Janus Kinase Inhibitors Ye Ankylosing Spondylitis Kurapa

Vanhu vamwe chete na ankylosing spondylitis Iva nesarudzo nyowani yekurapa iyo yaimboshandiswa kwerheumatoid arthritis. Uyu mushonga ndewekirasi inozivikanwa se JAK inhibitors. Ankylosing spondylitis inosanganisa marwadzo akabatana pamwe nekuderedza kufamba. Ankylosing spondylitis yakasiyana nekuti mune zvakakomba kesi, mapfupa ari mumuzongoza anogona kusangana pamwe chete, achinyatso kuderedza kufamba.   The chirwere chinowanzotanga nekurwadziwa uye kuomarara kumashure. Izvi zvinowanzoitika mushure menguva yekusaita basa. Zviratidzo zvinotanga pamberi pezera re45 uye zvinokura zvishoma nezvishoma. Iko hakuna mushonga we ankylosing spondylitis asi kune mishonga inogona kugadzirisa zviratidzo uye kuisa mamiriro acho mukuregererwa. Ankylosing spondylitis kurapwa ndiyo yakabudirira kwazvo painotaurwa nekukurumidza kusati kwadzoserwa kukuvara kwemajoini kunotanga.  

Janus Kinase Inhibitors

Janus kinase inhibitors akagara achishandiswa kurapa:

• Rheumatoid chearthritis
• Psoriatic arthritis
• Ulcerative colitis

Mushonga unoshanda nekuderedza chiitiko chemuviri. Janus kinase inhibitor zvinodhaka zvinokanganisa akawanda maseru macomputer akakosha mukusimudzira uye kufambira mberi kweankylosing spondylitis. Parizvino, kune matatu chete Janus kinase inhibitor mishonga inowanikwa muUnited States uye FDA-inogamuchirwa kurapa rheumatoid arthritis:

• Xeljanz
• Rinvoq
• Olumiant
• Imwe yeyakagamuchirwa inhibitors zvinangwa chaizvo enzymes

Ikozvino Ankylosing Spondylitis Mishonga

Janus kinase inhibitors haapihwe kune vanhu ipapo ipapo. Nekudaro, inogona kuve sarudzo kana yekutanga neyechipiri-mutsara marapirwo asiri kushanda. Mishonga inowanzo kuve ne:

Kutanga-Mutsara Kurapa

 

NSAIDs

Nonsteroidal anti-anogumbura mishonga ndiwo anonyanya kushandiswa kurapa ankylosing kuzvimba, kurwadziwa, uye kuomarara.

Chiropractic

Chiropractic kurapwa kwepanyama chikamu chikuru cheankylosing spondylitis kurapwa kuchengetedza musana kuchinjika uye sehutano sezvinobvira. A chiropractic / chaiko kurapa timu dhizaini uye nekuvandudza chaiwo masystem kukodzera munhu zvinodiwa, zvinosanganisira:

• Kutambanudza uye Range-ye-inofamba zviitwa zvinobatsira kuchengetedza kuchinjika mumajoini
• Kurara uye kufamba mamiriro ekugadzirisa maitiro
• Abdominal uye musana kurovedza kuchengetedza hutano hwakanaka
• Strength training

Yechipiri-Mutsetse Therapies

If nonsteroidal anti-immune mishonga usabvisa zviratidzo, ipapo mishonga yehupenyu inogona kupihwa. Iyi kirasi yemishonga inosanganisira:

• Tumor necrosis factor blockers
• Interleukin-17 inhibitors

Tumor Necrosis Chinhu

Tumor necrosis factor blockers inoshanda nekutarisa maseru protein ayo ari chikamu chemuviri, anozivikanwa se bundu necrosis alpha. Iyi protein inokonzeresa kuzvimba mumuviri, uye ma blocker anoidzvinyirira.  

Interleukin 17 Inhibitors

Interleukin 17 muma immune system anodzivirira kubva kuhutachiona. Inoshandisa mhinduro yekuzvimba kurwisa hutachiona. Iyo IL-17 inhibitors inodzvinyirira iyo yekuzvimba mhinduro uye inobatsira kudzikisa zviratidzo.  

Other Treatment Options

 

Mararamiro Ekugadzirisa

Kuteedzera chirongwa chekurapwa kunowanzo sanganiswa ne kudya uye mararamiro ekugadzirisa izvo zvinokurudzirwa kubatsira nemamiriro acho, izvi zvinosanganisira:

• Kuve sekushanda panyama sezvazvinogona kubatsira:

1. Kuvandudza / kuchengetedza hutano hwakanaka
2. Ramba uchichinja-chinja
3. Deredza marwadzo

• Kuisa kupisa nechando kunobatsira kurerutsa:

1. Pain
2. Kushushikana
3. Kuzvimba

• Kudzidzira mamiriro ekurovedza muviri

Surgery

Vazhinji vanhu vane ankylosing spondylitis havadi kuvhiyiwa. Nekudaro, chiremba anogona kukurudzira kuvhiyiwa kana kuriko kubatana kwekukuvara, hudyu-yakabatana inoda kuchinjwa, kana kana kurwadziwa kwacho kwakanyanya.  

Inhibitor Potential

Zvidzidzo zviri kuenderera mberi mukurapa ankylosing spondylitis. Mushonga uyu parizvino uri muPhase 3 miedzo yekurapa kwevakuru. Mhedzisiro yekuedzwa yakaratidza varwere vane anoshanda ankylosing spondylitis yakaratidza kuvandudza mu:

• Kuneta
• Kupisa
• Kutambudzika shure

Chidzidzo ichi chakanyoresa vanhu vakuru vane ankylosing spondylitis inoshanda avo vakatora angangoita maNSAID maviri aive asingabatsiri pakurapa zviratidzo. Vazhinji vevatori vechikamu vaive varume, avhareji zera re41, uye hapana kumbobvira kushandiswa kweiyo biologic chirwere-kugadzirisa antirheumatic zvinodhaka.

Janus kinase anogona kuve akajairwa kurapwa

Pachine kukwana kwakaringana kutsvagisa kwekufungidzira, asi iyo data iri kuvimbisa. Iyo inhibitors inoita senge yakachengeteka sarudzo kana ikashandiswa mune yakanyatsoongororwa, yakanyatsoenderana mamiriro ayo anosanganisira kugara uchiona. Iyo inhibitors inoita kunge inoshanda uye ine zvakanakira kutorwa nemuromo uye kushanda nekukurumidza.

---

Mutumbi Muumbi

---

 

Osteoarthritis uye kurasikirwa uremu

Kunyanya kufutisa kwakaratidza kuve chinhu chine njodzi huru mukusimudzira kwe chemajoini. Izvi hazvingori chete kubva pamhedzisiro yekuwedzera huremu pamajoini emuviri asi zvakare semhedzisiro yekuzvimba mhedzisiro yeadipose tishu. Musana wezasi, chiuno, nemabvi, zvinotakura huwandu hwehuremu hwomuviri. Yakawandisa huwandu hweadipose tishu pane yepakati yemuviri uye makumbo yakaratidzirwa kukanganisa zvakashata iyo majoini ane huremu. Kukurudzira Lean Muviri Misa uye kukurudzira kuonda kunodzora njodzi yeosteoarthritis uye kunatsiridza hupenyu hwemunhu. Kurovedza muviri kunoonekwa sekuchengetedzeka kune vanhu vane osteoarthritis uye inofanirwa kuverengerwa mukuvandudza kugadzirwa kwemuviri, kuderedza Muviri Mafuta Misa, kunatsiridza Lean Muviri Misa uye chengetedza huremu hune hutano.  

Dr. Alex Jimenez's Blog Post Disiki

Chiyero cheruzivo rwedu chinogumira kuchiropractic, musculoskeletal, mishonga yemuviri, hutano, uye zvine hutano nyaya dzehutano uye / kana anoshanda mushonga zvinyorwa, misoro, uye hurukuro. Isu tinoshandisa zvinoshanda zvehutano & hutano zvirongwa kuti tibate uye titsigire kuchengetedza kwekukuvara kana kusagadzikana kweiyo musculoskeletal system. Zvatinotumira, misoro, zvidzidzo, uye ruzivo rwunovhara nyaya dzemakiriniki, nyaya, uye misoro inoenderana uye inotsigira zvakanangana kana zvisina kunangana kwedu kweclinic maitiro. * Hofisi yedu yakaedza zvine mutsigo kupa tsigiro uye yakaratidza yakaringana research yekutsvagisa kana zvidzidzo zvinotsigira zvatatumira. Isu tinoitawo makopi ekutsigira ekutsvagisa zvidzidzo zviwanikwe kubhodhi uye kana kuruzhinji pakukumbira Isu tinonzwisisa kuti tinofukidza zvinhu zvinoda imwe tsananguro yekuti ingabatsire sei mune imwe chirongwa chekutarisira kana yekurapa protocol; Naizvozvo, kuti uenderere mberi nekukurukura nyaya iri pamusoro, ndapota inzwa wakasununguka kubvunza Dr.Alex Jimenez kana kutibata nesu pa915-850-0900. Mupiki (s) Anobvumidzwa muTexas & New Mexico *  

References

Hammitzsch A, Lorenz G, Moog P. Mhedzisiro yaJanus Kinase Inhibition pakurapa kweAxial Spondyloarthropathies. Miganhu mune Immunology 11: 2488, Gumiguru 2020; doi 10.3389 / fimmu.2020.591176. www.frontiersin.org/article/10.3389/fimmu.2020.591176, yakasvika pana Jan 21, 2021. van der Heijde D, Baraliakos X, Gensler LS, et al. Kubudirira uye chengetedzo ye filgotinib, inosarudzwa Janus kinase 1 inhibitor, mune varwere vane anoshanda ankylosing spondylitis (TORTUGA): mhedzisiro kubva kune yakasarudzika, inochengetedzwa ne placebo, chikamu chechipiri kutongwa.Lancet.Dec2018 Dec 1; 392 (10162): 2378-2387. doi: 10.1016 / S0140-6736 (18) 32463-2. Epub 2018 Gumiguru 22. PMID: 30360970pubmed.ncbi.nlm.nih.gov/30360970/Yakagamuchirwa Jan 19, 2021.