Kutsanya Kufunga Zvokudya Zvatsanangurwa

by Dr Alex Jimenez | Zvokudya, Kutsanya, Functional Medicine, utano, Holistic Medicine, Kubatana Kunoshanda Zvakanaka, Mishonga Inobatanidza, Natural Health, udyo, ProLon, Supplements, Wellness

Kunzwisisa iyo ProLon Kutsanya Kufananidza Kudya

Kutsanya kunobatanidza nehutano hwakawanda hunobatsira; kubva pakurema kurasikirwa kwenguva refu. Kune marudzi akawanda akasiyana-siyana ekutsanya nzira, zvakadai sekutsanya mukati. Kutsanya kutevedzera kudya kunokubvumira kuti uwane zvikomborero zvekutsanya kwepanyama pasina kubvisa muviri wako wezvokudya. Kusiyana kukuru kweMFM ndechokuti pane kunyatsopedza zvachose zvokudya zvose kwemazuva mazhinji kana masvondo, iwe unongogadzirisa koriori yako kudya kwemazuva mashanu kubva pamwedzi. The FMD inogona kuitwa kamwe chete pamwedzi kuti ikurudzire hupenyu.

Apo mumwe munhu anokwanisa kutevera FMD pachavo, i ProLon kutsanya kutevedzera kudya kunopa purogiramu yekudya ye5-zuva iyo yakave yakanyatsoiswa uye yakanyorwa kune rimwe zuva uye iyo inoshumira zvikafu zvaunoda zveMFD mune zvakakwana uye zvakasanganiswa. Purogiramu yezvokudya inoumbwa yekugadzirira-ku-kudya kana nyore kugadzirira, zvokudya zvinogadzirwa, zvinosanganisira mabhagi, mashopu, zvokudya zvekudya, zvinowedzera, zvinonwiwa, uye teas. Zvinhu izvi zvakagadzirwa nesayenzi uye kunonaka kukuru. Usati watanga ProLon kutsanya kuteedzera chikafu, 5-zuva rekudya chirongwa, tapota ita kuti utaure nenyanzvi yehutano kuti uone kana FMD yakakunakira iwe. Chinangwa chekutsvakurudza kwakaitwa pasi apa ndechekuratidzira nzira dzema molecular uye zvipatara zvekutsanya muFMD.

Kutsanya: Maitiro eMatemu uye Clinical Applications

Kutsanya kwave kuchiitwa kwemakumi emakore, asi chete ichangopfuura zvidzidzo zvakajekesa basa rayo mukugadzirisa mafungiro emagetsi anogadzirisa kukuvadza kwehutachiona nekuputika, kugadzirisa simba metabolism uye bolster kuchengetedzwa kwemasero. MuEukaryotes yakaderera, kusingagumi kusingaperi kunowedzera kurarama kwenguva refu kuburikidza nekurapa zvirongwa zvemagetsi uye kushungurudzika nzira. In rodents Kutsanya kwepakatikati kana nguva nenguva kunodzivirira chirwere cheshuga, kenza, chirwere chemoyo uye neurodegeneration, panguva yevanhu kunobatsira kuderedza kuneta, hypertension, asthma uye rheumatoid arthritis. Nokudaro, kutsanya kune mukana wekunonoka kukwegura uye kubatsira kudzivirira uye kubata zvirwere nekuderedza migumisiro inokonzerwa nekusingaperi kwezvirongwa zvekudya.

ziviso

Muvanhu, kutsanya kunowanikwa nekumedza kwete kana zvishoma zvikafu uye zvinwiwa zvecalori kwenguva iyo inowanzo kubva pamaawa gumi nemaviri kusvika kumavhiki matatu. Mapoka mazhinji ezvitendero anosanganisira nguva dzekutsanya mumitambo yavo kusanganisira maMuslim vanotsanya kubva mangwanani kusvika manheru mukati memwedzi weRamadan, uye maKristu, maJuda, maBuddha nemaHindu avo vanotsanya pamazuva akasarudzika evhiki kana gore rekarenda. Mumakiriniki mazhinji, varwere vava kuongororwa nevanachiremba vachiri pasi pemvura chete kana yakadzika kwazvo koriori (isingasviki mazana maviri kcal / zuva) nguva dzekutsanya dzinotora kubva pavhiki rimwe kana kupfuura kureba kwehuremu, uye nekudzivirira chirwere uye kurapwa. Kutsanya kwakasarudzika kubva ku caloric kudzvinyirira (CR) umo kwazvino koriori kudya kunodzikiswa zvisingaite ne12-200%, asi kuwanda kwekudya kunochengetwa. Nzara pachinzvimbo kushomeka kwehutano kunovaka uko kunowanzo shandiswa sekutsiva izwi rekuti kutsanya, kunyanya muma eukaryotes akadzika, asi izvo zvinoshandiswa zvakare kutsanangura nzira dzakanyanya dzekutsanya, dzinogona kukonzera kupera uye kufa. Isu tave kuziva kuti kutsanya kunoguma mu ketogenesis, inokurudzira shanduko ine simba munzira dzemagetsi uye maseru maseru sekumanikidza kwekushushikana, lipolysis uye autophagy, uye inogona kuve nemashandisirwo ekurapa ayo mune dzimwe nguva anoshanda seaya emishonga inogamuchirwa sekuderera kwekugumburwa uye kukanganisa-kwakabatana kukanganisa kwehuropi uye kuvandudza rheumatoid arthritis (Bruce-Keller et al., 1; Hartman et al., 20; Muller et al., 40). Sezvakatsanangurwa mune zvasara zvechinyorwa chino, zvakawanikwa kubva pakuferefetwa kwakanyatso chengetedzwa mumhuka dzekuyedza, uye zvitsva zvinowanikwa kubva kuvanhu zvidzidzo, inoratidza kuti nzira dzakasiyana dzekutsanya dzinogona kupa mazano anobatsira ekuderedza uremu, kunonoka kukwegura, uye kuwedzera utano. Pano tinoongorora zvinonakidza uye zvine simba zvinokonzerwa nemhando dzakasiyana-siyana dzekutsanya kusanganisira nguva yekutsanya (IF, kusanganisira zvimwe zuva rokutsanya, kana kudya kaviri kwevhiki, somuenzaniso) uye nguva yekutsanya (PF) inogara mazuva akawanda kana kupfuura kwenguva yose 2 kana mamwe mavhiki. Tinonyanya kufunga nezvekutsanya uye kuderedza kukurukurirana kweC CR, nyaya inongororwa kune dzimwe nzvimbo (Fontana et al., 2010; Masoro, 2005).

Zvidzidzo kubva kune Zvose Organisms

Iyo inokatyamadza mhedzisiro yeiyo chaiyo 20 CR40% CR pakukwegura nezvirwere mumakonzo nemakonzo zvinowanzoonekwa semhinduro dzakashanduka mumhuka dzinoyamwisa kuti dzienderane nenguva dzekushomeka kwekuwanika kwechikafu (Fontana naKlein, 2007; Fontana et al., 2010; Masoro, 2005; Weindruch naWalford, 1988). Nekudaro, maseru uye mamorekuru maitiro anodzivirira ekudzivirira kweCR anogona kunge akachinja mabhirioni emakore apfuura mumaprokaryotes achiedza kurarama munzvimbo yakatowanda kana isina zvachose masosi esimba uku uchidzivirira kukuvara kunoenderana nezera kunogona kukanganisa hutano. Muchokwadi, E. coli yakachinja kubva pa nutrient akafuma muto kune isina-calorie svikiro inorarama zvakapetwa ka4, mhedzisiro inodzoserwa nekuwedzerwa kwezvakasiyana zvinovaka muviri asi kwete acetate, sosi yekabhoni inosangana nenzara nzara (Mufananidzo 1A) (Gonidakis et al., 2010). Mhedzisiro yehupfumi hwepakati asi kwete acetate mukuderedza hurefu hunosimudza mukana wekuti ketone yemuviri-senge kabhoni sosi senge acetate inogona kuve chikamu che alternate metabolic program yakashanduka mabhirioni emakore apfuura muma microorganisms uye izvo zvino zvinobvumira zvipuka kuti zvirarame panguva dzekushomeka kwekudya nekuwana yakawanda yesimba nekukanganisa mafuta acids uye miviri ye ketone inosanganisira acetoacetate uye? -hydroxybutyrate (Cahill, 2006).

Mune mbiriso S. cerevisiae, kushandura masero kubva pahuwandu hwekukura kusvika kumvura kunokonzera kuwirirana kwe2-nguva yenguva yekuwedzera kwekuwedzera pamwe nekuwedzera kukuru kwekudzivirira kuwanda kwezvinetso (Mufananidzo 1B) (Longo et al., 1997; Longo et al., 2012). Nzira dzekudyiwa kwezvokudya zvinotarisirwa kudya zvinosanganisira pasi-murairo weamino acid response Tor-S6K (Sch9) mugwagwa pamwe chete glucose inopindura Ras-adenylate cyclase-PKA nzira inoita kuti kushandiswa kwe serine / threonine kinase Rim15, enzyme inobatanidza mhinduro dzekudzivirira (Fontana et al., 2010). Iyo inactivation ya Tor-S6K, Ras-AC-PKA uye kushandiswa kweRim15 mugumisiro mukuwedzera kudhindwa kwemajeni kusanganisira superoxide dismutases uye kupisa kunopisa mapuroteni anodzorwa ne kushungurudzika kugamuchira zvinyorwa zvinyorwa zvinonzi Msn2, Msn4 uye Gis1, inoda kuti huwandu hwezvidziviriro zvinokonzerwa nekushaiwa kwezvokudya (Wei et al., 2008). Zvinonzwisisika, kana zvichishandurwa kuzvokudya zvekudya, zvose mabhakitiriya uye mbiriso inopinda maitiro emagetsi anovabvumira kuderedza kushandiswa kwekuchengetedzwa kwebhoni uye anogonawo kuunganidza maitiro echetone muviri-akafanana neAactic acid, zvakaenzana nemamera.

Chimwe chimiro chikuru chemuviri umo kutsanya kunowedzera upenyu hwemhepo ndiyo nematode C. elegans. Zvokudya zvinotapudzwa zvinowanikwa nekudyisa mhonye zvishoma kana pasina mabhakitiriya, zvinotungamirira kukura kukuru kweupenyu (Mufananidzo 1C) (Kaeberlein et al., 2006; Lee et al., 2006), inoda kuti AMPK pamwe nekushungurudzika kwekunetseka kunyoresa chikonzero DAF-16, zvakafanana nechinzvimbo chezvinyorwa zvinyorwa zvinonzi Msn2 / 4 uye Gis1 mune mbiriso uye FOXOs mumapukanana uye mhuka dzinomwisa (Greer et al., 2007). Kudyidzana kwezvokudya zvisina kukwana kunowedzerawo upenyu mumaC. elegans nenzira inosanganisira duku GTPase RHEB-1 (Honjoh et al., 2009).

Muchizibu, zvidzidzo zvakawanda zvinoratidza kuti kuvhara kwezvokudya zvisingabatsiri hakubatsiri upenyu (Grandison et al., 2009). Zvisinei, kuderedzwa kwezvokudya kana kudyiwa kwezvokudya zvakave zvichiratidzika kuratidza kuderedza Drosophila longevity (Piper uye Partridge, 2007) inoratidza kuti nhunzi dzinogona kubatsirwa nechirongwa chekudya asi inogona kuva nehanya kunyange nenguva shoma dzenzara.

Vose pamwe chete izvi zvinoratidza kuti kurasikirwa kwezvokudya kunogona kuguma nehuwandu hwehupenyu hwehupenyu hwehupenyu hwakasiyana-siyana mumarudzi akasiyana-siyana ehupenyu, asiwo unotsanangura kuti zvipenyu zvakasiyana-siyana zvine mhinduro dzakasiyana dzekutsanya.

Mhinduro dzeAdaptive yekutsanya muna Mzvipenyu

Mumakumbo akawanda, chiropa chinoshanda semvura yakakura yeglucose, inochengetwa nenzira yeglycogen. Mune vanhu, zvichienderana nehuwandu hwavo hwekuita basa, 12 kumaawa e24 okutsanya kazhinji anoguma mu 20% kana kuti kuderera kukuru mu serum glucose uye kupera kwe hepatic glycogen, pamwe chete nechinoshandiswa kumagetsi rudzi mune iyo isina-hepatic glucose, mafuta-akawanikwa ketone miviri uye emahara fatty acids anoshandiswa senge magetsi manyoro (Mifananidzo 2 ne3). Ipo marisiki mazhinji anogona kushandisa mafuta acids esimba, panguva yakareba yekutsanya, huropi hunovimba nemitumbi yemaketone? -Hydroxybutyrate uye acetoacetate mukuwedzera kune glucose yekushandisa simba (Mufananidzo 3B). Mitumbi yeKetone inogadzirwa mu hepatocytes kubva kuacetyl-CoA inogadzirwa kubva? oxidation yemafuta acids yakaburitswa muropa neadipocyte, uye zvakare nekushandurwa kweketogenic amino acids. Mushure mekuparara kwehepatic glycogen, ketone miviri, glycerol inotorwa nemafuta, uye amino acids account yegluconeogenesis-inotenderera chizvarwa cheanenge makumi masere emamiriyoni / zuva reglucose, iro rinonyanya kushandiswa nehuropi. Zvichienderana nehuremu hwemuviri uye kuumbwa, iyo ketone miviri, yemahara fatty acids uye gluconeogenesis inobvumidza ruzhinji rwevanhu kuti vararame makumi matatu kana anopfuura mazuva mukushaikwa kwechikafu chero uye vobvumidza mamwe marudzi, akadai samambo penguin, kuti ararame kweinopfuura mwedzi mishanu. pasina chikafu (Eichhorn et al., 80) (Mufananidzo 30C). Muvanhu, panguva yekutsanya kwenguva refu, huwandu hweplasma hwe5 -? - hydroxybutyrate ingangoita ka2011 iyo yemahara fatty acids uye acetoacetic acid (Mufananidzo 3A uye 3B). Uropi uye dzimwe nhengo dzinoshandisa miviri ye ketone munzira inonzi ketolysis, mune iyo acetoacetic acid uye 3 -? - hydroxybutyrate inoshandurwa kuita acetoacetyl-CoA uyezve acetyl-CoA. Aya maitiro ekugadzirisa ekutsanya mumhuka dzinoyeuchidza nezvevaya vakatsanangurwa kare E. coli nembiriso, umo acetic acid inoungana mukupindura kushaya chikafu (Gonidakis et al., 2010; Longo et al., 2012). Mune mbiriso, glucose, acetic acid uye ethanol, asi kwete glycerol iyo inogadzirwawo panguva yekutsanya kubva pakuparara kwemafuta, mhanyisa kukwegura (Fabrizio et al., 2005; Wei et al., 2009). Nekudaro, glycerol inoshanda senge kabhoni sosi isinga gadzise nzira yekukwegura kwehutachiona yekuratidzira nzira asi inogona kugadziriswa nemaseru. Izvo zvichave zvakakosha kuti unzwisise kuti akasiyana sei macarbon sosi anogadzirwa panguva yekutsanya anokanganisa maseru ekudzivirira uye kuchembera. uye kuona kuti glycerol, yakatarwa ketone miviri kana mafuta acids inogona kupa chikafu ichidzikisa kukwegura kwemaseru mumhuka dzinoyamwisa, mukana ungafungidzirwa nezvakanaka zvinoitika zvekudya ketone preursor mune mbeva modhi yechirwere cheAlzheimer (Kashiwaya et al., 2012) . Izvo zvichave zvakare zvakakosha kudzidza, mune akasiyana mamodheru zvipenyu uye vanhu, kukwirira kwakawanda kwemhando dzakasiyana dzemafuta (ari pakati- vs. marefu- cheni mafuta acids, nezvimwewo) mukutsiva makabhohaidhiretsi uye mapuroteni anokanganisa gluconeogenesis uye glucose mazinga zvakare sekukwegura uye zvirwere.

Kutsanya uye Ubongo

Mune mhuka dzesimba, chirwere chakanyanya CR / kuparadzwa kwezvokudya kunoguma nekuderera kwehukuru hwezvikamu zvakawanda kunze kweuropi, uye mapepa ari munhurume yemurume (Weindruch naSohal, 1997). Kubva pakushanduka-shanduka mafungiro izvi zvinoreva kuti kugadziriswa kwepamusoro kunzwisisa inoshanda pasi pemamiriro ezvinhu ekushaiwa kwezvokudya ndeyekukosha zvakakosha. Zvechokwadi, tsika yakachengetedzeka yehutano hwemhuka dzose dzekudya ndeyekushanda kana uine nzara uye uchinge uchinge uchinge wanyarara. Mune mapurisa, mazuva akasiyana-siyana ezvokudya zvekudya nekutsanya (IF) inogona kuwedzera huropi hunoita sekunoratidzwa nekuvandudzika mukushanda kwekuzvibata kwekuongorora kwemazwi uye motokari basa (Singh et al., 2012) nekudzidza nekuyeuka (Fontan-Lozano et al. , 2007). Maitiro ehutano kune IF anenge akabatanidzwa nekuwedzera kwema-syntaptic plastiki uye kuwedzera kwekushandiswa kwetsva neuroni kubva ku-neural stem cells (Lee et al., 2002).

Kunyanya kunakidza pamusoro pekugadzirisa kugadzirisa kwehuropi kuve nekugadzikana kwekudya kwekudya panguva yekushanduka kwevanhu ndeye brain-derived neurotrophic factor (BDNF). Majini anokonzera BDNF uye rakagadziriswa TrkB yakaonekwa mumagenomeso munguva pfupi yapfuura sezvavaripo mumagetsi, asi aripo kubva kumhonye, ​​nhunzi nemhando dzakaderera (Chao, 2000). Dzakakurumbira basa reBDNF mukugadzirisa kwekushandisa simba uye kushandiswa kwezvipfuwo is yakasimbiswa nenyaya yekuti ma receptors ezvese BDNF uye insulin zvakabatanidzwa kune yakachengetedzwa zvakanyanya PI3 kinase-Akt, uye MAP kinase yekuratidzira nzira (Mufananidzo 4). Zvidzidzo zvemakonzo nemakonzo zvakaratidza kuti kumhanyisa vhiri rekurovedza muviri uye IF inowedzera kutaura kweBDNF mumatunhu akati wandei ehuropi, uye kuti BDNF muchikamu inopindirana nekurovedza muviri- uye IF-inosimudzira kukwidziridzwa kweiyo synaptic plastiki, neurogenesis uye neuronal kuramba kukuvara uye chirwere (ona zvikamu zvekutsanya uye neurodegeneration pazasi). BDNF inoratidzira muuropi inogona zvakare kupindirana maitiro uye metabolic mhinduro kune kutsanya uye kurovedza muviri kusanganisira kudzora kwekuda kudya, zviitiko zvezviitiko, peripheral glucose metabolism uye kuzvitonga kutonga kweiyo yemoyo uye yematumbu masisitimu (Mattson, 2012a, b; Rothman et al., 2012) .

Nzara inopindurwa kugadziriswa pakudyiwa kwezvokudya zvinosanganisira kushaya manzwiro, kunzwisisa uye neuroendocrine kuchinja kunokonzera uye kugonesa kudya zvinoda kudya. Ive yakarongedzwa kuti nzara-yakabatana neuronal network, neuropeptides uye mahormone anotamba akakosha mabasa mune anobatsira mhedzisiro yesimba kudzora pakukwegura uye chirwere chinobatika. Sehuchapupu, apo mbeva umo iyo hypothalamic hunger peptideP NPY inosarudzwa zvakasarudzwa inochengetwa pane CR chikafu, kugona kweCR kudzora bundu kukura kwakabviswa (Shi et al., 2012). Iyi yekupedzisira kudzidza yakaratidza zvakare kuti kugona kweCR kukwidziridza kutenderera kweadiponectin mazinga kwakakanganiswawo muNPY-isina mbeva mbeva, zvichiratidza chinzvimbo chakakosha cheiyo yepakati nzara kupindura mune yekumusoro endocrine kuchinjika kune simba kudzora. Adiponectin mazinga anowedzera zvakanyanya mukupindura kutsanya; uye dhata dzinoratidza mabasa eadiponectin mune zvinobatsira mhedzisiro ye IF pane yemoyo system (Wan et al., 2010). Iyo nzara yekupindura inogona zvakare kugadzirisa immune immune panguva yekukwegura sezvo ghrelin-inoshomeka mbeva dzinoratidza kukurumidza thymic kusagadzikana panguva yekukwegura, uye kurapwa kwemazera epakati mbeva ine ghrelin kunowedzera nhamba dze thymocyte uye kunovandudza kusiana kweanoshanda kweanotenderera T cell subsets (Peng et al., 2012 ). Pamusoro pezviito zvaro pane iyo hypothalamus uye peripheral endocrine maseru, kutsanya kunogona kuwedzera neuronal network chiitiko munzvimbo dzehuropi dzakabatanidzwa mukuziva, zvichikonzera kugadzirwa kweBDNF, yakagadziriswa synaptic plasticity uye yakagadziriswa kusagadzikana kushushikana (Rothman et al., 2012). Nekudaro, nzara inogona kunge iri chinhu chakakomba chakabatanidzwa mukupararira kwepakati nepakati pamagadzirirwo emhinduro kuchinetso chekushomeka kwechikafu kwenguva yakareba.

Kutsanya, Kukwegura, uye Kurwara MuHurumende Models

Kusiyana Nzira dzekutsanya nekukwegura

Kusiyana kwakakura pakati pe IF neFP mumakonzo ndehurefu uye huwandu hwekufamba kwenguva. KANA mitsara inowanzopedza maawa e24 uye imwe yemazuva mashomanana, asi PF inotora 2 kana mamwe mazuva uye inenge ichangopfuura 1 vhiki imwe chete, iyo inofanirwa kuti mhando dzivezve inowanikwa. Imwe misiyano mumasikirini ekuchinja anokonzerwa nemaitiro ezvokudya zvakasiyana-siyana inobatsira pane zvakasiyana-siyana zvekukura uye zvinokonzera kushandiswa kwemagetsi, neII zvichikonzera kakawanda asi zvishoma kudarika kuchinja kune PF. Zvichave zvakakosha kuziva kuti nguva yakawanda yekushandurwa kwakadai sekuderera kweGG-1 uye glucose inobatsira kudzivirirwa kwemagetsi, zvirwere uye longevity. Kunyanya kuongororwa yakawanda IF iyo nzira yekudzidza kwehupenyu hwekukwegura kwave kushandiswa zuva rimwe zuva (zvokudya zvinotorerwa kwemaawa 24 pamazuva mashoma, nemvura inopiwa ad libitum) (Varady uye Hellerstein, 2007). Ukuru hwemigumisiro yekutsanya kwemazuva mashoma pakurarama kwenguva yakareba mumakonzo kunobva pane zvipenyu uye zera pane regimen initiation, uye inogona kubva kune zvakaipa zvisingabatsiri kusvika pakuwedzera kwe80% yekuwedzera kweupenyu (Arum et al., 2009; Goodrick et al., 1990). KANA imwe zuva rimwe nerimwe rawedzera upenyu hwehave kupfuura kudya zuva rose 3rd kana 4th zuva (Carlson naHelzelzel, 1946). Kutsanya kwemaawa e24 kaviri pavhiki muupenyu hwose hwevanhu vakuru kwakaguma nekuwedzera kukuru kwehupenyu hwehu ratsvuku (Kendrick, 1973). Mumakonzo, kusanganiswa kwekutsanya kwezuva nezuva uye kuwedzera kwekuita basa kwakaguma mukugadzirisa kukuru kwemasimba kupfuura iyo yakaitwa IF kana kushandiswa chete (Sakamoto naGrunewald, 1987). Zvinofadza kuti kana rats akachengetwa kwemavhiki e10 pane kudya kwePP umo vakatsanya 3 mazuva anoitevera vhiki imwe neimwe, vakanga vasingawanzovi ne hypoglycemia munguva ye2 yekuoma kushambadzira muviri nekuda kwekuunganidza kwavo kukuru kwezvigadzirwa zveglycogen uye triglycerides (Favier naKoubi, 1988). Zvimwe zviitiko zvakakosha zvepanyama zvinoshandiswa pakutsanya zvakafanana nezvo zvinokonzerwa nekurovedza muviri kunosanganisira kuwedzera insulin senzwi uye kushandiswa kwemasimba kushungurudzika, kuderedzwa kwekudzivirira kwehutano hweropa uye kutengesa kwemoyo, uye kuwedzerwa kwemhepo kushanduka kwemaitiro sechikonzero chekuwedzera kwemazwi anonzwika (Mufananidzo 2) (Anson et al., 2003; Mager et al., 2006; Wan et al., 2003). Kubva kuwanikwa kunoratidza kuti kurovedza muviri uye IF kana kukanganisa kukwegura uye zvimwe zvirwere zvine chokuita nemakore zvakagadziriswa nenzira dzakagadziriswa dzinoshandiswa pakuvandudzwa kwemasero ekugadzirisa mafungiro (Stranahan naMattson, 2012). Zvisinei, mumhando mbiri dzakasiyana-siyana mazera, IF hazvina kuremedza hupenyu hwemakore uye kunyange kuderedza upenyu hwemazuva apo zvakatangwa pamwedzi 10 (Goodrick et al., 1990). Apo yakatangwa pamwedzi ye1.5, kana yakawedzera kwenguva refu kana kuti isina simba (Mufananidzo 1D) (Goodrick et al., 1990). Izvi zvinoguma mumakiritsi anongedzera kuchengetedza migumisiro yekutsanya muupenyu, asiwo kudikanwa kwekunzwisisa zviri nani rudzi rwekutsanya kunogona kuwedzera hupenyu hwaro hurefu uye nzira dzinokonzerwa nemigumisiro yakaipa iyo inogona kunge ichidzivisa kukwegura kwayo migumisiro. Semuenzaniso, imwe imwe nguva ndeyokuti kutsanya kunogona kugara kuchidzivirira mudiki uye pakati mapuroreti e laboratori ayo ari kuwana kana kuchengetedza uremu hwemuviri, asi inogona kukuvadza mumhuka dzakwegura izvo, zvakafanana nevanhu, dzinotanga kurasikirwa nemutoro vasati vafa. Zvinonzwisisika, asi mabhakitiriya, mbiriso uye vanhu vanogona kupona kwemavhiki mashoma kana kupfuura pasina michero, maronda akawanda emiti haakwanisi kurarama kwemazuva e3 pasina zvokudya. Kurasikirwa kwemazuva akawanda kunogona kuita kuti uku kunzwisisika kwenguva refu yekutsanya zvakanyanya.

Kutsanya uye Cancer

Kutsanya kunogona kuva nemigumisiro yakanaka in kurwisa kenza uye kurapwa. Mutsvina, kushandiswa kwezuva rimwe zuva kwakakonzera kuderedza kukuru kwezviitiko zve lymphomas (Descamps et al., 2005) nekutsanya kwezuva re1 pavhiki rakanonoka tumorigenesis pakarepo muzvikamu zveP53 zvakakosha (Berrigan et al., 2002). Zvisinei, kupera kukuru kweglucose, insulin uye IGF-1 inokonzerwa nokutsanya, iyo inofambidzana nefa rekufa uye / kana kuti atrophy mumhando dzakasiyana dzemaviri uye nhengo dzinosanganisira chiropa neitsvo, inoteverwa nenguva yepamusoro yepamusoro kuwedzera mukati memaviri aya anotungamirirwa mune chikamu nekudzorerwa kwekukura kwezvinhu panguva yekudzoka. Kana ichibatanidza necarcinogens panguva yekufevedza, izvi zvakanyanya kuita basa rinogona kuwedzera kacogogenesis uye / kana kuti vasati vagara nekenza mumatumbu kusanganisira chiropa nekoni (Tessitore et al., 1996). Kunyangwe izvi zvidzidzo zvinonyorera kudiwa kwe in depth kunzwisisa kwarinoita zviratidzo zvekuita, kutsanya kunotarisirwa kuva nekenza zvinodzivirira zvinoratidzika sezvinoratidzwa nezvidzidzo zviri pamusoro uye nezvakawanikwa kuti maitiro akawanda ezvokudya nguva nenguva anogona kunge akabudirira semishonga inokonzera chemotherapi pakuchengetwa mamwe makondombera mumakonzo (Lee et al ., 2012).

Mukurapa kwegomarara, kutsanya kwakaratidzirwa kuve kune zvimwe zvinowirirana uye zvakanaka mhedzisiro. PF yemazuva maviri ne2 yakaratidzwa kuchengetedza mbeva kubva kumakemikari akasiyana siyana, chinodanwa kunzi kusiyanisa kusagadzikana (DSR) kuratidza kusakwanisa kwemaseru egomarara kudzivirirwa zvichibva pabasa reoncogene mukugadzirisa zvisina kufanira kusagadzikana, nekudaro kupa masero ekenza, netsanangudzo, asingakwanise kudzivirirwa mukupindura mamiriro ekutsanya (Mufananidzo 3) (Raffaghello et al., 5). PF inokonzeresa kukurudzira kukuru kwemasero emukenza akasiyana siyana kune chemo-kurapwa, sezvo ichikurudzira nharaunda yakanyanyisa pamwe chete nekushushikana kunokonzerwa nekemotherapy. Kupesana nedunhu rakachengetedzwa rakapinda nemaseru akajairwa panguva yekutsanya, maseru emukenza haakwanise kuchinjika, chiitiko chinodaidzwa kuti differential stress sensitization (DSS), zvichibva nepfungwa yekuti shanduko zhinji dzinoshatisa uye kuti shanduko zhinji dzakaunganidzwa mumasero ekenza dzinokurudzira kukura. pasi pemamiriro ezvinhu akajairwa asi anozvipa zvakanyanyisa kushanda mukugadzirisa kune zvakanyanyisa nharaunda (Lee et al., 2008). Mune mbeva mhando dzemastastatic tumors, kusanganisa kwekutsanya uye chemotherapy inokonzeresa DSR neDSS, kunoguma makumi maviri kusvika makumi matanhatu muzana kenza-isina kenza kana ichienzaniswa nematanho akafanana echemotherapy kana kutsanya kwega, izvo zvisina kukwana kukonzera chero kenza-isina kurarama. (Lee et al., 2012; Shi et al., 20). Nekudaro, iyo pfungwa yekuti kenza inogona kurapwa nemavhiki ekutsanya chete, yakaitwa mukurumbira makumi emakore apfuura inogona kuva zvinongova zvokwadi zvishoma, zvichida kune rumwe rudzi rwekenza, asi zvinotarisirwa kuva zvisina kukodzera kune mamwe marudzi ekenza. Kubudirira kwekutsanya kwenguva refu chete (masvondo e2 kana kureba) mukurapa kenza kuchadikanwa kuongororwa mukunyatsorongedzwa kwekliniki miedzo iyo ine migumisiro yakasanganisira kushaya zvokudya uye zvichida kuoma simba rekudzivirira zvirwere uye kuwedzera kukurudzira kune zvimwe zvirwere zvinonyatsoongororwa. Kusiyana neizvi, zvinyorwa zvemashoko kubva kune dzakawanda laboratories zvinoratidza kuti kusanganiswa kwekutsanya maitiro ne chemotherapy kunonyanya uye kunogadzirisa kubudirira mukusimudzira chemotherapeutic index uye ine shanduro yakakwirira inogona. Mimwe miedzo inoramba ichienderera mberi inofanira kutanga kusarudza kushanda kwekutsanya mukusimudzira kurapwa kwekenza mumakiriniki.

Kutsanya uye Neurodegeneration

Zvichienzaniswa nead ad libitum-fed kutonga, makonzo nemakonzo akachengetedzwa pane IF chikafu chinoratidza kushomeka kweiyo neuronal kusagadzikana uye kupera, uye mashoma emakiriniki zviratidzo mumhando dzeAlzheimer's (AD), Parkinson'ss (PD) uye chirwere cheHuntington (HD). Aya mamodheru anosanganisira mbeva dzinoshandura dzinoratidza mutant genes dzevanhu dzinokonzeresa kugarwa nhaka AD (amyloid preursor protein uye presenilin-1) uye frontotemporal lobe dementia (Tau) (Halagappa et al., 2007), PD (? -Synuclein) (Griffioen et al. , 2012) uye HD (huntingtin) (Duan et al., 2003), pamwe neurotoxin-based modhi zvine chekuita neAD, PD uye HD (Bruce-Keller et al., 1999; Duan naMattson, 1999). Mhuka dziri pakudya kweFI zvakare dzinoenda zvirinani pane ad libitum-fed kutonga mushure mekukuvara kwakanyanya kusanganisira kwakanyanya pfari, kurohwa, uye kunetseka kwehuropi uye kukuvara kwemuzongoza (Arumugam et al., 2010; Bruce-Keller et al., 1999; Plunet et al., 2008).

Nzira dzinoverengeka dzakabatana dzemasero dzinoita kuti zvive nemigumisiro inofanirwa neII pahurongwa hwemitsipa kusanganisira kuderedza kuderedzwa kwemakemikorari anokanganisa oxidatively, kunatsiridza bioenergetics dzemasero, kusimbiswa neurotrophic factor signaling, uye kuderedza kupisa (Mattson, 2012a). Izvozvo zvinogadziriswa neuroprotective mechanisms zvinotsigirwa neongororo dzinoratidza kuti kana zvikafu zvinokurudzira maitiro ezvidzivirira zve antioxidant, neurotrophic factors (BDNF neFGF2) uye mapuroteni chaperones (HSP-70 ne GRP-78), uye kuderedza mazinga e pro- inflammatory cytokines (TNF?, IL-1? uye IL-6) (Mufananidzo 4) (Arumugam et al., 2010). KANA iyo inogona zvakare kukurudzira kudzoreredzwa kwekukuvara kwenzara maseru macircuit nekumutsa synapse kuumbwa uye kugadzirwa kweiyo nyuroni nyowani kubva kune neural stem maseru (neurogenesis) (Lee et al., 2002). Sezvineiwo, nepo zvichibatsira mumamodeli emazhinji emamiriro ezvinhu eurourogenerative, pane humbowo hwekuti kutsanya kunogona kukurumidza neurodegeneration mune mamwe mamodheru eanogarwa amyotrophic lateral sclerosis, pamwe nekuti mota mauroni akakanganiswa mune iwo mamodheru haakwanise kupindura zvine mutsigo kune zvine mwero kusagadzikana kunoiswa nekutsanya ( Mattson et al., 2007; Pedersen naMattson, 1999).

Kutsanya uye Semu Metabolic Syndrome

Metabolic syndrome (MS), inotsanangurwa sechizvaro chemuviri, pamwe chete nekusimbiswa kwe insulin, yakakwirira triglycerides uye / kana chirwere chepfupa, inowedzera zvikuru njodzi yehutano hwehutachiona, chirwere cheshuga, chirwere uye AD. Rats uye makonzo akachengetwa pasi pemazuva ose ad adumbitum chikafu chekudya chinokurudzira MS-seen phenotype sezvavanokura. MS inogonawo kuderedzwa mumhuka mishoma nekuvadyisa kudya kunowedzera mumafuta uye masukisi mashoma (Martin et al., 2010). KANA inogona kudzivirira uye kudzosera zvose zvese zveSMS mumakonzo: maziso emimba, kuvhunika uye BP yakaderedzwa, insulin senzwi inowedzerwa, uye mashandiro ehunyanzvi, euromuscular uye emoyo masisitimu anovandudzwa (Castello et al., 2010; Wan et al., 2003). Hyperglycemia inovandudzwa ne IF mumakonzo emhando yeshuga (Pedersen et al., 1999) uye moyo unodzivirirwa pakukuvara kweschemic mune myocardial infarction modhi (Ahmet et al., 2005). Kudzivirirwa kwekutsanya kurwisa ischemic renal uye kukuvara kwechiropa kunoitika nekukurumidza, iine 1- 3 mazuva ekutsanya kugadzirisa kugadzirisa kushanda mhedzisiro uye kuderedza kukuvara kwemasuru nekufa (Mitchell et al., 2010). Mazuva matanhatu pane kudya kunoshaya imwe chete yakakosha amino acid senge tryptophan inogona zvakare kukonzera shanduko mumetabolism uye kusagadzikana kusagadzikana, kwakafanana neaya anokonzerwa nekutsanya, ayo ndivo vanovimba neamino acid vachiona kinase Gcn2 (Peng et al., 2012).

Multiple hormonal change dzinofananidzira MS kuvanhu • a re re observed mumarangi akachengetwa pamafuta akakwirira uye kudya kwemashuga kusanganisira mazinga akareba e insulin uye leptin uye kuderedza mazinga e adiponectin uye ghrelin. Yakawanda yeeptin mazinga anowanzofungidzirwa a pro- inflammatory nyika, asi adiponectin uye ghrelin zvinogona kudzivisa kupisa uye kuwedzera insulin senzwi (Baatar et al., 2011; Yamauchi et al., 2001). Kurwisana kwemukati munharaunda ye hypothalamic nuclei iyo inodzora simba rekudya uye kushandiswa kunogona kuita kuti pave nesimba rakasimba muSMS (Milanski et al., 2012). Kutsanya kunoguma nekuderedza insulini uye mazinga eptin uye kukwirira kweadiponectin uye ghrelin mazinga. Nokuwedzera insulini uye leptin senzwi, kubvisa kuvhiringidza uye kukurudzira kuzvipira, kutsanya kunodzokorora kusakosha kukuru kweSMS mumakonzo (Singh et al., 2009; Wan et al., 2010). Pakupedzisira, kuwedzera kune zvizhinji zvayo zvinokonzerwa nemasero muhutano uye muuropi, IF ingaita kuti kuve nekushandurwa mumutambo microbiota unodzivirira kuM MS (Tremaroli uye Backhed, 2012). Zvinonzwisisika, dambudziko rekushandisa nzira yekutsanya-yakagadziriswa yekurapa MS mumunhu chinhu chikuru, sezvo vamwe vanhu vakaoma vanogona kuva nezvinetso mukutevera IF kwenguva refu.

Iyo ProLon yekutsanya kuteedzera chikafu chirongwa che5-zuva rekudya rine rakagadzirwa nesainzi uye rakaongororwa kiriniki, zvigadzirwa zvechisikigo izvo "zvinonyengera" muviri wemunhu kuita nzira yekutsanya. Iyo FMD yakaderera mune makabhohaidhiretsi pamwe nemapuroteni uye yakakwira mumafuta. Iyo ProLon yekutsanya kuteedzera chikafu inokurudzira akasiyana mabhenefiti ane hutano, anosanganisira kurasikirwa uremu uye kuderera kwemafuta emimba, zvese zvichichengetedza hutungamiriri hwemuviri, huwandu hwesimba hwakavandudzwa, ganda rakapfava uye rine hutano, pamwe nehutano hwese uye hutano. The FMD inogona kusimudzira upenyu hurefu.

Dr. Alex Jimenez DC, CCST Insight

Kutsanya, Kukwegura, uye Kurwara muHumans

Kutsanya uye Zviitiko Zvinobatsira Mukukwegura

Clinical uye epidemiological deta haisi yakakwana wit h mano ekutsanya kunodzora kukwegura uye zvirwere zvakabatana. Zvimwe zvinhu zvinokonzerwa nekukwegura, izvo zvizvarwa zvaro zvinowedzerwa nemararamiro emararamiro uye zvinononoka nekugadziriswa kwevanhu mukati mevanhu zvinosanganisira: 1) kukuvadza kwehutachiona kune mapuroteni, DNA uye lipids; 2) kuputika; 3) kuunganidza zvisingabatsiri mapuroteni uye organelles; uye 4) glucose yakakwirira, insulini uye IGF-I, kunyange zvazvo IGF-1decreases nekukwegura uye kushaya kwayo kwakanyanya kunogona kusanganiswa nedzimwe zvirwere (Bishop et al., 2010; Fontana naKlein, 2007). Serum markers ye-oxidative kukuvara nekuputika pamwe nezviratidzo zvechipatara inoderedzwa kwenguva yakareba ye2 4 mavhiki mune asthma varwere vanochengetwa pane rimwe zuva kudya kwekutsanya (Johnson et al., 2007). Saizvozvowo, kana pamazuva maviri / vhiki uchitsanya kudya vakadzi vakawandisa vari panjodzi yekenza yemazamu vakaratidza kuderedzwa kweiyo oxidative kusagadzikana uye kuzvimba (Harvie et al., 2) uye varume vakuru vakaratidza kudzikiswa kwehuremu hwemuviri nemafuta emuviri, uye nemamiriro akavandudzika (Teng et al., 2011). Kuwedzera mhedzisiro yekutsanya mumasero emunhu anogona kutariswa sezvingaite anti-kuchembera inhibition iyo mTOR nzira, kukurudzira kwe autophagy uye ketogenesis (Harvie et al., 2011; Sengupta et al., 2011).

Pakati pemigumisiro mikuru yekutsanya kunoenderana nekukwegura uye zvirwere zvinoshanduka muzvikamu zve IGF-1, IGFBP1, glucose, uye insulin. Kutsanya kwe3 kana mamwe mazuva kunokonzera 30% kana kuti kuderera kuderera pakupararira insulini uye glucose, pamwe nekuderera nokukurumidza mumazinga e insulin- kufanana kukura kwechikonzero 1 (IGF-1), iyo huru kukura mumakumbo, iyo pamwe ne insulin inobatanidza nekukurumidza kukwegura uye kenza (Fontana et al., 2010). Mune vanhu, mazuva mashanu ekutsanya anoita kuti kudarika kwe60% kuderedze muIgf-1 uye 5 kana kukura kwakanyanya mune imwe yeizivi yeGIF-1-inhibiting proteins: IGFBP1 (Thissen et al., 1994a). Ichi chiitiko chekutsanya kuIgf-1is kunyanya kunokonzerwa neproteine ​​rinogadziriswa, uye kunyanya kugadziriswa kwemaamino acids anokosha, asi inotsigirwa nekoriori kudziviswa sezvo kuderera kwezinga re insulin panguva yekutsanya kunosimudzira kuderedza muIgf-1 (Thissen et al., 1994a). Zvinonzwisisika, kuvanhu, chisingaperi chine calorie kurega hachiitisi kuderera kweIgf-1unless pamwe chete neprotein protection (Fontana et al., 2008).

KANA iyo inogona kuwanikwa mukati nekudzikira kushoma muhuwandu hwekoriori yekudyiwa kana nguva yekumisikidza mune izvo zvidzidzo zvekudya zvakanyanya zvichitariswa. Nekudaro, kutsanya kutenderera kunopa yakawandisa nzira inogoneka yekuzadzisa zvinobatsira zveCR, uye pamwe zvine simba mhedzisiro, pasina mutoro wekusingaperi underfeeding uye mimwe yemhedzisiro mhedzisiro mhedzisiro inosanganisirwa nehuremu hwekurema kana yakaderera kwazvo BMIs. Muchokwadi, izvo zvidzidzo zvine huremu hwakanyanya (BMI ye25-30) muhupenyu hwekupedzisira zvinogona kunge zvakadzora huwandu hwenzufu yekuenzaniswa kana zvichienzaniswa nehuremu hwakajairika (Flegal et al., 2013). Kunyangwe mhedzisiro iyi ingangokanganiswa nekuvapo kwevakawanda varipo kana kuvandudza materu muboka repasi rekudzora huremu, vanosimbisa kukosha kwekusiyanisa pakati pevechidiki nevakuru vanhu vangangoshandisa CR kana kutsanya kudzikisa huremu kana kunonoka kukwegura. Kunyangwe kupindira kwekudya kwakanyanyisa panguva yehuchembere kungaramba kuchidzivirira kubva kuzvirwere zvine chekuita nezera, zvinogona kuve nemhedzisiro kune immune system uye kugona kupindura kune zvimwe zvirwere zvinotapukira, maronda uye mamwe matambudziko (Kristan, 2008; Reed et al., 1996). Nekudaro, IF kana PF yakagadzirirwa kuchengetedza uremu uye kuwedzera chikafu ine mukana wekuve nemhedzisiro inobatsira pazvirwere zvinotapukira, maronda. uye zvimwe kutuka kunyange munguva yakare chaizvo. Kudya kwezvidzidzo kunogona kuwanikwa kuburikidza nekuzadzisa IF kana PF kuburikidza neChidiki neChikuru chekudzidza kuti kuongororwe zvinoitwa neFP kana PF zvinotarisa pamakonzera ekukwegura, kenza, cognition uye Kuneta kunowedzera (V. Longo naM. Mattson).

Kutsanya uye Cancer

Kutsanya kune mukana wekushandiswa mune zvose zvekudzivirira kenza uye kurapwa. Kunyange zvazvo pasina deta yevanhu inowanika pamigumisiro ye IF kana kuti PF mukudzivirira kenza, zvavanoita pakuderedza IGF-1, insulini uye glucose, uye kuwedzera kweGFBP1 uye kemikisi yemuviri inogona kuunza nzvimbo inodzivirira iyo inoderedza kuora kweDNA uye carcinogenesis, panguva panguva imwe chete achigadzira mamiriro ezvinhu akaipa kune tumor uye ma-pre-cancerous cells (Mufananidzo 5). Nekudaro, kukwirira kwakapararira IGF-1 inobatanidza nehuwandu hwekuwedzera mamwe kanzira (Chan et al., 2000; Giovannucci et al., 2000) uye vanhu vane chirwere chakakomba IGF-1deficiency yakakonzerwa nekushayikwa kwehomoni yakakura, kashoma kuwedzera kenza ( Guevara-Aguirre et al., 2011; Shevah naLaron, 2007; Steuerman et al., 2011). Uyezve, serum inobva kuIgf-1deficient zvidzidzo zvakachengetedzwa vanhu epithelial cells kubva pane zvinokonzera kushungurudzika-kunokonzerwa neDNA kukuvara. Uyezve, kana DNA yavo ichinge yaparara, masero aiwanzoita chirongwa chekufa kwesero (Guevara-Aguirre et al., 2011). Nokudaro, kutsanya kunogona kudzivirira kubva kune kenza kuburikidza nekuderedza masero uye DNA kukuvara asiwo nokuwedzera kufa kwema-pre-cancerous cells.

Pakutanga kuongorora nyaya dzeC10 nemhando dzakasiyana-siyana dzehuipi, kusanganiswa kwechemotherapy nekutsanya kwakaguma nekuderera kwehuwandu hwezviitiko zvinowanzoitika zvinokonzerwa nekemotherapy kana zvichienzaniswa nedzimwe nyaya dzichiwana chemotherapy panguva yekudya zvakakwana (Safdie et al., 2009). Nzira yekutsanya chemotherapy toxicity uye kufambira mberi kwekenza ikozvino iri kuongororwa mumakiriniki ekuedzwa muEurope uye neUnited States (0S-08-9, 0S-10-3).

Kutsanya uye Neurodegeneration

Nzwisiso yedu yezvino pamusoro pemigumisiro yeAIDS muhurongwa hwemitsipa uye maitiro ekugogodza anonyanya kutadzisa kubva kuongororo yemhuka (ona pamusoro). Zvidzidzo zvekupindira kuti zvione kushanda kwekutsanya muuropi kushanda uye neurodegenerative zvirwere zvinoshaya.

Mushure memwedzi mitatu ne3, CR yakavandudza kugona kwekuziva (verbal memory) mune vakadzi vakafuta (Kretsch et al., 4) uye mune vakura zvidzidzo (Witte et al., 1997). Saizvozvowo, apo zvidzidzo zvine hunyanzvi hwekukanganisa kugona zvakachengetedzwa kwemwedzi we2009 pane yakaderera glycemic kudya, ivo vakaratidza kunatsiridzwa kunonoka kutaridzika ndangariro, cerebrospinal fluid biomarkers eA? metabolism uye brain bioenergetics (Bayer-Carter et al., 1). Zvidzidzo umo kugona kwekuziva, dunhu rehuropi huwandu, neural network chiitiko, uye biochemical kuongororwa kwecebrospinal fluid kunoyerwa muzvidzidzo zvevanhu nguva isati yasvika uye mukati menguva yakareba ye IF inofanirwa kujekesa kukanganisa kweIF pane chimiro chehuropi hwemunhu uye mashandiro.

Kutsanya, Kuvhiringidza uye Hypertension

Muvanhu, kumwe kuratidzwa kwakanakisa kwemabhenefiti anobatsira ekutsanya kwenguva refu kwenguva yakareba kusvika kumavhiki matatu ari mukurapa rheumatoid arthritis (RA). Mukubvumirana nezvakabuda mumakonzo, hapana mubvunzo kuti panguva yekutsanya zvese kuzvimba uye kurwadziwa kunoderedzwa muRA varwere (Muller et al., 3). Nekudaro, mushure mekunge chikafu chakajairwa chatangwazve, kuzvimba kunodzoka kunze kwekunge nguva yekutsanya ikateverwa nechikafu chemuriwo (Kjeldsen-Kragh et al., 2001), musanganiswa wekurapa uyo une mhedzisiro inobatsira inogara kwemakore maviri kana kupfuura (Kjeldsen-Kragh et al., 1991). Iko kwechokwadi kwenzira iyi kunotsigirwa nezvidzidzo zvina zvakasiyana zvinodzorwa, kusanganisira maviri akasarudzika miedzo (Muller et al., 1994). Naizvozvo, kutsanya kwakabatanidzwa nechikafu chemuriwo uye pamwe nezvimwe zvakagadziriswa kudya kunopa zvinobatsira mukurapa RA. Rimwe zuva IF zvakare rakaguma nekudzikisira kwakakura muserum TNF? uye ma ceramides mune varwere veasima munguva yemwedzi miviri (Johnson et al., 2001). Iyi yekupedzisira kudzidza yakaratidza zvakare kuti mamaki eiyo oxidative kusagadzikana kunowanzo sangana nekuzvimba (protein uye lipid oxidation) zvakadzikiswa zvakanyanya mukupindura IF. Nekudaro, kune vazhinji varwere vanokwanisa uye vanoda kutsungirira kwenguva refu yekutsanya uye kugadzirisa zvachose chikafu chavo, kutsanya kutenderera kungave nekwanisi kwete kwete kungowedzera asi zvakare kutsiva aripo marapirwo ekurapa.

Mvura chete uye mamwe maitiro ekutsanya kwemazuva mazhinji akave akafanirwawo kuti ave nemigumisiro yakawanda yehutachiona. Avhareji yezuva 13 yemvura chete kutsanya kwakaguma mukubudirira kwe a systolic kuwedzera kweropa (BP) pazasi pe120 mu82% yezvidzidzo zvine hutachiona hweborderline ine chirevo che20 mm Hg kuderedzwa muBP (Goldhamer et al., 2002). BP yakaramba yakadzikira zvakanyanya kana ichienzaniswa neyekutanga kunyange mushure mekunge zvidzidzo zvadzorerazve chikafu chakajairwa paavhareji yemazuva matanhatu (Goldhamer et al., 6). Chidzidzo chidiki chekutyaira chevarwere vane hypertension (2002 mm uye pamusoro systolic BP) zvakare chakaratidza kuti mazuva gumi nehafu ekutsanya kwakakonzera kuderera kwe140-10 mm mu systolic BP (Goldhamer et al., 11). Izvi zvidzidzo zvekutanga zviri kuvimbisa asi zvichisimbisa kudiwa kweakakura akadzora uye akasarudzika makiriniki ezvidzidzo anotarisa pane dzimwe nguva nzira dzekutsanya dzinokwanisika kune chikamu chakakura chevagari.

Nokuda kwehutano hwehutano uye RA zvichave zvakakosha kukudziridza PF kutevedzera kudya kunobudirira sekushanya kwezvokudya zvinorondedzerwa pamusoro apa asi izvo zvinoremekedzwa nehuwandu hwevarwere.

Kutsanya uye Semu Metabolic Syndrome

Nguva yekutsanya inogona kuderedza zvinhu zvakawanda zvehutachiona hwemagetsi muvanhu: inowedzera insulin senzwi, inosimudzira kunyarara uye inoderedza kuwedzerwa kweropa. Mafuta omuviri uye kuwedzerwa kweropa zvakaderedzwa uye glucose metabolism yakavandudzwa mune zvidzidzo zvakanyanya mukupindura kune rimwe zuva rakashandurwa nokukurumidza (Klempel et al., 2013; Varady et al., 2009). Zvidzidzo zvepamusoro-soro zvakachengetwa kwemwedzi ye6 pane kaviri vhiki nevhiki KANA kudya kwavakadya ma500 600 macalori chete mumazuva ekutsanya, kurasikirwa nemimba mafuta, kwakaratidza kunatsiridza insulin senzwi uye kuderedzwa kweropa (Harvie et al., 2011). Vhiki nhatu dzekutsanya kwekumwe zuva kwakaguma nekudzikiswa kwemafuta emuviri uye insulin mazinga mukati normal weight varume nevakadzi (Heilbronn et al., 2005) uye Ramadan kudya (2 kudya / zuva rakaparadzaniswa nemaawa anenge 12) mune zvidzidzo neSMS zvakaita kuti kuderera kwemazuva ose kuwedzere, kuderera kwemazimbe emuviri weplasma uye kuwedzera insulin senzwi (Shariatpanahi et al., 2008). Zvidzidzo zvinotarisana nekoronary angiography iyo yakashuma kuti ivo vaitsanya nguva dzose vairatidza kupararira kwakaderera kwechirwere cheshuga kana vachienzaniswa nevasina kusimba (Horne et al., 2012). Anti-metabolic syndrome zvinokonzerwa neIIDS zvaionekwa zvakare muvarume vechidiki vane utano (BMI ye25) mushure memazuva e15 ezvimwe zuva rokutsanya kwezuva: muviri wavo wose weglucose huwandu hwekuwedzera huwandu hwakawanda kwazvo, miviri ye plasma ketone miviri uye adiponectin yakasimudzwa, iyo yose chakaitika pasina kupera kukuru muutoro hwemuviri (Halberg et al., 2005). Zvakawanikwa zvekupedzisira zvakafanana nedheta kubva kune zvidzidzo zvezvipfuwo zvinoratidza kuti kana zvichigona kuvandudza glucose metabolism kunyange nechinguva kana kusina kuchinja (Anson et al., 2003). Zvichave zvakakosha kuziva kuti kana nguva yakareba yekutsanya iyo inokurudzira kushandiswa kwakasimba kunopera mafuta uye ketone muviri-based metabolism, inogona kukonzera kwenguva yakareba uye zvinowedzera simba.

Mhedziso uye Mazano

Kubva pauchapupu huripo huripo hwemhuka uye hutsva hwevanhu hunotsanangurwa, tinoona kuti kune mikana yakawanda yehupenyu hunoisa nguva yekutsanya munguva yehupenyu hwevanhu vakuru kukurudzira hutano hwakanaka uye kuderedza dambudziko rezvirwere zvisingaperi, kunyanya kune avo vari kunyanya kukura uye vanogara. Zvidzidzo zvezvipfuwo zvakanyorwa zvakasimba uye zvinopindurwa zvinokonzerwa nekutsanya pane zvirwere zvehutano kusanganisira yakanyanya insulin senzwi, uye kuderedzwa kwehuwandu hweropa, mafuta omuviri, IGF-I, insulini, glucose, atherogenic lipids nekuputika. Kuzvinyima zvokudya kunogona kusimbisa zvirwere zvehutano uye kunatsiridza zvakagadziriswa zvinoshandiswa mumhando dzemhuka dzematambudziko dzinosanganisira myocardial infarction, chirwere cheshuga, chirwere, AD uye PD. Imwe nyanzvi yekugadzirisa kwekutsanya ndeyokuti inokonzera kugadziriswa kwemagetsi kushungurudzika mhinduro, izvo zvinokonzera kuwedzerwa kukwanisa kutsungirira kukura kwakanyanya uye kupikisa zvirwere zvirongwa. Mukuwedzera, nekudzivirira masero kubva kuDNA kukanganisa, kubvisa kushandiswa kwesero nekusimudzira kugadziriswa kwemasero akaora, kutsanya kunogona kurega uye / kana kudzivirira kuumbwa nekukura kwekenza.

Zvisinei, zvidzidzo zvekutsanya maitiro hazvina kuitwa muvana, ivo vekare kwazvo uye vane huremu hwevanhu, uye zvinokwanisika kuti IF nePF zvaizokuvadza kune vanhu ava. Nguva dzekutsanya dzinogara kwenguva yakareba kupfuura maawa makumi maviri nemana uye kunyanya idzo dzinogara mazuva matatu kana anopfuura dzinofanira kuitwa pasi pekutarisirwa nachiremba uye kunyanya mukiriniki. IF- uye PF-nzira dzakanangana nekurwisa madenda aripo ekuwedzeredza, chirwere cheshuga nezvirwere zvine hukama zvinofanirwa kutevedzwa muzvidzidzo zvevanhu uye zvirongwa zvekurapa. Misiyano yakati wandei yezvingangove zvekutsanya zvakatemwa zvakagamuchirwa pamusoro pezvinhu zvakawandisa zvinotenderera pamusoro wenyaya wakajairika wekurega kudya uye zvinwiwa zvine macaloriki kweanenge maawa gumi nemaviri kusvika makumi maviri nemana pazuva rimwe kana anopfuura mazuva pasvondo kana mwedzi, zvichienderana nehurefu, zvakasanganiswa nekugara uchirovedza muviri. Kune avo vakafutisa, varapi vanogona kubvunza varwere vavo kuti vasarudze yekutsanya-kwakavakirwa kupindira iyo yavanotenda kuti vanogona kutevedzera zvinoenderana neyavo ezuva nezuva uye evhiki mashedhi. Mienzaniso inosanganisira iyo -24: 3- KANA kudya (Harvie et al., 12), rimwe zuva rakashandurwa kudya kwekutsanya (Johnson et al., 24; Varady et al., 5), zuva 2 2011 nekukurumidza kana yakaderera koriori. asi kudya kwakanyanya kutsanya kuteedzera kudya kamwe chete pamwedzi imwe neimwe nehafu zvichiteverwa nekusvetuka kwekudya kukuru zuva rega rega kana zvichidikanwa (V. Longo, kiriniki kutongwa kuri kuenderera). Chimwe chezvinonetsa nekudya zvisina tsarukano zvakachinjika senge idzo idzo dzakaderera koriori dzinongocherechedzwa kwemazuva maviri pasvondo ndizvo zvingangoitika pamutambo we circadian uye endocrine uye masisitimu emudumbu, ayo anozivikanwa kuti anokanganiswa nemadyiro. Munguva yekutanga 2007 - 2009 mavhiki ekuitwa kweiyo nzira yekutsanya, chiremba kana chiremba akanyoreswa anofanirwa kugara achisangana nemurwere kuti aone mafambiro avo uye nekupa rairo nekutarisirwa.

Kutsanya marejimendi anogona zvakare kugadzirirwa chaiwo marwadzi seyakamira-yega kana yekubatanidza ekurapa. Mhedzisiro yemiedzo yekutanga yeIF (kutsanya mazuva maviri pavhiki kana rimwe zuva rimwe nerimwe) muzvidzidzo zvevanhu zvinoratidza kuti kune yakaoma nguva yekushanduka kwemasvondo matatu ne2 panguva iyo uropi nemuviri zvinowirirana nenzira nyowani yekudya nemanzwiro zvinowedzerwa (Harvie et al., 3; Johnson et al., 6). Kunyangwe ichifungidzira, zvinokwanisika kuti panguva yekupedzisira yekuchinja nguva huropi neurochemistry inoshanduka kuitira kuti "kupindwa muropa" nekudya nguva dzose kwezuva rese kwakundwa. Zvinonzwisisika, nzira dzakasiyana siyana dzekutsanya dzinogona kunge dziine hushoma hunyanzvi kunyanya pakukwegura nemamiriro ezvinhu kunze kwekuneta kunze kwekunge zvasanganiswa nezvikafu zvakadai seyakadzikama koriori inodya uye kazhinji chirimwa-chakavakirwa muMediterranean kana Okinawa mapuroteni madhayeti (2011 g protein / Kg yehuremu ), inogara ichibatanidzwa nehutano uye hupenyu hurefu.

Mune ramangwana, zvichave zvakakosha kusanganisa dambudziko repidemiological, zvidzidzo zvevanhu venguva refu varipo uye kudya kwavo, zvinoguma kubva kune zvipenyu zvekufananidza kusanganisa zvimwe zvikamu zvezvokudya zvekukwegura kwekare uye zvepro-zvirwere zvinokonzera, nedzidzo kubva kuongorori nezvekutsanya kwemazuva evanhu , kugadzira zvidzidzo zvekuchirapa zvakakura zvinosanganisa kudya nekudya kunozivikanwa sekudzivirira uye kunonakidza. Kunyatsonzwisisa zviri nani maitiro emakemikari ayo kutsanya kunobata zvakasiyana-siyana masero emasero uye zvirongwa zvegungu zvinofanira kutungamirira pakuvandudzwa kweinovel prophylactic uye nzira dzokurapa kwehutano hwakasiyana-siyana.

Tora Home Message

Kutsanya kutevedzera kudya kunopa zvipo zvakafanana zvekutsanya kwetsika kuburikidza nekudzivirira koriori yako kudya kwemazuva mashanu kubva pamwedzi panzvimbo pokubvisa zvachose zvokudya zvose kwemazuva akawanda kana masvondo. The ProLon kutsanya kutevedzera kudya kunopa purogiramu yekudya ye5-zuva iyo yakave yakanyatsoiswa uye yakanyorwa muhuwandu hwakakwana uye kuenzanisa kwezuva rimwe nerimwe. Kunyange zvazvo tsvakurudzo yakaitwa pamusoro apa yakaratidza hutano hunobatsira hwekutsanya, tapota ita nechokwadi chekutaura kune chiremba wehutano usati watanga ProLon kutsanya kuteedzera chikafu, 5-zuva rekudya chirongwa kuti uone kana FMD, kana chimwe chekudya, chakakunakira iwe.

Iyo yakabudiswa, iyo yakagadziridzwa yekupedzisira yerudzi rwekutsvakurudza kunotsanangurwa pamusoro apa yakaitwa kuwanikwa mune NIH Public Access Munyori Manuscript pane PMC February 4, 2015. Kuwanda kwemashoko edu kunongogumira chiropractic, nhau dzehutano hwepamuviri, uye zvinoshanda zvemishonga nyaya. Kuti uwedzere kukurukura nyaya yacho, tapota ivai vakasununguka kubvunza Dr. Alex Jimenez kana kuti tibvunzei nesu 915-850-0900 .

Yakarongedzwa naDkt Alex Jimenez

Inotsanangurwa kubva: Nih.gov

Yokuwedzera Nhaurirano Kukurukurirana: Acute Back Pain

Kutambudzika shure ndechimwe chezvikonzero zvakakosha zvikuru zvekuremara uye mazuva asina kukwana kubasa pasi rose. Kusuruvara kwakapinda kunokonzera chikonzero chechipiri chinowanzovhiringidzirwa nehofisi yehofisi, yakawandisa chete nepamusoro-kuputika kwezvirwere. Inenge 80 muzana yevanhu vanozova nemarwadzo mushure kamwechete muupenyu hwavo hwose. Mutsara wako chivakwa chakaoma chakagadzirwa nemapfupa, majoints, ligaments, uye mishonga, pakati pezvimwe zvinyoro zvishoma. Kukuvara uye / kana mamiriro ezvinhu akaoma, akadai herniated discs, zvinogona kutungamirira kune zviratidzo zvekurwadziwa shure. Kukuvara kwemitambo kana kukuvara kwepamberi yemotokari kazhinji kunowanzokonzera kukonzera kurwadziwa, zvisinei, dzimwe nguva kufamba kwakanyanya kunogona kuva nemigumisiro inorwadza. Nenzira yakanaka, nzira dzakasiyana dzokurapa, dzakadai sechiropractic, dzinogona kubatsira kuderedza marwadzo shure kuburikidza nekushandurwa kwepelinha nekugadzirisa maitiro, pakupedzisira kunatsiridza marwadzo ekurwadziwa.

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