Kuongorora Thyroid Regenerative Therapy

Sezvo tsvagiridzo ichiwedzera mumushonga wekuvandudza ine mukana wekukwanisa kudzoreredza matishu ehuroyi, kurapwa kwekuvandudza kunogona kubvisa kudiwa kwevarwere kutora thyroid yekutsiva mahormone?

Thyroid Regenerative Therapy

Tariro huru yeregenerative therapy ndiko kugona kukura utano nhengo. Imwe yenhengo iri kutariswa iganda rethyroid. Chinangwa ndechekukudza zvakare thyroid tishu mu:

• Vanhu vaifanira kubviswa gland nekuda kwegomarara rethyroid.
• Vanhu vakazvarwa vasina gland rakakwana.

Sezvo kufambira mberi kwesainzi uye tsvakiridzo yakawedzera kubva murabhoritari uye kuyedza kwemhuka kuti iedze chubhu yevanhu thyroid cell zvidzidzo, kushandiswa kwe stem cell therapy nekuda kweichi chinangwa hakusati kwavepo, sezvo tsvakiridzo yakakura ichidiwa pakufunga kwevanhu.

Human Research

Tsvagiridzo yekushandiswa kweiyo thyroid regenerative therapy yechirwere chethyroid haina kuburitsa zvidzidzo umo stem cell therapy yakaedzwa muvarwere vethyroid.

• Zvidzidzo zvakaitwa zvakaitwa mumakonzo, uye chero zvakawanikwa patsvagurudzo iyi hazvigone kushandiswa kuvanhu. (HP Gaide Chevronnay, et al., 2016)
• Mune thyroid tishu mu test tube zvidzidzo, kukurudzirwa kwemasero kwakawanikwa nenzira yakasimudza mubvunzo wekuita shanduko dzekenza zvakanyanya kana yaizoedza muvanhu. (Davies TF, et al., 2011)

Zvidzidzo Zvichangopfuura

• Tsvagiridzo yazvino inosanganisira kufambira mberi mukati Embryonic stem cell - ESC uye induced pluripotent stem cell - iPSC. (Will Sewell, Reigh-Yi Lin. 2014)
• ESCs, inozivikanwawo sepluripotent stem masero, inogona kuwedzera chero rudzi rwesero mumuviri.
• Iwo anokohwewa kubva kuma embryo akagadzirwa, asi asina kuisirwa, panguva yeIVF maitiro.
• iPSCs masero e-pluripotent akagadzirwa achishandisa reprogramming process yemasero evanhu vakuru.

1. Follicular masero masero ethyroid anogadzira mahomoni ethyroid - T4 uye T3 uye akagadzirwa kubva kune embryonic stem masero emakonzo.
2. Muchidzidzo chakaburitswa mupepanhau reCell Stem Cell muna 2015, masero aya akakwanisa kukura uye akakwanisawo kutanga kugadzira mahormone ethyroid mukati memavhiki maviri. (Anita A. Kurmann, et al., 2015)
3. Mushure memavhiki masere, masero akaiswa mumakonzo aive asina thyroid gland aive neyakajairwa mahormone ethyroid.

New Thyroid Gland

• Vaongorori paMount Sinai Hospital vakapinza masero emudumbu emunhu mumasero ethyroid.
• Vakanga vachitarisa mukana wekugadzira mutsva-senge thyroid gland muvanhu vakavhiyiwa thyroid yavo.
• Vakataura mhedzisiro yavo pamusangano wepagore we84 weAmerican Thyroid Association. (R. Michael Tuttle, Fredric E. Wondisford. 2014)

Ramangwana rinotaridzika richivimbisa kugona kukudzazve thyroid tishu uye kubvisa thyroid inotsiva hormone. Nekudaro, kutsvagisa kwakawanda kunodiwa kuti izvi zvitongwe sezvinogoneka.

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Kupwanya iyo Yakaderera Thyroid Code Assessment Guide

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References

Gaide Chevronnay, HP, Janssens, V., Van Der Smissen, P., Rocca, CJ, Liao, XH, Refetoff, S., Pierreux, CE, Cherqui, S., & Courtoy, PJ (2016). Hematopoietic Stem Cells Transplantation Inogona Normalize Thyroid Basa mune Cystinosis Mouse Model. Endocrinology, 157 (4), 1363-1371. doi.org/10.1210/en.2015-1762

Davies, TF, Latif, R., Minsky, NC, & Ma, R. (2011). Kuongororwa kwekiriniki: Iyo inobuda cell biology yethyroid stem masero. Iyo Journal yekiriniki endocrinology uye metabolism, 96 (9), 2692-2702. doi.org/10.1210/jc.2011-1047

Sewell, W., & Lin, RY (2014). Chizvarwa chethyroid follicular masero kubva kune pluripotent stem masero: mukana wekugadzirisa mushonga. Miganho mu endocrinology, 5, 96. doi.org/10.3389/fendo.2014.00096

Kurmann, AA, Serra, M., Hawkins, F., Rankin, SA, Mori, M., Astapova, I., Ullas, S., Lin, S., Bilodeau, M., Rossant, J., Jean, JC, Ikonomou, L., Deterding, RR, Shannon, JM, Zorn, AM, Hollenberg, AN, & Kotton, DN (2015). Kuvandudzwa kweThyroid Function neTransplantation yeDifferentiated Pluripotent Stem Cells. Sero stem cell, 17(5), 527–542. doi.org/10.1016/j.stem.2015.09.004

Tuttle, RM, & Wondisford, FE (2014). Kugamuchirwa kumusangano wepagore wechi84 weAmerican Thyroid Association. Thyroid: chinyorwa chepamutemo cheAmerican Thyroid Association, 24 (10), 1439-1440. doi.org/10.1089/thy.2014.0429