunobetsera kune zvakakosha muviri tishu. Izvi zvinosanganisira moyo, chiropa, pancreas, uye huropi.
Iwo mana metabolic anoti anokonzerwa nekutsanya anonzi kune akakurumidza-akapihwa kutenderera, uye ndeaya:
Nyika yakadyiswa Iyo post-inotora nyika Nyika yekutsanya Nyika yenzara
Hutano hwepanyama hwekusimbisa kutsanya hunogona zvakare kuwanikwa nekutevera chikafu cheketogenic, icho chine mafuta mazhinji uye yakaderera carbohydrate kudya. Ichi chinangwa chechinodyiwa ndechekuchinjisa muviri metabolic state kuti ive ketosis.
Zvakanakira Kutsanya
Kune matani ekutsvaga akaratidzira kuti kutsanya kuchinjisa kune huwandu hwakasiyana hwehutano hwakanaka, kusanganisira:
Kuonda Nyora 2 chirwere cheshuga kudzivirira uye manejimendi Yakavandudzwa cardiometabolic njodzi zvinhu Kucheneswa kwesero Kupera kupera Neuroprotection
Zvidzidzo zvakaratidzirwa kuti nzira dzinoverengeka dzakatsanangurwa dzinobatsira izvi hutano migumisiro yekutsanya kwekufamba kwenguva uye zvakaratidza kuve zvinobatsira kumararamiro emunhu.
mhedziso
Kutsanya kwepakati kwave kuchiitwa kwemazana emakore uye kwave kuzivikanwa mumakore apfuura. Izvo zvinosanganisira kurega kudya chikafu chenguva pfupi 12 maawa akateedzana nekushandura maseru emafuta ave simba kuti muviri uite. Izvo hutano hunobatsira hunopfuurira pakati pekutsanya hunopa hunobatsira kune munhu ari kuedza kuchengetedza hupenyu hune hutano. Vamwe zvinogadzirwa batsira kupa rubatsiro kune gastrointestinal system pamwe nekuita chokwadi chekuti shuga metabolism iri padanho rine hutano kuti muviri ushande.
Chiyero cheruzivo rwedu chinogumira kune chiropractic, musculoskeletal, uye hutano hwehutano hwehutano kana zvinyorwa zvemushonga zvinoshanda, misoro uye hurukuro. Isu tinoshandisa zvinoshanda hutano protocol kuti tibate kukuvara kana kusagadzikana kwemasculoskeletal system. Hofisi yedu yakaedza zvine musoro kuti ipe rubatsiro rwekutsigira uye yakaratidza kufanira kutsvaga kana zvidzidzo zvinotsigira zvatatumira. Isu tinoita zvakare makopi ekutsvagisa zvidzidzo zvekutsvagisa kuwanikwa kubhodhi uye kana kuruzhinji kana uchinge wakumbira. Kuti uenderere mberi nekukurukura nyaya yenyaya pamusoro, ndapota inzwa wakasununguka kubvunza Dr. Alex Jimenez kana kuti utibata 915-850-0900 .
References:
Dhillon, Kiranjit K. iBiochemistry, Ketogenesis. StatPearls [Internet]. , US National Library yeMishonga, 21 Apr. 2019, www.ncbi.nlm.nih.gov/books/NBK493179/#article-36345.
Hue, Louis, naHeinrich Taegtmeyer. Renduru Rendi Rakatangwazve: Musoro Mutsva weKare Hat American Nhoroondo yePhysology. Endocrinology uye Metabolism , American Physiological Society, Sep. 2009, www.ncbi.nlm.nih.gov/pmc/articles/PMC2739696/.
Stockman, Mary-Catherine, et al. Kutsanya Pakati Penguva: Iko Kumirira Kunokodzera Kurema? Dzazvino Zvakarekera Mishumo , US National Library yeMishonga, June 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5959807/.
Zubrzycki, A, et al. Basa reKudya Kwakaderera-Koriori uye Kutsanya Kwepakati Mukurapa Kufutisa uye Type-2 Chirwere cheshuga. Chinyorwa chePhysology uye Pharmacology: Chinyorwa Chakazvimirira chePoland Physiological Society , US National Library yeMishonga, Oct. 2018, www.ncbi.nlm.nih.gov/pubmed/30683819.
by Dr Alex Jimenez Kutsanya
Alessio Nencioni, Irene Caffa, Salvatore Cortellino uye Valter D. Longo
Abstract | Kukanganisa kwemasero emukenza kuva nehuwandu hwekudzivirira uye kuvimba kwavo pane metabolites chaiyo inotarisa zviratidzo zvekenza. Kutsanya kana kutsanya-kutevedzera kudya (FMDs) kunounza kuchinja kukuru mukukura kwezvinhu uye mumatanho emetabolite, zvichiita mamiriro ezvinhu anokwanisa kuderedza kukwanisa kwekenza masero kugadzirisa uye kupona uye nokudaro kuvandudza migumisiro yerapa remishonga. Mukuwedzera, kutsanya kana maMFM zvinowedzera kupikisa chemotherapy muzvakanaka asi kwete maitiro emukenza uye kukurudzira kugadziriswa mumagadzirirwo akadai, izvo zvingabatsira kudzivirira zvinogona kuipa uye zvingangove zvinopisa mungozi yemigumisiro yemishonga. Nekutsanya hazviregi kurambidzwa nevarwere, zvose mhuka uye zvidzidzo zvekurapa zvinoratidza kuti maitiro e-low-calorie FMDs anokwanisika uye akachengeteka zvachose. Mitezo yakawanda yekliniki inoongorora kukosha kwekutsanya kana maMFM pamigumisiro-inoshandiswa yakaipisisa uye pamigumisiro inobudirira iri kuenderera mberi. Tinokurudzira kuti kusanganiswa kweMFMs ne chemotherapy, immunotherapy kana mamwe marapirwo kunomirira nzira inogona kuvimbisa yekuwedzera kurapwa kwehutano, kudzivirira kushandiswa kwekudzivirira uye kuderedza madhara.
Zvokudya uye mararamiro ane chokuita nehupenyu ndizvo zvinokonzera kuisa njodzi yekuva nekenza , nemamwe magomarara ari kunyanya kutsamira pakudya pane mamwe1�9. Zvinopesana nemafungiro aya, kuneta kunofungidzirwa kukanganisa kwe14% kusvika ku20% yevose vanofa nekenza muUnited States7, zvichiita kuti tive nemirayiridzo pamusoro pekudya zvinovaka muviri uye kuita basa rekuita kuti kuderedze njodzi yekuvandudza cancer6. Uye zvakare, zvichipiwa kuwedzera kwecancer maseru, asi kwete eakajairika matishu, kusateerera anti-kukura zviratidzo (nekuda kweoncogenic mutations) 10 uye kutadza kwavo kunyatsoenderana nemamiriro ekutsanya11,12, pane kuwedzera kufarira mune mukana wekuti zvimwe zvinodyiwa zvine macalorie zvinogona zvakare kuve chikamu chakakosha chekudzivirira gomarara uye, pamwe, yekurapa kenza senzira yekuwedzera kushanda uye kushivirira kwevamiririri veacancer.
Kunyange zvazvo mumakore gumi adarika takaziva kuchinja kusati kwamboitika uye kufambira mberi kunoshamisa mukurapa kwekenza14,15, pane chimwe chinhu chinokosha chinodiwa kuti chibudirire uye, zvichida, nzira dzokurapa nokuti matumbo asi zvakare, uye sezvakakosha, nekuda kwekugadzirisa migumisiro yemigumisiro yekenza15,16. Nyaya yehutano-zviitiko zvinokuvadza zvinoitika (TEAEs) chimwe chezvipingamupinyi zvinokosha mukurapa incology15,16. Ichokwadi, varwere vazhinji vane kenza vane ruzivo uye / kana kwenguva yakareba migumisiro yekenza mishonga, iyo inogona kudikanwa muchipatara uye kurapwa kwechisimba (zvakadai semishonga inorwisa mabhakitiriya, haematopoietic kukura zvinhu uye kuwedzerwa ropa) uye zvakanyanya kuchinja unhu hwavo hwehupenyu (somuenzaniso, chemotherapyinduced peripheral neuropathy) 16. Nokudaro, nzira dzakagadzikana dzekuchera hutsinye hunofanirwa uye dzinofungidzirwa kuva nehutano hwakakura, hupfumi uye hupfumi huwandu hweXXUMUM.
Kutsanya kunoita kuti masero ane utano agone kupindira zvishoma nezvishoma uye yakachengetedzwa mamiriro ezvinhu anovadzivirira pakushorwa kunotapira kunobva pamishonga yekurwisa mishonga panguva yekukurudzira mhando dzakasiyana dzemasero ekenza kune idzirapeutics11,12,17. Uku kuwanikwa kunoreva kuti kupindira kwekudya kumwe chete kunogona kubatsira kutarisa zvakasiyana uye zvakaenzana zvinokosha zvekenza itachiona.
Muchikamu chino cheMagariro, tinokurukura maitiro ezvokudya nekutsanya kana kutsanya-kutevedzera kudya (FMDs) kune maEAE asina kunaka asiwo kudzivirira uye kubata chirwere. Isu tinofananidzawo mavhareji emayero aya eXXUMUMX uye yakabudiswa uye inoenderera mberi zvidzidzo zvekliniki umo kutsanya kana maMMM ave achishandiswa kuvarwere vane kenza.
Systemic & Cellular Kutsanya Kupindura
Kutsanya kunotungamirira kuchinjairo mumabasa emaitiro akawanda emagetsi anoshamwaridzana nechinoshandiswa mune imwe nzira inokwanisa kuunza simba uye metabolites vachishandisa kabhoni zvinowanzobudiswa zvikuru kubva pachimiro chechidimbu uye muchidimbu kubva mumasumbu. Kuchinja kwemazinga ekufambisa mahomoni uye metabolites kunoshandura pakuderedza kushandiswa kwesero uye basa remagetsi hwemazuva ose masero uye pakupedzisira unozvidzivirira kubva chemotherapeutic kutukwa11,12. Kanzerini masero, nokusateerera mirairo yekurwisana inokurudzirwa nemararamiro aya ekushaya nzara, inogona kuva nemhinduro yakasiyana yemasero ezvakanaka uye saka inokurudzirwa chemotherapy uye mamwe mishonga yekenza.
Kugadzirisa Kwazvo Kuzvinyima
Mhinduro yekutsanya yakarongedzwa muchidimbu nematanda ekupararira kweglucose, insulini, glucagon, kukura hormone (GH), IGF1, glucocorticoids uye adrenaline. Munguva yepakutanga post-absorptive phase, iyo inowanzoita 6 24hours, insulin mazinga anotanga kudonha, uye mazinga eglucagon anomuka, achikurudzira kuparara kwezvitoro zveropa glycogen (izvo zvakaneta mushure memaawa makumi maviri nemana) nekusunungurwa kweshuga kwesimba.
Glucagon uye yakaderera masosi e insulin zvakare inokonzeresa kuparara kwe triglycerides (ayo anonyanya kuchengetwa muadipose tishu) mu glycerol uye yemahara fatty acids. Panguva yekutsanya, akawanda matishu anoshandisa mafuta acids esimba, nepo uropi huchivimba neshuga uye nemitumbi yemaketone inogadzirwa nema hepatocyte (ketone miviri inogona kugadzirwa kubva kuacetyl-CoA inogadzirwa kubva kumafuta acid? -Xidation kana kubva ku ketogenic amino acids). Muchikamu che ketogenic chekutsanya, miviri ye ketone inosvika mukati me millimolar renji, kazhinji kutanga mushure memazuva maviri ne2 kubva pakutanga kwekutsanya. Pamwe pamwe nemafuta-anotorwa glycerol uye amino acids, ketone miviri mafuta gluconeogenesis, iyo inochengeta mazinga eglucose pakufungidzira ingangoita 3mM (4mg pa dl), iyo inonyanya kushandiswa nehuropi.
Glucocorticoids uye adrenaline inobatsirawo kutungamira kushandiswa kwemagetsi ku kutsanya , kubatsira kuchengeta shuga yehutachiona uye kukurudzira lipolysis20,21. Zvinonzwisisika, kunyange zvazvo kutsanya kunogona kuwedzera zvishoma nekanguva kuwedzera GH mazinga (kuwedzera gluconeogenesis uye lipolysis uye kuderedza piripheral glucose uptake), kutsanya kunoderedza IGF1 mazinga. Mukuwedzera, pasi pekutsanya, IGF1 basa rezvakaberekwa rinodzivirirwa muchikamu nekuwedzera kwemazinga e insulini-kufanana nekukura kunosunga mapuroteni 1 (IGFBP1), iyo inosungiridza kupararira IGF1 uye inodzivirira kusangana kwaro neinoenderana nesero surface receptor22.
Pakupedzisira, kutsanya kunoderedza maitiro ekupararira leptin, hormone yakawanda yakaitwa neadidicytes inodzivisa nzara, ichiwedzera huwandu hweadiponectin, iyo inowedzera fatty acid breakdown23,24. Nokudaro, pakugumisa, zviratidzo zvemammalian zvinogadziriswa nekutsanya zvikamu zvakaderera zveglucose uye insulin, yakakwirira ye glucagon uye miviri ye ketone, mazinga akadai eGF1 uye leptin uye yakakwirira mazinga adiponectin.
Mhinduro yeChechi KuKutsanya
Mhinduro yemasero ane hutano pakutsanya ndeyekushanduka-shanduka uye inopa kuchengetedzwa kwemasero, uye zvirinani muzvipenyu zvemuenzaniso, yakaratidzirwa kuwedzera hupenyu hwehupenyu uye healthspan12,22,25-31. Iyo IGF1 chiratidzo kukwira chiyi chinhu chiratidzo nzira inobatanidzwa mukugadzirisa mhedzisiro yekutsanya padanho remaseru. Pasi pechikafu chakajairika, protein kudyiwa uye kuwedzerwa mazinga eamino acids kuwedzera IGF1 mazinga uye kukurudzira AKT uye mTOR chiitiko, zvichidaro kuwedzera mapuroteni synthesis. Zvichienderana, panguva yekutsanya, IGF1 mazinga uye kudzika kwekuratidzira kuderera, kudzikisira AKT-mediated inhibition yemammalian FOXO zvinyorwa zvinyorwa uye kubvumira izvi zvinyorwa zvinyorwa kuti zvishandure magene, zvichikonzera kumisikidzwa kwema enzymes senge haem oxygenase 1 (HO1), superoxide dismutase ( SOD) uye catalase ine antioxidant zviitiko uye zvinodzivirira32. High glucose mazinga anomutsa protein kinase A (PKA) chiratidzo , iyo inorayira zvinoshandisa tenzi simba remagetsi AMP-activated protein kinase (AMPK) 35, iyo inobvisawo kutaura kwekushungurudzika kwepfungwa kushandiswa kwekutanga kukura kweproteinini 1 (EGR1) (Msn2 uye / kana Msn4 muviriswa) 26,36 .
Kutsanya uye kukonzeresa glucose kudzora kunodzivisa chiitiko chePKA, kuwedzera chiitiko che AMPK uye kumisikidza EGR1 uye nekudaro kuzadzisa maseru-ekudzivirira mhedzisiro, kusanganisira iwo ari mu myocardium22,25,26. Chekupedzisira, kutsanya uye maMFM (ona pazasi pekuumbwa kwavo) zvakare vane mukana wekusimudzira maitiro ekuvandudza (Bhokisi 1) nema mamolekemu maitiro, mamwe acho akaverengerwa mukenza, senge kuwedzera autophagy kana induction ye sirtuin chiitiko22,37-49 .
Zvokudya Zvokudya MuMagetsi eC Cancer
Idzo nzira dzekudya dzinoenderana nekutsanya kwakaferefetwa zvakanyanya mu oncology, zvese zvakanyanyisa uye zvekurapa, zvinosanganisira kutsanya kwemvura (kurega kubva pane zvese zvekudya nezvinwiwa kunze kwemvura) uye maMFM11,12,17,25,26,50-60 (Tafura 1). Yekutanga kiriniki dhata inoratidza kuti kutsanya kweinenge makumi mana nemasere maawa kungangodiwa kuti uwane zvinonzwisisika zvemakiriniki mune oncology, sekudzivirira chemotherapy-inokonzeresa kukuvara kweDNA kumatishu ane hutano nekubatsira kuchengetedza murwere hupenyu hwehupenyu panguva yechemotherapy52,53,61.
Nekudaro, varwere vazhinji vanoramba kana kuve nematambudziko ekupedzisa kutsanya kwemvura, uye njodzi dzinogona kuvepo dzekuwedzera kwekoriori uye kushomeka kwemicronutrient kunoenderana nazvo kunonetsa kutsigira. MaMFM ari ekurapa akagadzirwa madhayeti ehurongwa akadzika kwazvo mumacalorie (ndokuti, anowanzo pakati pe300 ne1,100kcal pazuva), mashuga nemapuroteni anodzokorodza mazhinji emhedzisiro yekutsanya kwemvura-chete asi nekuteerera kuri nani kwevarwere uye kudzikisira njodzi yehutano22,61,62, 3. Munguva yeFMD, varwere vanowanzo gashira huwandu hwemvura husina kuganhurirwa, zvidiki, zvakaenzana zvemuto muto, masobho, majusi, nzungu mabara, uye tii yemakwenzi, pamwe nekuwedzera kwemicronutrients. Mune kiriniki yekudzidza ye5 pamwedzi kutenderera kweiyo 1-zuva FMD mune yakajairika nyaya, chikafu chakabvumidzwa zvakanaka uye chakadzikiswa trunk uye akazara muviri mafuta, kuwedzerwa kweropa uye IGF62 mazinga3. Munguva yakapfuura uye inoenderera oncological kiriniki miedzo, kutsanya kana maMFM akawanzo kupihwa kwega kwega mavhiki e4, semuenzaniso, mukubatana nemakemikari regimens, uye nguva yavo yakatangira pakati pe1 ne5 mazuva52,53,58,61,63-68 . Zvakakosha, hapana zviitiko zvakakomba zvakashata (chikamu G3 kana pamusoro, zvinoenderana neCommin Terminology Criteria yeZviitiko Zvakaipa) zvakataurwa mune izvi zvidzidzo52,53,58,61.
Ketogenic Diets
Ketogenic dhayeti (KDs) madhayeti ezvokudya ane zvakajairika koriori, mafuta ane mafuta uye akadzika-macarhydrate zvemukati69,70. Mune yechinyakare KD, chiyero pakati pehuremu hwemafuta uye huremu hwakabatana hwehydrohydrate uye mapuroteni ndi4: 1. Nezve izvo, maMFM zvakare ari ketogenic nekuti iwo ane mafuta-ane zvemukati uye anokwanisa kukwidziridza kwakakura kukwirisa (? 0.5mmol per litre) mumatanho ekutenderera ketone miviri. Muvanhu, KD inogona zvakare kudzikisa IGF1 uye insulin mazinga (neanopfuura makumi maviri kubva muzana kubva pamatanho ekutanga), kunyange hazvo mhedzisiro iyi ichikanganiswa nematanho uye mhando dzemacarhydrate uye mapuroteni mune chikafu20. KDs inogona kudzikisa huwandu hweropa, asi ivo vanowanzo gara mukati meyakajairika renji (ndokuti,> 71mmol pa litita) 4.4.
Sezvineiwo, maKD anogona kuve anoshanda mukudzivirira kuwedzera kweshuga uye insulin inowanzoitika mukupindura PI3K inhibitors, iyo yakataurwa kudzikamisa kushanda kwayo72. Pachinyakare, maKD ave achishandiswa pakurapa pfari inokanganisa, kunyanya muvana69. Mune mbeva mhando, KDs inokonzeresa anticancer mhedzisiro, kunyanya mu glioblastoma70,72-86. Zvidzidzo zvekiriniki zvinoratidza kuti maKD anogona kunge asina basa rakakura rekurapa kana richishandiswa sevashandisi vasina kuroorwa mune varwere vane gomarara uye zvinoratidza kuti mabhenefiti ezvekudya izvi anofanirwa kutsvakwa pamwe chete nedzimwe nzira, senge chemotherapy, radiotherapy, antiangiogenic kurapwa, PI3K inhibitors uye FMDs72,73.
KDs dzakanzi dzive neuroprotective mhedzisiro mune yekumusoro tsinga uye mune hippocampus87,88. Nekudaro, zvinoramba zvichisimbiswa kuti KDs zvakare ine proregenerative mhedzisiro yakafanana nekutsanya kana maMFM (Bhokisi 1) uye kuti KDs zvakare inogona kushandiswa kudzivirira zvipenyu zvipenyu kubva kune huturu hwechemotherapy. Zvinonzwisisika, izvo zvinogadziriswazve mhedzisiro yekutsanya kana maMFM anoita kunge akawedzeredzwa neshanduko kubva kunenzara-mhinduro modhi, iyo inosanganisira kuparara kwemaseru maseru uye kufa kwemasero mazhinji, uye nguva yekudzoreredza, umo masero nematukisi zvinoitika kuvakazve22. Nekuti maKD haamanikidze kupinda mune nzara modhi, usasimudzire kuparara kukuru kwezvinhu zvemukati mezvitunha uye zvinyama uye hazvisanganise nguva yekumisikidza, hazvigone kukonzeresa rudzi rwekugadziriswazve kunoonekwa panguva yekudzoreredza kweMFM.
Calorie Restriction
Nepo chisingaperi macalorie anodzivisa (CR) uye kudya kunoshomeka mune chaiwo amino acids zvakasiyana zvakanyanya kubva nguva nenguva yekutsanya, ivo vanogovana nekutsanya uye maMFMs zvakanyanya kana zvishoma kusarudza kusarudza muhutano, uye vane anticancer mhedzisiro 81,89 112. CR inowanzo sanganisira chisingaperi 20-30% kudzikira kwesimba rekudya kubva pane yakajairwa koriori yekudyira iyo inobvumidza munhu kuti achengetedze yakajairwa113,114. Izvo zvinoshanda kwazvo mukuderedza zvemwoyo njodzi mungozi uye kenza zviitiko mune zvemuenzaniso zvisikwa, kusanganisira primates108,109,114.
Nekudaro, CR inogona kukonzera mhedzisiro, senge shanduko muchitarisiko chemuviri, kuwedzera kutonhora kwekunzwa, kuderedzwa kwesimba, kutadza kuenda kumwedzi, kushaya mbereko, kurasikirwa kwe libido, osteoporosis, inononoka ronda kupora, kudya kudya, kutsamwa, uye kushushikana. Mune varwere vane gomarara, pane kunetseka kwakanyanya uko kunogona kuwedzera kushaya chikafu zvinovaka muviri uye kuti zvinokonzeresa kurasikirwa kwakanyanya kwemuviri wakaonda18,113-116. CR inoderedza kutsanya kweropa glucose mazinga, asi ivo vanogara mukati meyakajairika renji114. Muvanhu, CR isingaperi haibate mazinga eGF1 kunze kwekunge mapuroteni ane mwero akaiswawo117.
Zvidzidzo zvinoratidza kuti nekuderedza mTORC1 kuonekwa muPaneth masero, CR inogadzira stem cell function uye kuti inodzivirira kuchengetedzwa kwemakumbo emasero kubva kuDNA damage118,119, asi hazvizivikanwe kana zvinowanzogadziriswa mune dzimwe nhengo zvinoshandiswa naRC. Nokudaro, iyo inowanikwa dare inoratidza kuti kutsanya uye maMFM zvinoumba chimiro chemagetsi, regenerative uye chekuchengetedza icho chakasiyana uye zvichida zvakanyanya kupfuura icho chakaitwa neKD kana CR.
Kutsanya & maMFM Mune Therapy: Mhedzisiro pane mahormone uye metabolite mazinga
Zvizhinji zvekuchinja kwemazinga ekupararira mahomoni uye metabolites ayo anowanzoonekwa pakupindura kutsanya ane simba rekushandisa zvinopisa zvinokonzera (kureva, kuderedzwa kwehutachiona, IGF1, insulini uye leptin uye kuwedzera mazinga e adiponectin) 23,120,121 uye / kana kuti kuchengetedza utachiona hwakanaka kubva pamigumisiro (kureva, kuderedza mazinga eGF1 uye glucose). Nokuti ketone miviri inogona kukanganisa histone deacetylases (HDACs), kuwedzera kwekutsanya-kuwedzerwa kwemitumbi yeketone kunogona kubatsira kuderera kwechirwere kukura uye kukurudzira kuparadzaniswa kuburikidza nemagadzirirwo epigenetic122.
Nekudaro, iyo ketone muviri acetoacetate yakaratidzirwa kumhanyisa, panzvimbo yekuderedza, kukura kwemamwe mamota, senge melanomas ine mutated BRAF123. Iko kushandurwa uko kune hwakasimba humbowo hwechikamu mune zvinobatsira mhedzisiro yekutsanya uye maMFM kurwisa kenza ndiko kuderedzwa mumatanho eGF1 uye glucose. Padanho rema molecular, kutsanya kana iyo FMD inoderedza mascacellular ekuisa chiratidzo macascades anosanganisira IGF1R AKT mTOR S6K uye cAMP PKA siginecha, inowedzera autophagy, inobatsira maseru akajairika kutsungirira kusagadzikana uye inosimudzira hutachiona hwehutachiona25,29,56,124
Kusiyanisa Kushungurudzika Kushungurudzika: Kuwedzerwa Chemotherapy Kutambura
Mamwe mbiriso incogene nyanzvi, dzakadai saRas uye Sch9 (nyanzvi yezvemagariro emamamalia S6K), inokwanisa kuderedza kusagadzikana kwepfungwa mumararamiro emuenzaniso27,28. Mukuwedzera, kushanduka kunoita kuti IGF1R, RAS, PI3KCA kana AKT, kana kuti iyo isingashandisi PTEN, iripo muzhinji hwevanhu vane kanzura10. Pamwe chete, izvi zvakakonzera kufungidzira kuti nzara yaizokonzera zvinopesana nekenza zvichienderana nemasero ezvakanaka maererano nekwanisi yavo yekudzivirira masero epfungwa, kusanganisira chemotherapeutics. Mune mamwe mazwi, nzara inogona kutungamirira zvakasiyana kushungurudzika kushorwa (DSR) pakati pezvakagara uye kenza masero.
Zvinoenderana neiyo DSR hypothesis, maseru akajairwa anopindura nzara nekudzora kuwanda kwakabatana uye ribosome biogenesis uye / kana magineti egungano, izvo zvinomanikidza maseru kuti apinde munzira yekuzvigadzirisa uye anovadzivirira kubva mukukuvara kunokonzerwa nekemotherapy, radiotherapy uye mamwe maronda ane chepfu. Kupesana, mumasero ekenza, iyi yekuzvigadzirisa modhi inodzivirirwa kuburikidza neoncogenic shanduko, iyo inokonzeresa kuita inhibition yekumanikidza kupindura nzira12 (Fig. 1). Zvinopindirana neiyo DSR modhi, nzara-yenguva pfupi nzara kana kubviswa kweproto-oncogene homologues (kureva, Sch9 kana maviri Sch9 uye Ras2) kuwedzera kuchengetedzwa kweSaccharomyces cerevisiae kurwisa oxidative kushungurudzika kana chemotherapy mishonga kusvika ku-100 puro kana ichienzaniswa nemasero masero anotaura nezvekushanda kwecogene ishamwari Ras2val19.
Mitsara yakafanana yakawanikwa mumasero emammalia: kuvharwa kwepasi-glucose media yakachengetedzwa mutsara weglia glia masero pakusvibiswa nehydrogen peroxide kana cyclophosphamide (a prooxidant chemotherapeutic) asi haana kudzivirira mapundu, ronda uye vanhu glioma uye neuroblastoma yerineni mitsetse. Zvinopesana nemashoko aya, a 2-zuva kutsanya zvakajeka kupona kwemakonzo aibatwa nehopeside yepamusoro yakaenzaniswa nemakwenzi asina kutsanya uye akawedzera kupona kweeuroblastoma allograftbearing manyowa akaenzaniswa newasingafungi maronda-ane mice12.
Zvidzidzo zvakatevera zvakawana kuti kuderedzwa kweGF1 kusaina mukupindura kutsanya kunodzivirira kwekutanga glia uye mauroni, asi kwete glioma uye maseru euroblastoma, kubva kucyclophosphamide uye kubva kune pro-oxidative macomputer uye inodzivirira mbeva embryonic fibroblast kubva doxorubicin29. Chiropa IGF1-inoshomeka (LID) mbeva, mhuka dzinochinja muviri dzine mamiriro echiropa Igf1 jeni kubviswa iyo inoratidza 70hibit80% kudzikira mukutenderera kweiyo IGF1 mazinga (mazinga akafanana neaya akawanikwa nekutsanya kwemaawa 72 mumakonzo) 29,125, aidzivirirwa matatu kubva mana emakemotherapy madhiragi akaedzwa, kusanganisira doxorubicin.
Histology zvidzidzo zvakaratidza zviratidzo zve doxorubicin-inosimudzira moyo myopathy mune chete doxorubicin-inorapwa mbeva dzekudzora asi kwete muLID mbeva. Mukuyedza mhuka dzine melanoma-dzinotakura dzakarapwa ne doxorubicin, hapana mutsauko maererano nekufambira mberi kwechirwere pakati pehutongi nembeva dzeLID zvakaonekwa, zvichiratidza kuti maseru egomarara haana kudzivirirwa kubva kumakemotherapy nemazinga akaderedzwa eGG1. Asi, zvakare, mbeva dzinotakura tumarara makonzo akaratidzira mukana unoshamisa wekupona uchienzaniswa nemhuka dzinodzora nekuda kwekugona kwavo kumira doxorubicin toxicity29. Nekudaro, zvakazara, mhedzisiro iyi yakasimbisa kuti IGF1 kudzikisira chinhu chakakosha nzira yekutsanya kunowedzera chemotherapy kushivirira.
Zvose dexamethasone uye mTOR inhibitor zvinowanzoshandiswa mukurapa kenza, zvichida nekuda kwekushanda kwavo se-anti-emetics uye anti-allergics (ndiko kuti, corticosteroids) kana kuti nokuda kwavo antitumour dzimba (kureva, corticosteroids uye mTOR inhibitors). Zvisinei, chimwe chezvakakosha uye nguva dzose maitiro emigumisiro emigumisiro ndeye hyperglycaemia . Zvinoenderana nepfungwa yekuti yakawedzera glucose cAMP PKA chiratidzo kunoderedza kusagadzikana nehupfukidzi hwemakemikarirapeutic mishonga12,26,126, zvose dexamethasone uye rapamycin inowedzera toxicity ye doxorubicin mu mouse cardiomyocytes uye mice26. Zvinonakidza kuti zvaikwanisika kudzosera utsvina hwakadaro kuburikidza nekuderedza kupararira kwemazinga emushuga kuburikidza nekutsanya kana kuti injulin injections26.
Aya mapindiro anoderedza chiitiko chePKA nepo ichiwedzera chiitiko cheAMPK uye nekudaro ichigadzirisa EGR1, zvichiratidza kuti cAMP PKA chiratidzo chinoratidzira iyo yekutsanya-inosimudzira DSR kuburikidza neEG1 (ref. 26). EGR1 inosimudzirawo kutaura kweyepiooprotective peptides, senge atrial natriuretic peptide (ANP) uye iyo B-mhando natriuretic peptide (BNP) mune yemoyo tishu, iyo inobatsira mukushora doxorubicin. Zvakare, kutsanya uye / kana FMD inogona kuchengetedza mbeva kubva ku doxorubicin-inokonzeresa chirwere chemoyo nekuwedzera autophagy, iyo inogona kusimudzira hutano hwemagetsi kuburikidza nekuderedza inoshanda yeoksijeni marudzi (ROS) kugadzirwa kuburikidza nekubviswa kweanoshaya mitochondria uye nekubvisa zvine chepfu zvikamu.
Kunze kwekudzora chemotherapy inokonzeresa huturu mumasero uye kuwedzera kupona kwemakemikari anorapwa nemakemikari, maitiro ekutsanya anokonzeresa mwongo wemapfupa uye kudzivirira kudzvinyirirwa kunokonzerwa necyclophosphamide mune PKA-inoenderana uye IGF1-nzira ine hukama25. Nekudaro, kumanikidza kwekufanobata mhedzisiro kunoratidza kugona kwekutsanya uye maMMMs kuwedzera chemotherapy kushivirira uye kudzivirira makuru mhedzisiro. Nekuti yekutanga kiriniki dhata inokweretesa rutsigiro kune izvi zvingave, izvi zvekumberi zvidzidzo zvinowaka chikonzero chakasimba chekutarisa maMMM mune akaomeswa emakiriniki miedzo neTEAEs sekutanga kwekupedzisira nzvimbo.
Kusiyanisa Kushungurudzika Sensitization: Kuwedzera Kufa kweCells Cells
Kana ikashandiswa yoga, nzira dzakawanda dzekudya, kusanganisira kudya uye maMFM, dzine zvishoma zvinokonzerwa nekenza kufambira mberi. Maererano nekusiyanisa kushungurudzika kwechisimba (DSS) pfungwa, kusanganisa kwekutsanya kana maMMM ane chirwere chechipiri kunowedzera kuvimbisa11,12. Iyi pfungwa inofungidzira kuti, nepo kenza yemasikirini inokwanisa kugadzirisa kusvika pakukanganiswa kweokisijeni uye kuwandisa kwezvibereko, mhando dzakawanda dzemasero ekenza hazvigone kuita shanduko dzinogona kubvumira kupona muzvakakwana-zvisingakoshi uye zvakashata zvinokonzerwa nekubatana kwekutsanya uye chemotherapy , Semuyenzaniso. Kuongorora kwepakutanga mukenza webonde, maranoma uye glioma masero akawana kuwedzera kunoshamisa kwekutaura kwemajeni anowedzera-kufanana kana kuti ribosome biogenesis uye magemu emagungano mukupindura kutsanya11,12. Kuchinja kwakadaro kwaifambidzana neAxpected AKT uye S6K kushandiswa, ruzivo rwekuita ROS uye DNA kukanganisa uye kukurudzira kusvika kune DNA-zvinodhaka zvinodhaka (via DSS) 11.
Tinofunga nezvekusaita kwakadaro kusina kukodzera kwemasero emukenza kumamiriro akashandurwa kusanganisira kuderedza kweGIF1 uye mazinga eaglucose anokonzerwa nekutsanya kana maMMM sechinhu chikuru chinoita kuti antitumour zvimiro zveaya mapindiro ezvekudya uye kugona kwavo kugona kupatsanura mhedzisiro yemishonga yekurapa nekenza pane zvakajairika maringe nemaseru akaipa11,12 (Fig. 1). Zvinoenderana neiyo DSS hypothesis, nguva nenguva yekutsanya kana maMFM akakwana kudzora kukura kwemarudzi mazhinji tumarara masero, kubva kune yakasimba tumarara maseru maseru kusvika kune lymphoid leukemia maseru, mune mbeva uye, zvakanyanya kukosha, kukurudzira maseru ekenza kune chemotherapeutics, radiotherapy uye tyrosine kinase inhibitors (TKIs) 11,17,22,25,50,54-57,59,60,124,127,128, XNUMX.
Nokuderedza kuwanikwa kweglucose uye kuwedzera mafuta asidi? -Oidation, kutsanya kana maMFM anogona kusimudzira switch kubva kuaerobic glycolysis (Warburg mhedzisiro) kune mitochondrial oxidative phosphorylation mumasero ekenza, izvo zvinodikanwa mukuchengetedza cancer maseru kukura munzvimbo ine huturu-isina hurombo 50 (Mufananidzo 2). Iyi switch inotungamira mukuwedzera ROS kugadzirwa11 semhedzisiro yekuwedzera mitochondrial yekufema chiitiko uye inogona zvakare kusanganisira kudzikiswa kwemaseru redox kugona nekuda kwekudzikira kwe glutathione synthesis kubva kune glycolysis uye iyo pentose phosphate nzira50. Iyo yakasanganiswa mhedzisiro yeROS yekuwedzera uye yakadzora antioxidant dziviriro inowedzera kushushikana kweiyo oxidative mumasero ekenza uye inowedzera chiitiko chechemotherapeutics. Zvinonzwisisika, nekuti chiitiko chepamusoro cheglycolytic chinoratidzirwa neakakwira-lactate kugadzirwa kunofungidzira kwehasha uye metastatic propensity mumhando dzinoverengeka dzekenza129, iyo inopesana neWarburg mhedzisiro yekutsanya kana FMD ine mukana wekunyanya kushanda pakurwisa cancer uye ine metastatic cancer.
Kunze kwekuchinja kwemasabetism, kutsanya kana maMMM anoita zvimwe zvigadzidzo zvinogona kukurudzira DSS mumasero ekenza yepancreatic. Kutsanya kunowedzera mazwi ekutaura kuenzana nucleoside mutakuri 1 (ENT1), mutakuri wegemcitabine kuyambuka membrane yeplasma, zvichitungamira mukuvandudza chiitiko cheichi chinodhaka128. Mumasero ekenza yemazamu, kutsanya kunokonzeresa SUMO2-mediated uye / kana SUMO3-yakagadziriswa modhiyo yeREV1, DNA polymerase uye p53-inosunga protein127. Iko kushandurwa kunodzora kugona kweREV1 kutadzisa p53, zvichitungamira mukuwedzera p53-yakagadziriswa kunyorwa kwema pro-apoptotic majini uye, pakupedzisira, kune cancer cancer demise (Fig. 2). Kutsanya kunowedzerawo kugona kweanowanzo kupihwa maTKI kumisa cancer cancer kukura uye / kana kufa nekusimbisa MAPK kuisa chiratidzo inhibition uye, nekudaro, kuvharidzira E2F kudhindisa chinhu-inoenderana geni kutaura asiwo nekuderedza glucose kutora 17,54.
Pakupedzisira, kutsanya kunogona kukonzera reptor leptin uye pasi kwayo chiratidzo kuburikidza neprotein PR / SET dura 1 (PRDM1) uye nekudaro inodzivisa kutanga uye kudzosera kufambira mberi kweB cell uye T cell acute lymphoblastic leukemia (ALL), asi kwete yechirungu chechimiro leukemia (AML) 55. Sezvineiwo, ongororo yakazvimiririra yakaratidza kuti B maseru epamberi anoratidza mamiriro ekurambidzwa kusingaperi muglucose nemagetsi zvinopihwa nezvakanyorwa zvinhu PAX5 uye IKZF1 (ref. 130). Shanduko mumageneti anonongedza aya mapuroteni, ayo aripo anopfuura makumi masere muzana ezviitiko zvepamberi-B maseru ZVESE, zvakaratidzwa kuwedzera kutora kweglucose uye mazinga eATP. Nekudaro, kugadzirisazve PAX80 uye IKZF5 mu preB-ese maseru kwakatungamira kune dambudziko remagetsi uye kufa kwesero. Kutorwa pamwechete pamwe nekudzidza kwakapfuura, iri basa rinoratidza kuti VOSE vanogona kutarisisa kunovaka muviri uye simba rekumanikidzwa rinoiswa nekutsanya, pamwe zvichimiririra mukiriniki akanaka kukwikwidza kuyedza kushanda kwekutsanya kana FMD.
Sezvineiwo, zvingangoita kuti mazhinji maseru emukenza maseru, anosanganisira AML29, anogona kuwana kushora nekudzivirira iyo metabolic shanduko inoiswa nekutsanya kana maMFM, mukana uyo unowedzerwa nekuwedzera kwehutachiona hwehutachiona hunoratidzira vazhinji kanzira129. Nekudaro, chinangwa chakakura chenguva yemberi iri padyo ichave yekuziva mhando dzekenza dzinonyanya kubatwa neaya madhimoni edhayeti kuburikidza nema biomarkers. Kune rimwe divi, kana zvabatanidzwa nemushonga wakajairika, kutsanya kana maMMM hazviwanzo kukonzera kuwanikwa kwekurwisa mukenza mbeva modhi, uye kuramba kwekutsanya kwakabatana nekemotherapy zvakare hakuwanzo muzvidzidzo mu vitro, ichiratidza kukosha kwekuziva marapirwo ayo, kana ichibatanidzwa neFMDs, zvinoguma zvine simba zvine chekuita nekenza maseru ane huturu hushoma kune akajairwa maseru uye matissue11,17,50,55 57,59,124.
Antitumour Immunity Kuvandudzwa nekutsanya kana FMD
Dzakaitika pfupi yapfuura zvinoratidza kuti kutsanya kana maMFM pachavo, uye kusvika pamwero mukuru kana uchibatanidzwa nekemotherapy, kunokonzera kuwedzera kwevatachiona ve lymphoid uye kukurudzira tumarara immune immune kuburikidza nenzira dzakasiyana25,56,60,124. FMD yakadzora kutaura kwe HO1, puroteni inopa chengetedzo kubva kukuvara kweiyo oxidative uye apoptosis, mumasero ekenza mu vivo asi yakasimudza HO1 kutaura mumaseru akajairwa124,131. HO1 kudzikisira mumasero emukenza inopindirana neFMD-inosimudzira chemosensitization nekuwedzera CD8 + bundu-rinopinda mukati lymphocyte-inoenderana cytotoxicity, iyo inogona kuve inofambiswa ne kudzikisira kwekutonga T masero124 (Fig. 2). Chimwe chidzidzo, chakasimbisa kugona kwekutsanya kana maMFM uye CR mimetics yekuvandudza anticancer immunosurveillance, zvinoreva kuti anticancer mhedzisiro yekutsanya kana maMFM anogona kushanda kune autophagy inokwanisa, asi kwete yekuzvimba-isina kukwana, kanzira56. Chekupedzisira, ongororo ichangoburwa yekutsanya-kwemazuva-kutsanya kwemavhiki maviri mune mbeva kenza yemakonzo modhi yakaratidza kuti, nekumisikidza autophagy mumasero ekenza, kutsanya kunodzora kutaura kweCD2 uye nekudaro kunodzora kugadzirwa kwemunosuppressive adenosine nekenza maseru73. Pakupedzisira, CD60 kudzora kwepasi kuburikidza nekutsanya kwakaratidzwa kudzivirira macrophage switch kune M73 immunosuppressive phenotype (Fig. 2). Pahwaro hwezvidzidzo izvi, zvinokatyamadza kufungidzira kuti maMFM anogona kunyanyobatsira pachinzvimbo kana mukubatana ne immune checkpoint inhibitors2, majekiseni emukenza kana zvimwe zvinodhaka zvinokurumidza antitumour kudzivirira, kusanganisira mamwe maitiro echemirochemrapeutics133.
Anticancer Zvokudya muMouse Models
Pakazara, mhedzisiro yezvidzidzo zvemberi zvekutsanya kana maMMM mune mhando dzemukenza yemhuka, kusanganisira mamodheru ekenza yemastastatic (Tafura 2), inoratidza kuti kutsanya kwenguva nenguva kana maMMMs anowana mhedzisiro yeanticancer anticancer mhedzisiro uye inogona kuita chiitiko chemhemotherapeutics uye maTKI apo uchipa simba rekudzivirira uye rekuvandudza. mune dzakawanda nhengo22,25. Kuzadzikisa mhedzisiro yakafanana pasina kutsanya uye / kana maMMM zvaizoda kutanga kuzivikanwa uyezve kushandiswa kwemazhinji anoshanda, anodhura uye anowanzo kuve nemishonga ine chepfu uye angangove asina mukana wekudzivirira hutano hwakanaka hwemasero. Zvinokosha kuti mune zvidzidzo zviviri zvinotsanya pamwe chete nemakemikari zvakaratidza kuti ndiko chete kupindira kunokwanisa kuzadzikisa bundu rakazara kana kupona kwenguva refu muchikamu chakaenzana chemhuka dzakarapwa11,59
Chronic KDs inoratidzawo a tumarara kukura-kunonoka kushanda kana uchishandiswa se monotherapy, kunyanya mukenza kenza mbeva mhando 77,78,80 82,84,134. Gliomas mumakonzo akachengetedzwa pane isingagumi KD akaderedza kutaura kweiyo hypoxia marker kabhoni anhydrase 9 uye ye hypoxia-inducible factor 1?, Yakaderedza nyukireya factor-? B activation uye yakadzora vascular marker expression (ndokuti vascular endothelial kukura factor receptor 2, matrix metalloproteinase 2 uye vimentin) 86. Mune isingabvumirwe mbeva modhi yeglioma, mbeva dzakapa KD kuratidzwa kwakawedzera tumor-reactive innate uye adaptive immune mhinduro dzainyanya kupindirana neCD8 + T masero79. KDs dzakaratidzwa kuvandudza mashandiro e carboplatin, cyclophosphamide uye radiotherapy muglioma, kenza yemapapu. uye neuroblastoma mbeva mhando73-75,135. Uye zvakare, ongororo ichangoburwa inoratidza kuti KD inogona kubatsira zvakanyanya pamwe chete nePI3K inhibitors72. Nekudzivirira insulin chiratidzo , ava vanokurudzira kuparara kweglycogen muchiropa uye kudzivirira glucose kuwanikwa mumusana wemasaga, izvo zvinotungamirira kune nguva hyperglycaemia uye kune inobhadharisa insulin kuburitswa kubva mupancreas (chiitiko chinozivikanwa se insulin feedback ). Nekudaro, izvi simudza mune insulin mazinga, ayo anogona kutapurika, kunyanya kune varwere vane insulin kudzvinyirira, inogadzirisazve PI3K mTOR chiratidzo in matumbo , nokudaro nekudzivirira zvakasimba kubatsirwa kwePI3K inhibitors. A KD yakaratidzwa kuva yakabudirira zvikuru pakudzivirira insulin mhinduro mukupindura kwemishonga iyi uye kusimbisa zvakasimba basa ravo rekuita basa mumushonga. Pakupedzisira, maererano nekuongorora mune murine tumor-induced cachexia model (MAC16 tumor), KDs inogona kubatsira kudzivirira kurasikirwa kwemafuta uye kusina mafuta mumuviri muvarwere vane cancer85.
CR yakadzora tumorigenesis mune geneti mbeva kenza mamodheru, mbeva modhi ane otomatiki tumorigenesis uye carcinogen inokonzera kenza mbeva modhi, pamwe nematsoko91,92,97,98,101,102,104-106,108,109,136-138. Kupesana, chidzidzo chakawana kuti CR kubva pakati pezera repakati inowedzera chiitiko cheplasma maseru neoplasms muC57Bl / 6 mice139. Zvisinei, muchidzidzo chimwe chete, CR yakawedzera hupenyu hwakareba neinosvika gumi neshanu muzana, uye kuwedzera kwakacherechedzwa kenza chiitiko kwakakonzerwa nekuwedzera kwehurefu hwemakonzo ari kuita CR, zera iro kuora-tora mbeve dziri kupinda CR dzakafa uye chikamu che kuora-tora mbeve dziri kupinda CR dzakafa. Nokudaro, vanyori vakapedzisa kuti CR inogona kunge ichidzorera kukurudzira uye / kana kufambira mberi kwekenza yekenza lymphoid. Meta-kuenzanisa chirevo chisingakoshi CR neC intermittent CR maererano nekukwanisa kwavo kudzivirira kenza mumakiritsi yakagumisa kuti mukati reR CR inonyanya kuve muine genetically engineered mouse mararamiro, asi hazvina kubudirira mumakemikari anokonzerwa nemakwenzi maZXXMUMX. CR yakaratidzwa kunonoka tumarara kukura uye / kana kuti kuwedzera kupona kwemapundu mumarudzi akasiyana-siyana emukenza mhando, kusanganisira ovarian uye pancreatic cancer140,94 uye neuroblastoma81.
Zvinonyanya kukosha, CR yakagadzirisa basa reanticancer kurapwa mukenza yakasiyana-siyana, kusanganisira basa re antiIGF1R antibody (ganitumab) rinorwisa kenza ye prostate141, cyclophosphamide inopesana neuroblastoma masero135 uye autophagy inhibition mujenografts yeHRAS-G12Vtransformed immortal baby mouse zvipembenene epithelial cells100. Zvisinei, CR kana kuti KD yakabatana nemishonga yekurapa inoratidzika seisingabatsiri kupfuura kutsanya. Chidzidzo chekutsvaga chakawana kuti, kusiyana nekutsanya oga, CR chete haikwanise kuderedza kukura kwekuwedzera kwechidiki GL26 mouse gliomas uye kuti, zvakare, kusiyana nekutsanya kwenguva pfupi, CR haina kuwedzera cisplatin basa ne subcutaneous 4T1 muchifuva tumours51. Muchidzidzo chakafanana, kutsanya kwakaratidzawo kuti kwakabudirira zvikuru kupfuura CR uye KD pakuwedzera kubvumira kwe doxorubicin51. Kunyangwe kutsanya kana FMD, CR uye KD inogona kunge yakagadzirisa uye inogadzirisa chiratidzo nzira, kutsanya kana FMD zvinogona kunge zvinokanganisa nzira dzakadaro nenzira yakanyanyisa panguva yakaoma chikamu chekuwedzera kwemazuva mashoma.
Chikamu chekudzorera zvingadaro nyasha kugadziriswa kwe-homeostasis yemuviri wose asiwo kushandisa uye kukurudzira nzira dzinogona kukurudzira kuzivikanwa nekubviswa kwe tumarara uye kuchinjazve masero ane utano. CR uye KD inopindira inogona kugadzirisa zvishoma nezvishoma kugadzirisa-kunzwisa nzira, zvichida pasina kusvika kune zvikamu zvakakosha zvakakosha kuvandudza migumisiro yemishonga inorwisa mishonga, panguva yekuisa mutoro unorema uye kazhinji kuwedzera kurasikirwa kwemahombekombe. CR uye KD sezvokudya zvinogara zvisingagumi kune vanorwara nekenza zvakaoma kushandisa uye zvinogona kutakura ngozi dzehutano. CR ingangodaro inotungamirira mukurashikirwa kwakanyanya kwemuviri wepachionda uye kuderedza steroid hormone uye pamwe nekudzivirira muviri142. Chronic KDs inobatanidzawo zvakafanana kunyange zvisinei nemigumisiro yakaoma143. Nokudaro, nguva yekutsanya uye mafomu emagetsi anogara asingapfuuri kwemazuva 5 anoshandiswa pamwe chete nemishonga yakawanda ine mikana yakakosha yekuvandudza kurapwa kwekenza panguva yekuderedza migumisiro yaro. Zvinonzwisisika, zvichave zvakakosha kudzidza chiitiko chekubatanidzwa kwe periodic FMDs, isingaperi KDs uye maitiro ekurapa, kunyanya mukurapa kwekenza dzine utsinye seglioma.
Kutsanya uye maMFM muChancer Prevention
Zvidzidzo zveEpidemiological uye zvidzidzo mumhuka, kusanganisira monkeys108,109,144, uye vanhu vanokweretesa kune pfungwa yokuti chitubu CR uye nguva yekutsanya uye / kana FMD inogona kuva nekenza-inodzivirira migumisiro yevanhu. Kunyange zvakadaro, CR haikwanise kushandiswa muhuwandu hwevanhu zvichienderana nehutano hwekuteerera uye kune zvingave nemigumisiro115. Nokudaro, nepo humwe humwe humwe humwe hunoti humwe hutano hunofanirwa hunodiwa (kana kuti hudzivise) uyewo mararamiro ekurudziro kuderedza chirwere chekenza chinotanga kuumbwa6,8,9,15, chinangwa chazvino ndechekucherechedza uye, zvichida, kuenzanirana zvakanaka zvakarambidzwa, nguva dzemazuva ezvekudya zvekudya zvakaderera kana kwete migumisiro uye kuongorora kenza-kudziviririra kushanda muzvidzidzo zvekliniki.
Sezvakakurukurwa pekutanga, mafungiro emagetsi anokonzera kuderedzwa kweGF1 uye glucose uye kuregererwa kweGGBBP1 nemitumbi yeketone, iyo inoshanduka yakafanana neyo inokonzerwa nokutsanya pachayo uye inoshandiswa kwekutsanya mhinduro22. Apo C57Bl / 6 mice (iyo inowanzobudirira matumbo , zvikurukuru lymphomas, sezvavanenge vava nemakore) vakafambisa FMD yakadaro kwemazuva 4 kaviri pamwedzi kubva pamakore emakore uye kudyidzana kwekudya kwemaidhi munguva iyo iri pakati peMFM, maitiro emapupa akasimudzwa kubva kunenge 70% mumashonga ari kutonga kudya kune anenge 40% mumakonzo muboka reMFD (rinowanikwa 43% kuderedza) 22. Mukuwedzera, iyo FMD yakasarudzwa nemwedzi inopfuura 3 kuitika kwekufa kwevana vasina kufanana, uye nhamba yemhuka ine zvipembenene zvisingawanzoshandiswa yakanga inopfuura katatu yakakwirira muboka rekutonga kupfuura mumashamba eFMD, zvichiratidza kuti vazhinji matumbo muMFD mice dzakanga dzisinganyanyi kurwisana kana kushaya bongo.
Chimwe chekutanga chekutsanya-zuva rokutsanya, iro rakaitwa pakati pemakwikwi epakati-kati kwemwedzi ye4, rakaonawo kuti kutsanya kwakaderedza kuitika kwe lymphoma, kuitora kubva ku33% (yekudzora mice) ku 0% (mukutsanya mhuka) 145, kunyange zvazvo nekuda kwenguva pfupi yekudzidza hazvizivikanwe kana iri regimiro yekutsanya inodzivirirwa kana kungoita kunonoka tumarara kutanga. Uyezve, kushandiswa kwezuva-zuva kunotora mazuva 15 pamwedzi wekutsanya kwakakwana kwemvura-chete, asi mukuedza kweMFM kunotsanangurwa pamusoro apa makonzo akaiswa pazvokudya zvakapa zvokudya zvishomanana kwemazuva 8 chete pamwedzi. Mune vanhu, 3 maitiro eFMF-day FMD kamwechete pamwedzi yakaratidzwa kuderedza kuderera kwepamuviri uye zviratidzo zvekuputika uye IGF5 uye mazinga eglucose muzvidzidzo nezvikamu zvakakwirira zvezviratidzo izvi1, zvichiratidza kuti kushandiswa nguva nenguva kweMFD kunogona kunge zvinodzivirira zvinokonzerwa nokuora-zvakabatana kana kuputika-zvine chokuita, asiwowo dzimwe, kanzira dzevanhu, sezvakaratidzwa mice62.
Nokudaro, zviitiko zvinokuvadza zvezvidzidzo zvekudzivirira zvinosanganiswa nekliniki data pamusoro pemigumisiro yeFMD pangozi zvinhu zvinowanikwa aging-associated zvirwere, kusanganisira cancer62, kukweretesa rubatsiro mune ramangwana rezvidzidzo zveMFMs sechinhu chinogona kushandiswa kudzivirira kenza, pamwe chete nezvimwe aging-associated zvisingaperi, mumunhu.
Clinical Applicability in Oncology
Zvidzidzo zvina zvekutsanya uye maMFM muvarwere vanopinda chemotherapy vakabudiswa sezuva ranhasi52,53,58,61. Mune imwe nyaya yevarwere ve10 vanorwara nemhando dzakasiyana-siyana dzekenza, kusanganisira mazamu, prostate, ovarian, chibereko, chirwere chepapu uye oesophageal, avo vakatsanya kudya kusvika ku140hours vasati vasvika uye / kana kusvika ku56hours vachitsvaga chemotherapy, pasina migumisiro mikuru inokonzerwa nokuzvitsanya pachavo kunze kwekuzara nenzara uye kuchena kwemavara kwakaparidzwa58. Varwere ivavo (vatanhatu) vakawana chemotherapi uye vasina kushanya vakaratidza kuderedza kuderedza kuneta, kushaya simba uye kwepamusoro kwezviitiko zvinotambudza panguva yekutsanya. Mukuwedzera, kune avo varwere umo kufambira mberi kwekenza kunogona kuongororwa, kutsanya hakuna kubvumira chemotherapy-kunokonzerwa kuderedzwa mumatomu yevhesi kana mumaronda. Mune rumwe ruzivo, vakadzi vechi13 vane HER2 (inozivikanwawo seEERBB2) yakaipa, chirwere chepachipiri II / III chepachifu chebonde chinogamuchira neo-adjuvant taxotere, adriamycin uye cyclophosphamide (TAC) chemotherapy yakashandurwa kutsanya (mvura chete) 24hours vasati vatanga chemotherapy kana kuti kune chikafu maererano nemitemo yakazara52.
Kutsanya-kwenguva pfupi kwaive kwakatsungirirwa zvakanaka uye kwakadzora kudonha mune zvinoreva erythrocyte uye thrombocyte kuverenga mazuva manomwe mushure memakemikari. Sezvineiwo, muchidzidzo ichi, iwo mazinga e? -H7AX (mucherechedzo wekukuvara kweDNA) yakawedzerwa maminetsi makumi matatu mushure memakemikari mumalukocyte kubva kuvarwere vasina kutsanya asi kwete kuvarwere vaitsanya. Muchidimbu kukura kwekutsanya mune varwere vari kurapwa platinum-based chemotherapy, makumi maviri evarwere (avo vainyanya kurapwa kurapwa kweiyo urothelial, ovarian kana kenza yemazamu) vakasarudzika kutsanya kwe2, 30 kana 20hours (yakakamurwa se24hours pamberi chemhemotherapy uye 48hours mushure mekemotherapy. 72. Maitiro ekugona (anotsanangurwa sezvikamu zvitatu kana kupfuura kubva pazvitanhatu zvidzidzo muboka rega rega rinodya? 48kcal pazuva panguva yekutsanya pasina kuwandisa huturu) zvakasangana. Kutsanya kwakabatana nekutsanya vaigara vaine gorosi 2 kana kuti pasi, iyo inowanzova kuva kuneta, kuora musoro uye chizoro. Sezvakaitwa mune zvekare, kuderedza DNA kuipa (sezvakaonekwa na comet assay) mu leukocytes kubva kune avo vakatsanya kusvika 48hours (kana vachienzaniswa nevaya vaizvinyima nokuda kwe24hours chete) vanogona kuonekwawo mumuedzo uyu muduku. Mukuwedzera, chimwe chinhu chisingaiti chekuita nechepakati peklasi 3 kana gorosi 4 neutropenia kune varwere vakatsanya nokuda kwe48 ne72hours pamwe neavo vakatsanya nokuda kwe24hours chete vakanyorwa zvakare.
Munguva ichangopfuura, chirongwa chekliniki chakakonzerwa nemaitiro chakashandiswa kuongorora migumisiro yeFMD pamusoro pehupenyu hwehupenyu uye nemigumisiro yechemotherapy mune vose varwere ve34 vane kenza yemazamu kana ovarian61. I-FMD yakave ye zuva nezuva caloric kudya kwe <400kcal, kunyanya nemajusi nemabhurosi, kutanga 36-48hours isati yatanga chemotherapy uye inogara kusvika makumi maviri nemana maawa apera chemotherapy. Muchidzidzo ichi, iyo FMD yakadzivirira iyo chemotherapy inokonzeresa kudzikiswa kwehupenyu hwehupenyu uye zvakare yakaderedza kuneta. Zvakare, hapana zviitiko zvakakomba zvakashata zveFMD zvakataurwa. Mamwe akati wandei emakiriniki ekuedzwa kweMMFs akabatana nekemotherapy kana nemamwe marudzi emishonga yekurapa irikuenderera mberi kuzvipatara zveUS neEuropean, kunyanya kune varwere vanoonekwa kuti vane cancer kana yeprostate cancer24-63,65. Iyi ingangove ruoko-rwechipatara kiriniki kuongorora FMD kuchengetedzeka uye kugona kana kusarongeka makiriniki ekuongorora anotarisana nemhedzisiro yeFMD pane huturu hwechemotherapy kana pahunhu hwehupenyu hwevarwere panguva yekemotherapy pachayo. Pamwe chete, izvi zvidzidzo zvave kunyoresa pamusoro pevarwere mazana matatu, uye mhedzisiro yavo yekutanga inotarisirwa kuwanikwa mu68.
Matambudziko muThe Clinic
Kuongorora nguva yekutsanya kana yeMFDs muincology haisi yekushungurudza, kunyanya maererano nekukwanisa kuti rudzi urwu rwezvokudya zvinogona kukonzera kusadya, kudya, sarcopenia, uye cachexia mune vakafanorongerwa kana vasina kusimba varwere (semuenzaniso, varwere vanovandudza anorexia semhedzisiro yekemotherapy) 18,19. Nekudaro, hapana zviitiko zveakakomba (pamusoro pegiredhi 3) kurasikirwa uremu kana kwekushomeka kwezvakakwana zvakataurwa muzvidzidzo zvekiriniki zvekutsanya pamwe nekemotherapy yakaburitswa sezvazvino, uye avo varwere vakawana kurasikirwa nekurema panguva yekutsanya kazhinji vakadzorera huremu hwavo pamberi pe inotevera kutenderera pasina kukuvara kunoonekwa. Zvakangodaro, isu tinokurudzira kuti nguva nenguva anorexia uye hutano mamiriro ekuongorora uchishandisa nzira dzegoridhe-dzakasarudzika18,19,146 should150 inofanirwa kuve chikamu chakakosha chedzidzo idzi uye kuti chero chinotevera chinokanganisa hutano kune varwere vari kutsanya uye / kana maMFM chinogadziriswa nekukurumidza.
mhedziso
Nguva nenguva yekutsanya kana maMMM anogara achiratidza zvine simba anticancer mhedzisiro mune mbeva kenza mhando kusanganisira kugona kugona chemoradiotherapy uye TKIs uye kukonzera anticancer immune. MaMFM macircuit anokwanisika kupfuura echinyakare madhayeti ezvekudya nekuti anotendera varwere kuti vadye chikafu nguva dzese panguva yeFMD, chengetedza chikafu chinowanzoitika pakati pemakomba uye hachigumisi pakurasikirwa zvakanyanya nekurema uye pamwe zvinokanganisa masisitimu ekudzivirira uye endocrine. Sezvineiwo, seyakazvimirira marapirwo, kutsanya nguva nenguva kana maMMM macircule angangotaridza kushanda kwakaringana pamusoro pemamota akasimba. Muchokwadi, mumakonzo, kutsanya kana maMMM anokanganisa kufambira mberi kwecancer yakati wandei zvakafanana nekemotherapy, asi voga, havawanzo fananidza mhedzisiro inowanikwa pamwe chete nekenza zvinodhaka izvo zvinogona kukonzeresa kuti murarame-musina gomarara11,59. Nekudaro, isu tinokurudzira kuti iko kusanganisa kwe periodic FMD kutenderera nematanho akajairika ayo ane mukana wepamusoro wekusimudzira kupona-kusina gomarara muvarwere, sezvakakurudzirwa nemhando dzemakonzo11,59 (Fig. 3).
Iko kusanganiswa kunogona kunge kwakanyanya kune zvikonzero zvakasiyana-siyana: kutanga, kenza yemishonga uye dzimwe nzira dzokurapa zvinogona kubudirira, asi chikamu chevarwere hazvipinduri nokuti kenza yemasera inotora dzimwe nzira dzinoshandiswa mumagetsi dzinotungamirira pakupona. Aya maitiro emamwe emagetsi anoshandiswa zvakanyanya kuoma kuchengetedza pasi nekutsanya kana ma FMD nekuda kwekushayikwa kana kuchinja kweglucose, mamwe amino acids, mahomoni, uye kukura zvinhu, uyewo mune dzimwe nzira dzisingazivikanwi dzinotungamirira kusero kufa. Chechipiri, kutsanya kana maMMM anogona kudzivirira kana kuderedza kushandiswa kwekusagadzikana. Chechitatu, kutsanya kana maMMM anochengetedza masero akare uye nhengo kubva pamigumisiro inokonzerwa nemhando dzakasiyana-siyana dzekenza zvinodhaka. Pachikonzero chekutarisa uye kuchipatara uchapupu hwekugona, kuchengeteka uye kubudirira (pakuderedza IGF1, mafuta e-visceral uye mishonga yemwoyo inokonzera ngozi), FMDs inoratidzika seyakakodzera kudya nzira yekudzidza mukudzivirira kenza. Chinhu chinokosha mune ramangwana chichava chekuziva avo matumbo iyo ndiyo yakanakisisa inobvumirwa kubatsirwa nekutsanya kana maMMM. Kunyangwe mumaronda emukenza izvo zviri pachena kuti hazviregi kuteerera kana kutsvaga maMMM, zvinogona kunge zvichigoneka kuziva zvirongwa zvekudzivisa uye kupindira nemishonga inokwanisa kugadzirisa kusagadzikana. Zvimwe, kuchenjerera kunofanira kugamuchirwa nemamwe marudzi ezvokudya, kunyanya kana yakakwirira mumakirori, sezvo zvaigona kutungamirira kuwedzerwa uye kwete kuvharwa kukura yevamwe kanzira. Somuenzaniso, KD inowedzera kukura yemuenzaniso we melanoma wakashandurwa BRAF mu mice123, uye yakaudzwa zvakare kukurumidza kufambira mberi kwezvirwere mumushonga AML model72.
Uyezve, zvakakosha kushandisa maDMD nekunzwisisa nzira dzekuita, kubva pakuita kwavo kana kushandiswa zvisina kururama zvinogona kuunza zvakaipa zvakaipa. Semuenzaniso, apo makonzo akazvinyima uye achibatwa nekemikari yakasimba vasati vashandura, izvi zvakaguma nekukura kwemafi anogara muropa, koni uye rectum kana ichienzaniswa neasina kutsanya151,152. Kunyange zvazvo nzira dzakabatanidzwa mune izvi zvisinganzwisiswi, uye idzi fokisi dzingave dzisina kuitika matumbo , izvi zvidzidzo zvinoratidza kuti nguva shoma ye24-48hours pakati pemakemikari kurapwa kurapwa uye kudzoka kune zvakajairwa kudya kwakakosha kudzivirira kusanganisa iyo regrowth zviratidzo zviripo panguva yekudzoreredza mushure mekutsanya nemazinga akakwirira emishonga ine chepfu senge chemotherapy. Iwo makiriniki ezvidzidzo zvekutsanya kana FMD mune varwere vari kurapwa chemotherapy tsigiro kugona kwayo uye kwakazara kuchengetedzeka52,53,58,61. Mune diki-saizi yakasarudzika muyedzo yakanyoresa varwere makumi matatu nemana, FMD yakabatsira varwere kuchengetedza hupenyu hwavo panguva yekemotherapy uye kuderedzwa kuneta34. Uye zvakare, yekutanga data inoratidza kugona kwekutsanya kana maMFMs kudzikisa chemotherapy induced DNA inokuvara mumasero ane utano muvarwere52,53.
Kuenderera mberi kwezvidzidzo zvekiriniki zveMMMs kune varwere vane gomarara63,65-68 ichapa mhinduro dzakasimba dzekuti kunyora nguva nenguva maMFM pamwe neanowanzoitwa anticancer vamiririri kunobatsira kugadzirisa kushivirirana uye chiitiko chekupedzisira. Izvo zvakakosha kuti utarise kuti maMFM haazove anoshanda mukuderedza mhedzisiro yekurapa kenza mune vese varwere uye zvakare havazoshanda kuvandudza kushanda kweese marapirwo, asi vane mukana wakakura wekuzviita zvirinani kwechikamu uye pamwe kwechikamu chikuru chevarwere uye zvinodhaka. Vakasviba kana vasina kudya zvinovaka muviri varwere kana varwere vari panjodzi yekushaya kudya zvinovaka muviri havafanirwe kunyoreswa muzvidzidzo zvekiriniki zvekutsanya kana maMMM, uye chimiro chevarwere chekudya uye anorexia inofanirwa kuongororwa zvakaringana mumakiriniki ekuedzwa. Anokodzera kudya mapuroteni, anokosha mafuta akawanda, mavitamini uye maminerari akabatanidzwa, kana zvichibvira, neine chiedza uye / kana kuti zvishoma nezvishoma basa rinoita kuti kuwedzera musuru uremu inofanira kushandiswa pakati pekutsanya kana maMFD maitiro kuitira kuti varwere varambe vachichengetedza muviri hutano hwakanaka hukuru18,19. Iyi nzira yekudya yakakwana inowedzera zvakanakisisa zvekutsanya kana maMMM panguva imwe chete kudzivirira varwere kubva pakushaiwa zvokudya.
References:
by Dr Alex Jimenez Kutsanya , udyo , ProLon
Vanhu vanowana mukana wakawandisa wemakoriro avo ezuva nezuva kubva kumagidhahydrates, zvakadai semichero, zviyo, uye mishonga yemashizha, zvinowanzoita kuti hurumende ishande, kana AFib. Ichi chinetso cheutano ndechimwe chepfungwa dzakapararira mukati mehutano hwenheyo, maererano nehutsva hutsvakurudzo hunobudiswa paAmerican College of Cardiology's 68th Annual Scientific Session.
Chidzidzo chekutsvaga chakaongorora zvinyorwa zvehutano zvevanhu vangangoita zviuru gumi nemana vakatora makumi maviri kana anopfuura makumi emakore. Vatsvakurudzi vakaunza dhata kubva kuAtherosclerosis Risk in Communities, kana ARIC, ongororo yekuongorora yakadzorwa neNational Institutes of Health iyo yakaitwa kubva muna 14,000 kusvika 1985. Pakati pevane chiuru chimwe nevatori vechikamu vakaonekwa kuburikidza neanoreva makore makumi maviri nemaviri ekutevera, ruzhinji yeavo akaonekwa neAFib nevatsvakurudzi. Ruzivo rwekutsvagisa rwakatsanangurwa pazasi.
AFB neCarbohydrate
Vatsvakurudzi vekutsvakurudza vakakumbirwa kuti vataure zuva nezuva kushandiswa kwezvinhu zveC66 zvakasiyana zvezvokudya mumusarudzo. Vatsvakurudzi vakashandisa ruzivo urwu kuti vaenzanise huwandu hwemakoriyori aibva kumakrobohydrates kubva kune umwe neumwe wevatori vechikamu. Makhahydrates aiva mune inenge hafu yemakoriori ezuva nezuva anotorwa nevatori vechikamu.
Vatsvakurudzi vakabva vaparadzanisa vatori vechikamu mumapoka matatu akasiyana-siyana akaenzaniswa nehuwandu, huwandu, uye huwandu hwezvokudya zvehydrohydrate, zvinomiririra kudya kwekudya apo mahydrohydrates aive akaderera pasi pe44.8 muzana yemakori awo ezuva nezuva, akazotevera 44.8 kusvika ku52.4 muzana, uye pakupedzisira apo mahydrohydrates aiva akawanda kupfuura 52.4 muzana yemakoriori avo ezuva nezuva, zvichienderana.
Vatori venhau vanozivisa kuderedzwa kwemakinhydrate muropa ndivo ndivo vaiva nehutano hwakanyanya hwekuvandudza AFib, maererano nevatsvakurudzi. Sezvo nhamba dzekutsvakurudza kwakazotevera dzakaratidza, avo vatori vechikamu vakanga variwo 18 muzana yehuwandu hwekuuya neAfib kuenzaniswa neavo vane mazana ehydrohydrate ekudya uye 16 muzana inowanzoita kuti iuye neAfib kana ichienzaniswa neavo vane makemikari eupidhyrate akawanda. Zvimwe kudya zvinogonawo kubatsira kuderedza dambudziko remwoyo rhythm disorders.
Mhando yemakhahydratesiti yaunodya inogona kuita kusiyana kukuru muhutano hwako hwose uye hukama hwakanaka. Mahydrohydrates akakomba anochera zvishoma nezvishoma pane mashoga ega ega-ehydrates uye aya anosunungura kusununguka kwakasimba kweshuga, kana kuti glucose, muropa. Mahydrohydrates akawandisa, anowanzotumidzwa se "starchy" zvokudya, anosanganisira magirasi, miriwo yemashizha, zviyo zvakakwana, uye fiber. Maererano nekutsvakurudza kwakaitwa munyaya inotevera, kupedza zvishoma mazana ehydrohydrates, ayo anowanzobatanidza michero, miriwo, uye zviyo zvakakwana, zvinogona kuita kuti zvirwere zvepfungwa, zvakadai seyereyri fibrillation. Kana zvasvika pamakhahydrates, zvakakosha kudya iyi macronutrient inokosha yehutano hwakakwana uye hukama.
Dr. Alex Jimenez DC, CCST Insight Nutrition ye AFAB
Kudzivirira makhahydratesiti yakagadzirwa nepurogiramu yakakosha yekurasika. Zvokudya zvakawanda, zvakadai sePaleo uye ketogenic, zvinoratidza kushandiswa kwemapuroteni. Maererano naXiaodong Zhuang, MD, PhD , chiremba wezvemwoyo uye munyori anotungamira wekutsvaga kwekutsvaga, "Kukanganiswa kwenguva refu kwecarhydrate kudzvinyirira kunoramba kuchinetsa, kunyanya zvine chekuita neicho chinokonzeresa pachirwere chemoyo." "Tichifunga nezve zvinogona kuitika pa arrhythmia, yedu yekutsvagisa kudzidza inoratidza kuti ino inozivikanwa inozivikanwa uremu sisitimu inofanirwa kukurudzirwa nokungwarira," akadaro mune chirevo chakaburitswa neACC.
Zvakawanikwa zvinowedzera zvidzidzo zvekare zvekutsvakurudza, dzakawanda dzave dzakabatanidza zvose zvinyorwa zvepolumuidhed uye zvepamusoro-carbohydrate nehukuru hwekufa. Kunyange zvazvo zvidzidzo zvekare zvekare zvakaratidza kuti chikamu ichi chekudya chakanga chakakanganisa matanho emigumisiro akawanikwa, chidzidzo chekutsvakurudza chaicho chakanga chisina kugadzirisa izvi zvakawanikwa. "Zvidye zvakanyanya zvegorobhahydrate zvakabatanidzwa nehutano hukuru hwekuvandudza AFib pasinei nemafuta kana puroteni inoshandiswa kuisa marhydrohydrate," akadaro Zhuang.
"Nzira dzinoverengeka dzinogona kutsanangura kuti nei kudzikisira makabhohaidhiretsi kunogona kubatsira kuAfib," akadaro Zhuang. Imwe ndeyekuti vanhu vanodya yakaderera-makabhohaidhiretsi chikafu kazhinji vanodya mashoma michero, miriwo, uye zviyo zvakakwana. Pasina izvi zvekudya, vanhu vanogona kusangana nekupararira kwakawanda, uko kwakabatana neAfib. Zvinoenderana nechidzidzo chekutsvaga, another zvinogona kutsanangurwa ndezvokuti kudya mafuta akawanda uye mapuroteni panzvimbo yezvokudya zvakagadzirwa ne-carbohydrate zvinogona kuguma nekushungurudzika kwezvinokanganisa, izvo zvave zvichibatanidzwa neA AFIB. Izvozvo zvinogona kuenzaniswa nehuwandu hwehutano hwemamwe marudzi evanhu vane chirwere chemwoyo.
Urongwa Hwekudya Kwemakore Akawanda, huri mubhuku naDkt. Valter Longo, hunobvisa kushandiswa kwezvokudya zvakagadziridzwa zvinogona kukonzera kuvhiringidza, kukurudzira hupenyu hwakanaka uye hupenyu hurefu. Kunyange zvazvo chirongwa ichi chekudya chisingafungi nezvekurasikirwa kwemazivi, kusimbiswa kwerongwa hwekudya kwenguva refu kuri kudya kudya. Urongwa Hwekudya Kwemakore Akawanda hwave huratidzwa kuti hubatsire kushandura tsvina ye-cell-based renewal, kuderedza mafuta emimba, uye kudzivirira kufanana-nehutano hunosangana nepfupa uye kurasikirwa kwemasisipo, pamwe nekuwedzera kusagadzikana kukura kwehutano hwepfungwa.
Kutsanya kufanana nezvokudya, kana FMD, kunobvumira kuti uwane zvikomborero zvekutsanya kwepanyama pasina kubvisa muviri wako wezvokudya. Kusiyana kukuru kweMFM ndechokuti pane kunyatsopedza zvachose zvokudya zvose kwemazuva mazhinji kana masvondo, iwe unongogadzirisa koriori yako kudya kwemazuva mashanu kubva pamwedzi. I-FMD inogona kuitwa kamwe chete pamwedzi kuti ibatsire kukurudzira hutano hwakakwana uye hukama.
Apo mumwe munhu anokwanisa kutevera FMD pachavo, i ProLon kutsanya kutevedzera kudya kunopa purogiramu yekudya ye5-zuva iyo yakave yakanyatsoiswa uye yakanyorwa kune rimwe zuva, iyo inoshumira zvikafu zvaunoda zveMFD mune zvakakwana uye zvakasanganiswa. Purogiramu yezvokudya inoumbwa yakagadzirira-ku-kudya uye nyore-kugadzirira, zvokudya zvinogadzirwa, zvinosanganisira mabhagi, mashopu, zvokudya zvekudya, zvinowedzera, zvinonwiwa, uye teas. Usati watanga ProLon kutsanya kuteedzera chikafu, 5-zuva rekudya chirongwa , kana imwe yemararamiro ekurarama anorondedzerwa pamusoro apa, tapota onai kuti mutaure nenyanzvi yezvehutano kuti uone kana chirongwa ichi chekudya chiri chakanaka kwauri.
Uyezve, kutsvakurudza kwakaitwa hakuna kuongorora vatori vechikamu neAymymomatic AFib, kana vanhu vaiva neAfib asi havana kumbobvumirwa kupinda kuchipatara. Izvo hazvina kuongorora zvinyorwa zveAfib, saka hazvizivikanwe kana varwere vainge vakanyanya kuva nezvikamu zvekusimudzira kana kugadzirisa AFib. Zhuang vakashuma kuti tsvakurudzo yekutsvakurudza haina kuratidza chikonzero nemigumisiro. Muedzo unongororwa unogona kudiwa kuti uone kubatana kweAlb neyakakodha yekodhydrate kuongorora mugumisiro mune huwandu hwakasiyana-siyana.
Kuwanda kwemashoko edu kunongogumira chiropractic, nhau dzehutano hwepamupano, uye functional medicine articles, nyaya, nekukurukurirana. Kuti uwedzere kukurukura nyaya iri pamusoro apa, tapota usununguka kubvunza Dr. Alex Jimenez kana kuti tibvunze nesu 915-850-0900 .
Yakarongedzwa naDkt Alex Jimenez
Yokuwedzera Nhaurirano Kukurukurirana: Acute Back Pain
Kutambudzika shure ndechimwe chezvikonzero zvakakosha zvikuru zvekuremara uye mazuva asina kukwana kubasa pasi rose. Kusuruvara kwakapinda kunokonzera chikonzero chechipiri chinowanzovhiringidzirwa nehofisi yehofisi, yakawandisa chete nepamusoro-kuputika kwezvirwere. Inenge 80 muzana yevanhu vanozova nemarwadzo mushure kamwechete muupenyu hwavo hwose. Mutsara wako chivakwa chakaoma chakagadzirwa nemapfupa, majoints, ligaments, uye mishonga, pakati pezvimwe zvinyoro zvishoma. Kukuvara uye / kana mamiriro ezvinhu akaoma, akadai herniated discs , zvinogona kutungamirira kune zviratidzo zvekurwadziwa shure. Kukuvara kwemitambo kana kukuvara kwepamberi yemotokari kazhinji kunowanzokonzera kukonzera kurwadziwa, zvisinei, dzimwe nguva kufamba kwakanyanya kunogona kuva nemigumisiro inorwadza. Nenzira yakanaka, nzira dzakasiyana dzokurapa, dzakadai sechiropractic, dzinogona kubatsira kuderedza marwadzo shure kuburikidza nekushandurwa kwepelinha nekugadzirisa maitiro, pakupedzisira kunatsiridza marwadzo ekurwadziwa.
XYMOGEN s Exclusive Professional Formulas inowanika kuburikidza nekusarudza vadzidzisi vehutano hwehutano. Inotengesa kutengesa uye kugoverwa kwemafomu eXYMOGEN zvakarambidzwa zvachose.
Kuzvikudza, Dr. Alexander Jimenez inogadzira XYMOGEN mafomu anowanikwa chete kune varwere pasi pedu.
Ndapota svitsai hofisi yedu kuitira kuti isu tipe chiremba kubvunzurudza kuti tive nekuwana nyore.
Kana uri murwere we Kukuvadza Medical & Chiropractic Clinic , unogona kubvunza nezve XYMOGEN nekushevedzera 915-850-0900 .
Nekuda kwako nekudzokorora kwe XYMOGEN zvishandiso chinyorwa ngororongedzerei inotevera inoteveraXYMOGEN-Catalog- Download
* Zvose zviri pamusoro apa zve XYMOGEN zvinoramba zvichiri kushanda.
***
by Dr Alex Jimenez chisingaperi Pain , Kutsanya , ProLon
Iwe dzimwe nguva unonzwa sokuti kurwadziwa kwako kusingaperi kunowedzera kuipa pashure pokudya zvimwe zvokudya here? Sezvakaitika, zvitsvakurudzo zvekutsvakurudza zvakaratidza kuti kudya mhando dzakasiyana siyana dzezvokudya zvinogona kukonzera kupikisa kwemuviri mumuviri womunhu. Uye isu tose tinoziva kuti kuvhiringidza kunogona kuva chimwe chezvikonzero zvinokonzerwa nemarwadzo enyu asingagumi. Tisati takurukura nezvezvokudya zvinogona kukonzera kutuka uye zvokudya zvinogona kurwisana nekuputika, regai tikurukure kuti kuvhiringidza uye sei iwe unogona kuyera kupisa.
Chii Chirwere?
Kuvhiringidza ndiyo maitiro edziviriro ezvirwere zvekuzvidzivirira. Inoshanda nekudzivirira muviri wevanhu kubva mukukuvara, kurwara, uye utachiona. Kuvhiringidza kunobatsira kuchengetedza hutano hwakakwana uye hukama hwakanaka. Allergic response can also result in inflammation. Kana ukakuvara kana une hutachiwana, unogona kuona zviratidzo zvekuputika: kana kuvhupa, tsvuku, uye zvinotyisa. Zvisinei, kuputika kunogona kuonekwa kusina chikonzero. Nzira yakanaka yekuziva kuti kuputika ndeyekuyera zviyero zvinokonzerwa neropa.
Iyo pro-C-reactive, kana CRP, chinhu chinobudiswa nechiropa, ndechimwe chezvinhu zvakanakisisa zvinowedzera kuvhiringidza. Nhamba dzeRPP dzinowedzera sezvo kupisa kunowedzera, saka, unogona kuziva zvakawanda pamusoro pezviri kuitika mukati memuviri wako pachakutarisa kumazinga ako eCPP. Maererano neAmerican Heart Association neCenters for Disease Control and Prevention, CRP yakanyanyogadziriswa pasi peC1.0 mg / L inoratidzira dambudziko rakanyanya remibvunzo yemoyo; pakati pe1.0 kusvika ku3.0 mg / L inoratidza huwandu hwehupenyu hwehupenyu; uye pamusoro pe3.0 mg / L inoratidzira njodzi huru yemibvunzo yemoyo. Zvimwe zvikamu zveRPP (mukuru kupfuura 10 mg / L) zvinogonawo kuratidza hutano hwekuvandudza dzimwe nyaya dzehutano.
Mamwe ma biomarker senge akaomeswa monocyte, cytokines, chemokines, akasiyana adhesion mamorekuru, adiponectin, fibrinogen, uye serum amyloid alpha, mamwe mabiomarker ayo anogona kuyerwa kuburikidza neropa bvunzo kuti uongorore kuzvimba. Zvirwere zvekuzvimba zvine chekuita nekunzwira tsitsi, kushushikana kweiyo oxidative, nuclear factor kappaB (NF-kB) activation, uye proinfigueatory cytokine kugadzirwa.
Masoja matsvuku eropa anoita chikamu chinokosha mumuviri wemuviri wemuviri. Nguva dzose kana mabhakitiriya kana hutachiona huchipinda muropa, masero eropa, kana kuti leukocytes, anoziva uye anoparadza vatorwa vokunze. Iwe unogona kutenda kuti kuwedzerwa kwechichena cheyero rega rega kunogona kubatsira sezvo masero eropa ropa achirwisana nehutachiona, zvisinei, izvi zvingasava saizvozvo. Kuwedzerwa kuchena kwemajeri eropa kuverengera kunogona kuratidza kuvapo kweimwe dambudziko rehutano, kunyange chichena chikuru chemuviri weropa kwete dambudziko pacharo.
Zvokudya Zvinokonzera Kupisa
Hazvishamisi kuti mhando dzezvokudya izvo zvinogona kukonzera kutuka zvinowanzoonekwa sezvakaipa kune hutano hwedu, zvakadai sekugadzirwa kwemakinehydrates, uye sodas uye nyama yakatsvuka, uye nyama inogadzirwa. Kuvhiringidza chinhu chakakosha chinogadzirisa maitiro akave akabatanidzwa nehuwandu hwehutachiona hwezvirwere zvisingaperi sezvinonzi chirwere cheshuga 2 uye chirwere chemwoyo, pakati pezvimwe zvehutano.
Zvokudya zvisina kunaka zvinokonzera kuwedzera kuwedzera, iyo pachayo ingozi inokonzerwa nokuputika. Mune zvidzidzo zvakasiyana-siyana zvekutsvakurudza, kunyange mushure mokunge vatsvakurudzi vakatora kuninikidzwa mukufunga, kuwirirana pakati pekuputika uye izvozvi zvokudya zvakasara, izvo zvinoratidza kuti kuwedzera kukura hakusi chikonzero chekuputika. Zvimwe zvekudya zvine huwandu hwekuvhiringidza uye kuwedzerwa kwekodori.
Zvokudya zvinogona kukonzera kupisa zvinosanganisira:
Akakonzerwa nemahydrohydrates, akadai sechingwa chena uye mafura Fries fries nezvimwe zvokudya zvakabikwa Sodasi nedzimwe shuga-zvinonwiwa zvinwiwa Nyama tsvuku yakadai sejiggers uye steaks pamwe nekugadzirwa nyama sembwa dzinopisa nemaseji Margarine, kupfupisa, uye mafuta Zvokudya Zvinorwisana Nokuputika
Zvimwe, pane zvokudya zvinorwisana nekuputika, uye pamwe nayo, chirwere chisingaperi. Zvimwe michero nemiriwo, zvakadai se-blueberries, maapulo, uye mashizha ane mashizha, zvakakwirira muma polyphenols uye antioxidants, izvo zvikamu zvinogona kunge zvine anti-inflammatory effects. Ongororo dzekutsvakurudza zvakare dzakabatanidza nutswe nemaitiro ekuderedza zvekuvhiringidza uye kuderedzwa kwengozi yehuga nehutano hwemwoyo. Kofi inogona kudzivirira kupisa, zvakare. Sarudza zvinopesana nezvokudya uye iwe unogona kuvandudza utano hwako hwose uye hukama hwakanaka. Sarudza zvokudya zvinopisa uye iwe ungawedzera mukana wekuputika uye kurwadziwa kusingaperi.
Zvokudya zvinogona kurwisana nekuputika zvinosanganisira:
madomasi Olive mafuta Miti yemashizha emuGreen, zvakadai sipinashi, kare, uye collards Nutsu akaita samarmonds uye walnuts Fatty hove, dzakadai salmon, tuna, mackerel, uye sardines Zvibereko zvakasvibiswa nemashizha, blubhebheri, cherries, uye oranges Vashandi vehutano vari kudzidza kuti imwe yenzira dzakanakisisa dzekudzivirira kuputika inowanikwa. kwete mune mishonga cabinet, asi mune firiji. Zvokudya zvinopesana nokuvhiringidza zvingaguma zvichibatsira kubatsira kuderedza kupindura kwemuviri wemunhu. Zvirwere zvemuviri zvinokonzera kutuka kudzivirira muviri wevanhu kubva mukukuvara, kurwara, uye utachiona. Asi kana kuputika kuchienderera mberi, kunogona kukonzera hutano hwakasiyana-siyana, kusanganisira zvirwere zvisingaperi. Ongororo dzekutsvakurudza dzakaratidza kuti zvimwe zvokudya zvinogona kukanganisa migumisiro yekuputika mumuviri womunhu.
Dr. Alex Jimenez DC, CCST Insight Anti-Inflammatory Diets
Kuti uderedze kuputika, tarisa kutevera kurara kwehutano hwakakwana. Kana uri kutsvaga zvokudya zvinopesana nokuputira, funga nezvekudya kweMediterranean, iyo yakakwirira mumichero, miriwo, nutswe, mbeu yose, hove, uye mafuta. Urongwa Hwekudya Kwemakore Erefu, huri mubhuku naDkt. Valter Longo, hunobvisawo kudya zvinogona kukonzera kutuka, kukurudzira hupenyu uye hupenyu hurefu. Kuchengeta, kana kugadziriswa kwechirori, kwave kwenguva refu ichizivikanwa kuti kuderedza kushushikana kwehutano uye kuderedza nzira dzekukwegura muzvipenyu zvakasiyana-siyana.
Uye kana kutsanya kusati kwauri, chirongwa chaDkt Valter Longo chirongwa chekudya kwenguva refu chinosanganisira kutsanya kunongedza kudya, kana FMD, iyo inokubvumira kuti uwane zvikomborero zvekutsanya kwepanyama pasina kurasa muviri wako wezvokudya. Mhedzisiro huru yeFMD ndeyokuti panzvimbo yekubvisa zvokudya zvose kwemazuva mazhinji kana masvondo, iwe unongopedza koriori yako kudya kwemazuva mashanu kubva pamwedzi. IFDD inogona kuitwa kamwechete pamwedzi kuti ibatsire kukurudzira hutano hwakakwana uye hutano pamwe nekubatsira kuderedza kuputika uye kurwadziwa kusingaperi.
Kunyange zvazvo ani zvake anokwanisa kutevera FMD pachavo, Dr. Valter Longo anopa ProLon kutsanya kutevedzera kudya, chirongwa chekudya chezuva 5-zuva rakagadzirwa uye rakanyorwa kuti rinoshumira zvikafu zvaunoda zveMFD mune zvakakwana uye zvakasanganiswa. Purogiramu yezvokudya inosanganisira kugadzirira-ku-kudya uye nyore-kugadzirira, zvokudya zvinogadzirwa, zvinosanganisira mabhagi, mashopu, zvokudya zvekudya, zvinowedzera, zvinonwiwa, uye teas. Zvisinei, before kutanga ProLon kutsanya kuteedzera chikafu, 5-zuva rekudya chirongwa , kana imwe yemararamiro ekurarama anorondedzerwa pamusoro apa, tapota onai kuti mutaure nachiremba kuti muone kuti chirwere chinorwadza chisingaperi ndechei.
Mukuwedzera pakuderedza kuputika, kumwe kudarika, kushandiswa kuderedzwa kunogona kuve nemigumisiro inooneka pamutano wako uye mumuviri. Kuwanda kwemashoko edu kunongogumira chiropractic, nhau dzehutano hwepamupano, uye functional medicine articles, nyaya, nekukurukurirana. Kuti uwedzere kukurukura nyaya iri pamusoro apa, tapota usununguka kubvunza Dr. Alex Jimenez kana kuti tibvunze nesu 915-850-0900 .
Yakarongedzwa naDkt Alex Jimenez
Yokuwedzera Nhaurirano Kukurukurirana: Acute Back Pain
Kutambudzika shure ndechimwe chezvikonzero zvakakosha zvikuru zvekuremara uye mazuva asina kukwana kubasa pasi rose. Kusuruvara kwakapinda kunokonzera chikonzero chechipiri chinowanzovhiringidzirwa nehofisi yehofisi, yakawandisa chete nepamusoro-kuputika kwezvirwere. Inenge 80 muzana yevanhu vanozova nemarwadzo mushure kamwechete muupenyu hwavo hwose. Mutsara wako chivakwa chakaoma chakagadzirwa nemapfupa, majoints, ligaments, uye mishonga, pakati pezvimwe zvinyoro zvishoma. Kukuvara uye / kana mamiriro ezvinhu akaoma, akadai herniated discs , zvinogona kutungamirira kune zviratidzo zvekurwadziwa shure. Kukuvara kwemitambo kana kukuvara kwepamberi yemotokari kazhinji kunowanzokonzera kukonzera kurwadziwa, zvisinei, dzimwe nguva kufamba kwakanyanya kunogona kuva nemigumisiro inorwadza. Nenzira yakanaka, nzira dzakasiyana dzokurapa, dzakadai sechiropractic, dzinogona kubatsira kuderedza marwadzo shure kuburikidza nekushandurwa kwepelinha nekugadzirisa maitiro, pakupedzisira kunatsiridza marwadzo ekurwadziwa.
XYMOGEN s Exclusive Professional Formulas inowanika kuburikidza nekusarudza vadzidzisi vehutano hwehutano. Inotengesa kutengesa uye kugoverwa kwemafomu eXYMOGEN zvakarambidzwa zvachose.
Kuzvikudza, Dr. Alexander Jimenez inogadzira XYMOGEN mafomu anowanikwa chete kune varwere pasi pedu.
Ndapota svitsai hofisi yedu kuitira kuti isu tipe chiremba kubvunzurudza kuti tive nekuwana nyore.
Kana uri murwere we Kukuvadza Medical & Chiropractic Clinic , unogona kubvunza nezve XYMOGEN nekushevedzera 915-850-0900 .
Nekuda kwako nekudzokorora kwe XYMOGEN zvishandiso chinyorwa ngororongedzerei inotevera inoteveraXYMOGEN-Catalog- Download
* Zvose zviri pamusoro apa zve XYMOGEN zvinoramba zvichiri kushanda.
***
