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Back Clinic Cannabinoids. Zvirimwa mishonga, uye sezvo tsvakurudzo inoenderera mberi nemishonga iyi yakasiyana, ruzivo rwakawanda runowanikwa kana zvasvika kune zvingasarudzwa zvekurapa kwezvirwere zvakasiyana-siyana, mamiriro, zvirwere, zvirwere, nezvimwewo ... Chiropractor Dr. Alex Jimenez anoongorora uye anounza nzwisiso mumishonga iyi inokura, sei vanogona kubatsira varwere, zvavanogona kuita, nezvavasingagoni kuita.

Iyo mbanje chirimwa ndiwo maziviro mazhinji nezve cannabinoids. Ndiyo inonyanya kuzivikanwa cannabinoid tetrahydrocannabinol (THC), iyo ndiyo inokonzera manzwiro euphoria.

Masayendisiti akaona cannabinoids chete mu cannabis. Nekudaro, kutsva kutsva kwakawana hunhu hwakafanana hwekurapa mumiti yakawanda, kusanganisira pepuru nhema, broccoli, karoti, clove, echinacea, uye ginseng.

Iyi miriwo kana zvinonhuwira hazvikuise iwe kumusoro, asi kunzwisisa kuti izvi zvirimwa zvakasiyana zvinokanganisa sei muviri wemunhu zvinogona kutungamira kune zvakakosha kuwanikwa kwehutano.

Kutarisa Kwakadzika MuMetabolic Syndrome | El Paso, TX (2021)

Kutarisa Kwakadzika MuMetabolic Syndrome | El Paso, TX (2021)

by | Back Clinic Podcast, Cannabinoids, Functional Medicine, utano, Metabolic Syndrome, udyo, Remedies, Mishonga, Video, Kuonda, Wellness

Mune podcast yanhasi, Dr. Alex Jimenez, mudzidzisi wehutano Kenna Vaughn, mupepeti mukuru Astrid Ornelas vanokurukura nezve metabolic syndrome kubva kune imwe nzvimbo yekuona pamwe chete, zvakasiyana-siyana zvinovaka muviri kurwisa kuzvimba.

 

Dr. Alex Jimenez DC*: Tikugashirei, vakomana, tinogamuchirwa kupodcast yaDr. Jimenez uye vashandi. Isu tiri kukurukura nezve metabolic syndrome yanhasi, uye tichave tichiikurukura kubva kune imwe nzira yekuona. Isu tinokupa akanakisa, anobatsira matipi anogona kuita zvine musoro uye ari nyore kuita kumba. Metabolic syndrome ipfungwa yakakura kwazvo. Rine nyaya huru shanu. Iine shuga yeropa yakakwira, ine dumbu remafuta kuyerwa, ine triglycerides, ine HDL nyaya, uye ine yakanaka kwazvo ine conglomeration yesimba rinofanirwa kuyerwa muchikonzero chose chatinokurukura metabolic syndrome nekuti inobata nharaunda yedu zvakanyanya. zvakawanda. Saka, tichave tichikurukura nyaya idzi uye kuti tingadzigadzirisa sei. Uye kukupa kugona kugadzirisa mararamiro ako kuti usazopedzisira wava nawo. Ndiyo imwe yematambudziko akanyanya kubata mushonga wemazuva ano, ndoda kana tangonzwisisa. Kwese kwaunoenda, unoona vanhu vazhinji vane metabolic syndrome. Uye icho chikamu chenzanga, uye ndicho chinhu chaunoona muEurope zvakanyanya. Asi muAmerica, nekuti isu tine chikafu chakawanda uye mahwendefa edu anowanzo hombe, isu tinokwanisa kugadzirisa miviri yedu zvakasiyana nezvatinodya chete. Hapana kusagadzikana kuchachinja nekukurumidza uye nekukurumidza senzira yakanaka uye yakanaka protocol yekukubatsira iwe ne metabolic kusagadzikana uye metabolic syndrome. Saka tataura izvozvo, nhasi tine boka revanhu. Tine Astrid Ornelas naKenna Vaughn, vanozokurukura nekuwedzera ruzivo rwekutibatsira kuburikidza nekuita. Zvino, Kenna Vaughn ndiye mudzidzisi wedu wehutano. Ndiye anoshanda muhofisi yedu; pandinenge ndiri chiremba anodzidzira pamishonga yemuviri uye pandinenge ndichishanda nevanhu mumwe pane mumwe, tine vamwe vanhu vanoshanda nenyaya dzekudya uye zvinodiwa zvekudya. Chikwata changu pano chakanyanya, chakanaka. Tine zvakare muongorori wedu wepamusoro wekiriniki uye munhu anochengetedza tekinoroji yedu yakawanda uye ari pamucheto wezvatinoita nesainzi yedu. NdiMai. Ornelas. Mrs. Ornelas kana Astrid, sezvatinomudana, ari ghetto neruzivo. Anotanga kushata nesainzi. Uye ndizvo chaizvo, patiri chaizvo. Nhasi, tiri kurarama munyika umo tsvakurudzo iri kuuya nekupfira kunze kweNCBI, iyo inochengeterwa kana PubMed, iyo vanhu vanogona kuona isu tinoshandisa ruzivo urwu uye tinoshandisa zvinoshanda uye chii chinozviita. Hasi ruzivo rwese rwakakwana muPubMed nekuti une maonero akasiyana, asi zvakada kuita sechigunwe pane pulse kana taisa chigunwe chedu mukati. Tinogona kuona zvinhu zvinorikanganisa. Nemamwe mazwi akakosha uye mamwe chenjedzo, tinoziviswa nezve shanduko, toti, nyaya dzeshuga dzekudya kana nyaya dze triglyceride dzine mafuta, chero nezve metabolic kusagadzikana. Isu tinokwanisa kuuya neprotocol yekurapa inorarama yakagadziridzwa kubva kuna vanachiremba nevatsvaguri uye maPhD kutenderera pasirese nekukasira, kunyangwe vasati vaburitswa. Somuenzaniso, nhasi inoitika February 1st. Hazvisizvo, asi tichange tichiwana mibairo uye zvidzidzo zvakaunzwa neNational Journal yeCardiology iyo ichabuda munaKurume kana zvine musoro. Kuti ruzivo irworwo rwutange rwuchipisa panhau, uye Astrid inotibatsira kufunga zvinhu izvi uye kuona, "Hei, unoziva, takawana chimwe chinhu chinopisa uye chimwe chinhu chekubatsira varwere vedu" uye inounza iyo N yakaenzana, inova nemoyo murefu- chiremba akaenzana nemumwe. Murwere uye murapi akaenzana uyo isu hatiite chaiwo maprotocol kune wese wese. Isu tinoita maprotocol chaiwo kumunhu wega wega isu patinenge tichipfuura nekuita. Saka patinoita izvi, rwendo rwekunzwisisa metabolic syndrome rine simba uye rakadzama kwazvo. Tinogona kutanga kubva pakungotarisa mumwe munhu kune basa reropa, nzira yese yekuchinja kwekudya, kune shanduko yemetabolism, nzira yese kudzika kune cellular chiitiko icho chiri kushanda nesimba. Isu tinoyera nyaya neBIA uye BMI, izvo zvatakaita nemapodcasts apfuura. Asi isu tinogonawo kupinda muzinga, genomics uye kuchinja kwekromosomes uye telomeres mumakromosomes, izvo zvatinogona kukanganisa nekudya kwedu. OK. Migwagwa yese inotungamira kune zvekudya. Uye izvo zvandinotaura neimwe nzira isinganzwisisike, migwagwa yese inotungamira kune smoothies, OK, smoothies. Nokuti kana tikatarisa pa smoothies, tinotarisa zvikamu zve smoothies uye tinouya nemasimba ayo anokwanisa kuchinja ikozvino. Chandinotarisa ndechekuti pandinotsvaga marapiro, ndinotarisa zvinhu zvinoita kuti hupenyu hwevanhu huve nani, uye izvi tingazviita sei? Uye nokuda kwaamai vose ivavo, vanonzwisisa kuti vangasaziva kuti vanoita izvi, asi amai havamuki vachiti, Ndichapa mwana wangu zvokudya. Aiwa, ari kuita manyawi epfungwa ekuunza kicheni yese nekuti anoda kupinza chikafu chakanyanya kumwana wavo uye nekupa mhando yavo yakanakisa yesarudzo kuti mwana wavo apfuure nenyika kana yekuchengeta vana kana chikoro chepuraimari, kuburikidza nechikoro chepakati, kuburikidza nechikoro chesekondari kuitira kuti mwana akure zvakanaka. Hapana anobuda achifunga kuti ndichapa mwana wangu junk uye. Uye kana zviri izvo, zvakanaka, pamwe hakusi kurera vana kwakanaka. Asi isu hatizotaura nezvazvo zvakanaka; tichataura nezvekudya kwakanaka uye kugadzirisa zvinhu izvozvo. Saka ndoda kusuma Kenna izvozvi. Uye achange achikurukura zvishoma nezvezvatinoita kana tikaona munhu ane metabolic kusagadzikana uye maitiro edu pazviri. Saka paanenge achipfuura neizvozvo, anozokwanisa kunzwisisa maitiro atinoongorora nekuongorora murwere uye nekumuunza kuti isu titange kuwana hutongi hudiki hwemunhu iyeye.

 

Kenna Vaughn: Zvese zvakanaka. Saka chekutanga, ini ndinongoda kutaura nezve smoothies zvishoma zvishoma. Ini ndiri amai, saka mangwanani, zvinhu zvinopenga. Iwe haumbove nenguva yakawanda sezvaunofunga iwe, asi iwe unoda izvo zvinovaka muviri uye ndizvo zvinoita vana vako. Saka ndinoda smoothies. Vanokurumidza kukurumidza. Unowana zvese zvaunoda. Uye vanhu vazhinji vanofunga kuti kana uchidya, unenge uchidya kuti ugutse dumbu rako, asi uri kudya kuti uzadze masero ako. Masero ako ndiwo anoda kudya ikoko. Ndizvo zvinokutakura iwe nesimba, metabolism, zvese izvo. Saka iwo masmoothies isarudzo yakakura kwazvo, yatinopa varwere vedu. Isu tinotova nebhuku rine 150 smoothie mabikirwo akanakira kurwisa kuchembera, kubatsira chirwere cheshuga, kuderedza cholesterol, kudzora kuzvimba, nezvimwe zvakadaro. Saka ndiyo imwe sosi yatinopa kuvarwere vedu. Asi isu tine dzimwe nzira dzakawanda dzevarwere vanouya nechirwere chemetabolic.

 

Dr. Alex Jimenez DC*:  Usati wapinda imomo, Kenna. Rega ndingowedzera kuti zvandadzidza ndezvekuti tiite zvirinyore. Taifanira kuenda kudzimba kana kutake away. Uye zvatiri kuedza kuita isu tiri kuyedza kukupa maturusi anogona kukubatsira mukuita ikoko. Uye tichaenda newe kukicheni. Tichakubata nenzeve, sekutaura, uye tichakuratidza nzvimbo dzatinofanira kutarisa. Saka Kenna yave kuda kutipa iyo ruzivo maererano nesmoothies inozotibatsira nekuchinja kwekudya kwatinogona kupa mhuri dzedu nekuchinja njodzi yayo yemetabolism inobata vanhu vazhinji vanonzi metabolic syndrome. Enderera mberi.

 

Kenna Vaughn: OK, so sezvaaitaura nema smoothies iwayo. Chinhu chimwe chete chaunofanira kuwedzera kune yako smoothie ndechekuti, chandinoda kuwedzera mune yangu sipinashi. Sipinachi isarudzo yakanaka nekuti inopa muviri wako zvimwe zvinovaka muviri. Uri kuwana kumwe kupihwa kwemuriwo, asi haugone kuravira, kunyanya kana yakafukidzwa nekutapira kwepanyama kwaunowana mumichero. Saka iyo yakanakisa sarudzo kana zvasvika kune iyo smoothies. Asi chimwe chinhu chaitaurwa naDr. Jiménez ndezvimwe zvinhu zviri mukicheni. Saka kune zvimwe zvinotsiva izvo zvatiri kuda kuti varwere vedu vashandise nekuita. Unogona kutanga zvishoma, uye zvinozoita mutsauko mukuru nekungodzima mafuta auri kubika nawo. Uye iwe unozotanga kuona kuvandudzwa mumajoini ako, vana vako, uye munhu wese anongovandudza zvakanyanya. Saka chinhu chimwe chatinoda kuti varwere vedu vashandise mafuta iwayo, semafuta ekotapeya, kokonati mafuta, uye… Mafuta emuorivhi? Mafuta omuorivhi. Hongu, ndatenda, Astrid.

 

Dr. Alex Jimenez DC*: Aya aiva mafuta omuorivhi. Ndiyo yaive Astrid kumashure. Tiri kuburitsa chokwadi zvakanaka uye toenderera mberi.

 

Kenna Vaughn: Paunoshandura izvo kunze, muviri wako unopwanya zvinhu zvakasiyana neaya asina kuzara mafuta. Saka ingori imwe sarudzo yauinayo mukicheni iyoyo kunze kwekugadzira iwo masmoothies. Asi sezvandambotaura, ndiri pamusoro pekukurumidza, nyore, nyore. Zviri nyore kushandura mararamiro ako kana uine timu yese yakakukomberedza. Uye kana zviri nyore, hauite. Iwe hausi kuda kubuda uye kuita kuti zvese zviome zvakanyanya nekuti mikana yekuti iwe unamatira pairi haina kunyanya kukwira. Saka chinhu chimwe chete chatinoda kuita kuve nechokwadi chekuti zvese zvatiri kupa varwere vedu zviri nyore kuita uye zvinogoneka muhupenyu hwemazuva ese.

 

Dr. Alex Jimenez DC*: Ndiri kuona zvakanyanya. Saka pandinoenda kukicheni, ndinofarira kugadzira kicheni yangu kuti ifanane necocina kana chero yavanoti kuItaly, cucina uye ini ndine mabhodhoro matatu ikoko, uye ndine mafuta ekotapeya. Ndine mafuta ekokonati, uye ndine mafuta emuorivhi ipapo. Kune mabhodhoro makuru ipapo. Vanovaita vakanaka, uye vanotarisa Tuscan. Uye, munoziva, handina basa kana riri zai, handina basa nazvo. Dzimwe nguva, kunyangwe pandinenge ndichinwa kofi yangu, ndinotora mafuta ekokonati, ndodira iwo mukati ndogadzira java ine kokonati mafuta mairi. Saka, hongu, enda mberi.

 

Kenna Vaughn: Ndaizotaura kuti isarudzo huru zvakare. Saka ini ndinonwa yegirinhi tii, uye ndinowedzera kokonati mafuta mune iyo girini tii kubatsira kusimudzira zvese uye kupa muviri wangu imwe dosi yeaya ane fatty acids atinoda.

 

Dr. Alex Jimenez DC*: Ndine mubvunzo kwauri kana iwe uine kofi yako saizvozvo; kana uine mafuta mukati, zvinoita sokuzora miromo yako.

 

Kenna Vaughn: Inoita zvishoma. Saka zvakafananawo chapstick.

 

Dr. Alex Jimenez DC*: Hongu, zvinoita. Zvakafanana, Ah, ndinoida. OK, enda mberi.

 

Kenna Vaughn: Ehe, ini ndinofanirawo kumutsa zvishoma kuti ndive nechokwadi chekuti zvese zvinofamba zvakanaka. Ehe. Uyezve chimwe chinhu kungotaura nezve chimwe chinhu varwere vedu vanogona kuita kana zvasvika kumba, kune matani ezvisarudzo zvakasiyana nekudya hove. Kuwedzera hove dzako dzakanaka dzekudya mukati mevhiki, izvo zvichabatsira zvakare. Uye nekuda kwekuti hove dzinopa zvinhu zvikuru zvakawanda senge omegas, ndinoziva Astrid zvakare ine rumwe ruzivo nezve omegas.

 

Dr. Alex Jimenez DC*: Ndine mubvunzo Astrid asati apindamo. Munoziva, tarisai, kana tichitaura pamusoro pemakabhohaidhiretsi, vanhu, ndicho chinonzi carbohydrate here? Ah, vanhu vanoti apuro, bhanana, zvihwitsi, uye marudzi ese ezvinhu vanhu vanogona kucheka macarbohydrates kana mapuroteni. Huku, nyama yemombe, chero chavanogona kuzvipisa. Asi chimwe chezvinhu zvandakaona kuti vanhu vane nguva yakaoma nacho ndechekuti mafuta akanaka chii? Ndinoda zvishanu. Ndipe mafuta gumi akanaka nemiriyoni yemadhora. Ndipei mafuta ane gumi akanaka, akaita samafuta, senyama; Kwete, izvi ndizvo zvatiri kutaura nezvazvo. Nekuti iyo yakapusa chokwadi yatinoshandisa uye isu tichawedzera zvimwe kwairi yakashata ichave mafuta ekotapeya. Mafuta omuorivhi. Iwo kokonati mafuta here? Tinogona kushandisa zvinhu zvakaita semafuta ebhota, mhando dzakasiyana dzemiganho, uye kwete miganho, asi marudzi ebhota anobva, munoziva, mhou dzakadyiswa uswa. Isu tinogona kupera macreamer, munoziva, asiri-nondairy creams, chaiwo makirimu, avo vatinopera, handiti? Kutsanya chaiko. Saka zvakafanana, chii chimwe chinonzi mafuta, handiti? Uye tobva tazvitsvaga. Saka imwe yedzakanakisa nzira dzekuzviita ndeyekuti isu hatisi kuzogara tichiisa creamer pamusoro kana bota redu pamusoro, izvo nenzira, mamwe makofi anawo, vanoisa bhotela mukati uye vanosanganisa, uye vanogadzira. a fantastic little java hit. Uye munhu wese anouya neginger yavo diki nemafuta nekofi yavo uye vanogadzira espresso kubva kudenga, handiti? Saka chii chimwe chatingaita?

 

Kenna Vaughn: Tinogona, sezvandakataura, kuwedzera idzo hove mukati, izvo zvichabatsira kupa miviri yedu mamwe eiyo omegas. Uye isu tinokwanisawo kuita mimwe miriwo yepepuru, uye iyo inozopa muviri wako mamwe antioxidants. Saka ndiyo yakanaka sarudzo kana zvasvika kune girosari. Mutemo wechigumwe wandinoda uye wandakanzwa kare ndewekuti usatengese mumikoto ndeyekuedza kutenga kumacheto nekuti kumacheto ndiko kwaunowana izvo zvinyoro zviyo nenyama dzese dzakaonda. Ndopaunotanga kupinda mumikoto iwawo, ndipo pauchatanga kuwana, unoziva, zviyo, izvo zvakaipa makabhohaidhiretsi, iwo macarbohydrates ari nyore ayo chikafu cheAmerica chasvika pakuda asi hazvidi hazvo. The Oreos?

 

Kenna Vaughn: Ehe.

 

Dr. Alex Jimenez DC*: Nzira yezvihwitsi iyo mwana wese anoziva. Hongu, hongu. 

 

Kenna Vaughn: Saka ingori imwe pfungwa huru ipapo. Saka kana iwe uchipinda muhofisi yedu, kana iwe uchirwara ne metabolic syndrome kana chero chinhu chakajairika, isu tinoita hurongwa hwako hwakanyanya hwemunhu uye tinokupa iwe akawanda matipi. Isu tinoteerera mararamiro ako nekuti izvo zvinoshanda kune mumwe munhu zvinogona kusashanda kune mumwe. Saka isu tinoita shuwa kuti tinokupa iwe ruzivo rwatinoziva kuti uchabudirira narwo uye nekupa dzidzo nekuti ndicho chimwe chikamu chikuru chayo.

 

Dr. Alex Jimenez DC*: Migwagwa yese inoenda kukicheni, huh? Rudyi? Hungu, vanodaro. Zvakanaka, saka ngatitarisei zvakanyanya kune mafuta uye zvinovaka muviri. Ini ndoda kukupa zano rekuti ndeupi rudzi rwekudya kunovaka muviri kwakakodzera kwatiri nekuti tinoda kutsikisa idzi nyaya shanu dzinobata metabolic syndrome dzatakakurukura. Vakomana vashanu ndivanaani? Handei mberi tivatange. Ishuga yepamusoro, handiti?

 

Kenna Vaughn: Glucose yeropa, yakaderera HDLs, inova iyo yakanaka cholesterol inodiwa nemunhu wese. Ehe. Uye ichange iine high blood pressure, iyo isingafungidzirwe yakakwirira kubva kune chiremba wechiremba, asi inofungidzirwa kuti yakasimudzwa. Saka ndicho chimwe chinhu; tinoda kuona kuti iyi i metabolic syndrome, kwete chirwere chemetabolism. Saka kana ukaenda kwachiremba uye BP yako iri 130 pamusoro pemakumi masere neshanu, ndicho chiratidzo. Asi zvakadaro mupi wako anogona kunge asiri kutaura kuti BP yako yakakwira zvakanyanya. 

 

Dr. Alex Jimenez DC*: Hapana chimwe chezvirwere izvi pano pachazvo inzvimbo dzekiriniki, uye, mumwe nemumwe, zvinongori zvinhu. Asi kana ukabatanidza ese aya mashanu, une metabolic syndrome uye unonzwa sekunge isina kunyanya kunaka, handiti?

 

Astrid Ornelas: Ehe, hongu.

 

Kenna Vaughn: Imwe ichange iri huremu hwakawandisa hwakatenderedza dumbu uye nepamusoro triglycerides.

 

Dr. Alex Jimenez DC*: Zviri nyore kuona. Unoona kana munhu ane dumbu rakarembera sechisipiti, handiti? Saka isu tinogona kuona kuti unogona kuenda kwairi dzimwe nguva maresitorendi echiItaly uye kuona mubiki mukuru. Uye dzimwe nguva ndinotofanira kukuudza, dzimwe nguva zvinongodaro, munoziva, takataura naChef Boyardee anga asiri munhu mutete. Ndinofunga kuti Chef Boyardee, unoziva chii? Uye mukomana wePillsbury, handiti? Zvakanaka, yakanga isina hutano hwakanyanya, handiti? Vese vari vaviri vanotambura ne metabolic syndrome kubva pakutanga. Saka iri nyore kuona. Saka izvi ndizvo zvinhu zvatinenge tichifunga nezvazvo. Astrid ichaenda pamusoro pezvimwe zvinovaka muviri, mavhitaminzi, uye zvimwe zvekudya zvatingagona kuvandudza zvinhu. Saka heino Astrid, uye heino sainzi yedu curator. Asi heino Astrid, enda mberi.

 

Astrid Ornelas: Hongu, ndinofungidzira tisati tapinda mune zvinovaka muviri, ndinoda kujekesa chimwe chinhu. Senge taitaura nezve metabolic syndrome. Metabolic syndrome haisi, uye ndinofungidzira per se, chirwere kana nyaya yehutano pachayo. Metabolic syndrome iboka remamiriro ezvinhu anogona kuwedzera njodzi yekuvandudza humwe hutano hwakaita seshuga, sitiroko, uye chirwere chemoyo. Nekuti metabolic syndrome haisi, iwe unoziva, iyo chaiyo nyaya yehutano pachayo, zvakanyanya kudaro boka iri, iri muunganidzwa wemamwe mamiriro, emamwe matambudziko anogona kukura kuita akanyanya kuipa hutano nyaya. Nekuda kweiyo chokwadi, metabolic syndrome haina zviratidzo zvinooneka pachayo. Asi chokwadi, sezvatakanga tichitaura nezvazvo, zvinhu zvishanu zvine njodzi zvakanyanya izvo zvatakakurukura: mafuta akawandisa muchiuno, kukwira kweropa, shuga yeropa, yakakwira triglycerides, yakaderera HDL, uye sekureva kwevashandi vehutano. Kuna vanachiremba nevatsvaguri, unoziva kuti une metabolic syndrome kana uine zvitatu kubva pane izvi zvishanu zvine njodzi.

 

Dr. Alex Jimenez DC*: Ehe. Tatu. Zvino, hazvirevi kuti kana unazvo, une zviratidzo. Sezvandiri kuona zvaionekwa pa. Asi ndinofanira kukuudza muchiitiko changu kana mumwe munhu aine anopfuura matatu kana matatu. Vanotanga kunzwa kunyungudika. Havanzwi zvakanaka. Vanongonzwa sekunge, munoziva, hupenyu hauna kunaka. Vanongova nehovhorosi. Havatarisi zvakanaka. Saka uye ini handivazivi, pamwe. Asi mhuri yavo inoziva kuti havaratidziki zvakanaka. Saamai havataridzike zvakanaka. Baba vanotaridzika zvakanaka.

 

Astrid Ornelas: Ehe, hongu. Uye metabolic syndrome, sezvandakataura, haina zviratidzo zvinooneka. Asi iwe unoziva, ini ndanga ndichienda neimwe yenjodzi nemafuta muchiuno, uye apa ndipo paunoona vanhu vane yaunoti apuro kana muviri wakaita sepear, saka vane mafuta akawandisa padumbu ravo. Uye kunyangwe izvo zvisiri zvehunyanzvi zvinoonekwa sechiratidzo, chinhu chinogona; Ndinofungidzira kuti inogona kupa pfungwa kune vanachiremba kana vamwe vashandi vehutano kuti munhu uyu, iwe unoziva, ane prediabetes kana ane chirwere cheshuga. Uye, iwe unoziva, ivo vane huremu hwakawandisa uye kufutisa. Vanogona kuve nenjodzi yakawedzera ye metabolic syndrome uye nekudaro kukura, munoziva, kana ikasiiwa isina kurapwa, kugadzira dzimwe nyaya dzehutano senge chirwere chemoyo uye sitiroko. Ndofunga zvichinzi; zvino tichazopinda mune nutraceutical.

 

Dr. Alex Jimenez DC*: Ndinoda izvi, ndinoda izvi. Tiri kuwana zvinhu zvakanaka, uye tiri kuwana mamwe mashoko.

 

Astrid Ornelas: Uye ndinofungidzira nezviri kutaurwa, tichapinda mune zvinovaka muviri. Senge, Kenna aitaura nezvechii chinotorwa? Iwe unoziva, isu tiri pano tichitaura nezve idzi nyaya dzehutano, uye tiri pano kutaura nezve metabolic syndrome nhasi. Asi chii chekutora? Chii chatingaudza vanhu? Chii chavanogona kuenda nacho kumba pamusoro pehurukuro yedu? Chii chavanogona kuita kumba? Saka pano isu tine akati wandei nutraceuticals, yandakanyora akati wandei zvinyorwa mublog redu uye ndakatarisa. 

 

Dr. Alex Jimenez DC*:  Iwe unofunga, Astrid? Kana iwe ukatarisa zvinyorwa zve100 zvakanyorwa muEl Paso, zvirinani munharaunda yedu, zvese zvakagadziriswa nemumwe munhu. Ehe. Zvese zvakanaka.

 

Astrid Ornelas: Ehe. Saka isu tine akati wandei manutraceuticals pano akaongororwa. Vatsvagiri vakaverenga zvese izvi zvidzidzo zvekutsvagisa uye vakawana kuti vanogona kubatsira neimwe nzira uye imwe fomu inovandudza, munoziva, metabolic syndrome uye izvi zvine chekuita nezvirwere. Saka yekutanga yandinoda kukurukura ndeye B mavhitaminzi. Saka chii chinonzi B vitamini? Aya ndiwo aungawanzovawana pamwe chete. Unogona kuzviwana muchitoro. Iwe unovaona seB-yakaoma mavhitaminzi. Iwe uchaona sechirongo chidiki, uye zvino chinouya neanoverengeka mavhitamini B. Zvino, sei ndichiunza B mavhitaminzi e metabolic syndrome? Saka chimwe chezvikonzero zvakaita sevatsvaguri chaona kuti chimwe chazvo, ndinofungidzira, chimwe chezvikonzero zve metabolic syndrome chinogona kuve kushushikana. Saka nezviri kutaurwa, isu tinofanirwa kuve neB mavhitamini nekuti kana isu tichinetseka kana isu tine zuva rakaoma pabasa patinenge tine, ndinofungidzira vazhinji munoziva, zvinhu zvakawanda zvinoshungurudza kumba kana nemhuri, kutya kwedu. system ichashandisa aya mavhitamini B kutsigira tsinga yedu basa. Saka kana tine kushushikana kwakawanda, tichashandisa mavhithamini aya, izvo zvinowedzera kushungurudzika; munoziva, muviri wedu uchagadzira cortisol. Iwe unoziva, iyo inoshanda basa. Asi isu tese tinoziva kuti yakawandisa cortisol, yakawandisa kushushikana inogona chaizvo. Zvinogona kutikuvadza. Inogona kuwedzera njodzi yedu yechirwere chemoyo.

 

Dr. Alex Jimenez DC*: Iwe unoziva, sezvandinorangarira patakaita izvi, migwagwa yose inoenda kukicheni maererano nekudzorera chikafu mumuviri wako. Migwagwa yese inotungamira kune mitochondria kana zvasvika kune nzvimbo yekuputsika. Nyika yekugadzira simba reATP yakakomberedzwa uye yakaputirwa ne nicotinamide, NADH, HDP, ATPS, ADP. Zvinhu izvi zvese zvine hukama nevhitamini B yemarudzi ese. Saka mavhitamini B ari painjini iri muturbine yezvinhu zvinotibatsira. Saka zvine musoro kuti iyi yaive yepamusoro yevhitamini uye yakanyanya kukosha. Uye zvakare ane mamwe mamagumo pano paniacin. Chii chinonzi niacin? Chii chawaona ipapo?

 

Astrid Ornelas: Zvakanaka, niacin imwe B vhitamini, munoziva, kune akati wandei mavhitamini B. Ndicho chikonzero ini ndiinayo ipapo pasi pehuwandu hwayo uye niacin kana vhitamini B3, sezvainonyanya kuzivikanwa. Vazhinji vakati wandei vakangwara. Tsvakurudzo dzakawanda dzekutsvakurudza dzakawana kuti kutora vhitamini B3 kunogona kubatsira kuderedza LDL kana cholesterol yakaipa, kubatsira kuderedza triglycerides, uye kuwedzera HDL. Uye ongororo dzinoverengeka dzakawana kuti niacin, kunyanya vhitamini B3, inogona kubatsira kuwedzera HDL ne30 muzana.

 

Dr. Alex Jimenez DC*: Incredible. Paunotarisa NADP neNADH, Aya ndiwo N ndiyo niacin, nicotinamide. Saka mumushonga webiochemical, niacin ndiyo yakambozivikanwa nevanhu kuti kana ukaitora yakanaka kana iyo inofanirwa kunge iri, unonzwa uku kuyerera uye kunoita kuti ukwenye nhengo yako yese yemuviri, uye inonzwa. zvakanaka kana uchikwenya nekuti zvinoita kuti unzwe saizvozvo. Zvakanaka, zvakanaka. Uye ichi chikuru.

 

Astrid Ornelas: Ehe. Hongu, uye zvakare, ini ndinongoda kusimbisa pfungwa nezve B mavhitaminzi. B mavhitaminzi akakosha nekuti anogona kubatsira kutsigira metabolism yedu patinodya, munoziva, makabhohaidhiretsi nemafuta, mafuta akanaka, hongu, uye mapuroteni. Kana muviri uchifamba nemetabolism, inoshandura aya makabhohaidhiretsi, mafuta, uye mapuroteni. Mapuroteni anoshanduka kuita simba, uye B mavhitaminzi ndiwo anonyanya kuita basa rekuita izvozvo.

 

Dr. Alex Jimenez DC*: Latinos, muhuwandu hwedu, tinoziva kuti tagara tichinzwa nezve mukoti kana munhu anopa jekiseni revhitamini B. Saka makanzwa zvinhu izvozvo. Rudyi. Nokuti wakaora mwoyo, wakasuruvara, vaizoita sei? Zvakanaka, iwe unoziva chii chaizovabaya neB12, handiti? Ndeapi mavhitamini eB, handiti? Uye munhu wacho aizobuda sekuti, Hongu, uye ivo vaizofara, handiti? Saka isu takaziva izvi, uye iyi ndiyo elixir yekare. Vaya vatengesi vaifamba, vaive nemishonga uye mafuta ekuzora, vairarama nekupa B vitamin complex. Zvinwiwa zvekutanga zvesimba zvakatanga kugadzirwa neB complex, munoziva, kurongedza. Zvino heino dhiri. Zvino zvatadzidza kuti zvinwiwa zvesimba zvinokonzeresa nyaya dzakawanda, zvekuti tave kudzokera kumaB complexes kuti tibatsire vanhu zvirinani. Saka vhitamini inotevera yatinayo ipapo ndeyekuti isu tine D, isu tine vhitamini D.

 

Astrid Ornelas: Hongu, iyo inotevera yandaida kutaura nezvayo ndeye vitamin D. Saka pane zvidzidzo zvakawanda zvekutsvakurudza pamusoro pevhitamini D uye zvakanakira, zvakanakira vhitamini D ye metabolic syndrome, uye chete kuti ndakakurukura sei mavhitamini eB anobatsira kune metabolism yedu. Vitamin D inobatsirawo kumetabolism yedu, uye inogona kubatsira kudzora shuga yedu yeropa, kunyanya glucose yedu. Uye izvo pachazvo zvakakosha nekuti, senge chimwe chezvinhu zvinokonzeresa zve metabolic syndrome, yakakwira shuga yeropa. Uye iwe unoziva, kana iwe usingadzoreki yakakwira shuga yeropa, inogona kutungamirira kune, iwe unoziva, inogona kutungamirira kune prediabetes. Uye kana izvozvo zvikasarapwa, zvinogona kukonzera chirwere cheshuga. Saka zvidzidzo zvekutsvagisa zvakawanawo kuti vhitamini D pachayo inogona zvakare kuvandudza insulin kuramba, iyo yakanaka kwazvo inogona kutungamirira kuchirwere cheshuga.

 

Dr. Alex Jimenez DC*:  Iwe unoziva, ini ndaingoda kuisa kunze vhitamini D haisi kunyange vhitamini; ihomoni. Yakawanikwa mushure meC naLinus Pauling. Pavakaiwana, vakaramba vachingotaura tsamba inotevera. Zvakanaka, saka sezvo iri hormone, unofanira kungoitarisa. Iyi chaiyo vhitamini D kana iyi hormone tocopherol. Izvo chaizvo zvinogona kushandura zvakawanda zvakadaro zvemetabolism mumuviri wako. Ndiri kutaura nezve mazana mana kusvika mazana mashanu akasiyana maitiro atiri kuwana. Gore rakapera vaiva 400. Iye zvino tatova mamwe 500 mamwe maitiro ebiochemical anokanganisa zvakananga. Zvakanaka, zvine musoro. Tarisai, nhengo yedu inonyanya kukosha mumuviri iganda redu, uye kazhinji yenguva, taimhanya tichitenderera nemhando yehembe dzakapfava, uye takanga tiri muzuva zvakanyanya. Zvakanaka, hatina kumira kuti tifunge kuti nhengo iyoyo inogona kuburitsa simba rakawanda rekuporesa, uye vhitamini D inozviita. Inogadzirwa nechiedza chezuva uye inoshandiswa. Asi nyika yanhasi, tingave tiri maArmenian, maIran, tsika dzakasiyana kuchamhembe, seChicago, vanhu havawane chiedza chakawanda. Saka zvichienderana nekushanduka kwetsika uye vanhu vakavharwa vanogara nekushanda mune zviedza zvefluorescent izvi, tinorasikirwa nehupenyu hwevhitamini D uye tinorwara zvikuru. Munhu anotora vhitamini D ane hutano hwakanyanya, uye chinangwa chedu ndechekusimudza vhitamini D ine mafuta-inonyungudika vhitamini uye iyo inonyungudika nayo uye inoponeswa muchiropa pamwe chete nemafuta ari mumuviri. Saka unokwanisa kuisimudza zvishoma nezvishoma paunenge uchiitora, uye yakaoma kuwana mwero wechepfu, asi idzo dzinenge zana nemakumi maviri neshanu ema nanograms pa deciliter dzakanyanyisa. Asi vazhinji vedu tinomhanya negumi kusvika makumi maviri, izvo zvakaderera. Saka, muchidimbu, nekusimudza izvo, iwe uchaona kuti shanduko yeshuga yeropa ichaitika iyo Astrid iri kutaura nezvayo. Ndezvipi zvimwe zvezvinhu zvatinoona nezvazvo, kunyanya vhitamini D? Chero chii?

 

Astrid Ornelas: Ndinoreva, ndichadzokera kuvhitamini D zvishoma; Ini ndinoda kukurukura zvimwe zveimwe nutraceuticals kutanga. OK. Asi yakawanda vhitamini D inobatsira nekuti inobatsira kuvandudza metabolism yako, uye inobatsira kuvandudza yako insulin kuramba, zvirinani kune metabolic syndrome.

 

Dr. Alex Jimenez DC*: Zvakadini necalcium?

 

Astrid Ornelas: Saka calcium inoenda-in-ruoko nevhitamini D, uye chinhu chandaida kutaura nezvacho nevhitamini D uye calcium pamwechete. Isu tinowanzo funga nezvezvinhu zvishanu izvi zvatakambotaura izvo zvinogona kukonzera metabolic syndrome. Zvakadaro, pane, iwe unoziva, kana iwe uchida kufunga nezvazvo, senge ndezvipi zvinokonzeresa zvezvizhinji zveizvi njodzi zvinhu? Uye senge, iwe unoziva, kufutisa, mararamiro ekugara, vanhu vasingaite maekisesaizi kana kuita zvemuviri. Chimwe chezvinhu zvinogona kufanomirira munhu kana kuwedzera njodzi yavo ye metabolic syndrome. Rega ndiise mamiriro acho. Zvakadini kana munhu ane chirwere chisingaperi chinorwadza? Zvakadini kana vane chimwe chinhu chakaita se fibromyalgia? Vanogara vachirwadziwa. Havadi kufamba, saka havadi kuita maekisesaizi. Havadi kuwedzera zviratidzo izvi. Dzimwe nguva, vamwe vanhu vane kurwadziwa kusingaperi kana zvinhu zvakaita se fibromyalgia. Handei zvishoma zvishoma zvakakosha. Vamwe vanhu vanongorwara nemarwadzo ekudzokera shure, uye iwe haudi kushanda kunze. Saka iwe hausi kusarudza sevamwe vevanhu ava havasi kusarudza kusashanda nekuti vanoda. Vamwe vevanhu ava vari mumarwadzo zviri pamutemo, uye pane zvidzidzo zvakawanda zvekutsvaga, uye izvi ndizvo zvandaizosunga muvhitamini D uye calcium nevhitamini D uye calcium. Iwe unoziva, tinogona iwe unogona kuvatora pamwe chete. Vanogona kubatsira kuvandudza kurwadziwa kusingaperi kune vamwe vanhu.

 

Dr. Alex Jimenez DC*: Incredible. Uye isu tese tinoziva kuti calcium ndeimwe yezvikonzero zvetsandanyama spasms uye relaxers. Matani ezvikonzero. Tichapinda mune chimwe nechimwe cheizvi. Tichava nepodcast pane vhitamini D chete uye nyaya dziri mucalcium nekuti tinogona kudzika. Isu tichaenda zvakadzama, uye isu tichaenda nzira yese kune genome. Iyo genome is genomics, inova sainzi yekunzwisisa kuti hutano uye majini kutamba sei pamwechete. Saka isu tichaendako, asi isu tinoita setiri kupinza zvishoma nezvishoma mukuita uku nekuti isu tinofanirwa kutora nyaya zvishoma nezvishoma. Chii chinotevera?

 

Astrid Ornelas: Saka zvinotevera, isu tine omega 3s, uye ndinoda kunyatso simbisa kuti tiri kutaura nezve omega 3s neEPA, kwete DHA. Saka idzi iEPA, inova ndiyo yakanyorwa kumusoro uko, uye DHA. Iwo marudzi maviri akakosha e omega 3s. Chaizvoizvo, ese akakosha zvakanyanya, asi akati wandei tsvakiridzo uye ndakaita zvinyorwa pane izvi zvakare ndakaona kuti ndinofungidzira kutora omega 3s chaizvo neEPA, inongo pfuura mumabhenefiti ayo kupfuura DHA. Uye kana tichitaura nezve omega 3s, idzi dzinogona kuwanikwa muhove. Kazhinji yenguva, iwe unoda kutora omega 3s; unovaona muchimiro chemafuta ehove. Uye izvi zviri kudzokera kune zvakambotaurwa naKenna, sekutevera kudya kweMediterranean, iyo inonyanya kukoshesa kudya hove dzakawanda. Apa ndipo paunowana kutora kwako omega 3s, uye zvidzidzo zvekutsvagisa zvakawana kuti omega 3s pachayo inogona kubatsira kusimudzira hutano hwemoyo, uye inogona kubatsira kudzikisa yakashata cholesterol kune yako LDL. Uye izvi zvinogonawo kuvandudza metabolism yedu, sevhitamini D.

 

Dr. Alex Jimenez DC*: Kuda kuenderera mberi nekuputira zvinhu zvese izvi pasi pekuti isu tiri kutarisawo, uye kana tave kubata ne metabolic syndrome, tiri kubata nekuzvimba. Kuzvimba uye omega kwave kuchizivikanwa. Saka chatinofanira kuita kuburitsa chokwadi chekuti maomega anga ari mukudya kweAmerica, kunyangwe mukudya kwaambuya. Uye zvakare, senge zvakare, tinonzwa kumashure muzuva apo mbuya kana mbuya-mbuya vaikupa mafuta echiropa checod. Zvakanaka, hove yepamusoro-soro inotakura omega ndiyo herring, iyo inenge 800 milligrams pakudya. Iyo cod inotevera kana yave kutenderera 600. Asi nekuda kwekuwanikwa, kadhi rinowanikwa zvakanyanya mune dzimwe tsika. Saka munhu wese aizova nemafuta echiropa checod, uye vaibva vakuita kuti uvhare mhino dzako wonwa, uye vaiziva kuti zvaienderana. Vangafunga kuti mafuta akanaka. Zvakadaro, yaive anti-kuzvimba yakanangana nevanhu, uye kazhinji, vanambuya vaiziva nezvekodzero iyi vanobatsira nematumbu, vanobatsira kuzvimba, vanobatsira majoini. Vaiziva nyaya yese kumashure. Saka isu tichapinda mukati meOmegas mune yedu yakazotevera podcast. Tine mumwe ari pano. Inonzi berberine, handiti? Ndeipi nyaya paberberine?

 

Astrid Ornelas: Zvakanaka, yakawanda seti inotevera yezvokudya zvinovaka muviri zvakanyorwa pano, berberine, glucosamine, chondroitin, acetyl L-carnitine, alpha-lipoic acid, ashwagandha, zvakanaka chaizvo zvose izvi zvakasungirirwa mune zvandakambotaura pamusoro pekurwadziwa kusingaperi uye zvose. nezvenyaya dzehutano idzi. Ndakazvinyora pano nekuti ndakaita zvinyorwa zvakati wandei. Ndakaverenga tsvakiridzo dzakasiyana siyana dzakafukidza izvi mumayedzo akasiyana uye nepamusoro pezvidzidzo zvetsvakiridzo dzakawanda nevazhinji vatori vechikamu. Uye ava vakawana zvakawanda, munoziva, boka iri rezvokudya zvinovaka muviri pano rakanyorwa; izvi zvakasungwawo kuti zvibatsire kuderedza marwadzo asingagumi. Iwe unoziva, uye sezvandakambokurukura, sekurwadziwa kusingaperi, iwe unoziva, vanhu vane fibromyalgia kana kunyange kufanana, iwe unoziva, ngatiendei zvishoma vanhu vakareruka vane kurwadziwa shure, munoziva, vanhu ava vasingashande vane mararamiro ekugara. nekuda kwekurwadziwa kwavo uye vanogona kuve panjodzi ye metabolic syndrome. Zvizhinji zveidzi tsvakurudzo zvidzidzo zvakawana izvi nutraceuticals pachavo zvinogona kubatsirawo kuderedza marwadzo asingagumi.

 

Dr. Alex Jimenez DC*: Ndinofunga iyo itsva inonzi alpha-lipoic acid. Ndiri kuona acetyl L-carnitine. Tichava neanogara biochemist pane inotevera podcast kuti tipinde zvakadzama mune izvi. Ashwagandha izita rinonakidza. Ashwagandha. Zvitaure. Dzokorora. Kenna, unogona here kundiudza zvishoma nezve ashwagandha uye zvatakwanisa kuwana nezve ashwagandha? Nekuti izita rakasiyana uye chimwe chikamu chatinotarisa, tichataura nezvaro zvakanyanya. Tichadzokera kuAstrid mune yechipiri, asi ini ndichamupa kuzorora zvishoma uye senge, regai Kenna andiudze zvishoma zveashwagandha.

 

Kenna Vaughn: Ini ndaizowedzera mune chimwe chinhu nezve berberine iyo.

 

Dr. Alex Jimenez DC*: O, zvakanaka, ngatidzokere kuberberine. Aya ndiwo berberine uye ashwagandha.

 

Kenna Vaughn: Zvakanaka, kuitira kuti berberine yakaratidzawo kubatsira kuderedza HB A1C mune varwere vane shuga yeropa dysregulation, iyo inodzoka kune yose prediabetes uye nyora mamiriro maviri echirwere cheshuga anogona kuitika mumuviri. Saka iyo imwe zvakare yakaratidzwa kuderedza iyo nhamba kudzikamisa shuga yeropa.

 

Dr. Alex Jimenez DC*:  Pane chinhu chose chatichava nacho paberberine. Asi chimwe chezvinhu zvatakaita maererano ne metabolic syndrome zvechokwadi chakaita runyorwa rwepamusoro pano rwekuita. Saka pane ashwagandha uye berberine. Saka tiudze zvese nezve ashwagandha. Zvakare, ashwagandha ndiyo. Saka maererano neshuga yeropa, iyo A1C ndiyo kuverenga kweshuga yeropa iyo inokuudza chaizvo izvo shuga yeropa inoita pamusoro pemwedzi mitatu. Iyo glycosylation yehemoglobin inogona kuyerwa nekuchinja kwema molecular kunoitika mukati mehemoglobin. Ndosaka iyo Hemoglobin A1C iri mucherechedzo wedu wekuona. Saka kana ashwagandha neberberine vauya pamwe chete voshandisa izvo zvinhu, tinogona kushandura iyo A1C, inova mwedzi mitatu yerudzi senge nhoroondo yezviri kuitika. Takaona shanduko pane izvozvo. Uye ndicho chimwe chezvinhu zvatinoita izvozvi maererano nemadosi uye nezvatinoita. Isu tichaenda pamusoro pazvo, asi kwete nhasi nekuti izvo zvishoma zvakanyanya kuoma. Soluble fibers anga ariwo chikamu chezvinhu. Saka zvino, kana tichibata nemafuta anonyungudika, sei tiri kutaura nezve soluble fibers? Chokutanga pane zvose, chikafu chezvipembenene zvedu, saka tinofanira kuyeuka kuti nyika yeprobiotic chinhu chatisingakanganwi. Vanhu vanofanira kunzwisisa kuti, kunyange zvakadaro, kuti probiotics, kana iri Lactobacillus kana Bifidobacterium strains, kana iri ura duku, ura hombe, pakutanga ura, kune mabhakitiriya akasiyana kusvika kumagumo kuona kuuya kumucheto shure. Saka ngatidaidze iyo nzvimbo inobuda zvinhu. Kune mabhakitiriya kwese kwese pamatanho akasiyana, uye rimwe nerimwe rine chinangwa chekuwana izvozvo. Pane vitamini E uye green tea. Saka ndiudze, Astrid, nezve aya dynamics maererano negirinhi tii. Chii chatinoona maererano ne metabolic syndrome?

 

Astrid Ornelas: OK. Saka green tea ine zvakawanda zvinobatsira, munoziva? Asi, iwe unoziva, vamwe vanhu havadi tii, uye vamwe vari mukofi, munoziva? Asi kana iwe uchida kupinda mukunwa tii, iwe unoziva, zvirokwazvo nekuda kwehutano hwayo hunobatsira. Green tii inzvimbo yakanaka yekutanga uye maererano ne metabolic syndrome. Green tii yakaratidzwa kubatsira kuvandudza hutano hwemoyo, uye inogona kubatsira kudzikisa izvi njodzi zvinhu zvine chekuita ne metabolic syndrome. Inogona kubatsira, iwe unoziva, akati wandei tsvakurudzo zvidzidzo zvakawana kuti green tea inogona kubatsira kuderedza cholesterol, yakaipa cholesterol, LDLs.

 

Dr. Alex Jimenez DC*: Ko green tea inotibatsira here nemafuta edu edumbu?

 

Astrid Ornelas: Ehe. Pane imwe yemabhenefiti egreen tea yandaverenga nezvayo. Yakanaka imwe yeayo angangove anonyanya kuzivikanwa ndeye kuti green tea inogona kubatsira nekuonda.

 

Dr. Alex Jimenez DC*: Maiwe zvangu. Saka zvakanyanya mvura uye green tea. Ndizvozvo, varume. Ndizvo zvose. Isu tinodzikamisa hupenyu hwedu huri zvakare, ndinoreva, isu takakanganwa kunyangwe chinhu chine simba kwazvo. Inotarisira iwo maROS, ayo ari reactive oxygen marudzi, edu antioxidants, kana oxidants muropa redu. Saka zvinongozvidzvanya uye zvinovaburitsa kunze uye zvinotonhodza kutonhorera kwavo uye kudzivirira kunyangwe kuparara kwakajairika kunoitika kana kuwanda kwakanyanya kunoitika mukuparara kwemetabolism yakajairwa, inova chigadzirwa chinova ROS, mhando dzeokisijeni dzinoshanda dziri musango, dzinopenga. maoxidants, ayo atine zita rakanaka rezvinhu zvinozvipwanya nekudzikamisa uye nekuzviisa muhurongwa hwavanodaidza kuti antioxidants. Saka mavhitaminzi ari antioxidants ndeye A, E, uye C ane antioxidants, zvakare. Saka izvo midziyo ine simba yatinobata nayo sezvatinodzikisa huremu hwemuviri. Tinosunungura huturu hwakawanda. Uye sezvo tii yegirinhi inopinda mu squirt, svina, inotonhodza, uye inovabvisa mugiya. Fungidzira pane imwe nhengo inobatsira nekugadzirwa kwe insulin yese, inova itsvo. Itsvo dzinobuda negreen tea zvobva zvabatsirawo. Ini ndinoona kuti chinhu chimwe chete chausina kuita, Astrid, chakaitwa zvinyorwa pane turmeric, handiti?

 

Astrid Ornelas: Oo, ndakaita zvinyorwa zvakawanda pamusoro peturmeric. Ini ndoziva nekuti, kubva pane iyo rondedzero iri kumusoro uko, turmeric uye curcumin ingangoita seimwe yandinoda nutraceuticals kutaura nezvayo.

 

Dr. Alex Jimenez DC*: Ehe, akafanana nekutsenga mudzi uye kakati wandei.

 

Astrid Ornelas: Ehe, ndine mamwe mufiriji yangu izvozvi.

 

Dr. Alex Jimenez DC*: Ehe, iwe unobata iyo turmeric, uye unogona kurasikirwa nemunwe. Chii chakaitika kumunwe wangu? Wakasvika pedyo neturmeric yangu here? Mudzi, handiti? Saka. Saka tiudze zvishoma nezve zvimiro zve turmeric uye curcumin maererano ne metabolic syndrome.

 

Astrid Ornelas: OK. Ndakaita akati wandei, munoziva, akawanda ezvinyorwa pane turmeric uye curcumin. Uye isu takambokurukura izvozvo kare, uye akati wandei ekare edu podcasts uye turmeric ndeyekuti yero yero inogona kutaridzika orenji kune vamwe vanhu, asi inowanzonzi yero mudzi. Uye inonyanya kufarirwa muIndia cuisine. Ndicho icho chiri chimwe chezvinhu zvakakosha zvauchawana mu curry. Uye curcumin, chokwadi vamwe venyu imi vanhu vakanzwa nezve curcumin kana turmeric, munoziva? Chii chakasiyana? Zvakanaka, turmeric chirimwa chinotumbuka, uye ndiwo mudzi. Isu tinodya mudzi weturmeric, uye curcumin inongova chinhu chinoshanda muturmeric chinopa iyo yero ruvara.

 

Dr. Alex Jimenez DC*: Varume, ini handingaregi chero chinhu kunze kwemhando yepamusoro yecurcumin uye turmeric zvigadzirwa zviwanikwe kune varwere vavo nekuti pane musiyano. Mamwe anogadzirwa aine chaiwo, ndinoreva, isu tine zvinonyungudutsa, uye nemabudiro atinoita zvinhu uye zvecurcumin uye turmeric kana kunyange zvinhu zvakaita secocaine, unofanirwa kushandisa distillate. OK? Uye ingava mvura, acetone, benzene, OK, kana imwe mhando yezvakagadzirwa, tinoziva nhasi kuti benzene inoshandiswa kugadzira akawanda marudzi ezvekuwedzera, uye mamwe makambani anoshandisa benzene kuti abudise zvakanakisa kubva muturmeric. Dambudziko ndere benzene inogadzira gomarara. Saka tinofanira kungwarira zvikuru makambani atinoshandisa. Acetone, fungidzira izvozvo. Saka kune maitiro aripo ekubvisa turmeric nemazvo uye anobatsira. Saka kuwana yakakodzera turmeric, ese maturmeric haana kufanana. Uye ndicho chimwe chezvinhu chatinofanira kuongorora sezvo iine zvigadzirwa zvakawanda munyika iri kupenga chaizvo kuyedza kugadzirisa turmeric uye chaizvo, kunyangwe chiri chinhu chekupedzisira chatiri kukurukura nhasi pane yedu nyaya. Asi ndechimwe chezvinhu zvakakosha nhasi. Hatitombonzwisisi aspirin. Tinoziva kuti inoshanda, asi hukuru hwayo husati hwataurwa. Nekudaro, turmeric iri muchikepe chimwe chete. Isu tiri kudzidza zvakawanda pamusoro pazvo zvekuti zuva rega rega, mwedzi wega wega, zvidzidzo zviri kugadzirwa pamusoro pekukosha kweturmeric mukudya kwechisikigo, saka Astris inopindirana pane chinangwa pane izvo. Saka ndine chokwadi chekuti achaunza zvimwe zvacho kwatiri, handiti?

 

Astrid Ornelas: Ehe saizvozvo. 

 

Dr. Alex Jimenez DC*: Saka ini ndinofunga zvatingaite nhasi kana tatarisa izvi, ndinoda kubvunza Kenna, kana tichitarisa metabolic syndrome kubva mukuratidzwa kwezviratidzo kana kunyange kubva kuzvidzidzo zvemurabhoritari. Chivimbo chekuziva kuti N yakaenzana chimwe ndechimwe chezvinhu zvakakosha zvatinazvo iye zvino mukurapa unoshanda uye maitiro ehutano anoshanda ayo akawanda emishonga yemuviri vanachiremba vari kuita muchikamu chavo chekudzidzira. Nekuti munyaya dzemetabolism, haugone kubvisa metabolic kubva mumuviri. Iyo metabolism inoitika mudambudziko remusana here? Isu tinocherekedza kuwirirana nekukuvara kwemusana, kurwadziwa kwemusana, nyaya dzekumusana, kusagadzikana kwemabvi kwenguva refu, kusagadzikana kwekubatana kwe musculoskeletal disorders, uye metabolic syndrome. Saka hatigoni kuzviseka. Saka tiudze zvishoma, Kenna, patiri kuvhara nhasi zvishoma zvezvingatarisirwa nemurwere kana vauya kuhofisi yedu, uye vanobva vaiswa mu "Oops, une metabolic syndrome." Saka boom, tozvifambisa sei?

 

Kenna Vaughn: Tinoda kuziva mabviro avo nekuti, sezvawataura, zvese zvakabatana; zvinhu zvose zvakadzika. Pane ruzivo rwatinoda kuziva zvese kuti tigone kugadzira iyo yakasarudzika hurongwa. Saka chimwe chezvinhu zvekutanga zvatinoita igwaro refu remibvunzo neLiving Matrix, uye chishandiso chikuru. Zvinotora nguva diki, asi zvinotipa nzwisiso yakawandisa mumurwere, zvinova zvakanaka nekuti zvinotitendera, sezvandakataura, kuchera zvakadzika toona, munoziva, marwadzo angave akaitika ari kutungamira mukuzvimba. , izvo zvaitaurwa naAstrid zvino zvinotungamira mararamiro ekugara, izvo zvinozotungamira kune iyi metabolic syndrome kana kungodzika munzira iyo. Saka chimwe chezvinhu zvekutanga zvatinoita kuita iro remibvunzo remibvunzo, tobva tagara pasi totaura newe mumwe nemumwe. Isu tinovaka timu uye tinokuita iwe chikamu chemhuri yedu nekuti zvinhu izvi hazvisi nyore kufamba nazvo uri wega, saka kubudirira kwakanyanya kana iwe uine iyo mhuri yakabatana, uye uine rutsigiro irworwo, uye isu tinoedza kuva izvo iwe.

 

Dr. Alex Jimenez DC*: Takatora ruzivo urwu tikaona kuti rwakanga rwakaoma zvikuru makore mashanu apfuura. Zvakanga zvakaoma. 300 300-mapeji emibvunzo. Nhasi tine software yatinokwanisa kuziva. Inotsigirwa neIFM, iyo Institute of Functional Medicine. The Institute of Functional Medicine yakatanga mumakore gumi apfuura uye yakave yakakurumbira, ichinzwisisa munhu wese semunhu. Iwe haugone kupatsanura mboni yeziso kubva kune rudzi rwemuviri sezvo iwe usingakwanise kupatsanura iyo metabolism kubva kune ese mhedzisiro yainayo. Kana iwo muviri iwoyo uye chikafu ichocho, iyo nutraceutical iyo kudya inopinda mumuviri wedu. Kune rimwe divi remuromo wedu pane zvinhu zviduku zvinorema zvinonzi machromosome. Vari kutenderera, uye vari kuchururuka, uye vari kugadzira maenzayimu nemapuroteni zvichibva pane zvatinovadyisa. Kuti tizive zviri kuitika, tinofanira kuita rondedzero yemibvunzo ine chekuita nekunamata kwemuviri wepfungwa. Iyo inounza mumakanika ekugayiwa kwakajairwa, mashandiro anoita kupinza, uye kuti chiitiko chekurarama chese chinoitika sei mumunhu. Saka kana isu tichifunga nezveAstrid naKenna pamwechete, isu tinofunga nzira yakanakisa, uye isu tine maitiro akagadzirirwa emunhu wega wega. Isu tinoidza iyo IFM imwe, mbiri, uye mitatu, iyo mibvunzo yakaoma inotibvumira kukupa kuongororwa kwakadzama uye kuparara kwakarurama kwekuti chikonzero chinogona kuva chii uye nutraceuticals iyo inovaka muviri iyo yatinotarisa nayo. Isu tinosundidzira iwe nzira kwayo kune iyo ine basa mukicheni. Isu tinopedzisira takudzidzisa iwe nemhuri yako nzira yekudyisa kuitira kuti iwe uve wakanaka kune iwo genetic genomes, zvauri, sezvandinogara ndichitaura, ontogeny, recapitulate phylogeny. Isu tiri zvatiri kubva kare kusvika kuvanhu, uye vanhu ivavo vane shinda pakati pedu neyangu yekare, uye munhu wose ari pano akapfuura. Uye iyo ndiyo genetics yedu, uye genetics yedu inopindura kune zvakatipoteredza. Saka kunyangwe zvichienda kumaodzanyemba nekukurumidza kana kufumurwa kana kufanotungamira, isu tichakurukura izvo, uye isu tichapinda munyika ye genomics munguva pfupi iri kutevera mukuita uku sezvatinopinda mukati meiyo metabolic syndrome maitiro. Saka ndinokutendai mose nekuteerera kwatiri uye kuziva kuti tinogona kubatika pano, uye vachakusiyirai nhamba. Asi isu tine Astrid pano iri kuita research. Tine timu yakavambwa nevanhu vazhinji vanogona kukupa ruzivo rwakanyanya runoshanda kwauri; N yakaenzana neimwe. Tine Kenna pano iyo inogara iripo uye tiri pano tichichengeta vanhu mutaundi redu rakanaka reEl Paso. Saka ndatenda zvakare, uye tarisira kune inotevera podcast, ingangove mukati memaawa mashoma anotevera. Kungotamba. Zvakanaka, zvakanaka, varume. 

Kuchinja Kwehupano Kunobatanidza Nekusingaperi Kunetseka

Kuchinja Kwehupano Kunobatanidza Nekusingaperi Kunetseka

by | Cannabinoids, chisingaperi Pain, Clinical Neurophysiology, Research Studies, Mishonga

Marwadzo ehupenyu hwemuviri wehupenyu hwekuzvarwa nekukuvara kana kurwara, uye kazhinji inyevero kuti chimwe chinhu chakaipa. Kana dambudziko racho rapora, tinowanzorega kuona zviratidzo izvi zvinorwadza, zvisinei, chii chinoitika apo marwadzo anoenderera kwenguva refu mushure mokunge mhaka yacho yapera? Kurwara kwenguva refu rinorondedzerwa sehutano hunoramba huripo hunoita 3 kumwedzi 6 kana kupfuura. Kurwara kwepanguva inenge iri mamiriro ezvinhu akaoma kuti ugare naye, zvichikanganisa zvose kubva pamabasa emunhu wega uye kukwanisa kwavo kushanda pamwe chete nehukama hwavo hwepamwe uye nemafungiro epfungwa. Asi, iwe unoziva here kuti kurwadziwa kusingaperi kunogona kuchinjawo maitiro uye basa rehupi hwako? Icho chinopera kuti uropi hunochinja hunoita kuti tive nemafungiro ekufungisisa uye mupfungwa.

 

Kuora mwoyo kwenguva refu hakungogadziri nzvimbo imwe chete yepfungwa, sechinhu chaicho, inogona kuguma nekuchinja kune nzvimbo dzakawanda dzinokosha dzeuropi, dzakawanda dzayo dzinobatanidzwa mune zvakawanda zvinoitwa nekuita uye mabasa. Kutsvakurudza kwakasiyana-siyana kwemakore kwakatsvaga kuchinja kune hippocampus, pamwe nekuderedza grey nenyaya kubva ku dorsolateral prefrontal cortex, amygdala, brainstem uye nechokunyoresa cortex, kutumidza vashomanana, vanobatana nekurwadziwa kusingaperi. Kuparara kwezvikamu zvishomanana zvezvivako zvezvikamu izvi uye mabasa avo akafanana zvinogona kubatsira kuisa uropi huno kuchinja mumamiriro ezvinhu, nokuda kwevanhu vakawanda vane kurwadziwa kusingaperi. Chinangwa chehurukuro inotevera ndechekuratidzira pamwe nekukurukura maitiro ehutano uye hunoita hunochinja hunoenderana nekurwadziwa kusingaperi, kunyanya pane izvo izvo zvinoratidza kuti hazvikuvadzi kana kuti atrophy.

 

Chimiro cheBurin Kuchinja Mukurwara Kusingaperi Kuratidza Zvichida Hapana Kukuvara Kana Atrophy

 

ngovepo

 

Kurwadziwa kusingaperi kunoratidzika kunge kunosanganisirwa nehuropi grey nyaya yekudzikisira munzvimbo dzinofungidzirwa kutapurirana kwekutambudzika. Ma morphological maitiro anokonzeresa shanduko idzi, pamwe zvichitevera kugadziriswazve kushanda uye kwepakati pepurasitiki muuropi, zvinoramba zvisina kujeka. Marwadzo muhudyu osteoarthritis ndeimwe yeaya mashoma maronda ekurwadziwa asingarapike ayo anonyanya kurapwa. Isu takaongorora varwere makumi maviri vane kurwadziwa kusingaperi nekuda kweiyo unilateral coxarthrosis (zvinoreva makore 20 63.25 (SD) makore, gumi mukadzi) pamberi pechiuno kubatana opoprosthetic kuvhiyiwa (kurwadziwa nyika) uye kuongororwa kwehuropi shanduko shanduko kusvika pagore rimwe mushure mekuvhiyiwa: mavhiki matanhatu ne9.46. , 10 1 mavhiki uye 6 8 mwedzi painorwadza zvachose. Varwere vane marwadzo asingagumi nekuda kweiyo unilateral coxarthrosis vaive neakaonda grey zvakanyanya kana ichienzaniswa neanodzora mune anterior cingate cortex (ACC), insular cortex uye operculum, dorsolateral prefrontal cortex (DLPFC) uye orbitofrontal cortex. Aya matunhu anoshanda seakawanda-anobatanidza masisitimu panguva yechiitiko uye kutarisira kurwadziwa. Varwere pavakarwadziwa vakasununguka mushure mekupora kubva mukuvhiya kwekupedzisira, grey nyaya inowedzera munzvimbo dzinenge dzakawanikwa. Isu takawanawo kuwedzera kunofambira mberi kwehuropi grey zvinhu mu premotor cortex uye yekuwedzera mota nzvimbo (SMA). Isu tinopedzisa kuti grey zvinhu zvisina kujairika mukurwadziwa kusingaperi handicho chinokonzeresa, asi chechipiri kuchirwere uye zvirinani muchikamu nekuda kwekushandurwa kwemotokari mashandiro uye kusangana kwemuviri.

 

ziviso

 

Uchapupu hwekushanda nekugadzirisa kurongeka kwevarwere vasingaperi vanorwadziwa vanotsigira pfungwa yekuti kurwadziwa kusingaperi hakufanirwe kungofungidzirwa sekushandurwa kwenyika inoshanda, asi zvakare semhedzisiro yekushanda uye kuumbwa kwehuropi hwepurasitiki [1], [2], [3], [4], [5], [6]. Mumakore matanhatu apfuura, zvidzidzo zvinopfuura makumi maviri zvakaburitswa zvichiratidza shanduko yehuropi mu20 syndromes echirwere chisingaperi. Chinhu chinokatyamadza pane zvese izvi zvidzidzo inyaya yekuti grey nyaya shanduko haina kugoverwa zvisina kurongeka, asi inoitika mune yakatsanangurwa uye inoshanda zvakanyanya nzvimbo dzehuropi - kureva, kubatanidzwa mune supraspinal nociceptive kugadzira. Izvo zvakanyanya kuzivikanwa zvakawanikwa zvaive zvakasiyana kune yega marwadzo chirwere, asi zvakaputirwa mune cingate cortex, iyo orbitofrontal cortex, iyo insula uye dorsal pons [14]. Zvimwe zvivakwa zvine thalamus, dorsolateral prefrontal cortex, basal ganglia uye hippocampal nzvimbo. Izvi zvakawanikwa zvinowanzokurukurwa senge cellul atrophy, inosimbisa iyo pfungwa yekukuvara kana kurasikirwa kwehuropi grey nyaya [4], [7], [8]. Muchokwadi, vaongorori vakawana kuwirirana pakati peuropi grey nyaya inoderera uye nguva yekurwadziwa [9], [6]. Asi iyo nguva yekurwadziwa inosanganisirwa nezera remurwere, uye zera rinotenderera pasirese, asi zvakare kudunhu kwakatarisana kuderera kweye grey kwakanyatsoratidzwa [10]. Kune rimwe divi, idzi shanduko dzemamiriro ezvinhu dzinogona zvakare kuve kuderera kwemasero maseru, zvinwiwa zvemukati memvura, synaptogenesis, angiogenesis kana kunyangwe nekuda kwekuchinja kweropa [11], [4], [12]. Chero zvingave zvichibva, kududziro yedu yezviwanikwa zvakakosha kuti uone izvi morphometric zviwanikwa muchiedza cheupfumi hwezvidzidzo zve morphometric mukuita muviri kunoenderana nepurasitiki, zvichipiwa kuti nharaunda dzakasarudzika huropi shanduko dzakaratidzirwa kakawanda zvichitevera kugona kwekuziva uye kwemuviri [ 13].

 

Hazvina kunzwisiswa kuti nei chikamu chidiki chete chevanhu vachikura chirwere chisingaperi chekurwadziwa, tichifunga kuti kurwadziwa chiitiko chepasi rose. Mubvunzo unomuka kana mune vamwe vanhu musiyano wehurongwa pakati pehurombo hwekuparadzira masisitimu anogona kuita se diathesis yekurwadziwa kusingaperi. Grey nyaya inoshanduka mukurwadziwa kwepantom nekuda kwekutemwa [15] uye kukuvara kwemuzongoza [3] zvinoratidza kuti morphological shanduko yehuropi, zvirinani muchikamu, mhedzisiro yekurwadziwa kusingaperi. Zvisinei, kurwadziwa muhudyu osteoarthritis (OA) ndechimwe chevashoma chisingaperi kurwadziwa chirwere icho chinonyanya kurapwa, sezvo 88% yevarwere ava vanogara vasina marwadzo zvichitevera kuvhiyiwa kwechiuno kwese (THR) [16]. Mune chidzidzo chekutyaira isu takaongorora varwere gumi vane hudyu OA vasati uye munguva pfupi mushure mekuvhiyiwa. Isu takawana kuderera kweye grey nyaya mune anterior cingulated cortex (ACC) uye insula panguva yekurwadziwa kusingaperi pamberi pekuvhiyiwa kweTHR uye takawana kuwedzera kwenyaya yegrey munzvimbo dzinoenderana dzehuropi mumamiriro ekurwadziwa akasununguka mushure mekuvhiyiwa [17]. Tichitarisa pane uyu mhedzisiro, isu ikozvino takawedzera zvidzidzo zvedu tichiongorora vamwe varwere (n? =? 20) mushure mekubudirira THR uye kuongororwa kwehurongwa hwehuropi shanduko mukati menguva ina dzenguva, kusvika pagore rimwe zvichitevera kuvhiyiwa. Kudzora kweyegrey nyaya shanduko nekuda kwekuvandudza mota kana kushushikana isu zvakare takapa mibvunzo yemibvunzo inotarisana nekuvandudzwa kwemota basa uye hutano hwepfungwa.

 

Zvinhu uye Nzira

 

Vazvipiri

 

Varwere vanotaurwa pano iboka revarwere makumi maviri kubva pavarwere makumi matatu nevaviri vakaburitswa nguva pfupi yadarika avo vakafananidzwa nezera- nevakadzi-vakaenzana vane hutano hweboka [20] asi vakapinda mune rimwe gore rekutevera ongororo. Mushure mekuvhiyiwa 32 varwere vakasiya nekuda kwechipiri opoprosthetic kuvhiyiwa (n? =? 17), chirwere chakakomba (n? =? 12) uye kubviswa kwemvumo (n? =? 2). Izvi zvakasiya boka revarwere makumi maviri vane unilateral primary hip OA (zvinoreva makore 2 8 (SD) makore, gumi mukadzi) vakaferefetwa kane: vasati vavhiyiwa (kurwadziwa nyika) uyezve 63.25 9.46 uye 10-6 masvondo uye 8 12 mwedzi mushure mekuvhiyiwa kwekupedzisira, apo painorwadza zvachose. Vese varwere vane hudyu hwepakutanga OA vaive nenhoroondo yekurwadziwa kwenguva yakareba kupfuura mwedzi gumi nemaviri, kubva pa18 kusvika pamakore makumi matatu nematatu (zvinoreva makore 10) uye zvinorehwa zvinorwadza zve14 (kubva pa12 kusvika 1) pane inoonekwa analogue scale (VAS) kubva 33 (hapana kurwadziwa) kusvika zana (kurwadziwa kwakanyanya kufungidzira) Isu takaongorora chero zviitiko zvezviitiko zvidiki zvekurwadziwa, kusanganisira mazino-, nzeve- uye nemusoro kusvika kumavhiki e7.35 pasati chidzidzo. Isu takasarudzira zvakasarudzika dhata kubva kumakumi maviri ezvepabonde- uye zera rakaenzana kutonga zvine hutano (zvinoreva makore 65.5 40 (SD) makore, gumi mukadzi) wemakumi matatu nemaviri ezvidzidzo zvataurwa pamusoro apa [90]. Hapana mumwe wevarwere makumi maviri kana vevane makumi maviri ezvepabonde- uye zera rakaenzana nevanozvipira vane hutano vaine chero nhoroondo yehutano kana yemukati nhoroondo yekurapa. Chidzidzo chakapihwa mvumo yetsika nekomiti yemunharaunda yeEthics uye mvumo yakanyorwa ine ruzivo yakawanikwa kubva kune vese vatori vechikamu kudzidza usati waongororwa.

 

Dhiyabhorosi Data

 

Isu takaunganidza dhata pamusoro pekushungurudzika, kushushikana, kushushikana, kurwadziwa uye hutano hwepanyama uye hwepfungwa kune vese varwere uye ese mana nguva mapoinzi vachishandisa anotevera akaenzana emibvunzo: Beck Depression Inventory (BDI) [18], Pfupi Chiratidzo Inventory (BSI) [19], Schmerzempfindungs-Skala (SES? =? Kurwadziwa kusingafadzi chiyero) [20] uye Hutano Ongororo 36-Item Pfupi Fomu (SF-36) [21] uye Nottingham Hutano Mbiri (NHP). Takaita matanho anodzokororwa ANOVA uye takabatana maviri-miswe-t-Miedzo yekuongorora iyo yakareba nzira yekuita data tichishandisa SPSS 13.0 yeWindows (SPSS Inc., Chicago, IL), uye tikashandisa Greenhouse Geisser kururamisa kana fungidziro yechitema ikatyorwa. Iyo yakakosha nhanho yakaiswa pa p <0.05.

 

VBM - Data Acquisition

 

Image acquisition. Yakakwira-resolution MR scanning yakaitwa pane 3T MRI system (Siemens Trio) ine yakajairwa 12-chiteshi musoro coil. Kune yega yega yenguva ina mapoinzi, tarisa ini (pakati pe1 zuva nemwedzi mitatu pamberi pekuvhiya kwekupedzisira), scan II (mavhiki matanhatu kusvika masere mushure mekuvhiyiwa), tarisa III (vhiki gumi nemasere kusvika gumi nemasere mushure mekuvhiyiwa) uye tarisa IV (3-6 mwedzi mushure mekuvhiyiwa), T8 yakaremerwa yakarongeka MRI yakawanikwa kune mumwe murwere achishandisa 12D-FLASH kuteedzana (TR 18 ms, TE 10 ms, flip angle 14 , 1 mm zvimedu, FOV 3 15, voxel size 4.9 25 1 mm).

 

Image Processing uye Statistical Analysis

 

Data pre-processing uye kuongororwa kwakaitwa neSPM2 (Wellcome Dhipatimendi reCognitive Neurology, London, UK) inoshanda pasi peMatlab (Mathworks, Sherborn, MA, USA) uye ine voxel-based morphometry (VBM)-toolbox ye data longitudinal, iyo yakavakirwa pakugadziriswa kwepamusoro 3D MR mifananidzo uye inobvumira kushandisa voxel-huchenjeri manhamba kuona misiyano yedunhu mugrey nyaya density kana mavhoriyamu [22], [23]. Muchidimbu, pre-processing yaisanganisira spatial normalization, grey matter segmentation uye 10 mm spatial smoothing neGaussian kernel. Pamatanho ekutanga-kugadzirisa, takashandisa optimized protocol [22], [23] uye scanner- uye kudzidza-chaiyo grey nyaya template [17]. Isu takashandisa SPM2 pane SPM5 kana SPM8 kuita kuti ongororo iyi ifanane neyedu yekudzidza [17]. sezvo ichibvumira yakanakisa normalization uye segmentation yelongitudinal data. Nekudaro, sekuvandudzwa kwazvino kweVBM (VBM8) kwave kuwanikwa nguva pfupi yadarika (dbm.neuro.uni-jena.de/vbm/), takashandisawo VBM8.

 

Cross-Sectional Analysis

 

Isu takashandisa maviri-sampuro t-bvunzo kuitira kuti tione musiyano wedunhu muuropi grey nyaya pakati pemapoka (varwere panguva yekutora scan ini (kurwadziwa kusingaperi) uye hutano hwakanaka). Isu takaisa chikumbaridzo che p <0.001 (isina kukamurwa) kuyambuka huropi hwese nekuda kwesimba redu rekufungidzira, iro rakavakirwa pazvidzidzo zve9 zvakazvimirira uye macohort anoratidza kuderera kweyegrey nenyaya yevarwere vasingarware [7], [8], [ 9], [15], [24], [25], [26], [27], [28], kuti grey nyaya inowedzera ichaonekwa munzvimbo imwechete (yekugadzirisa kurwadziwa kwakakodzera) kumatunhu sekudzidza kwedu kwendege (17 ). Iwo mapoka akafananidzwa nezera uye bonde pasina mutsauko wakakura pakati pemapoka. Kuti tiongorore kana mutsauko uripo pakati pemapoka wakachinja mushure megore rimwe, isu takafananidza varwere panguva yekutora IV (kurwadziwa pasina, gore rimwe kuteedzerana) kuboka redu rekutonga rine hutano.

 

Longitudinal Analysis

 

Kuona misiyano pakati penguva nguva (Scan I IV) takafananidza zviyero tisati tavhiyiwa (mamiriro ekurwadziwa) uyezve mavhiki matanhatu ne6 ne8 uye gumi nemwedzi mushure mekuvhiyiwa kwekupedzisira (kurwadziwa pasina) sekudzokororwa chiyero ANOVA. Nekuti chero huropi hunoshanduka nekuda kwekurwadziwa kusingaperi kungangoda imwe nguva kudzora kuteedzera nekumiswa kwemarwadzo uye nekuda kwekurwadziwa kwekuvhiya kwepashure kunorondedzerwa nevarwere, isu takafananidza mune yekureba kuongorora scan I uye II ne scan III uye IV. Zvekuona shanduko dzisina kubatana zvakanyanya nekurwadziwa, isu takatarisirawo shanduko inofambira mberi pamusoro penguva dzese dzenguva. Isu takabvarura huropi hwevarwere vane OA yechiuno chekuruboshwe (n? =? 12) kuitira kuti vagadzikane nerutivi rwekurwadziwa kune ese ari maviri, iro boka rekuenzanisa uye nehurefu hwekuongorora, asi zvakanyanya kuongorora iyo isina kuvhurwa dhata. Isu takashandisa iyo BDI mamaki secovariate mune modhi.

 

Results

 

Dhiyabhorosi Data

 

Vese varwere vakarondedzera kurwadziwa kwechiuno kusati kwaitwa oparesheni uye vaisarwadziwa (maringe nekurwadziwa kusingaperi) nekukurumidza mushure mekuvhiyiwa, asi vakarondedzera kurwadziwa kwakanyanya mushure mekuvhiyiwa pa scan II yaive yakasiyana nemarwadzo nekuda kweosteoarthritis. Hutano hwepfungwa mamaki eSF-36 (F (1.925 / 17.322)? =? 0.352, p? =? 0.7) uye iyo BSI yepasi rose mamakisi GSI (F (1.706 / 27.302)? =? 3.189, p? =? 0.064 ) haina kuratidza shanduko pane iyo kosi yenguva uye hapana kusagadzikana kwepfungwa. Hapana chimwe chezviremera chakataura chero kurwadziwa kwakanyanya kana kusingaperi uye hapana chakaratidza chero zviratidzo zvekuora mwoyo kana kuremara kwepanyama / kwepfungwa.

 

Asati avhiyiwa, vamwe varwere vakaratidza zvinyoro nyoro kusvika pakuenzanisa zviratidzo zvekushushikana muBDI zvikoro zvakadzikira zvakanyanya pakuongorora III (t (17)? =? 2.317, p? =? 0.033) uye IV (t (16)? =? 2.132, p? =? 0.049). Uyezve, iyo SES zvikoro (kurwadziwa kusingafadzi) kwevarwere vese zvakagadziriswa zvakanyanya kubva pakuongorora I (pamberi pekuvhiya) kuongorora II (t (16)? =? 4.676, p <0.001), scan III (t (14)? =? 4.760, p <0.001) uye scan IV (t (14)? =? 4.981, p <0.001, 1 gore mushure mekuvhiyiwa) sekurwadziwa kusagadzikana kwakaderera nekurwadziwa kwakanyanya. Iyo yekurwadziwa chiyero pane scan 1 uye 2 yaive yakanaka, chiyero chakafanana pazuva re3 ne4 risina kunaka. Iyo SES inongotsanangudza mhando yemarwadzo anoonekwa. Saka zvaive zvakanaka pazuva 1 ne2 (kureva 19.6 pazuva 1 uye 13.5 pazuva 2) uye zvisina kunaka (na) pazuva 3 & 4. Zvisinei, vamwe varwere havana kunzwisisa maitiro aya uye vakashandisa iyo SES seyero yepasi rose. yehupenyu chiyero. Ichi ndicho chikonzero vese varwere vakabvunzwa pazuva rimwe chete mumwe nemumwe uye nemunhu mumwechete nezve marwadzo anoitika.

 

Muchidimbu fomu ongororo yehutano (SF-36), iyo ine zviyero zvepfupiso zvePhysical Health Score uye Mental Health Score [29], varwere vakavandudza zvakanyanya muchikamu chePhysical Health kubva pakuongorora ini kuongorora II (t ( 17)? =? 4.266, p? =? 0.001), scan III (t (16)? asi kwete muMental Health Score. Mhedzisiro yeNHP yaive yakafanana, mune subscale pain (reversed polarity) takaona shanduko yakakura kubva pakuongorora I to scan II (t (8.584)? = ?? 0.001, p <12, scan III (t (7.148) = ?? 0.001, p <14 uye scan IV (t (5.674)? (t (0.001)? = ?? 12, p? =? 7.040) uye scan IV (t (0.001)? = ?? 10, p? =? 3.258) .Pakave pasina shanduko yakakosha pakati pe scan I uye scan II ( vhiki nhanhatu mushure mekuvhiyiwa).

 

Structural Data

 

Cross-sectional analysis. Isu takasanganisira zera secovariate mune yakajairika modhi modhi uye hatina kuwana zera rinovhiringidzika. Kuenzaniswa nebonde uye zera rakaenzana kutonga, varwere vane hudyu yekutanga OA (n? =? 20) vakaratidzira pre-operatively (Scan I) yakadzora grey nyaya mune anterior cingate cortex (ACC), iyo insular cortex, operculum, dorsolateral prefrontal cortex ( DLPFC), kurudyi kwenguva tempile uye cerebellum (Tafura 1 uye Mufananidzo 1). Kunze kwekurudyi putamen (x? =? 31, y? = ?? 14, z? = ?? 1; p <0.001, t? =? 3.32) hapana kuwedzera kwakakura kweiyo grey nyaya kuwanda kwakawanikwa kune varwere vane OA vachienzaniswa kudzora zvine hutano. Kuenzanisa varwere panguva yekumisikidza scan IV pamwe neyakaenzana kutonga, mhedzisiro yakafanana yakawanikwa senge muchikamu chemuchinjikwa-chikamu uchishandisa scan ini ndichienzanisa neanodzora.

 

Mufananidzo 1 Statistical Parametric Maps

Mifananidzo 1: Mepu dzematsetseti ematanho anoratidza maitiro akasiyana-siyana mumatambudziko ane chirwere chisingagumi nekuda kwekutanga kwechiuno OA kana ichienzaniswa nekutonga uye kwenguva yakareba kufananidzwa navo pachavo. Yakakosha grey nyaya shanduko inoratidzwa yakakwidziridzwa muvara, muchinjikwa-chikamu chikamu data inoratidzwa mune tsvuku uye kureba dhata mune yero. Ndege yeAxial: iyo yekuruboshwe yemufananidzo ndeye kuruboshwe rwehuropi. kumusoro: Nzvimbo dzekuderera kwakakosha kwegrey nyaya pakati pevarwere vane kurwadziwa kusingaperi nekuda kwekutanga hudyu OA uye zvisina kukanganiswa kudzora zvidzidzo. p <0.001 pazasi isina kugadziriswa: Grey nyaya inowedzera mumarwadzo makumi maviri evarwere vakasununguka panguva yechitatu neyechina yekutora nguva mushure mekuvhiya kwese kwechiuno, zvichienzaniswa neyekutanga (preoperative) uye wechipiri (mavhiki masere kusvika masere mushure mekuvhiyiwa) scan. p <20 Zvirongwa zvisina kurongeka: Makosi ekufungidzira uye 6% Nguva yekuvimba, mhedzisiro yekufarira, zvikamu zvekupokana. x-axis: kusiyanisa kwenguva ina, y-axis: fungidziro yekufungidzira pa? 8, 0.001, 90 yeACC uye fungidziro yekufungidzira pa4, 3, 50 ye insula.

 

Tafura 1 Cross-Sectional Data

 

Kubhedhenura data revarwere vane hudyu kuruboshwe OA (n? =? 7) uye kuvaenzanisa nehutano hwakanaka hakuna kushandura mhedzisiro zvakanyanya, asi pakuderera kwetalamus (x? =? 10, y? = ?? 20, z? =? 3, p <0.001, t? =? 3.44) uye kuwedzera kwecerebellum yekurudyi (x? =? 25, y? = ?? 37, z? = ?? 50, p <0.001, t? =? 5.12) iyo isina kusvika pakukosha mune isina kuvhurwa dhata yevarwere kana ichienzaniswa nemaitiro.

 

Longitudinal analysis. Mukuongorora kwenguva refu, kuwedzera kukuru (p <.001 isina kugadziriswa) yegrey nyaya kwakaonekwa nekufananidza yekutanga neyechipiri scan (kurwadziwa kusingaperi / kurwadziwa kwepashure kwekuvhiyiwa) neyechitatu neyechina scan (isina marwadzo) muACC, insular cortex, cerebellum uye pars orbitalis mune varwere vane OA (Tafura 2 uye Mufananidzo 1). Grey nyaya yakadzikira nekufamba kwenguva (p <.001 yakazara uropi kuongororwa isina kugadziridzwa) mune yechipiri somatosensory cortex, hippocampus, midcingate cortex, thalamus uye caudate nucleus mune varwere vane OA (Mufananidzo 2).

 

Mufananidzo 2 Inowedzera muBurin Grey Matter

Mufananidzo 2: a) Kuwedzera kwakakosha muuropi grey nyaya zvichitevera kushanda kwakabudirira. Axial maonero ekuderera kukuru kweiyo grey nyaya kune varwere vane kurwadziwa kusingaperi nekuda kwekutanga hudyu OA uchienzaniswa nekutonga zvidzidzo. p <0.001 isina kugadziriswa (kuyambuka-chikamu chikamu kuongorora), b) Kureba kwekuwedzera kwegrey nyaya nekufamba kwenguva muyero uchienzanisa scan I & IIscan III> scan IV) mune varwere vane OA. p <0.001 isina kugadziriswa (ongororo yehurefu). Rutivi rworuboshwe rwemufananidzo irworuboshwe rweuropi.

 

Tafura 2 Longitudinal Data

 

Kufambisa iyo data yevarwere vane kuruboshwe chiuno OA (n? =? 7) haina kuchinja mhedzisiro zvakanyanya, asi pakuderera kwehuropi grey nyaya muHeschl s Gyrus (x? = ?? 41, y? = ?? 21, z? =? 10, p <0.001, t? =? 3.69) uye Precuneus (x? =? 15, y? = ?? 36, z? =? 3, p <0.001, t? =? 4.60) .

 

Nekusiyanisa iyo yekutanga scan (presurgery) nematanho 3 + 4 (postsurgery), takawana kuwedzera kwegrey nyaya kumberi kwekortex uye mota cortex (p <0.001 isina kugadziriswa). Isu tinocherekedza kuti uyu musiyano hauna kuomesesa sezvo isu tine zvino zvishoma zviyero pamamiriro (marwadzo vs. asiri ekurwadziwa). Kana tikadzikisa chikumbaridzo tinodzokorora izvo zvatakawana tichishandisa kusiyana kwe1 + 2 vs. 3 + 4.

 

Nekutsvaga nzvimbo dzinowedzera pamusoro penguva dzese dzenguva, takawana kuchinja kwehuropi grey nyaya munzvimbo dzemotokari (nzvimbo 6) kune varwere vane coxarthrosis inotevera kuchinjwa kwehudyu yose (scan I.dbm.neuro.uni-jena.de/vbm/) tinogona kudzokorora kuwanikwa uku mune anterior uye pakati-cingulate cortex uye zvose anterior insulae.

 

Isu takaverenga kukura kwemhedzisiro uye kuyambuka-chikamu chikamu (varwere vs. kudzora) kwakapa Cohen sd ye1.78751 mune yepamusoro voxel yeACC (x? = ?? 12, y? =? 25, z? = ?? 16). Isu takaverengawo Cohen sd yekutarisa kwenguva refu (kusiyanisa scan 1 + 2 vs. scan 3 + 4). Izvi zvakaguma neCohen sd ye1.1158 muACC (x? = ?? 3, y? =? 50, z? =? 2). Nezve iyo insula (x? =? 33, y? =? 21, z? =? 13) uye inoenderana nemusiyano mumwe chete, Cohen sd ndeye 1.0949. Pamusoro pezvo, takaverenga zvinorehwa neasina zero zero voxel kukosha kweiyo Cohen sd mepu mukati meiyo ROI (ine chikamu chepamberi checingate gyrus uye subcallosal cortex, yakatorwa muHarvard-Oxford Cortical Structural Atlas): 1.251223.

 

Dr-Jimenez_White-Coat_01.png

Dr. Alex Jimenez's Insight

Varwere vanopererwa varwere vanogona kuona hupenyu hwehutano hwakasiyana-siyana kwenguva, kunze kwezviratidzo zvavo zvave zvichinyanyisa. Semuenzaniso, vanhu vakawanda vachawana zvinetso zvekurara nekuda kwekutambudzika kwavo, asi chinonyanya kukosha, kurwadziwa kusingaperi kunogona kutungamirira kune zvakasiyana-siyana nyaya dzehutano hwepfungwa pamwe chete, kusanganisira kushushikana uye kuora mwoyo. Migumisiro iyo inorwadza inogona kuva nayo pauropi inogona kuoneka yakanyanya kukura asi uchapupu hunokura hunoratidza kuti uropi hunochinja huri husingaperi uye hunogona kushandurwa apo varwere vasingaperi varwere vanowana kurapa kwakakodzera kwehupenyu hwehutano hwavo. Maererano nenyaya yacho, gorosi dambudziko risingakanganwiki rinowanikwa mukurwadziwa kusingaperi hakuratidzi kukanganisa kwehuropi, asi pane, iyo inogadziriswa inogadzirisa iyo inowanzoita apo marwadzo anogadziriswa zvakakwana. Nenzira yakanaka, nzira dzakasiyana-siyana dzekurapa dziripo kuti dzibatsire kusunungura zvirwere zvisingaperi zvezvirwere uye kudzorera chimiro uye basa reropi.

 

hurukuro

 

Kuongorora mamiriro ese ehuropi nekufamba kwenguva, tinosimbisa uye nekuwedzera yedu data yemutyairi yakaburitswa munguva pfupi yadarika [17] Isu takawana shanduko muhuropi grey nyaya mune varwere vane epakutanga hip osteoarthritis mune isingagumi marwadzo mamiriro, ayo anodzosera chikamu kana ava varwere vasingarwadziwe vakasununguka, zvichitevera chiuno chakabatana endoprosthetic kuvhiya. Iko kuwedzera kwakasarudzika kwegrey nyaya mushure mekuvhiyiwa kunenge kuri munzvimbo imwechete uko kuderera kwechena nyaya kwakaonekwa pamberi pekuvhiyiwa. Kubaya data revarwere vane hudyu yekuruboshwe OA (uye nekudaro kuomesa divi remarwadzo) kwaingova nemhedzisiro diki pamhedzisiro asi nekuwedzera kwakaratidza kuderera kweyegrey muHeschl s gyrus uye Precuneus yatisingakwanise kutsanangura uye, sezvo pasina a priori fungidziro iripo, tarisa nokungwarira kukuru. Nekudaro, mutsauko unoonekwa pakati pevarwere uye nehutano kudzora pakuongorora ini ndanga ndichiri kucherechedzwa muchinjika-chikamu chikamu kuongorora pa scan IV. Kuwedzera kwehukama hwegrey pamusoro penguva saka kune hunyengeri, kureva kuti hazvina kukwana zvakakwana kuva nemhedzisiro pakuongorora kwechikamu chemuchinjikwa, kutsvaga kwakatoratidzwa muzvidzidzo zvichiongorora chiitiko chinoenderana nepurasitiki [30], [31]. Tinocherekedza kuti chokwadi chekuti isu tinoratidza zvimwe zvikamu zvehuropi-shanduko nekuda kwekurwadziwa kusingaperi kudzoserwa hazvireve kuti zvimwe zvikamu zveiyi shanduko hazvigadzirisike.

 

Zvinofadza kuti takaona kuti gorosi inowedzera muAAC mune varwere vasingaperi vasati vasangana nekuvhiyiwa inoita seinoenderera mberi kwemavhiki e6 mushure mekuvhiyiwa (scan II) uye inongowedzera kuongororwa III ne IV, zvichida nekuda kwekurwadziwa kwepashure, kana kuderera mumotokari basa. Izvi zvinowirirana nehutano hwehutano hwepanyama yekufamba kwepanyama yakabatanidzwa muNHP, iyo inotevera musingarati yakaratidza kushanduka kwakakosha panguva yakasarudzwa II asi yakanyanya kuwedzera kuenzana III uye IV. Nhoroondo, varwere vedu vanoti hapana marwadzo muhudyu mushure mekuvhiyiwa, asi akazovhiyiwa mushure mekuvhiyiwa marwadzo mumisungo yakakomba uye ganda iro rakaonekwa zvakasiyana zvikuru nevarwere. Zvisinei, sezvo varwere vachiri kurondedzera marwadzo ekutsvaga II, isu takafananidzawo yekutanga scan (pre-surgery) nekarwere III + IV (mushure mekuvhiyiwa), kuratidza kuwedzera kwemukati mutsvuku mumakona epamberi uye motori cortex. Tinocherechedza kuti kuenzanisa uku hakusi nyore pane zvishoma zvishoma pamamiriro ezvinhu (kurwadziwa kana kusina kurwadziwa). Apo patinoderedza chikumbaridzo tinodzokorora zvatakawana tichishandisa kusiyana kweI + II vs. III + IV.

 

Nhoroondo yedu inonyatsoratidza kuti grey nyaya shanduko muvarwere vasingaperi vanorwadziwa, ayo anowanzo kuwanikwa munzvimbo dzinobatanidzwa mukugadzira kwepasipasipo nociceptive [4] hazvikonzerwe neuronal atrophy kana kukuvara kwehuropi. Icho chokwadi chekuti shanduko dzinoonekwa mune chisingaperi chinorwadza mamiriro hachidzokere zvachose chinogona kutsanangurwa neiyo pfupi pfupi nguva yekucherechedza (gore rimwe mushure mekushanda maringe nerevo yemakore manomwe ekurwadziwa kusingaperi pamberi pekuvhiya). Neuroplastic huropi shanduko dzinogona kunge dzakasimudzira pamusoro pemakore akati wandei (semhedzisiro yekugara uchiratidzira kweinociceptive) inoda ingangove imwe nguva yekudzosera zvachose. Imwe nzira ingangoita kuti kuwedzerwa kwegrey nyaya kungoonekwa chete murefu urefu data asi kwete muchinjikwa-chikamu data (kureva pakati pemapoka panguva ye IV) ndeyekuti huwandu hwevarwere (n? =? 20) ishoma kwazvo. Izvo zvinofanirwa kuratidzwa kuti mutsauko uripo pakati pehuropi hwevanhu vakati wandei hwakakura uye kuti data rehurefu rine mukana wekuti mutsauko wacho uri mudiki sezvo iwo uropi hwakavhenekwa kanoverengeka. Nekudaro, shanduko dzisinganzwisisike dzinongowanikwa chete murefu kwenguva data [30], [31], [32]. Ehezve isu hatigone kusarudzira kuti shanduko idzi dzinenge pamwe dzinenge dzisingachinjiki kunyangwe izvo zvisingaite, zvichipiwa zvakawanikwa zvekurovedza muviri zvakasarudzika mapurasitiki nekugadzirisazve [4], [12], [30], [33], [34]. Kuti upindure uyu mubvunzo, zvidzidzo zvenguva yemberi zvinofanirwa kuongorora varwere kakawanda pamusoro pemafuremu akareba, pamwe makore.

 

Tinocherechedza kuti tinogona kungogumisa zvishoma pamusoro pemaitiro ehutano hwemarphological kuchinja munguva. Chikonzero ndechokuti patakagadzira chidzidzo ichi mu2007 uye chakaonekwa mu2008 uye 2009, chakanga chisingazivikanwe kana kuchinja kwemuitiro kwaizoitika zvachose uye nokuda kwechikonzero chekuita kwatakasarudza mazuva ekuongorora uye nguva dzakasarudzwa sezvinotsanangurwa pano. Mumwe anogona kutaura kuti gorozi inoshanduka munguva, izvo zvatinotsanangura zveboka revarwere, zvingadaro zvakaitika muboka rekutonga pamwe (nguva yekuita). Zvisinei, kuchinja chero kupi zvako kunokonzerwa nekukwegura, kana zvachose, kwaizotarisirwa kuva kuderera kwezwi. Kupiwa yedu priori pfungwa, pana 9 akazvimirira zveBhaibheri nevarwi kuratidza kunodzikira mune wachena nyaya marwadzo varwere [7], [8], [9], [15], [24], [25], [26], [27], [28], takatarira kuwedzera kwenharaunda kwenguva uye saka tinotenda kuti isu tinoona kuti haisi nguva yakaoma. Nhoroondo, hatigoni kutonga kuti gorosi inoderera kudarika nguva yatakawana muboka revarwere rinogona kuitika nekuda kwenguva, sezvo tisina kuongorora boka redu rekutonga panguva imwechete. Zvichigovera zvitsva, zvidzidzo zvemangwana zvinofanira kuronga nguva uye nguva shomanana, zvichizopiwa kuti maitiro anoenderana ne morphometric uropi hunoitika hunogona kuitika nokukurumidza sekunge 1 yevhiki [32], [33].

 

Mukuwedzera kune zvinokonzerwa nehupiceptive hutano hwehupfungwa hwehupfungwa hupfungwa huripo [17], [34] takaona kuti kuchinja mumotokari basa kunogonawo kuwedzera kuchinjwa chemugadziro. Takawana motokari uye nzvimbo dzinotangira nzvimbo (nzvimbo 6) kuti dziwedzere kudarika nguva dzese dzenguva (Mufananidzo 3). Intuitively izvi zvinogona kunge zvakakonzerwa nekuvandudzwa kwemotokari inoshandiswa kwenguva yakareba sezvo varwere vakanga vasingacharegi kurarama hupenyu hwehupenyu. Zvakanakira isu hatina kutarisa pamotokari basa asi kuvandudzwa mumarwadzo ekurwadziwa, kupa chido chedu chepakutanga chekuongorora kana kuderedzwa kunonyatsozivikanwa muhutano hwepfungwa muhutano husingaperi huripo huri kuchinja zvakare. Nekudaro, isu hatina kushandisa zvigadzirwa zvakananga kuti tiongorore motokari basa. Kunyange zvakadaro, (zvinoshandiswa) motokari cortex reorganization muvarwere vane marwadzo syndromes akanyatsoratidzwa [35], [36], [37], [38]. Uyezve, injini cortex ndeimwe chipfuro mune kuchirapa nzira mu pakurapa intractable marwadzo varwere vachishandisa zvakananga pfungwa dzishande [39], [40], transcranial zvakananga dzishande ano [41], uye yokudzokorora. transcranial rinobva dzishande [42], [43]. Nzira chaiyo dzekufananidza kwakadaro (kufambidzana kana kupindira, kana kungopindira muhutano hwakabatana) hazvina kujekeswa [40]. Ongororo yapfupi yakaratidza kuti chimwe chiitiko chemotokari chinogona kugadzirisa chimiro cheuropi [13]. Synaptogenesis, kugadziriswa kwemafambiro ekufambisa uye angiogenesis mumoto cortex inogona kuitika nezvikumbiro zvakakosha zvebasa remotokari. Tsao et al. akaratidzazve kugadziriswa mumoto cortex yevarwere vane chirwere chisingaperi chisingarware shure chinoratidzika sechinorwadza-chinonzi [44] uye Puri et al. akacherechedza kuderedzwa kwevasiyamu supplemental motokari grey nhau mumagetsi e fibromyalgia [45]. Chidzidzo chedu chakanga chisina kugadziriswa kuti tisazvinyengedze zvinhu zvakasiyana siyana zvingashandura uropi mukurwadziwa kusingaperi asi tinoshandura dheinhau redu pamusoro pehupfumi hwenyaya yehupfumi iyo iyo isingangori mirati yemigumisiro yekugara kwekushaya nociceptive. Kutaura zvazviri, kuongorora kwechangobva kuitika muhutano hwehutano hwehutano hwakaratidza kusakanganiswa kwehutano hwehutano hunobatana nemanzwiro evanhu, maonero ezvokuita, uye ekurwadziwa, zvichireva kuti vanoita basa rakakosha mumakiriniki epasi pose ekurwadziwa kusingaperi [28].

 

Mufananidzo 3 Statistical Parametric Maps

Mufananidzo 3: Statistical parametric mepu inoratidza kuwedzera kwakakura kwehuropi grey zvinhu munzvimbo dzemotokari (nzvimbo 6) mune varwere vane coxarthrosis vasati vaenzaniswa neakatevera THR (ongororo yehurefu, scan I Misiyano yekufungidzira pa x? =? 19, y? = ?? 12, z? =? 70.

 

Zvidzidzo zviviri zvemauto zvenguva pfupi zvakakonzerwa nehup replacement therapy mu osteoarthritis varwere, chete chirwere chisingaperi chinorwadza chirwere chinonyanya kuporesa nehuwandu hup replacement [17], [46] uye idzi data dzakabatwa nechidzidzo chechangobva kuitika mune varwere vasingaperi vanorwadziwa kurwadziwa [ 47]. Izvi zvidzidzo zvinoda kuonekwa muchiedza chenguva yakawanda yekuongorora zvidzidzo-zvinoenderana neuronal plastiki pakati pevanhu pachirongwa che [structural level] [30], [31] uye kuongorora kwechangobva kuitwa pamusoro pehupi hwehutano hunochinja kune vanozvipira vane ruzivo vanowedzera kukurudzira kunorwadza [34] . Mhedziso inokosha yezvose izvi zvidzidzo ndeyokuti kusiyana kukuru muhutano hwehutano pakati pevarwere vanorwadziwa uye kutonga kunogona kugadzikana apo marwadzo anopora. Zvisinei, inofanira kuonekwa kuti haisi kungojekesa kana kuchinja kwevarwere vasingagumi varwere kunongokonzerwa nekutora maitiro kana nekuda kwemigumisiro yemarwadzo kana maviri. Zvinonyanya kuitika kuti maitiro ekuchinja, zvakadai sekudzivirira kana kusimbiswa kwehukama hwevanhu, simba, kudzidzisa muviri uye mararamiro ehupenyu hunoita kuti hugadzire uropi [6], [12], [28], [48]. Kunyanya kuora mwoyo sekusagadzikana kana kukonzera marwadzo chinhu chinonyanya kukosha kutsanangura kusiyana kwevarwere nekutonga. Boka duku revarwere vedu vane OA rakaratidza zvishoma kusvika pakuenzanisa kuora mwoyo zviratidzo zvakashanduka nenguva. Hatina kuwana maitiro ekugadzirisa kuti zvive zvakakosha neBDI-chikwata asi mubvunzo unomuka maitiro mazhinji emamwe maitiro anochinja nekuda kwekusavapo kwemarwadzo nekuvandudzwa kwemotokari kunogona kuita kuti zvigumisiro uye kusvika pahuwandu hwavanoita. Izvi zvinogona kuchinja maitiro zvinogona kuita kuti gorosi iwedzere muhutwa husingaperi uye nenyaya yeguru inowedzera apo marwadzo apera.

 

Chimwe chinhu chinokosha chinogona kukanganisa kududzirwa kwemigumisiro ndeyekuti vanenge vose varwere vane marwadzo asingagumi vakatora mishonga pakurwadziwa, izvo vakamira apo vairwadziwa pasina. Mumwe anogona kutaura kuti NSAIDs dzakadai saDiclofenac kana ibuprofen dzine zvimwe zviitiko pane neural systems uye zvakafanana ndezvechokwadi kune opioid, antiepileptics uye antidepressants, mishonga inowanzoshandiswa muhutano husingaperi. Izvo zvinokonzera kuuraya vanouraya uye mamwe mishonga pane morphometric zvitsva zvinogona kunge zvakakosha (48). Hapana chidzidzo kusvika kure zvakaratidza migumisiro yemishonga inorwadza muuropi morphology asi mapepa akawanda akawana kuti kuchinja kwehutano hwehutano muvarwere vasingaperi vanorwara hakutsanangurwi chete nemarwadzo ane chokuita nekusaita [15], kana nemishonga inorwadza [7], [9], [49]. Zvisinei, zvidzidzo zvakananga zviriko. Kuwedzera kutsvakurudza kunofanira kutarisa ruzivo-runoenderana nekuchinja kwekortical plastiki, iyo inogona kuva nehutano hukuru hwekurapwa kwehupenyu husingaperi.

 

Isu takawanawo kuderera kwejena nyaya mukuongorora kwenguva refu, zvichida nekuda kwekugadzirisazve nzira dzinoenderana nekuchinja mumotokari uye kushungurudzika kwekuona. Pane zvishoma zvinyorwa zvinowanikwa pamusoro pekushanduka kwenguva refu muuropi hupfumi mumamiriro ezvinhu ekurwadziwa, nokuda kwechikonzero ichi hatina chikonzero chemuviri weguru kuderera munzvimbo idzi mushure mekushanda. Teutsch et al. [25] akawana kuwedzerwa kwehupfungwa hwepfungwa hupfungwa mumusatosensory uye pakati pekototikiti muvashandi vane hutano vakawana kukurudzirwa kunorwadza mune protocol yezuva rimwe kwemazuva masere anotevera. Kuwanikwa kwejena nyaya kunowedzera mushure mekuedza kwekuita nhengo yekushaya maitiro inoputika zvakananga kusvika pane imwe nguva nekuderera kweruzivo rwepfungwa dzepfungwa muchidzidzo ichi kune varwere vakaporeswa nekurwadziwa kwenguva refu. Izvi zvinoreva kuti rubatsiro rwekushaya ruzivo rwevamwe vanozvipira rwunofambisa kune hutano hunoenderana nekugadzirisa maitiro, sezvo zvichida kune varwere vane marwadzo asingagumi, uye kuti izvi zvinoshanduka zvinodzokorora kune avo vanozvipira vane hutano apo nhengo inopikisa inopera. Nekudaro, kuderera kwehupfumi muzviitiko zvakaratidzwa kune varwere vane OA zvinogona kududzirwa kutevera imwecheteyo inokosha: kushandiswa kwemishonga kunoshanduka kunochinja huropi hunochinja [50]. Sezvisiri nzira dzisina kukanganisa, MR Morphometry ndiyo yakakosha yekutsvaga kutsvaga morphological substrates yezvirwere, kuwedzera kunzwisisa kwedu kwehukama pakati pehutano hwehutano uye basa, uye kunyange kutarisa matanho ekurapa. Rimwe rematambudziko makuru mune ramangwana ndechokushandura chigadziro ichi chakasimba chemakondomu uye maitiro ekurapa ekurwadziwa kusingaperi.

 

Zvikanganiso zveChidzidzo ichi

 

Kunyangwe chidzidzo ichi chiri chekuwedzera kwedzidzo yedu yapfuura kuwedzera dhata rekutevera kusvika kumwedzi gumi nemaviri uye kuongorora varwere vazhinji, pfungwa yedu yekuona kuti morphometric uropi hunochinja mukurwadziwa kusingaperi hunodzoserwa pane kungwara. Masikirwo acho madiki (ona pamusoro) uye mhedzisiro yacho inofambiswa nekumwe kuderedzwa kwehuropi hwegrey grey nyaya vhoriyamu panguva-yekutarisa 12. Kana tikabvisa iyo data kubva pakuongorora 2 (chaiko mushure mekuvhiya) zvakakosha chete inowedzera muuropi grey nyaya yemota cortex uye yepamberi cortex inopona pachikumbaridzo che p <2 isina kugadziriswa (Tafura 0.001).

 

Tafura 3 Longitudinal Data

 

mhedziso

 

Hazvibviri kukwanisa kusiyanisa kusvika pamatongerwo emararamiro ezvatakatarisa ndeyekushandurwa kwekuisa nociceptive, kuchinja mumotokari basa kana kushandiswa kwemishonga kana kuchinja mune hupenyu hwakadaro. Kuchengetedza boka rakasiyana-siyana nekutanga uye rokupedzisira rakatarisana nemumwe rakaratidza zvishoma kusiyana kudarika zvakatarirwa. Zvichida, kuchinja kweuropi kunokonzera kurwadziwa kusingaperi nemigumisiro yose iri kukura pane nguva yakareba kwenguva refu uye inogonawo kudikanwa nguva yekudzoka. Kunyange zvakadaro, izvi zvinowanzobudisa zvirongwa zvekugadzirisa zvakare, zvakanyatsoratidza kuti chisinganzwisisiki neciceptive input uye kukanganisa motokari mune ava varwere zvinoita kuti kuchinjwa kugadziriswe munzvimbo dzekortical uye zvichienderana nekugadzirisa kwehuropi hunochinja huripo huripo hunozoshandurwa.

 

Kutenda

 

Tinoonga vose vanozvipira kuti vabatanidzwe muchidzidzo ichi uye boka re Physics uye Methods paNeuroImage Nord muHamburg. Chidzidzo chacho chakapiwa mvumo yepamutemo kuburikidza neKomiti yeMitemo yepamutemo uye kubvumwa kwakanyorwa kwakanyorerwa kwakawanikwa kune vose vadzidza kudzidza vasati vaongorora.

 

Mari yeNhepfenyuro

 

Basa iri rakatsigirwa nezvipo kubva kuDFG (German Research Foundation) (MA 1862 / 2-3) uye BMBF (Federal Federal Education and Research) (371 57 01 neNeuroImage Nord). Vaya vaibhadhara mari vakanga vasina ruzivo mukugadzira kudzidza, kuunganidza deta uye kuongorora, chisarudzo chokubudisa, kana kugadzirira gwaro racho.

 

Endocannabinoid System | El Paso, TX Chiropractor

 

Iyo Endocannabinoid Sisitimu: Iyo Yakakosha Sisitimu Iwe yausina Kumbonzwa Nezve

 

Kana iwe usina kunzwa nezve endocannabinoid system, kana ECS, hapana chikonzero chokunyara. Kudzoka muC1960, vatsvakurudzi vakava nehanya nehupenyu hweCannabis pakupedzisira vakawana mazana emakemikari ayo anoshanda. Zvakatora imwe makore 30, zvisinei, kune vatsvakurudzi vanoongorora mhando dzemhuka kuti vawane mukana wemakemikari aya e ECS muhupenzi hwemakonzo, kuwanikwa kwakazarura nyika yose yekubvunzurudza mukati mekugara kwe ECS uye izvo zvinangwa zvepanyama.

 

Isu iye zvino tinoziva kuti mhuka dzakawanda, kubva kune hove kune shiri kuenda kumhuka, dzine demo endocannabinoid, uye tinoziva kuti vanhu havasi kungozvigadzira ivo pachavo pachavo vanobatana nehurongwa urwu, asi tinogadzirawo mamwe maitiro anobatana neEECS, avo iyo inowanikwa mumiti yakasiyana-siyana uye zvokudya, kunyanya kupfuura kweCannabis.

 

Sezvo chirongwa chemuviri womunhu, ECS haisi iyo yakasarudzwa yakarongwa senhandare yehurumende kana yemagetsi. Panzvimbo pezvo, iEECs inenge yakagadziriswa yakawanda yakapararira mumuviri wose iyo inoshandiswa kuburikidza nemagadzirirwe e ligands isu pamwe chete tinoziva sekuti endocannabinoids, kana endogannous cannabinoids. Zvose zvinotsigirwa zvinogamuchirwa zvinongonzi CB1 uye CB2, kunyange kune zvimwe zvakasarudzirwa. PPAR neTPP mitsara inobatanidza mamwe mabasa. Saizvozvowo, uchawana mbiri dzakanyorwa zvakanyorwa endocannabinoids: anadamide uye 2-arachidonoyl glycerol, kana 2-AG.

 

Uyezve, zvakakosha kune endocannabinoid system ndiyo inymesiti inogadzira uye inoparadza endocannabinoid. Endocannabinoids inofungidzirwa kuti inogadzirwa mune imwe nheyo inoda. Izvozvo zvinokonzerwa nemakemikari zvinosanganisira diacylglycerol lipase uye N-acyl-phosphatidylethanolamine-phospholipase D, iyo iyo inobatanidza 2-AG uye anandamide. Iyo miviri miviri inonyadzisa yakawanda inonzi fatty acid amide hydrolase, kana FAAH, iyo inoputsa anandamide, uye monoacylglycerol lipase, kana MAGL, iyo inoputsa 2-AG. Mutemo weiyi maviri enzymes inogona kuwedzera kana kuderedza kuenzanisa kweEECS.

 

Basa rei re ECS?

 

IEECs ndiyo inonyanya kugadzirisa zvirongwa zvemuviri. Inogona kuonekwa nyore nyore semuviri wepakati adaptogenic system, nguva dzose kushanda kuti ichengetedze kuenzanisa kwezvinhu zvakasiyana-siyana. Endocannabinoids yakawanda yakashanda seyeuromodulators uye, saizvozvowo, inodzora huwandu hwakawanda hwezvirongwa zvenyama, kubvira pakubereka kusvika pakurwadziwa. Mamwe emabasa aya anozivikanwa zviri nani kubva kune ECS ndeaya anotevera:

 

huta System

 

Kubva pakati penheyo yenheyo, kana CNS, kukurudzirwa kwevanhu vakawanda veCX1 receptors kuchadzivisa kusunungurwa kwe glutamate uye GABA. MuCSS, iyo ECS inobatanidzwa mukuyeuka kugadzirisa uye kudzidza, inokurudzira neurogenesis mu hippocampus, inotungamirirawo neuronal kusununguka. IEECs inobatanidzwawo nenzira iyo uropi huchaita pakukuvara nekuputika. Kubva pamutsipa weropa remutsipa, ECS inoderedza marwadzo ekuratidza uye inowedzera mhuka dzakasununguka. Munharaunda yehutachiona yehutachiona, iyo CB2 yakagadziriswa inotungamirira, ECS inoshandisa kunyanya muhurongwa hwemutsitsi unonzwira tsitsi kuronga mabasa ematurumbu emukumbo, urinary, uye kubereka.

 

Kushungurudzika uye Maitiro

 

Izvo zveEECs zvinokanganisa zvakanyanya pamusana pekushushikana kwepfungwa nekuraira kwepfungwa, sekutanga kwemukana uyu wemuviri kune zvakanyanya kushungurudzika nekugadziriswa kwechinguva kusvika kune dzimwe nguva kwenguva refu manzwiro, zvakadai sekutya uye kuzvidya mwoyo. A healthy working endocannabinoid system inokosha kumabatiro anoita vanhu pakati pehuwandu hunogutsa hwekumutsa nekuenzaniswa nehuwandu huwandu uye husingafadzi. IEECs inobatsirawo pakuyeuchidza uye zvichida nenzira iyo iyo uropi hunoita kuti zviyeuchidzo kubva pakunetseka kana kukuvara. Nokuti ECS inoderedza kusunungurwa kwedopamine, noradrenaline, serotonin, uye cortisol, inogonawo kuita kuti vanhu vakawanda vaite manzwiro nemafungiro.

 

Digestive System

 

Nzira yekudya inowanikwa neyese CB1 uye CB2 receptors inodzora zvinhu zvinoverengeka zvinokosha zvehutano hweGI. Zvinofungidzirwa kuti ECS inogona kunge iine "kusina kubatana" mukutsanangura kugadzirisa-utachiona-hutachiona hunobatsira hunoita hutano hunoshanda hwehutano hwekudya. IEECS inoronga mutumbi wehutachiona, pamwe nekudzivirira masimba ezvirwere zvekuzvidzivirira kubva pakuparadza maruva ane utano, uyewo kuburikidza nekugadzirisa kwechiratidzo chechitokine. IEECS inogadzirisa zvinokonzerwa nokuputika kwepanyama mumugwagwa wezvokudya, izvo zvinoita kuti zvive nehuwandu hwehutano hwakasiyana-siyana. Gastric uye general GI motility inoratidzika kunge inotungamirirwa neEECS.

 

Appetite uye Metabolism

 

IEECS, kunyanya yeBEC1 receptors, inotora chikamu mukudya, kusagadzikana kwemasikirini, nekugadzirisa muviri wemafuta. Kukurudzirwa kwevanokwidziridza CB1 kunosimudzira maitiro ekutsvaga kwekudya, kunosimudzira kuziva kwekunhuhwira, uye kunotarisa simba rekuita. Zvose mhuka nevanhu vane uremu hwepamusoro vane ECS dysregulation iyo inogona kuita kuti chirongwa ichi chive chisina kunaka, izvo zvinoita kuti zvose kudya uye kuderedza simba rekushandisa mari. Kupararira mazinga eAnandamide uye 2-AG ave akaratidzirwa kuti akakwidziridzwa mukudisa, izvo zvingave zviri chikamu pamusana pokuderera kwekugadzirwa kwe FAAH inonyadzisa enzyme.

 

Immune Health and Resplammatory Response

 

Masero uye nhengo dzomuviri wechirwere chekuzvidzivirira muviri dzakapfuma ne endocannabinoid receptors. Cannabinoid receptors inoratidzwa mu thymus gland, spleen, tonsils, uye marrow bone, pamwe neT-B ne-B-lymphocytes, macrophages, mast cells, neutrophils, uye masero ehupenyu anouraya. IEECs inonzi inofambisa mutungamiriri we immune system balance uye homeostasis. Kunyange zvazvo zvisingaiti mabasa ose eEEC kubva mumuviri wezvirwere zvinonzwisiswa, ECS inoratidzika kutonga kukwidziridzwa kwegytokine uyewo kuva nechinangwa mukudzivirira kusagadzikana mune zvirwere zvemuviri. Kuvhiringidza chikamu chemuviri wehutachiona hwemuviri, uye chinotamba chikamu chakanaka mukunyomba kwakanyanya mumuviri, kusanganisira kukuvara uye zvirwere; zvisinei, kana zvisiri kuchengetedzwa zvinogona kuva zvisingagumi uye zvinokonzera kukonzera zvinetso zveutano zvakashata, zvakadai sekurwadziwa kusingaperi. Nokuchengetedza maitiro ekudzivirira zvirwere mumuviri, checker ECS inobatsira kuchengetedza kupindira kwakanyanyisa kupindura kuburikidza nemuviri.

 

Dzimwe nzvimbo dzehutano dzinotungamirirwa neEECS:

 

  • Bone utano
  • Fertility
  • Ganda rehutano
  • Arterial and breathing respiratory
  • Kurara uye circadian rhythm

 

Nzira yekugadzirisa zvakanakisisa ECS ine utano ndeye mubvunzo vazhinji vatsvakurudzi vari kuedza kupindura. Ramba wakatarisa kuti uwane mamwe mashoko pamusoro penyaya iyi inotangira.

 

Mukupedzisa,Uturu hwehutachiona hwave huchibatanidzwa nekuchinja kwehuropi, kusanganisira kudzikiswa kweruvara rwegrey. Nekudaro, chinyorwa chiri pamusoro chakaratidza kuti kurwadziwa kusingaperi kunogona kuchinja mamiriro ese uye mashandiro ehuropi. Kunyangwe kurwadziwa kusingaperi kuchizotungamira kune izvi, pakati pezvimwe zvehutano nyaya, kurapwa kwakakodzera kwezviratidzo zvevarwere kunogona kudzora shanduko dzehuropi uye kutonga grey zvinhu. Uyezve, zvidzidzo zvekutsvagisa zvakabuda shure kwekukosha kweiyo endocannabinoid system uye iri basa mukudzora pamwe nekugadzirisa kurwadziwa kusingaperi uye nezvimwe zvehutano. Ruzivo rwunotsanangurwa kubva kuNational Center yeBiotechnology Ruzivo (NCBI) .Kureba kweruzivo rwedu kunogumira kuchiropractic pamwe nekukuvara kwepamuviri nemamiriro. Kuti ukurukure nyaya yacho, ndapota inzwa wakasununguka kubvunza Dr. Jimenez kana kutibata nesu pa us915-850-0900 .

 

Yakarongedzwa naDkt Alex Jimenez

Green-Call-Now-Button-24H-150x150-2-3.png

Zvimwe Zvinyorwa: Kubva Painini

Kutambudzika shure ndechimwe chezvikonzero zvakakosha zvikuru zvekuremara uye mazuva asina kukwana kubasa pasi rose. Sezvakangoitika, kurwadziwa kwekudzokera shure kwave kuchiitwa sechipiri chikonzero chikuru chechiremba chekushanyira, chakanyanya kupfurikidza nehutachiona hwepamusoro-kuporesa. Inenge 80 muzana yevanhu vanozoona rumwe rudzi rwemarwadzo emutsipa kamwechete kamwe chete muupenyu hwavo hwose. Iyo musana inorongwa yakaoma yakaumbwa nemapfupa, mafundo, magirasi nemasumbu, pakati pezvimwe zvinyoro zvishoma. Nemhaka yeizvi, kukuvadzwa uye / kana mamiriro ezvinhu akawandisa, akadai herniated discs, zvinogona kutungamirira kune zviratidzo zvekurwadziwa shure. Kukuvara kwemitambo kana kukuvara kwepamberi yemotokari kazhinji kunowanzokonzera kukonzera kurwadziwa, zvisinei, dzimwe nguva kufamba kwakanyanya kunogona kuva nemigumisiro inorwadza. Nenzira yakanaka, nzira dzakasiyana dzokurapa, dzakadai sechiropractic, dzinogona kubatsira kuderedza marwadzo shure kuburikidza nekushandurwa kwepelinha nekugadzirisa maitiro, pakupedzisira kunatsiridza marwadzo ekurwadziwa.

 

 

 

blog chinyorwa chekartoon paperboy makuru makuru

 

NHAURWA INOKOSHA INOKOSHA: Low Back Pain Management

 

DZIMWE NYAYA: DZIMWE DZIMWE DZIDZISO: ronicKusingaperi Kurwadziwa & Marapirwo

 

Hazvina kuchena
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Close Accordion
Biochemistry Of Pain

Biochemistry Of Pain

by | Cannabinoids, chisingaperi Pain, Clinical Neurophysiology, kusuruvara

Biochemistry of Pain:LlAll syndromes ekurwadziwa ane chimiro chekuzvimba. Mbiri yekuvhiringidza inogona kusiyana kubva pamunhu kusvika pamunhu uye inogona zvakare kusiyana mumunhu mumwe panguva dzakasiyana. Kurapa kwemarwadzo syndromes ndeyekunzwisisa iyi yekuzvimba chimiro. Marwadzo syndromes anorapwa zvemishonga, ekuvhiya kana ese ari maviri. Chinangwa ndechekudzivirira / kudzvinyirira kugadzirwa kwevanomiririra vamiririri. Uye mhedzisiro inobudirira ndeimwe inokonzeresa kuzvimba kushoma uye zvechokwadi marwadzo mashoma.

Biochemistry Of Pain

Zvinangwa:

  • Ndivanaani vheyi vatambi
  • Ndezvipi zvirongwa zvehupenyu hwehupenyu?
  • Ndezvipi zvinoguma?

Kufuridzira Ongororo:

Key Players

biochemistry of pain el paso tx.

biochemistry of pain el paso tx.

biochemistry of pain el paso tx.

biochemistry of pain el paso tx.Nei Bhegi Rangu Richirwadza? Ongororo YeNeuroanatomical & Biochemical Basis YePafudzi Pain

KUTANGA

Kana murwere akabvunza kuti "sei pfudzi rangu richirwadza?" Hurukuro yacho inokurumidza kutendeukira kune dzidziso yesainzi uye dzimwe nguva isingabvumirwe fungidziro. Kazhinji, chiremba anoziva nezve iyo miganho yesainzi hwaro hwetsananguro yavo, zvichiratidza kusakwana kwekunzwisisa kwedu chimiro chemarwadzo epafudzi. Kuongorora uku kunotora nzira yakarongeka yekubatsira kupindura mibvunzo yakakosha ine chekuita nekurwadziwa kwepafudzi, nechinangwa chekupa ruzivo rwekutsvagurudza mune ramangwana uye nzira nyowani dzekurapa kurwadziwa kwepafudzi. Tichaongorora zvinoitwa ne (1) zvinokamurwa zvinogamuchirwa, (2) periipheral pain processing kana nociception , (3) musana wesipinha, (4) uropi, (5) nzvimbo yemagamuchira mumapfudzi uye (6) ) iyo neural anatomy yepafudzi. Isu tinotarisawo kuti izvi zvinhu zvinogona sei kubatsira mukusiyana kweiyo kiriniki mharidzo, kuongororwa uye kurapwa kwemarwadzo epafudzi. Nenzira iyi isu tinovavarira kupa muongororwo wezvikamu zvehurongwa hwekuona kurwadziwa kwekurwadziwa uye epakati pekugadzirisa maratidziro ekurwadziwa kwepafudzi ayo anofambidzana kuburitsa kiriniki kurwadziwa.

NHANGAMIRIRO: CHINHU CHINOKOSHA CHINHU CHENYAYA YESAYENYU INOKOSHA KUTI VANHU VAKADHA

Hunhu hwekurwadziwa, kazhinji, hwave chinhu chekupokana kukuru pamusoro pezana ramakore rapfuura. Muzana ramakore rechi 17 Descartes theory1 yakaratidza kuti kukura kwemarwadzo kwaive kwakanangana zvakaringana nehuwandu hwehukama hwakabatana hwemanyama uye kuti marwadzo akagadziriswa mune imwe nzira yakasarudzika. Dzidziso zhinji dzekare dzaivimba neiyi inonzi ualdualist Descartian uzivi, ichiona kurwadziwa semhedzisiro yekusimudzirwa kweaspecific peripheral pain receptor muuropi. Muzana ramakore rechimakumi maviri kurwa kwesainzi pakati pedzidziso mbiri dzinopokana kwakazotevera, kureva hushe hwedzidziso uye dzidziso yemhando. Iyo Descartian specificity theory yakaona kurwadziwa senge yakasarudzika nzira yekunzwa yekuisa neyemidziyo yayo, nepo "dzidziso yepashure" yakanzwa kuti kurwadziwa kwakakonzerwa nekusimudzirwa kwakanyanya kweasina-chaiwo ma receptors.20 Muna 2, Wall neMelzack s 1965 gedhi dzidziso yekurwadziwa yakapa humbowo hwemuenzaniso umo marwadzo ekuona akarongedzwa neese mhinduro yekunzwa uye yepakati tsinga system. Kumwe kufambira mberi kukuru mukutenda kwekutambudzika panguva imwechete yakaona kuwanikwa kweiyo chaiyo nzira yezviito zveopioid.3 Shure kwaizvozvo, kufambira mberi kwazvino mukuita neuroimaging uye mishonga yemamorekuru zvakawedzera zvakanyanya kunzwisisa kwedu kwese kwekutambudzika.

Saka izvi zvinoenderana sei nekurwadziwa kwepafudzi?Kurwadziwa kwepamuviri kunowanzova chinetso chechipatara, uye kunzwisisa kwakasimba kwenzira iyo marwadzo anogadziriswa nemuviri kwakakosha kuti unyatso kuongorora uye kurapa kurwadziwa kwemurwere. Kufambira mberi muruzivo rwedu rwekugadzirisa kurwadziwa kuvimbisa kutsanangura kusanzwisisika pakati pehurwere uye maonero ekurwadziwa, zvinogona zvakare kutibatsira kutsanangura kuti nei vamwe varwere vachitadza kupindura kune kumwe kurapa.

KUSANGWA KUNHU KWEVANHU

Peripheral sensory receptors: iyo mechanoreceptor uye iyo nociceptor

Kune akawanda marudzi eeperiipheral sensory receptors aripo mune yemunhu musculoskeletal system. 5 Vanogona kuve vakapatsanurwa zvichibva pakufara kwavo (sema mechanoreceptors, thermoreceptors kana nociceptors) kana morphology (yemahara mhedzisiro mhedzisiro kana mhando dzakasiyana dzeakavharirwa ma receptors). kuvapo kwevamwe makemikari mamaki. Iko kune akakosha kupindirana pakati pezvakasiyana zvinoshanda makirasi eanogamuchira, semuenzaniso

Peripheral Pain Kugadziriswa: ocNociception

Kukuvara kwetishu kunosanganisira akasiyana mamiririri ekuputira ari kuburitswa nemaseru akakuvara anosanganisira bradykinin, histamine, 5-hydroxytryptamine, ATP, nitric oxide uye mamwe maion (K + uye H +). Iko kushandiswa kwe arachidonic acid nzira inotungamira mukugadzirwa kwe prostaglandins, thromboxanes uye leuko- trienes. Cytokines, kusanganisira iyo interleukins uye tumor necrosis factor?, Uye maurotrophins, senge nerve yekukura chinhu (NGF), anoburitswa uye anobatanidzwa zvakanyanya mukufambisa kwekuzvimba.15 Zvimwe zvinhu zvakaita seanosimudzira amino acids (glutamate) uye opioid ( endothelin-1) zvakave zvichisanganiswazve nemhedzisiro yekuzvimba.16 17 Vamwe veavo vamiririri vanogona kumisikidza nociceptors zvakananga, nepo vamwe vachiunza kuunganidzwa kwemamwe maseru ayo anozoburitsa mamwe maanoshanda. 18 Iyi maitiro emuno zvichikonzera kuwedzera kwekuteerera ye nociceptive neurons kune yavo yakajairwa yekuisa uye / kana kuunganidzwa kwemhinduro kune zvakajairika subthreshold zvinowedzerwa zvinonzi "peripheral senitization ". Mufananidzo 1 inopfupisa dzimwe nzira dzakakosha dzinobatanidzwa.

biochemistry of pain el paso tx.NGF uye yekupedzisira receptor inogona cation chiteshi subfamily V nhengo 1 (TRPV1) receptor ine hukama hwekufananidza kana zvasvika pakukuvadza uye nociceptor senitization. Iwo ma cytokines anogadzirwa mumoto unopisa unoguma nekuwedzera mukugadzirwa kweNNG.19 NGF inokurudzira kuburitswa kwe histamine uye serotonin (5-HT3) nemaseru maseru, uye zvakare inosimudzira ma nociceptors, pamwe achichinja zvivakwa zveA? tambo dzakadai sekuti chikamu chikuru chichava nociceptive. Iyo TRPV1 yekugamuchira irimo mune kuwanda kweanonyanya kufefitera tambo uye inoitwa ne capsaicin, kupisa uye proton. Iyo TRPV1 receptor inogadzirwa mukati memutumbi wesero weiyo inosanganisa fiber, uye inoendeswa kune ese ari maviri epiri uye epakati ma terminals, uko kunopa kunzwisisika kweanociceptive afferents. Kuzvimba kunoguma mukugadzira NGF pariperi iyo inozosunga kune tyrosine kinase receptor type 1 receptor pane nociceptor terminals, NGF inozotakurirwa kumuviri wesero uko inotungamira kune kumusoro mutemo weTrPV1 kudhindisa uye nekudaro kuwedzera nociceptor senzwi. 19 20 NGF uye vamwe vamiririri vanoputira vanokurudzira TRPV1 kuburikidza nemhando dzakasiyana dzechipiri nzira dzevatumwa. Mazhinji mamwe maresitoreti anosanganisira cholinergic receptors,? -Aminobutyric acid (GABA) receptors uye somatostatin receptors inofungidzirwa kuve inobatanidzwa mune yekunze nociceptor senitivity.

Huwandu hukuru hwevamiririri vekuputira hwakanyatso kuverengerwa mukurwadziwa kwepafudzi uye rotator cuff chirwere. Idzi shanduko dzinogona kuve kwekutanga- kushandurwa kana kunonoka kunyorwa kunoenderana. Mienzaniso yeiyo yekutanga shanduko muiyo TRPV21 receptor kana mumagetsi- gated ion chiteshi chinokonzerwa nephosphorylation ye membrane-yakasungwa mapuroteni. Mienzaniso yeiyo yekupedzisira inosanganisira iyo NGF-inokwidziridzwa kuwedzera muTRV25 chiteshi kugadzirwa uye calcium-inokonzeresa activation yeiyo intracellular zvinyorwa zvinyorwa.

Nzira dzeMakemikari YaNociception

Kunzwa kwekutambudzika kunotinyevera kukuvara chaiko kana kuri kuuya uye kunokonzeresa mhinduro dzakakodzera dzekudzivirira. Nehurombo, kurwadziwa kazhinji kunopfuura kushanda kwayo seyambiro system uye pachinzvimbo kunogara kusingaperi uye kuchikanganisa. Iyi shanduko kuenda kuchikamu chisingaperi inosanganisira shanduko mukati memutsipa wepelinha uye huropi, asi kune zvekare kushamisa modulation uko mameseji ekurwadziwa anotangwa - padanho repuraisheni yekunzwa neuron. Kuedza kuona kuti mauroni aya anoona sei marwadzo-anoburitsa chinhu chinopisa, chinogadzirwa kana chemakemikari chakaratidza nzira nyowani dzekuratidzira uye dzakatisvitsa padhuze nekunzwisisa zviitiko zvema molecular zvinofambisa shanduko kubva kuacute kusvika pakurwadziwa kusingaperi.

biochemistry of pain el paso tx.The Neurochemistry Of Nociceptors

Glutamate ndiyo inonzi neurotransmitter inokurudzira kune dzose ma nociceptors. Histochemical studies of adult DRG, zvisinei, inoratidza mbiri dzakawanda dzisingazivikanwe C fiber.

Makemikari Transducers Kuti Aite Marwadzo Akaipisisa

Sezvinorondedzerwa pamusoro apa, kukuvadza kunowedzera marwadzo edu kuburikidza nekuwedzera kunzwisiswa kweavoiceice kune zvose zvinopisa uye zvinogadziriswa. Izvi zvinowanzoitika, mune chimwe chikamu, kubva pakugadzirwa uye kusunungurwa kwemakemikari emakemikari kubva pachirwere chekutanga chinotyisa uye kubva kune zvisiri-neural cells (somuenzaniso, fibroblasts, mast cells, neutrophils uye platelets) mumamiriro ezvinhu36 (Fig. 3). Zvimwe zvikamu zvehutu hunoputika (somuenzaniso, proton, ATP, serotonin kana lipids) zvinogona kuchinja neuronal kusununguka zvakananga nekubatana neyoni mitsara pane nociceptor surface, asi vamwe (semuenzaniso, bradykinin neNNG) vanosunga kumagadzirirwo emasabotropic uye kuratidzira migumisiro yavo kuburikidza nechipiri-mumiririri kuisa cascades11. Kufambira mberi kwakanyanya kwave kuchiitwa pakunzwisisa maitiro ezvinyorwa zvekugadzirisa zvinhu.

Extracellular Proton & Tissue Acidosis

Nharaunda yemasisitosis acidosis inoratidzirwa mupfungwa yekugadzirisa mukukuvara, uye chirwere chekurwadziwa kwakasangana kana kusagadzikana kwakanyatsobatanidzwa nehukuru hweacidification37. Kushandiswa kwesidhi (pH 5) kune ganda kunounza kusununguka kwakachengetwa mune chechitatu kana kupfuura zvema polymodal nociceptors izvo zvisina kukodzera munda unogamuchira 20.

biochemistry of pain el paso tx.Cellular & Molecular Maitiro Ekurwadziwa

ngovepo

Nenzira yehutano inoona uye inotsanangura zvakasiyana-siyana zvekushisa uye kushandiswa kwemajini pamwe chete nekuchengetedzwa kwemhepo uye kusagadzikana kwemakemikari anotsamwisa. Kana zvakanyanya, izvi zvinokonzera kurwadziwa kwakanyanya, uye mumamiriro ezvinhu ekukuvadza kunoramba kuripo, zvose zviri mumativi uye nheyo dzenhepfenyuro yezvirongwa zvehutano hwekutambudza mugwagwa unoratidzira kuputika kwepurasitiki, kuwedzera zvirwere zvinorwadza nekubudisa hutachiona. Apo plastiki inobatsira mafungiro ekuchengetedza, zvinogona kubatsira, asi kana kuchinja kuchiripo, chirwere chisingaperi chinogona kuguma. Genetic, electrophysiological, uye zvidzidzo zvemaprojekiti zviri kujekesa nzira dzema molecule dzinoita kuti kuve nokuona, kukodha, uye kugadzirisa zvinotyisa zvinokonzera marwadzo.

Nhanganyaya: Zvakanaka Kupesana Nokuramba Uchirwadziwa

biochemistry of pain el paso tx.

biochemistry of pain el paso tx.Mufananidzo 5. Mutsara wechipfuva (Central) Sensitization

  1. Glutamate / NMDA zvakagamuchirwa pamwe chete.OllowKutevera kukurudzira kwakanyanya kana kukuvara kusingaperi, yakaitwa C uye A? nociceptors anoburitsa akasiyana maurotransmitter anosanganisira dlutamate, chinhu P, calcitonin-geni inoenderana peptide (CGRP), uye ATP, kune inoburitsa mauroni mumamina I erunyoro rwekuseri runyanga (tsvuku). Semhedzisiro, inowanzo nyarara NMDA glutamate receptors iri mune postsynaptic neuron ikozvino inogona kuratidza, kuwedzera intracellular calcium, uye kumutsa yakawanda calcium inoenderana nzira yekuratidzira nzira uye yechipiri vatumwa vanosanganisira mitogen-activated protein kinase (MAPK), protein kinase C (PKC) , protein kinase A (PKA) uye Src. Uku kupaza kwezviitiko kuchawedzera kunakidzwa kweiyo inoburitsa neuron uye kufambisa kufambiswa kwemashoko ekurwadziwa kuuropi.
  2. Disinhibition.NderPasi pemamiriro ezvinhu akajairika, inhibitory interneurons (bhuruu) inoramba ichiburitsa GABA uye / kana glycine (Gly) kudzikisira kusarudzika kwemamina I kuburitsa mauroni uye kugadzirisa kurwadziwa kwekutapudza (inhibitory toni). Zvisinei, mumamiriro ekukuvara, izvi zvinodzivisa zvinogona kurasikirwa, zvichikonzera hyperalgesia. Pamusoro pezvo, disinhibition inogona kugonesa isiri-nociceptive myelinated A? primary afferents yekuita marwadzo ekuparadzira mafirita akadai ayo anowanzo kuve asina hunhu zvinoonekwa sekurwadza. Izvi zvinoitika, muchidimbu, kuburikidza neiyo disinhibition yeinofadza PKC? kuratidza ma interneuron mukati memamina lamina II.
  3. Microglial activation.ErPeripheral nerve kukuvara kunosimudzira kuburitswa kweATP uye chemokine fractalkine iyo inosimudzira ma microglial maseru. Kunyanya, kumisikidzwa kwepurinergic, CX3CR1, uye maToll-kunge receptors pane microglia (yepepuru) zvinoguma nekuburitswa kweuropi-yakatorwa neurotrophic factor (BDNF), iyo kubudikidza nekumisikidza kweTrkB receptors inoratidzwa ne lamina I kuburitsa mauroni, inosimudzira kuwedzera kusununguka kuwedzerwa kurwadziwa mukupindura kune zvese zvinotyisa uye zvisina mhosva kukurudzira (ndokuti, hyperalgesia uye allodynia). Yakagadziriswa microglia zvakare inoburitsa yakawanda cytokines, senge bundu necrosis chinhu? (TNF?), Interleukin-1? uye 6 (IL-1?, IL-6), uye zvimwe zvinhu zvinopa kukurudzira kwepakati.

Chimiro Chimiro Chekuvhiringidza

Peripheral sensitization zvinowanzoitika kubva mukuzvimba-kwakabatana shanduko mune kemikari nharaunda yeiyo nerve fiber (McMahon et al., 2008). Nekudaro, kukuvara kwemasuru kunowanzo kuperekedzwa pamwe nekuunganidzwa kwezvinhu zvisingagumi zvinoburitswa kubva kune akaomeswa nociceptors kana asiri-neural maseru anogara mukati kana kupinda mukati menzvimbo yakakuvara (kusanganisira mast mast, basophils, maplatelet, macrophages, neutrophils, endothelial maseru, keratinocytes, uye Fibroblasts). Pamwe chete. izvi zvinhu, zvinodaidzwa kuti infigueatory soup , inomiririra huwandu hwakawanda hwekusainisa mamorekuru, anosanganisira maurotransmitter, peptides (chinhu P, CGRP, bradykinin), eicosinoids uye zvine hukama lipids (prostaglandins, thromboxanes, leukotrienes, endocannabinoids), maurotrophins, cytokines , uye chemokines, pamwe nema extracellular proteases nemaproton. Zvinoshamisa kuti, ma nociceptors anoratidza imwe kana anopfuura maseru epasiromendi anokwanisa kucherechedza nekupindura kune yega yeaya pro-anogumbura kana pro-algesic vamiririri (Mufananidzo 4). Kudyidzana kwakadaro kunowedzera kunakidzwa kweiyo fiber fiber, nokudaro ichisimudzira kunzwisisika kwayo kune tembiricha kana kubata.

Hapana mubvunzo kuti nzira inowanzoita yekuderedza kunetseka kunokonzera kunosanganisira kudzivisa kubatanidza kana kuunganidza zvikamu zvehutu hunopisa. Izvi zvakanakisisa zvinoratidzwa ne-non-steroidal anti-inflammatory drugs, zvakadai sa aspirin kana ibuprofen, izvo zvinoderedza marwadzo ekuputira uye hyperalgesia nekudzivisa cyclooxygenase (Cox-1 uye Cox-2) inobatanidzwa mu prostaglandin synthesis. Nzira yechipiri ndeyokudzivisa zviito zvezvokuvhiringidza vashandi ku-nociceptor. Pano, tinosimbisa mienzaniso inopa hutsva hutsva mumagadzirirwo emagetsi ekunze kwekushungurudzika, kana kuti iyo inoumba hwaro hwemishonga matsva ekurapa kurwadza nekuputika.

NGF ingangodaro inonyatsozivikanwa nokuda kwebasa rayo seurourotrophic chinotarisirwa kuponesa uye kukura kwezvinonzi sensory neurons panguva yembryogenesis, asi kune munhu mukuru, NGF inogadzirwawo mumamiriro ezvinhu ekukuvara kwepanyama uye inoumba chikamu chinokosha chekuvhiringidza muto (Ritner et al., 2009). Pakati pezvinangwa zvaro zvemasero, NGF inonyatsoshanda pa peptidergic C fiber nociceptors, iyo inoratidzira ukama hwakasimba hweNFF receptor tyrosine kinase, TrkA, uyewo hukama hwakaderera neurotrophin receptor, p75 (Chao, 2003; Snider naMcMahon, 1998). NGF inobereka hukuru hwehutachiona hwekupisa nekupisa uye kushandiswa kwemagetsi kuburikidza nemaitiro maviri akasiyana kwenguva. Pakutanga, kutaurirana kwe NGF-TrkA kunobatsira nzira dzekuyerera pasi, kusanganisira phospholipase C (PLC), mitogen-activated protein kinase (MAPK), uye phosphoinositide 3-kinase (PI3K). Izvi zvinokonzera kushanda kwemaitiro ezvirongwa zvepuroteni pane imwe nzvimbo ye nociceptor terminal, kunyanya TRPV1, zvichiita kuti kuve nekukurumidza kushanduka mumasero uye maitiro ekupisa kwehuni (Chuang et al., 2001).

Zvisinei nemaitiro avo epro-nociceptive, kupindira neurotrophin kana chiratidzo checytokine rave zano rakakura rekudzora chirwere chinoputika kana kurwadziwa kunokonzerwa. Maitiro makuru anosanganisira kuvhara NGF kana TNF-? chiito nechirwere chinopesana. Munyaya yeTNF-?, Izvi zvave zvichinyatso shanda mukurapa kweakawanda autoimmune hosha, kusanganisira rheumatoid arthritis, zvichikonzera kudzikira kukuru mukuparadza kwese kwenyama uye kuperekedza hyperalgesia (Atzeni et al., 2005). Nekuti zviito zvikuru zveNNGF pane mukuru nociceptor zvinoitika mukugadzika kwekuzvimba, mukana weiyi nzira ndeyekuti hyperalgesia inoderera isina kukanganisa kunzwisisika kurwadziwa kwepfungwa. Zvechokwadi, zvirwere zvinopesana neNNG zvinowanikwa mumakiriniki ekuedza kurapwa kwezvirwere zvinokonzera kurwadziwa (Hefti et al., 2006).

Glutamate / NMDA Receptor-Mediated Sensitization

Kunetseka kwakanyanya kunoratidzwa nekubudiswa kwema glutamate kubva kumativi ekupedzisira emascicptptors, zvichiita kuti pave nemasikirati emashure-synaptic currents (EPSCs) muchipiri chegorosi rehondo neuron. Izvi zvinowanzoitika kuburikidza nekushanda kwe postsynaptic AMPA uye kainate subtypes ye ionotropic glutamate receptors. Kupfupisa kwechikamu chechikamu cheEPSCs mumashure endsynaptic chizoguma chichiita chiito chinogona kupisa uye kutumirwa kwehurombo hwemashoko kusvika kune yepamusoro neurons.

Zvimwe zvidzidzo zvinoratidza kuti kuchinja kwekuratidzwa neuron, iyo pachayo, kunobatsira pakuita zvinodzivisa. Semuenzaniso, kuputika kweropa kunenge kuchidzika-kunogadzirisa K + - Cl-co-transporter KCC2, iyo inokosha kuti uchengetedze kazhinji K + uye Cl-gradients pamativi ose eplasma (Coull et al., 2003). Kunyoresa KCC2, iyo inoratidzirwa mumarina I kujekesa neurons, inoguma pakuchinja kweC Cl-gradient, zvakadai kuti kushandiswa kweGABA-A receptors kuderedza, panzvimbo yekusimudzira marina I projection neurons. Izvi zvingaitawo kuti zviwedzere kufadza uye kuwedzerwa kurwadziwa kwekutambudzika. Zvechokwadi, kudzivirirwa kwemapurisa kana siRNA-mediated downregulation yeKCC2 muhutano inotes mechanical allodynia.

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Nei mafudzi angu achikuvadza? Kuongororwa kwehutano hwehutano nehupenyu hwehutambudzi hwemapfudzi

Benjamin John Floyd Dean, Stephen Edward Gwilym, Andrew Jonathan Carr

Nzira uye Maitiro Maitiro Okurwadziwa

Allan I. Basbaum1, Diana M. Bautista2, Gre? Gory Scherrer1, naDavid Julius3

1Department of Anatomy, University of California, San Francisco 94158

2Department of Molecular and Cell Biology, University of California, Berkeley CA 94720 3Department of Physiology, University of California, San Francisco 94158

Nzira dzemu Molecule dzomusanaciception

David Julius * & Allan I. Basbaum

*Dhipatimendi reCellular uye Molecular Pharmacology, uye �Dhipatimendi reAnatomy nePhysiology uye WM Keck Foundation Center yeIntegrative Neuroscience, University of California San Francisco, San Francisco, California 94143, USA (e-mail: julius@socrates.ucsf.edu)

Nhoroondo yePathophysiology yeNeuropathic Pain

Nhoroondo yePathophysiology yeNeuropathic Pain

by | Cannabinoids, chisingaperi Pain, Clinical Neurophysiology, Nerve Injury, Neuropathy, Mishonga

Uturu hweNeuropathic ihwo hwakaoma, hunogara husingaperi huripo hunoenda pamwe nekurwara kwemavara. Kutambudzika kweurouropathi kunowanikwa muchechi yekliniki uye kunowedzera zvinetso kuvarwere uye navanachiremba zvakafanana. Nemarwadzo europathy, hutachiona hwehutano pachahwo hungave hunove hwakakuvadzwa, husingaiti kana hukuvara. Utano hweNeuropathic hunokonzera kukanganisa kubva mumatambudziko kana zvirwere kusvika kune imwe nzvimbo kana pakati penheyo system, apo chironda chinogona kuitika pane chero nzvimbo. Somugumisiro, izvi zvinokanganisa tsinga dzesimbi zvinogona kutumira zviratidzo zvisina kunaka kune dzimwe nzvimbo dzinorwadza. Izvozvo zvinoshandiswa nehutachiona hwekukuvara zvinoshandiswa nechinoshandiswa neural nechokuita, zvose munharaunda yekukuvadzwa uyewo kune chakakomberedza kukuvara. Zviratidzo zvehutano hwepurovhesi zvinowanzobatanidza manzwiro evanhu, zvakadai sekurwadziwa kwepakati, paresthesias uye hyperalgesia.

 

Hurukuro yeurouropathi, sezvinotsanangurwa neInternational Association of the Study of Pain kana IASP, kurwadziwa kwakatangwa kana kunokonzerwa nechirwere chepakutanga kana kusagadzikana kwemamiriro emagetsi. Izvozvo zvinogona kuguma nekukuvara kupi zvako kune neuraxis: purogiramu yenheyo yenheyo, musipinha kana supraspinal nervous system. Tsika dzinosiyanisa marwadzo europathika kubva kune mamwe marudzi ekurwadziwa dzinosanganisira kurwadziwa uye zviratidzo zvinotarirwa zvinogara zvisingaperi nguva yekudzoka. Inoratidzwa nevanhu kuburikidza nekurwadziwa kwepachivande, allodynia, kana ruzivo rwekusava nekutya kunotyisa sezvinorwadza, uye causalgia, kana kurwadziwa kunopisa kunopfuurira. Kurwadziwa kwepanyama kunosanganisira kunzwa kwe "pini uye nheyo", kupisa, kupfura, kupwanya uye kupisa kwepodysysmal, kana kushamiswa kwemagetsi sekurwadziwa, kazhinji kunobatanidza nedysesthesias uye paresthesias. Izvi zvinonzwa kwete kungogadzirisa mafungiro evarwere, asiwo murwere, hutano, kufunga uye kufunga. Hurwa neuropathic inoumba zviratidzo zviviri "zvisina kunaka," zvakadai sokurasikirwa kwekunzwa uye kuonekwa kwekunzwa, uye "zviratidzo" zvakadai, paresthesias, kurwadziwa kwepfungwa uye kuwedzera kurwadziwa.

 

Mamiriro ezvinhu anowanzoenderana nemarwadzo europathic anogona kuiswa mumapoka maviri makuru: kurwadziwa kunokonzerwa nekuparara mukati mehutano hwehutano nekurwadziwa nekuda kwekuvhiringidzwa kwehutachiona hwehutachiona hwehutano. Cortical and sub-cortical strokes, zvinoshungurudza ruvara rwemutsara, syringo-meria uye syringobulbia, trigeminal uye glossopharyngeal neuralgias, neoplastic nedzimwe nzvimbo dzinoshandiswa-zvipembenene zvipatara zvinenge zviri zveboka rekare. Nhere compress or entrapment neuropathies, ischemic neuropathy, puroopheral polyneuropathies, plexopathies, nerve root compression, post-amputation stump uye kurwadziwa kwomuviri kwepfungwa, neuralgia yepamusoro uye neuropathies zvine chokuita nekenza ndeyezvipatara zvinenge zviri zveboka rekupedzisira.

 

Pathophysiology yeNeuropathic Pain

 

Iyo pathophysiologic maitiro uye pfungwa dzinotangira marwadzo europathika akawanda. Usati wavhara matanho aya, kubvunzurudzwa kwezvakawanda zvinorwadza kutenderera kunokosha. Kurwisana kunogara kwenguva dzose kunosanganisira kushandiswa kwekwenciceptor, iyo inozivikanwawo seyakagamuchira kurwadziwa, mukupikisa kukurudzira kunorwadza. Chimwe chemafuridziro chinopiwa kune-first-order neurons, pamwe chete neyamudium inomhanya nenzira dzeyerodium uye potasium ichimhanya kunze. Neurons inopera muuropi inowanikwa mumusara wetatu kana kuti mune runyanga rwenzira yepelinha. Iko pano apo chiratidzo chinotanga magetsi-gated calcium chiteshi mu-pre-synaptic terminal, zvichiita kuti calcium inopinda. Calcium inobvumira glutamate, neurotransmitter yekunakidza, kuti ibudiswe muS synaptic. Glutamate inosunga kune avo vanopinda NMDA pamusana wechipiri-neurons, zvichikonzera kuora mwoyo.

 

Aya neuroni anoyambuka nomumutsipa wepelinha uye anofamba kusvikira thalamus, uko vanobatanidza pamwe ne-third-order neurons. Izvi zvinobatanidza kune chimbichikiti uye cerebral cortex. Ikoko kunewo nzira inodzivisa iyo inodzivisa kurwadziwa kwechiratidzo chekuparidzira kubva kune runyanga rwenheyo. Anti-nociceptive neurons inotangira muuropi dzinokonzera uye inofamba pasi musambo weropa remusana apo inopindirana nemapfupi ekutsvaga mukati meganda rekudzivirira nekubudisa dopamine uye norepinephrine. Iro interneurons inogadzirisa synapse pakati pekutanga-order neuron uye yechipiri-kuronga neuron nokubudisa gamma amino butyric acid, kana GABA, inonzi neurotransmitter inhibitory. Somugumisiro, kurwadziwa kupera kunokonzerwa nekudziviswa kwemasapapapakati pakati pekutanga neyechipiri neurons, apo kuwedzera kunorwa kunogona kuva mugumisiro wekudziviswa kwechibvumirano chechibvumirano.

 

Pathophysiology yeNeuropathic Pain Diagram | El Paso, TX Chiropractor

 

Izvo zvinokonzera marwadzo europathic, zvisinei, hazvisi zvakajeka. Zvidzidzo zvezvipfuwo zvakasiyana siyana zvakaratidza kuti nzira dzakawanda dzingave dzakabatanidzwa. Zvisinei, mumwe anofanirwa kuyeuka kuti izvo zvinoshandiswa kune zvisikwa zvingasawanzoshanda kuvanhu. Kutanga neurons yekutanga kunogona kuwedzera kupisa kwavo kana vakanganisa zvishoma uye kuwedzera huwandu hwemigero ye sodium. Ectopic discharges inokonzerwa nekudengenyeka kwepamusoro kune dzimwe nzvimbo panzvimbo ye fiber, zvichikonzera kurwadziwa kwepfungwa uye kushungurudza-kwakabatana. Zvirwere zvekudzivirira zvinogona kuderedzwa mumwero weguruva runyanga kana uropi hunokonzera masero, uyewo zvose zviri zviviri, zvichibvumira zvinetso zvekurwa kuti zvifambe zvisina kukanganiswa.

 

Mukuwedzera, panogona kuve nekuchinjwa mukati mekugadzirisa marwadzo apo, nekuda kwekutambudzika kusingaperi uye kushandiswa kweimwe mishonga uye / kana mishonga, yechipiri-uye chechitatu-order neurons inogona kuve "nekuyeuka" kwekutambudzika uye kunzwisiswa. Iko zvino kunzwisisika kunzwisisika kwepinini neuroni uye kuderedzwa kushandiswa kwemiromo. Imwe nyanzvi inoratidzira pfungwa yekunzwira tsitsi-yakachengetwa neuropathic kurwadziwa. Iyi pfungwa yakaratidzwa neanalgesia inotevera sympathectomy kubva kumhuka nevanhu. Zvisinei, kusanganiswa kwema mechanics kunogona kusanganiswa mune dzakawanda zvisingaverengeki neuropathic kana zvakasanganiswa somatic uye mamiriro ekurwadziwa kweuropathy. Pakati pezvinetso mumunda unorwadziwa, uye zvakanyanya zvakanyanya sekureva kurwadziwa kweuropa, ndiko kukwanisa kuzviongorora. Pano pane chikamu chechipiri kune izvi: kutanga, kuongorora unhu, kuwedzera uye kufambira mberi; uye wechipiri, kunyatsoongorora chirwere cheuropathy.

 

Kune, zvisinei, zvimwe zvishandiso zvinoshandiswa zvinogona kubatsira vhigirizheni mukuongorora kuora kweuropathi. Kutanga, zvidzidzo zvehutano hwehutano uye zvinogona kuonekwa-zvinokanganisa zvinogona kuziva uye kuenzanisa kuwanda kwekuvhiringidzika kwemazwi, asi kwete maitiro, maitiro nekutarisa neurophysiological mhinduro kumagetsi emagetsi. Uyezve, kuwanda kwezvinhu zvinongororwa kuongororwa matanho ekuona kusangana kune zvinowedzera kunze kwekutsvaga kwakasimba kuburikidza nekushandura kweganda. Inyanzvi yehutachiona yehutachiona hunogadziriswa inotaridzwa nemashandisirwo akadai, anosanganisira von Frey vhudzi, pinprick ine nheyo dzinopindira, pamwe nekuderera kwekudzivirira pamwe chete nema vibrameter uye kupisa kwemafuta ne thermodes.

 

Zvinonyanya kukosha kuti uite zvakananga neurological assessment kuti uone motokari, manzwiro uye kuvhiringidzika. Pakupedzisira, kune mibvunzo yakawanda inoshandiswa kusiyanisa marwadzo europathik mukurwadziwa kwema nociceptive. Zvimwe zvacho zvinosanganisira mibvunzo yekubvunzurudza (semuenzaniso, Mibvunzo yeNeuropathic uye ID Pain), asi vamwe vane mibvunzo yekubvunzurudza uye miedzo yenyama (semuenzaniso, Leeds Assessment ye Neuropathic Symptoms and Signs scale) uye iyo chaiyo inozive chinhu, Kuongororwa Kwemaitiro Pain, iyo inobatanidza mibvunzo mitanhatu yekukurukurirana uye gumi yekuongorora kwepanyama.

 

Neuropathic Pain Diagram | El Paso, TX Chiropractor

 

Kurapa Kuenzanisa Neuropathic Pain

 

Dzidzo yepamusoro yepamusoro inotarirwa nenzira dzehutano hwepfungwa. Zvisinei, zvose pharmacologic uye kwete-pharmacologic mishonga inopa ruregerero rwakakwana kana rusununguko anenge anenge hafu yevarwere. Uzhinji hunopupurirwa hunopupurirwa hunoti hunoshandisa kusanganiswa kwezvinodhaka uye / kana mishonga yekushandira nzira dzakawanda sezvingagona. Ruzhinji rwekutsvakurudza rwakatsvakurudza kunyanya post-herpetic neuralgia uye kurwadza kwechirwere cheshuga neuropathies asi zvinoguma zvisingashandisi kune zvose zvinorwadza neuropathic.

 

Antidepressants

 

Zvinodhaka zvinokonzera synaptic serotonin uye norepinephrine mazinga, zvichiita kuti iwedzere kuguma kwechirwere chechirwere chinokonzera marwadzo europathic. Vanga vari iyo inonyanya kukosha yehutano hwehutano hwehutano. Maitiro anonzi Analgesic angangodaro anokonzerwa ne-nor-adrenaline uye dopamine reuptake blockade, iyo inogona kunge ichiwedzera kukura kwekudzivirira, NMDA-receptor kupikisana uye sodium-channel blockade. Tricyclic vanodzvinyirira, zvakadai seTCAs; somuenzaniso, amitriptyline, imipramine, nortriptyline uye doxepine, vane simba pakurwisana nekuputika kana kurwadziwa kunopisa pamwe nekurwadziwa kwepfungwa.

 

Tricyclic zvinodzvinyirira zvakave zvichiratidzwa zvakajeka zvakanyanya pakurwadziwa kweuropathic kupfuura serotonin reuptake inhibitors, kana SSRIs, zvakadai se fluoxetine, paroxetine, sertraline uye citalopram. Chikonzero chinogona kunge chiri chokuti vanovhara reuptake ye serotonin uye nor-epinephrine, nepo SSRI inongorambidza serotonin reuptake. Tricyclic vanodzvinyirira vanogona kuva nemigumisiro yakaipa, kusanganisira kushungurudza, kuvhiringidzika, kutengesa mwoyo mukati, tachycardia uye ventricular arrhythmias. Zvinogonawo kuita kuti uwedzere uremu, chidimbu chinoputika chikumbaridzo uye hutachiona hwehutano. Tricyclics inofanira kushandiswa nekutarisira kune vakwegura, avo vari kunyanya kunetseka pamigumisiro yavo yakaoma. Mushonga wezvinodhaka muropa unofanira kuongororwa kuti urege kutyisa kune varwere vanononoka mishonga metabolizers.

 

Serotonin-norepinephrine reuptake inhibitors, kana SNRIs, iboka idzva revanodzvinyirira. Kufanana neTCAs, vanoita sevanoshanda kupfuura SSRIs pakurapa marwadzo europathic nokuti vanodzivisa zvakare reuptake yezvose kana-epinephrine uye dopamine. Venlafaxine inoshanda zvakasimba pakurwisana nehutachiona hwepuroneuropathies, dzakadai sekurwadziwa kwechirwere cheshuga yeuropathy, semipramine, mukutaura kweTCA, uye iyo mbiri inokosha zvikuru kupfuura placebo. Kufanana neTCAs, SNRIs inoratidzika kuti inopa rubatsiro rusununguko rwemagariro avo anodzvinyirira. Zvimwe zvinokonzera zvinosanganisira sedation, kuvhiringidzika, kuwedzera kwehutano uye kuregera chirwere.

 

Antiepileptic Zvinodhaka

 

Antiepileptic zvinodhaka zvinogona kushandiswa sekurapa kwekutanga-kunyanya kune mamwe marudzi ekurwadziwa kweuropathy. Vanoita nekugadzirisa magetsi-gated calcium uye michina ye sodium, kuburikidza nekuvandudza migumisiro yekudzivirira yeGABA uye nekudzivisa kupindira kwekutengesa glutaminergic. Anti-epileptic mishonga haina kuratidzirwa kuti inoshanda mukurwadziwa kwakanyanya. Mumakumbo asingagumi, antiepileptic zvinoratidzika seinobudirira chete muzvitatu zveeuralgia. Carbamazepine inowanzoshandiswa pane izvi. Gabapentin, iyo inoshanda nekudzivisa calcium channel inoshanda kuburikidza nezviito zveagonist pa alpha-2 delta subunit ye ​​calcium channel, inozivikanwawo kuti inobudirira pakurwadziwa kweuropathi. Zvisinei, gabapentin inoshanda mukati uye inogona kukonzera kuneta, kuvhiringidzika uye kunyarara.

 

Kwete-Opioid Analgesics

 

Pane kushaikwa kwemashoko akasimba anotsigira kushandiswa kwemishonga isina-steroidal anti inflammatory, kana kuti NSAIDs, mukuzorora kwekutambudzika kweuropati. Izvi zvingave zvakakonzerwa nokushayikwa kwechirwere chekuvhiringidza pakuderedza marwadzo. Asi zvakashandiswa zvakasiyana-siyana neapioid sevanokurudzira mukurapa kurwadziwa kwekenza. Izvo zvakambove zvichirondedzerwa, kunyange zvakadaro, kunyanya mune zvakanyanya kuora mwoyo varwere.

 

Opioid Analgesics

 

Opioid analgesics ndeyekukakavadzana kukuru mukuderedza marwadzo europathic. Vanoita kuburikidza nekudzivisa hukuru hukwira hunova nemarwadzo ekurwadza. Nenzira, marwadzo europathic akamboonekwa kuti ane opioid-resistant, umo maopioid ndiyo yakakodzera nzira dzekodonary uye somatic nociceptive marwadzo emarudzi. Vanachiremba vazhinji vanodzivisa kushandisa maopioid kurapa marwadzo europathic, muchikamu chikuru nekuda kwekunetseka pamusoro pekushandisa zvinodhaka, kukanganisa uye nyaya dzekutonga. Asi, pane mimwe miedzo yakawana maangeso opioid kuti abudirire. Oxycodone yaive yakakwirira pane placebo yekudzivirira marwadzo, allodynia, kuvandudza kurara nekuremara. Opioids inodzorwa-yakasunungurwa, maererano nehurongwa hwakarongerwa, inorumbidzwa kune varwere vane marwadzo anogara achikurudzira kuti varambe vachiwedzera maitiro ealgesia, kudzivirira kuchinja kwehutachipa reropa uye kudzivirira zviitiko zvakashata zvine chokuita nepamusoro dosing. Kazhinji kazhinji, kugadzirira muromo kunoshandiswa nekuda kwekusununguka kwavo kwekushandisa nekudhura-kubudirira. Kutenda-dermal, parenteral uye kugadziridza kwemashure kunowanzoshandiswa kune varwere vasingagoni kubvumira zvinodhaka zvemuromo.

 

Local Anesthetics

 

Pedyo nekuita anesthetics inofadza nokuti, nekuda kwekuita kwavo kwemuganhu, vane minda yakaipa. Vanoita nekugadzirisa miviri ye sodium pamakwikoni emakona ekutanga-neurons. Vanoshanda zvakanakisisa kana paine kungoerekana kusarura musungo uye kupfurikidza nemigero ye sodium yakaunganidzwa. Nyaya dzepamusoro lidocaine ndiye mumiririri anonyatsodzidza wedzidzo yekutambudzika kweuropati. Kunyanya, kushandiswa kweiyi 5 yeputi lidocaine patch ye-post-herpetic neuralgia yakakonzera kugamuchirwa naRFA. Chigamba chinoratidzika sechishanda zvakanaka kana chichikuvadzwa, asi chakachengetedzwa, purogiramu yenherera system nociceptor basa kubva kune iyo inobatanidza dermatome inoratidza sa allodynia. Inofanirwa kuiswa zvakananga munzvimbo ine chiratidzo chemaawa e12 uye yakabviswa kune imwe nguva yama12 uye inogona kushandiswa kwemakore nenzira iyi. Kunze kwekuita kweganda remukati, zvinowanzomirirwa zvakanaka nevarwere vakawanda vane marwadzo europathic.

 

Zvimwe zvinodhaka Zvinodhaka

 

Clonidine, an alpha-2-agonist, yakaratidzwa kuti inoshanda mune imwe sarudzo yevarwere vane chirwere cheshuga chinoputika neuropathy. Zvinyorwa zvinogona kuwanika kuti zvinobatsira pakuedza kuenzanisa marwadzo emhuka mumhando yezvipfuwo uye uchapupu hwehubudirira huri kuunganidza. CB2-selective agonists inoparadza hyperalgesia uye allodynia uye kuisa pasi maitiro ekudzivirira pasina kukanganisa marwadzo.

 

Interventional Pain Management

 

Mishonga inogadziriswa inogona kuonekwa kune varwere vane chirwere chisingaiti chinonzi neuropathic. Izvi zvinosanganisira zvipembenene zvepidural kana pineinural yeanesthetics yepanyika kana corticosteroids, kuiswa kwepidural uye intrathecal zvinoshandiswa pakushandisa zvinodhaka uye kuiswa kwemutsipa wepelinha stimulators. Iyi nzira yakachengeterwa varwere vane marwadzo asingagoneki neuropathic avo vasina kukanganisa kurapwa kwekuchengetedzwa kwezvokurapa uyewo vakave nekuongororwa kwakakwana kwepfungwa. Mune chidzidzo chaKim et al, zvakaratidzwa kuti muspinha tsvimbo stimulator yakashanda mukurapa marwadzo europathic emutsipa midzi.

 

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Dr. Alex Jimenez's Insight

Nemarwadzo europathic, zvirwere zvisingaperi zvinosuruvara zvinoitika nekuda kwehutachiona hwehutano pachahwo huri kukuvadzwa, husina basa kana kuti hukuvara, kazhinji hunoendeswa nekukuvadza kwemavara kana kukuvara. Somugumisiro, izvi zvinokonzera mutsara zvinogona kutanga kutumira zviratidzo zvisina kunaka kune dzimwe nzvimbo dzomuviri. Migumisiro yemarwadzo europathy anokonzerwa nekukuvara kwehutachiona inosanganisira kugadziriswa kwehutano hunoshanda panzvimbo yekukuvadzwa uye munzvimbo dzakapoteredza kukuvara. Kunzwisisa pathophysiology yekutambura kwepfungwa kwave kuri chinangwa chevashandi vazhinji vehutano, kuitira kuti vaone zvakajeka nzira yekurapa kubatsira kubatsira nekugadzirisa zviratidzo zvayo. Kubva kushandiswa kwezvinodhaka uye / kana mishonga, kuchipatractic kuchengetedza, kurovedza muviri, kuita zvekuita uye kudya kunovaka muviri, nzira dzakasiyana-siyana dzokurapa dzinogona kushandiswa kubatsira kubvisa marwadzo europathic kune zvinodiwa nomunhu mumwe nomumwe.

 

Zvimwe Zvinyorwa Zvitsva Neuropathic Pain

 

Vakawanda vevarwere vane marwadzo europathic vanotevera kuwedzera pamwe uye mamwe maitiro ekurapa maitiro ekurapa marwadzo europathic. Zvimwe zvirongwa zvinoshandiswa pakurapa marwadzo europathic zvinosanganisira kugadziriswa, kushandiswa kwemagetsi emagetsi ekusimudzira, kutengesa magetsi emagetsi ekusimudzira, kufungidzira kwekuita maitiro, kurapa motokari yemifananidzo uye kutsigira kurapa, uye kurovedza muviri. Pakati pavo, chiropractic ndeye nzira inozivikanwa yekurapa inowanzoshandiswa kubatsira kubata marwadzo europathic. Chiropractic kuchengetedza, pamwe nekurapa kwepanyama, kurovedza muviri, kudya kunovaka muviri uye kugadzirisa mararamiro eupenyu kunogona kupedzisira kunopa rubatsiro rwezviratidzo zvekurwadziwa kweuropathic.

 

Chiropractic Care

 

Izvo zvinozivikanwa ndezvokuti kushandiswa kwakakwana kwekushanda kunokosha mukurwisana nemigumisiro yekutambudzika kwepfungwa. Nenzira iyi, chiropractic kutarisira chirongwa chakakwana chekurapa chinogona kubudirira mukudzivirira nyaya dzehutano dzakabatana nehutano hwehutano. Chiropractic inopa rubatsiro kuvarwere vane mamiriro mazhinji akasiyana, kusanganisira avo vane marwadzo europathic. Vanorwara nehutano hweuropathy vanowanzoshandisa mishonga isina-steroidal-anti-inflammatory, kana kuti NSAIDs, dzakadai se ibuprofen, kana kuti nzara inorayirirwa pazvinillers kuti vabatsire kunetsa marwadzo europathic. Izvi zvinogona kupa chirongwa chenguva pfupi asi chinoda kushandiswa nguva dzose kugadzirisa marwadzo. Izvi zvinogara zvichiita kuti zvive nemigumisiro yakaipa uye mumamiriro ezvinhu akaipisisa, kushandiswa kwechirongwa chekushandisa zvinodhaka.

 

Chiropractic kuchengetedza inogona kubatsira kuvandudza zviratidzo zvehutano hwepfungwa uye kusimbisa kugadzikana kunze kwezvikonzero izvi. Imwe nzira yakadai sechiropractic inotarisira inopa purogiramu yakasiyana-siyana yakagadzirirwa kuti ione kuti chii chinokonzera nyaya yacho. Nokushandiswa kwemagunha uye magwaro, chiropractor inogona kunyatsogadzirisa chero upi noupi hwepelinha, kana kuti kuwedzerwa, kunowanikwa pamwe nehupamhi hwepamusoro, iyo inogona kuderedza migumisiro yeropa wracking kuburikidza ne realigning yemasana. Kudzorera kutenderera kwepelinha kunokosha kuti uchengetedze hurongwa hwepamusoro hwehutano hwemagetsi.

 

A chiropractor anogonawo kuva kwenguva yakareba kurapwa pakunatsiridza hupenyu hwako hwose. Kunze kwekugadziriswa kwemusana uye nzira dzekushandisa, chiropractor inogona kupa mazano ekudya, zvakadai sokurondedzera kudya kwakachengetedzeka mune antioxidants, kana kuti inogona kugadzira chirwere chepanyama kana chirongwa chekurovedza muviri kurwisa kurwadziwa kwemitsipa flair-ups. Chirwere chemazuva mazhinji chinoda chirongwa chemazuva mazhinji, uye mune izvi, mudzidzisi wehutano anonyanya kuisa mukukuvara uye / kana mamiriro ezvinhu anokonzera musishungurudzo uye manzwiro emagetsi, akadai sachiremba wechiropractic kana chiropractor, angave anokosha sezvaanoshanda kuti kuenzanise kuchinja kunofadza kwenguva.

 

Kurapa kwepanyama, maitiro uye mafambiro ekumiririra maitiro ave akaratidzwa kuti anobatsira kurapa kurwadziwa kweukama. Chiropractic kuchengetedza inopawo mamwe maitiro ekurapa angangobatsira kune vatungamiri kana kuvandudza marwadzo europathic. Low level laser therapy, kana LLLT, somuenzaniso, yakave yakakurumbira sekurapa kwekutambudzika kweuropathi. Maererano nekutsvakurudza kwakasiyana-siyana, zvakagadziriswa kuti LLLT yakava nemigumisiro yekudzora marwadzo ekurwadziwa kweuropathic, zvisinei, zvidzidzo zvekare zvinowanzotarisirwa kurondedzera zvirongwa zvekurapa zvinopfupikisa migumisiro yepamusoro yezinga laser therapy muhutano hwehutano hwehutano.

 

Chiropractic kuchengetedzawo inosanganisira mazano ekudya, izvo zvinogona kubatsira kudzora zvirwere zvinokonzerwa nechirwere cheshuga neuropathy. Munguva yekutsvakurudza kwekutsvakurudza, kudya kwakaderera kwemafuta kunokonzerwa nekudyara kwakaratidzwa kuvandudza glycemic control muvarwere vane chirwere chechirwere cheshuga 2. Mushure memavhiki e20 echidzidzo chekutsvaga, avo vaibatanidzwa vakazivisa kuchinja muhutano hwavo hwemagetsi uye electrochemical skin conductance mutsoka yakanzi yakagadziridzwa nekupindira. Tsvakurudzo yakatsvakurudza yakaratidza kuti inogona kukosha mune zvakaderera-miti inogadziriswa mishonga yekupindira kwechirwere cheshuga neuropathy. Uyezve, zvidzidzo zvekuchirapa zvakawana kuti kunyora kushandiswa kwe magnesium L-threonate kunogona kudzivirira pamwe nekudzorera kukanganwa kwepfungwa kunobatanidza nehupenzi hwepfungwa.

 

Chiropractic kuchengetedza inogona kupawo mamwe maitiro ekurapa ekukurudzira kushandiswa kwemishonga. Nenzira imwecheteyo, kukurudzira kushandiswa kwemasikoni kwakarongedzwa kubatsira kubatsira kuvandudza kushandiswa kwehutano mushure mekurwa kwehutano hwemagetsi. Kukurudzira magetsi, pamwe chete nekurovedza muviri kana mabasa epanyama, zvakawanikwa kukurudzira kushandiswa kwemishu mushure mekurumidza kunonoka kugadziriswa kwevanhu nemakonzo, maererano neongororo dzechangobva kuitwa. Zvose zvekugadzirisa magetsi uye yekurovedza muviri zvakagadziriswa kuva nekupikira kurapa kwekuedza kweropa rekushaya mungozi rinoratidzika kugadzirira kuendeswa kuchipatara. Zvimwe zvidzidzo zvekutsvaga zvinogona kudiwa kuti zvigadzirise zvakakwana mhinduro dzeizvi kune varwere vane marwadzo europathic.

 

mhedziso

 

Kurwadziwa kweNeuropathic chinhu chakasiyana-siyana chisina mirau yekutarisira. Izvo zvakanaka zvinogoneswa uchishandisa nzira dzakasiyana siyana. Kurapa manejimendi kunoda kuenderera kwekuongorora, dzidzo yemurwere, kuverengera kuteedzera kwevarwere uye kuvimbiswa. Kurwadziwa kweNeuropathic chiitiko chisingaperi chinoita kuti sarudzo yekurapa kwakanyanya kuome. Kuzvimiririra kurapwa kunosanganisira kufunga nezve maratidziro ekurwadziwa pahupenyu hwemunhu, kushushikana uye hurema pamwe nekuenderera mberi nedzidzo uye kuongorora. Neuropathic marwadzo ekudzidza, ese ari maviri mamorekuru uye mumhando dzemhuka, iri nyowani asi inovimbisa zvikuru. Kugadziridza kwakawanda kunotarisirwa mune yekutanga uye yekiriniki minda yekurwadziwa kweuropathic nekudaro kuvhura madhoo ekuvandudzwa kana nyowani marapirwo maitiro eiyi mamiriro ekuremadza. Chiyero cheruzivo rwedu chinogumira kuchiropractic pamwe nekukuvara kwepamuviri nemamiriro. Kuti ukurukure nyaya yacho, ndapota inzwa wakasununguka kubvunza Dr. Jimenez kana kuti tibate isu pa 915-850-0900 .

 

Yakarongedzwa naDkt Alex Jimenez

 

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Zvimwe Zvinyorwa: Kubva Painini

 

Kutambudzika shure ndechimwe chezvikonzero zvakakosha zvikuru zvekuremara uye mazuva asina kukwana kubasa pasi rose. Sezvakangoitika, kurwadziwa kwekudzokera shure kwave kuchiitwa sechipiri chikonzero chikuru chechiremba chekushanyira, chakanyanya kupfurikidza nehutachiona hwepamusoro-kuporesa. Inenge 80 muzana yevanhu vanozoona rumwe rudzi rwemarwadzo emutsipa kamwechete kamwe chete muupenyu hwavo hwose. Iyo musana inorongwa yakaoma yakaumbwa nemapfupa, mafundo, magirasi nemasumbu, pakati pezvimwe zvinyoro zvishoma. Nemhaka yeizvi, kukuvadzwa uye / kana mamiriro ezvinhu akawandisa, akadai herniated discs, zvinogona kutungamirira kune zviratidzo zvekurwadziwa shure. Kukuvara kwemitambo kana kukuvara kwepamberi yemotokari kazhinji kunowanzokonzera kukonzera kurwadziwa, zvisinei, dzimwe nguva kufamba kwakanyanya kunogona kuva nemigumisiro inorwadza. Nenzira yakanaka, nzira dzakasiyana dzokurapa, dzakadai sechiropractic, dzinogona kubatsira kuderedza marwadzo shure kuburikidza nekushandurwa kwepelinha nekugadzirisa maitiro, pakupedzisira kunatsiridza marwadzo ekurwadziwa.

 

 

 

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Kurasikirwa Kurara Kunowedzera Ngozi Yokunyanyisa

Kurasikirwa Kurara Kunowedzera Ngozi Yokunyanyisa

by | Cannabinoids, Natural Health, Wellness

Kurasikirwa nehope kunowedzera mukana wekuve wakakwana, maererano nekuSweden kuongorora. Vatsvakurudzi vanobva kuUppsala University vanoti kusagona kwehope kunokanganisa simba metabolism kuburikidza nekuvhiringidza kurara uye kugadzirisa mhinduro yemuviri kune zvokudya nekurovedza muviri.

Kunyange zvazvo zvidzidzo zvakasiyana-siyana zvakawana kuwirirana pakati pokurara kwekurara uye kuwedzera kuwedzera, chikonzero chakanga chisina kunyatsojeka.

Dr. Christian Benedict nevamwe vake vakaita zvidzidzo zvevanhu kuti vaongorore kuti kurasikirwa kurara kungaita sei simba remasabolism. Izvi zvidzidzo zvakayera nekufungidzira maitiro, zvepanyama, uye zvinyorwa zvezvinyorwa zvezvokudya zvinotevera kusarara kwakanyanya.

Nhoroondo yehutano inoratidza kuti mararamiro ane utano hwakanaka, kurara-asingabhadharwi nevanhu vanotora zvimwe zvikamu zvakakura zvezvokudya, kutsvaka mamwe makoriori, kuratidzira zviratidzo zvekuwedzera kusagadzikana kwakabatana nechikafu, uye kushandisa simba shoma.

Zvidzidzo zvezvemagariro eboka zvinoratidza kuti kurasikirwa nekurara kunoshandura hutori hwemahomoni kubva kumahomoni anokurudzira kuzadza (satiety), akadai se GLP-1, kune avo vanosimudzira nzara, zvakadai seghrelin. Kurambidzwa kwehope kwakawedzerawo maitiro e endocannabinoids, ayo anozivikanwa kuti afadze chido.

Mukuwedzera, kutsvakurudza kwavo kwakaratidza kuti kurasikirwa kwakanyanya kwekurara kunoshandura chikero chegomba mabhakitiriya, ayo ave akabatanidzwa zvakanyanya senzira yekuchengetedza utachiona hwemagetsi. Chidzidzo ichocho chakawanawo kuderera kunononoka kune insulin mushure mekurasikirwa kurara.

"Kubvira kurara kunokonzerwa nehutano hwakafanana nehupenyu hwemazuva ano, zvidzidzo izvi zvinoratidza kuti hazvishamisi kuti zvinetso zvemagetsi, zvakadai sokuwedzeredza zviri kuwedzerawo," akadaro Benedict.

"Zvidzidzo zvangu zvinoratidza kuti kurasikirwa nehope kunobatsira kuwana kuwedzera kwevanhu," akadaro. "Zvinogonawo kugumiswa kuti kubudirira kurara kunogona kuva mararamiro anovimbisa mararamiro ekuderedza dambudziko rekuwedzerwa kwemahombekombe."

Kwete kungoshaya kwehope kuwedzera mapaundi, mamwe tsvakurudzo akawana kuti chiedza chakawanda paunenge wakarara kunogonawo kuwedzera dambudziko rako rekuneta. Kuongorora kweBritain kwevakadzi vechi113,000 vakawana kuti kana chiedza chavo chava pachena pane nguva dzekurara, inowedzera dambudziko ravo rokuva mafuta. Chiedza chinokanganisa muviri we circadian rhythm, iyo inokanganisa kurara uye mapoka ake, uye inobatawo kugadzirisa kwemasabolism.

Asi kuwana kujekesa kuchiedza mumaawa ekutanga anomuka kunogona kubatsira kuwedzera uremu. Chidzidzo kubva kuNorthwestern University yakagamuchira kuti vanhu vane zvakawanda zvekutsvaga kwezuva, kunyange kana yakasvibiswa, mangwanani-ngwanani ezuva raive nechepasi mashoma manyorerwo (BMI) kupfuura avo vane zuva ravo rekutsvaga mushure mezuva, zvisinei nokuti basa, caloric kudya, kana makore.