Neuropathic Pain Uye Neurogenic Inflammation | El Paso, TX.

Kana iyo sensory system ikakanganiswa nekukuvara kana chirwere, tsinga dziri muchirongwa icho hadzigone kushanda mukufambisa kwekunzwa kuhuropi. Izvi zvinogona kutungamira mukunzwa kwehusimbe, kana kushaya kwekunzwa. Mune zvimwe zviitiko kana sisitimu yekukuvara ikakuvara, vanhu vanogona kurwadziwa munzvimbo dzakabatwa. Kurwadziwa kweNeuropathic hakutange nekukurumidza kana kupera nekukurumidza. Husingaperi mamiriro anotungamira kunezviratidzo zve kurwadziwa kunoramba kuripo. Kune vakawanda, kukwirira kwezviratidzo kunogona kuuya nekufamba zuva rose. Hurwa neuropathic inofungidzirwa kuti inobatanidzwa nehutachiona hwehutano hwezvinetso, kureva chirwere chinokonzerwa nechirwere cheshuga, spinal stenosis, kukuvara kwouropi kana musana wemagunha kunogonawo kutungamirira mukurwadziwa kusingaperi kweurouropathic.

NEUROPATHIC PAIN

Zvinangwa:

• Chii ichochi?
• Chii chinonzi pathophysiology shure kwayo?
• Ndezvipi zvinokonzera
• Ndeipi dzimwe nzira dzenzira
• Tingarigadzirisa sei?

NEUROPATHIC PAIN

• Urombo hwakatangwa kana hunokonzerwa nechirwere chepakutanga kana kusakosha mukati mehutano hwemanyore.
• Nhamo yeurouropathic inowanzosingaperi, yakaoma kurapa uye kazhinji isinganzwisisiki nemaitiro akafanana ekugadzirisa.

PATHOGENESIS WEMUNYARA WEMUNYANYA

• MASHOKO ANOKUDZIDZA
• Mushure mokunge mutsara wechirwere chendangariro, neuroni dzinonyanya kunzwisisika uye dzichiwedzera kusagadzikana kusinganzwisisiki uye kukudzwa kwepamusoro pakukurudzira
• Izvi zvinozivikanwa se ... Peripheral Sensitization!

• CENTRAL MECHANISMS
• Sezvo mugumisiro wekuita unongoramba uripo unobuda mumharaunda, neurons inokura kuwedzera kwekuita basa, kuwedzerwa minda yekugamuchira uye kuwedzerwa mhinduro kune mafungiro akasiyana, kusanganisira zvinowanzoitika zvinokanganisa tactile
• Izvi zvinozivikanwa se ...Central Sensitization!

ZVINOKOSHA

Zvipembenene kana zvirwere zvemutokisi wenheatensoryory zvinogona kutungamirira kukutapurirwa uye kusagadzikana kwekutenderera kwemashoko anonzwika mumutsipa wepelinha uye uropi; Mamiriro ezvinhu akajairika anowanikwa nekutambudzika kweuropathy anosanganisira:

• Postherpetic neuralgia
• Trigeminal neuralgia
• Painful radiculopathy
• Diabetes neuropathy
• HIV utachiona
• Maperembudzi
• Amputation
• Utachiona hwehutachiona hwekurwadza kwehutano
• Stroke (mumamiriro ekumanikidzwa mushure mekurwadza)

PHANTOM LIMB MARWADZO & YAKATSAMUKWA CHOKWADI

• Phantom Limb Pain uye AR

NEUROGENIC INFLAMMATION

Zvinangwa:

• Chii ichochi?
• Chii chinonzi pathophysiology shure kwayo?
• Ndezvipi zvinokonzera
• Tingarigadzirisa sei?

NEUROGENIC INFLAMMATION

• Neurogenic kuvhiringidzika inoratidzika kudiwa, inzvimbo yekuvhiringidzika inowanzoonekwa nevasodilation, yakawedzera vascular permeability, mast cell degranulation, uye kusunungurwa kweeuropeptides kusanganisira SP uye calcitonin peptide yakabatana-peptide (CGRP)
• Inoratidzika kuti inotora basa rinokosha mumapathogenesis ezvirwere zvakawanda kusanganisira migraine, psoriasis, asthma, fibromyalgia, eczema, rosacea, dystonia uye multiple chemical sensitivity

ZVINOKOSHA

• Ikoko kune nzira dzakawanda dzinoshandiswa neurogenic kuvhuvhuta. Inonyatsorongedzerwa, kushandiswa kwemhuka mbiri uye maitiro ega ega inorro in vitro, iyo capsaicin, kupisa, proton, bradykinin, uye tryptase zviri kumativi ekuronga we intracellular calcium influx, izvo zvinoguma nekuputira neuropeptide kusunungurwa. Kusiyana neizvi, zvinofungidzirwa kuti prostaglandin E2 uye I2, cytokines, interleukin-1, interleukin-6, uye tumor necrosis chinokonzera hazviiti kuti neurotransmitter isunungurwe ivo pachavo, asi kunakidza zvinoratidzira neurons uye nokudaro kuderedza chikumbaridzo chekuuraya uye kubvisa kusunungurwa kwakanyanya neuropeptides.
• Nepo chirwere chekushaya ropa chinenge chakanyatsodzidza uye chakanyatsorongedzerwa mumakumbo emakungwa, kusvikira munguva pfupi pfungwa yekutsamwa kweurostenic mukati meCSS yakaramba isina kunyanya kushandiswa. Zvichipiwa simba rekuvhiringidza neurogenic kuchinja maitiro ezvinyorwa uye kunotungamirira kumagenisi e edema, iko zvino yakave yakafuridzirwa zvakanyanya nokuda kwekugona kwayo kukanganisa BBB kukwanisa uye vasogenic edema mukati meuropi nemutsipa wesipinha pasi pemamiriro ezvinhu akasiyana-siyana.

Anatomy Of The Brain