Kubatana kweMetabolic pakati peChirwere Chisingaperi (Chikamu 1)

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ziviso

Dr. Alex Jimenez, DC, anoratidza kuti kuwirirana kwemetabolism kunokonzera sei ketani kune zvirwere zvakakura zvisingaperi mune iyi 2-chikamu mutsara. Zvinhu zvakawanda zvinowanzoita basa muhutano hwedu uye hutano. Inogona kutungamira kune yakawandisa njodzi zvinhu zvine chekuita nemarwadzo-sezviratidzo mumamhasuru, majoini, uye nhengo dzinokosha. Chikamu 2 chinoenderera mberi nemharidzo yekubatanidza metabolic nezvirwere zvisingaperi. Isu tinotaura nezvevarwere vedu kune vane certified varapi vekurapa vanopa aripo marapirwo ekurapa kune vanhu vanorwara nechirwere chisingaperi chine chekuita nekubatana kwemetabolic. Tinokurudzira murwere wega wega pazvinenge zvakakodzera nekuvaendesa kune vanosanganisirwa varapi maererano nekuongororwa kwavo kana zvavanoda. Isu tinonzwisisa uye tinobvuma kuti dzidzo inzira inoshamisa kana tichibvunza mibvunzo yakakosha yevanotipa pachikumbiro uye nemvumo yemurwere. Dr. Jimenez, DC, anoshandisa ruzivo urwu sebasa rekudzidzisa. Disclaimer

 

Kuti Kuzvimba Kunobata Sei Muviri

Dr. Alex Jimenez, DC, anopa: Saka pano une seti yakaonda yeadipocyte kuruboshwe, uye zvino pavanotanga kuzara nehuremu hwemasero, unoona macrophage aya, mabhunu egirinhi achiuya achitarisa, achiti, “Heyi, chii chiri kuitika pano? Hazvina kutaridzika zvakanaka." Saka vari kuferefeta, uye izvi zvinokonzeresa kufa kwesero renzvimbo; chinongova chikamu chekuputika kwechirwere. Saka pane zvakare imwe nzira iri kuitika pano. Adipocytes iwayo haasi kungowedzera kudonha netsaona; inowanzoenderana nekoriori surfette. Saka ichi chekudya chakawandisa chinokuvadza iyo endoplasmic reticulum, zvichiita kuti kuwedzere kuzvimba. Izvo masero aya uye adipocytes ari kuedza kuita kuzvidzivirira kubva kune glucose uye lipo toxicity.

 

Uye yesero yese, iyo adipocyte cell, iri kugadzira macaps aya ari kuyedza kuti, "Ndapota mira, isu hatichatora imwe glucose, hatichatora mamwe lipids." Iyo nzira yekudzivirira inozivikanwa se insulin resistance. Hachisi chimwe chinhu chinongoitika. Ndiyo nzira yemuviri yekuedza kudzivirira glucose uye lipotoxicity. Iye zvino iyo alarm yekuzvimba iri kuitika kupfuura kungoita muadipocytes, iri kuwana systemic. Mamwe matishu uye nhengo dziri kutanga kunzwa mutoro mumwe chete wecalorie surfette, zvichikonzera kuzvimba uye kufa kwesero. Saka glucose uye lipotoxicity zvinotaridzika sechiropa chine mafuta kana uchibata nechiropa. Uye iwe unogona zvakare kuve nazvo sekuti chiropa chine mafuta chinoenda ku cirrhosis nehepatocyte kufa. The same mechanism iri kuitika mumaseru mhasuru. Saka skeletal tsandanyama masero edu anonyatso kuona sero kufa mushure mekuzvimba uye kuona mafuta ekuisa.

 

Nzira yakanakisa yekufunga nezvazvo ndeye, semuenzaniso, mhou dzakapfuudzwa kuti dzidyiwe uye kuti dzave nemarble. Saka ndiko kuisa mafuta. Uye muvanhu, unogona kufunga nezvekuti vanhu vanova sei sarcopenic pavanenge vachiwedzera kuramba insulin. Ndizvo zvimwe chete zvinoitika kana nyama yemuviri ichiedza kuzvidzivirira kubva kuglucolipotoxicity, zvichikonzera mhinduro yekuzvimba munharaunda. Inova mhinduro ye endocrine painotanga kunanga mamwe matishu ari padyo, ingave chiropa, tsandanyama, bhonzo, kana uropi; ndizvo chete zviri kuitika; vari mu visceral adipocytes inogona kuitika mune mamwe manyama. Saka ndiyo paracrine effect yako. Uye zvino inogona kuenda kuhutachiona, kana uchida.

 

Kuzvimba kwakabatana neInsulin Resistance

Dr. Alex Jimenez, DC, anopa: Uri kuwana iyi yemuno uye systemic pro-kuzvimba mhinduro yakasanganiswa ne insulin kuramba, uchidzokera kune iyi nzira yekudzivirira kubva kune glucose uye lipotoxicity. Pano iwe unoona kuti tsinga dzeropa dziri mutsinga dzedu dzinobatwa sei muchiuno chekuisa mafuta uye kufa kwesero. Saka iwe uchaona tsinga dzeropa dzinodonha uye mafuta anoiswa, uye iwe uchaona kukuvadzwa uye pro-atherogenesis. Zvino, ichi chinhu chatakatsanangura muAFMCP cheiyo cardiometabolic module. Uye ndiyo physiology kuseri kwe insulin receptor. Izvi zvinozivikanwa sekiyi yekukiya uye jiggle. Saka iwe unofanirwa kuve ne insulin yekuvhara mukati me insulin receptor kumusoro kumusoro., iyo inozivikanwa sekiyi.

 

Uyezve pane phosphorylation cascade inonzi jiggle iyo inobva yagadzira iyi cascade inozopedzisira yaita kuti glucose-4 nzira dzivhure glucose-4 receptors kuti ipinde muchitokisi kuti ive ipapo iyo glucose, iyo inobva yashandiswa simba. kugadzirwa nemitochondria. Ehe, insulin kuramba ndiko uko iyo receptor haina kunamira kana seinoteerera. Uye saka haungotadzike chete kuisa glucose muchitokisi kuti igadzire simba, asi iwe uri kupawo hyper insulin mamiriro munharaunda. Saka iwe unowana hyperinsulinemia pamwe ne hyperglycemia mune iyi nzira. Saka chii chatingaita nezvazvo? Zvakanaka, zvakawanda zvinovaka muviri zvakaratidzwa kuvandudza kukiya uye jiggle zvinhu zvinogona kuvandudza glucose-4 vatakuri vanouya vakananga kunharaunda.

 

Anti-Inflammatory Supplements Inoderedza Kuzvimba

Dr. Alex Jimenez, DC, anopa: Iwe unoona izvi zvakanyorwa pano: vanadium, chromium, sinamoni alpha lipoic acid, biotin, uye mumwe mutambi mutsva, berberine. Berberine ndeye botanical iyo inogona kudzikamisa ese ekutanga pro-kuzvimba masaini. Saka chii chinotangira izvi comorbidities kazhinji uye iko insulin kusashanda. Zvakanaka, chii chinotangira insulin kusagadzikana kakawanda? Kuzvimba kana huturu. Saka kana berberine iri kubatsira iyo yekutanga kuzvimba nyaya, inogadzirisa kudzika kwe insulin kuramba uye zvese comorbidities zvinogona kuitika. Saka funga berberine sechisarudzo chako. Saka zvakare, izvi zvinokuratidza kuti kana iwe uchigona kuderedza kuzvimba kumusoro kumusoro, unogona kuderedza akawanda cascade mhedzisiro kuzasi. Berberine inonyatsoita senge ichiita muiyo microbiome layer. Inogadzirisa gut microbiota. Inogona kugadzira kumwe kushivirira kwekudzivirira kwemuviri, nekudaro kwete kupa kuzvimba kwakawanda.

 

Saka funga berberine seimwe yezvishandiso zvaunogona kushandisa kutsigira insulin kusashanda uye insulin kushorwa-ane chekuita necomorbidities. Berberine inoita seinowedzera insulin receptor kutaura, saka kukiya uye jiggle inoshanda zvakanyanya uye inovandudza cascade nevatakuri veglucose-4. Ndiyo imwe nzira yaunogona kutanga nayo kutsvaga chikonzero cheakawanda emamiriro atakakurukura paunoona paracrine uye endocrine glucose toxicity, lipotoxicity organ kukuvara. Iye zvino imwe nzira yekuti iwe ufunge nezvekushandisa NF kappa B. Saka chinangwa ndechekuita kuti NF kappa B irambe iripo nekuti chero isingatapuke, zviratidzo zvekuzvimba zvakawanda hazvibatike.

 

Saka chinangwa chedu ndechekuchengetedza NF kappa B yakadzikama. Tingazviita sei? Zvakanaka, isu tinogona kushandisa NF kappa B inhibitors. Saka mune iyi mharidzo yesarudzo dzekurapa kune chero comorbidities ine chekuita nekusashanda kwe insulin, kune nzira dzakawanda dzekudzikisa aya anopindirana mamiriro anobata miviri yedu. Saka iwe unogona kukanganisa zvakananga insulin kuramba kuburikidza ne-anti-inflammatory supplements kana zvisina kunanga kubatsira insulin kuramba kana insulin kusashanda nekusimudzira zvinhu kurwisa kuzvimba. Chikonzero kana iwe uchirangarira, insulin kusashanda ndiko kunokonzeresa zvese izvo comorbidities. Asi chinokonzeresa kusashanda kwe insulin kazhinji kuzvimba kana chepfu. Saka chinangwa chedu ndechekugadzirisa zvinhu zvepro-inflammatory. Nekuti kana tikakwanisa kugadzirisa zvinhu zvepro-kuzvimba uye nekudzvanya kusashanda kwe insulin mubud, tinogona kudzivirira kukuvadzwa kwenhengo yepasi kana kusashanda kwenhengo.

 

Kuderedza Kuzvimba Mumuviri

Dr. Alex Jimenez, DC, anopa: Ngatienderere mberi kune chikamu chinotevera chaunogona kukwidziridza kana kuderedza kuzvimba uye kukuvara kwesobho ye insulin kana uchida, kuti majini anogeza mumuviri. Iyi ndiyo yaunowanzonzwa mumharidzo yedu, uye imhaka yekuti, mukurapa unoshanda, tinobatsira kugadzirisa ura. Ndiko kazhinji kwaunoda kuenda. Uye iyi ndiyo pathophysiology nei tichiita izvozvo mu cardiometabolic mushonga. Saka kana iwe uine chikafu chisina kunaka kana chinosiririsa, icho chemazuva ano chikafu chekumadokero chine mafuta akaipa, chinokuvadza zvakananga microbiome yako. Shanduko iyoyo mumicrobiome inogona kupa kuwedzera kwemukati memukati. Uye zvino lipopolysaccharides inogona kufambisa kana kubuda muropa. Kusvika ipapo, immune system inoti, "Aiwa, shamwari. Haufanire kunge uri muno." Iwe une aya endotoxins imomo, uye ikozvino kune yemuno uye systemic kuzvimba mhinduro yekuti kuzvimba kunotyaira kusashanda kwe insulin, izvo zvinokonzeresa kusagadzikana kwe metabolic kunouya mushure meizvozvo.

 

Chero zvingave zvakaita genetically yemunhu, inodzvanywa pane epigenetically. Saka rangarira, kana uchikwanisa kudzima kuzvimba muiyo microbiome, zvichireva kugadzira iyi inoshivirira uye yakasimba microbiome, unogona kuderedza kuzvimba kwemuviri wese. Uye kana iwe uchidzikisa izvo, zvakaratidzwa kuti inoseta insulin senitivity. Saka kudzika kwekuzvimba, kunowedzera insulin senitivity ine chekuita neiyo microbiome. Saka zvinoshamisa, zvakaratidzwa kuti probiotics inosanganiswa nekuvandudzwa kwe insulin senitivity. Saka maprobiotics akakodzera anozogadzira immune kushivirira. Microbiome simba uye modulation inoitika nemaprobiotics. Uye saka insulin senitivity inochengetedzwa kana kudzoserwa zvichienderana nekwauri. Saka ndokumbirawo ufunge kuti seimwe nzira isina kunanga kana nzira yekurapa yekurevesa cardiometabolic hutano kune varwere.

 

Probiotics

Dr. Alex Jimenez, DC, anopa: Saka kana zvasvika kune maprobiotics, isu tinoashandisa mune mumwe munhu angangovewo panguva imwe chete anotsamwisa bowel syndrome kana chikafu allergies. Tinogona kutora maprobiotics pamusoro peNF kappa B inhibitors kana vainewo insulin kuramba nyaya. Asi kana vaine matambudziko akawanda ekuziva, tinogona kutanga neNF kappa B. Saka, ndiyo nzira yaunokwanisa kusarudza kuti ndezvipi zvekusarudza. Zvino, rangarira, kana uchitaura nevarwere, zvakakosha kukurukura kuti madyiro avo ari kukonzera kuzvimba sei mumiviri yavo. Zvakakoshawo kuziva kuti haisi nyaya yemhando chete; ihurukuro yehuwandu uye hurukuro yekudzivirira zvirwere.

 

Izvi zvinokuyeuchidza kuti kana iwe ukagadzirisa ura nekuidyisa zvakanaka uye kuderedza inzwi rayo rinoputika, unowana humwe humwe hunobatsira hwekudzivirira; unomira kana kuti zvishoma kuderedza simba rekusashanda. Uye iwe unogona kuona izvo, pakupedzisira zvinogona kuderedza njodzi inowandira yekufutisa, chirwere cheshuga, uye metabolic syndrome. Isu tiri kuyedza kutyaira kumba kuti metabolic endotoxemia, kana kungo maneja iyo microbiome, chishandiso chine simba kubatsira yako insulin-inodzivirira kana cardiometabolic varwere. Yakawanda data inotiudza kuti isu hatigone kungoita hurukuro nezvekudya zvakanaka uye kurovedza muviri.

 

Zvakanyanya kupfuura izvozvo. Saka patinonyanya kuvandudza gut microbiota, tinogona kushandura masaini ekuzvimba kuburikidza nekudya kwakaringana, kurovedza muviri, kudzora kushushikana, kurara, zvimwe zvinhu zvese zvatave kutaura nezvazvo, nekugadzirisa matinji nemazino. Izvo zvishoma kuzvimba, kushomeka kwe insulin kusashanda uye, nekudaro, kushoma kwese kwese kwese kwese kwechirwere mhedzisiro. Saka izvo zvatinoda kuve nechokwadi kuti unoziva kuenda kudumbu uye kuve nechokwadi chekuti gut microbiome inofara uye inoshivirira. Ndiyo imwe yenzira dzakasimba dzekupesvedzera ane hutano cardiometabolic phenotype. Uye parutivi, kunyangwe chaive chinhu chikuru makore gumi apfuura, asiri-caloric artificial sweetener anoita sezvaanogona kunge asiri-caloric. Uye saka vanhu vanogona kunyengerwa kuti vafunge kuti zero shuga.

 

Asi heino dambudziko. Aya ekutapira ekugadzira anogona kukanganisa hutano hwemicrobiome nziyo uye kukurudzira mamwe marudzi maviri phenotypes. Saka, kunyangwe iwe uchifunga kuti uri kuwana bhenefiti pasina macalorie, uri kuzowedzera njodzi yako yechirwere cheshuga zvakanyanya kuburikidza nemhedzisiro yayo pagut microbiome. Zvakanaka, Takazviita kuburikidza nechinangwa chekutanga. Ndinovimba, iwe wakadzidza kuti insulin, kuzvimba, adipokines, uye zvimwe zvinhu zvese zvinoitika mukupindura kwe endocrine zvinobata nhengo dzakawanda. Saka ngatitangei kutarisa kune ari kubuda engozi mamaki. Zvakanaka, takataura zvishoma nezve TMAO. Zvakare, iyo ichiri pfungwa yakakodzera pano ine gut uye insulin kuramba. Saka isu tinoda kuve neshuwa kuti iwe unotarisa TMAO kwete semagumo ese ese asi semumwe ari kubuda biomarker anogona kukupa ruzivo nezve microbiome hutano mune zvese.

 

Kutsvaga The Inflammatory Markers

Dr. Alex Jimenez, DC, anopa: Tinotarisa TMAO yakakwirira kubatsira murwere kuziva kuti vakashandura kudya kwavo. Kazhinji yenguva, tinobatsira varwere kuderedza mapuroteni emhuka asina kunaka uye kuwedzera kudya kwavo kwezvirimwa. Zvinowanzoita kuti vangani vanachiremba vanoishandisa mune yakajairwa kurapwa. Zvakanaka, ikozvino imwe biomarker iri kubuda, zvakanaka, uye zvinonzwika zvinosetsa kuidaidza kuti iri kubuda nekuti inoita sezviri pachena, uye ndiyo insulin. Chiyero chedu chekutarisira chiri pakati peglucose, kutsanya glucose, kune yedu postprandial glucose A1C seyero yeglucose. Isu tiri glucose yakanyanya centric uye tinoda insulin seyakasimukira biomarker kana tikaedza kudzivirira uye kuita basa.

 

Uye sezvaunorangarira, takataura nezuro kuti insulin yekutsanya muzasi peyekutanga quartile yereferensi yako yekutsanya insulin ingave kwaunoda kuenda. Uye kwatiri isu muUS, izvo zvinoita kunge zviri pakati peshanu nenomwe seyuniti. Saka cherechedza kuti iyi ndiyo pathophysiology yemhando yechipiri chirwere cheshuga. Saka mhando mbiri yechirwere cheshuga inogona kuitika kubva kune insulin kuramba; inogonawo kuitika kubva kumatambudziko emitochondrial. Saka pathophysiology yerudzi rwechipiri chirwere cheshuga chinogona kunge chiri chekuti pancreas yako haisi kubudisa insulin yakakwana. Saka zvakare, ichi ndicho chiya chidiki che20% chatinotaura pamusoro peruzhinji rwevanhu vari kubatwa nechirwere cheshuga cherudzi rwechipiri; kunobva mukuramba insulin, sezvatingafungira, kubva mudambudziko re hyper insulin. Asi kune boka iri revanhu vakakuvadza mitochondria, uye havasi kuburitsa insulin.

 

Saka shuga yavo yemuropa inokwira, vobva vabatwa nechirwere cheshuga cherudzi rwechipiri. Zvakanaka, saka mubvunzo ndewokuti, kana paine dambudziko nepancreatic beta masero, nei paine dambudziko? Glucose iri kukwira here nekuti mhasuru dzine insulin inodzivirira, saka haikwanise kubata nekuunza glucose? Saka ndicho here chiropa chinoshingirira muropa ne insulin chisingagoni kutora glucose kuti chiwane simba? Sei glucose iyi ichitenderera muropa? Ndiko kuri kududzira uku. Saka kupa basa, unofanira kutarisa adipocytes; iwe unofanirwa kutarisa visceral adiposity. Iwe unofanirwa kuona kana munhu uyu achingori hombe dumbu mafuta ekuputika-senge catalyst. Chii chatingaita kuderedza izvozvo? Iko kuzvimba kunobva kune microbiome?

 

mhedziso

Dr. Alex Jimenez, DC, anopa: Kunyange itsvo inogona kuita basa mune izvi, handiti? Senge zvichida itsvo yakawedzera glucose reabsorption. Sei? Zvingave nekuda kwekushushikana kweiyo oxidative kuitsvo, kana kuti ingave iri muhPA axis, hypothalamus pituitary adrenal axis kwauri kuwana iyi cortisol mhinduro uye iyi inonzwira tsitsi sisitimu mhinduro iri kugadzira kuzvimba uye kutyaira iyo insulin yeropa uye kukanganiswa kweshuga yeropa? MuChikamu 2, tichataura pano nezvechiropa. Mutambi akajairika kuvanhu vazhinji, kunyangwe vasina fulminant fatty chiropa chirwere; kazhinji mutambi akapusa uye akajairika kune vanhu vane cardiometabolic dysfunction. Saka rangarira, isu tine visceral adiposity inokonzera kuzvimba uye insulin kuramba neatherogenesis, uye chiropa chakafanana neasina mhosva akamira akabatwa mumutambo. Zviri kuitika dzimwe nguva isati yatanga atherogenesis.

 

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